Clinical trials are starting for a new Ebola vaccine developed by the University of Oxford, designed to tackle the two strains responsible for nearly all outbreaks and deaths worldwide.
The university has launched a Phase I trial to test the vaccine in human volunteers, with the first jabs taking place today.
The study is currently recruiting for further volunteers.
There are four species of the Ebola virus which are known to cause disease in humans.
The new vaccine is designed to tackle the Zaire and Sudan strains, of which Zaire is the most lethal form – causing death in 70% to 90% of cases if left untreated.
Advertisement
Zaire is also responsible for most outbreaks, including the 2014-16 West Africa outbreak, and the 2018 outbreak in eastern Democratic Republic of Congo, which resulted in more than 32,000 people infected and more than 13,600 deaths.
Other Ebola vaccines do exist based on the Zaire species, but Oxford researchers hope the new jab will have a wider reach.
More on Ebola
Related Topics:
In these new clinical trials, 26 people aged between 18 and 55 will receive one dose of the ChAdOx1 biEBOV Ebola vaccine at the University of Oxford.
Please use Chrome browser for a more accessible video player
3:56
2019: Deadly Ebola outbreak in DR Congo ‘now a global emergency’
They will then be monitored over the course of six months, with results expected in the second quarter of 2022.
The vaccine is based on a weakened version of a common cold virus that has been genetically modified so it cannot replicate in humans.
Teresa Lambe, associate professor at the Jenner Institute and lead scientific investigator at the University of Oxford, said: “Sporadic Ebolavirus outbreaks still occur in affected countries, putting the lives of individuals – especially frontline health workers – at risk.
“We need more vaccines to tackle this devastating disease.”
Dr Daniel Jenkin, principal investigator of the trial at the Jenner Institute, added: “Recent advances have led to the approval of vaccines against one of the viruses that causes Ebola virus disease.
Please use Chrome browser for a more accessible video player
3:56
2019: Deadly Ebola outbreak in DR Congo ‘now a global emergency’
“However, this disease can be caused by several different species of virus and each of these may require a targeted immune response to offer protection.
“We have designed our new vaccine to target the two species of virus that have caused nearly all Ebolavirus outbreaks and deaths, and now look forward to testing this in Phase I clinical trials.”
The drive into the village of Jiljiliya is not what you expect on the West Bank. Imposing mansions line the route, with grand gates and lavish decorations.
That’s because this is where Palestinian Americans return to build their dream homes after years of hard work in the land of opportunity.
Like Omar Assad who came back after 45 years in Milwaukee. But for him, retirement was neither long nor happy. It was cut brutally short one freezing night in January 2022.
He was returning from a game of cards when he was stopped at a makeshift checkpoint set up by the notorious Israeli army unit, Netzah Yehuda.
The IDF says he did not cooperate so the 78-year-old was detained with force.
Mraweh Mahmoud was with him.
“They took us down from the car and pushed me by the head,” he told Sky News. “The soldier was standing there and put an M16 in my head and said now I’ll shoot you.”
Mr Assad was tied up, gagged and blindfolded, Mr Mahmoud said, and forced to lie next to him. When the soldiers eventually left Mr Mahmoud realised Mr Assad was dead.
Advertisement
“I took his jacket off his head, I checked there’s no pulse, I shouted Omar, Omar,” he said.
Palestinian doctors say Mr Assad died in freezing temperatures of a stress-induced heart attack. An Israeli military report condemned the soldiers’ “moral failure and poor decision-making”.
No link between death and soldiers’ errors, military prosecutors say
Netzah Yehuda’s battalion commander was reprimanded and two officers were dismissed but Israeli military prosecutors decided against pursuing criminal charges because they said there was no link between the errors made by soldiers and Mr Assad’s death.
But now the unit the soldiers came from is expected to be singled out by the US government and cut off from American funding, in the first-ever such move against any part of the Israeli military.
Reports claim the US State Department will apply the so-called Leahy Law against the unit, which prohibits US assistance to foreign military units guilty of gross human rights violations when their government fails to take sufficient action.
Why has Netzah Yehuda become infamous?
The Netzah Yehuda battalion was set up to help ultra-orthodox Jews serve in the army. It mixes religion and soldiering. But in its ranks are also elements of extremist settler groups.
It has become infamous, implicated in one case of alleged abuse of Palestinians after another, many of which its soldiers have filmed on their own phones. Its soldiers have been prosecuted for human rights violations and accused of unlawful killings, electrocution, torture and sexual assault.
Israel’s government has fought a rearguard action against the looming US action.
