Since then he had been in critical condition, in a coma and in intensive care.
‘Messages of support and love’
He never regained consciousness, Mr Lago said, adding that he had died in his sleep with his brother Paul and twin boys Jayden and Jagger, 17, at his side.
Mr Lago said