Its prime minister called the prospect absurd and its defence minister Yoav Galant showed solidarity with the battalion’s soldiers this week saying “no one in the world can teach us about morals and values”.
But one organisation of ex-soldiers opposed to Israel’s occupation of Palestinian territories says the Israeli government knows this could be just the beginning of action against its military.
‘They’re terrified of the possible results’
Ori Givati from the NGO Breaking the Silence told Sky News: “They understand that this might open the Pandora’s box of what the occupation really is, and how it looks like to occupy millions with the military.
“And if that Pandora’s box will be opened and it is starting to open in recent months, I think they’re terrified of the possible results because they want to continue to occupy.”
Back in Jilijilya, Mr Assad’s family welcomes reports America will act against the soldiers they blame for his death but say that’s not enough – they want them brought to justice too.
Nazmia, Mr Assad’s widow, said: “God willing it will be good if they do this, but also punish them like what they did with him, arrest them and fire them from their positions.”
The parents of an Israeli hostage have told him “we love you, stay strong, survive” after he appeared with part of his arm missing in a video released by Hamas.
Hersh Goldberg-Polin was kidnapped at the Nova musical festival when Hamas attacked Israel on 7 October.
The video shows him with his lower left arm missing; witnesses said it was blown off when he helped throw grenades out of a shelter where people were hiding.
He reportedly used his shirt as a tourniquet to stem the bleeding, but was captured.
Clearly under duress in the undated video, the 23-year-old criticises Prime Minister Benjamin Netanyahu and his government, saying they should be “ashamed” for not securing the hostages’ release.
He also claims Israeli bombings have killed “about 70 detainees like me” and that the rest are living in an “underground hell without water, food, or sun”.
Mr Goldberg-Polin, who wears a red shirt and sits against a plain white wall, finishes with an appeal to his parents, telling them “stay strong” and “I love you so much, and miss you so much”.
His parents responded to Wednesday’s video by filming their own emotional response.
Follow Sky News on WhatsApp
Keep up with all the latest news from the UK and around the world by following Sky News
Jon Polin says hearing his son for the first time in more than 200 days is “overwhelming”.
“We are relieved to see him alive but we are also concerned about his health and wellbeing as well as that of all the other hostages, and all of those suffering in this region,” he says.
Mr Polin calls for the countries involved in negotiations to “be brave, lean in, seize this moment and get a deal done to reunite all of us with our loved ones and end the suffering in this region”.
His mother, Rachel Goldberg-Polin, stares resolutely into the camera and tells him: “Hersh, if you can hear his, we heard your voice today for the first time in 201 days… I am telling you – we are telling you – we love you, stay strong, survive.”
The 23-year-old was born in California but moved to Jerusalem with his family when he was younger.
He was among about 250 Israelis and foreigners kidnapped in the initial Hamas attack, which also killed around 1,200 people.
Please use Chrome browser for a more accessible video player
1:00
Baby saved from womb of dying mother
Israel’s aim to wipe out Hamas has so far killed more than 34,000 people in Gaza, according to the Hamas-run health authority.
Hundreds of thousands are also said to be on the brink of starvation and have been forced to flee the violence.
Fears are growing that a ground assault on the southern city of Rafah – where more than a million people are sheltering – is imminent after Mr Netanyahu said Israel was “moving ahead” with its plans.
“Because it’s built to withstand both biological and chemical attacks,” Dr Yehezkel Caine told Sky News as we entered the complex, “we have an airlock which is built of two separate sets of blast doors”.
Beyond they have installed a whole new level of wards below the existing underground hospital, ripping out a logistics floor and installing more beds and equipment.
The bunkers would be activated should other hospitals closer to the front need evacuating.
More on Israel
Related Topics:
They are planning for worst-case scenarios here like an all-out war with Hezbollah.
“The hospitals in the north will be overwhelmed with casualties and they themselves will come under fire, in which case they would have to evacuate their patients to the centre of the country, the same as we did in the first weeks of the war in the south,” said Dr Caine.
He and his staff know the 7 October attack last year by Hamas and Iran‘s missile and drone barrage earlier this month have changed everything for the people of Israel.
“For the civilian population since the war of independence we’ve never been in a situation where the threat to the civilian population has been as great,” he said.
Above ground, the Herzog Medical Centre continues with its peacetime specialisms.
It has Israel’s largest ventilator unit, treating adults and children, but also excels in psycho-trauma treatment and geriatric rehabilitation.
Many of those suffering PTSD from the trauma in this conflict are treated here.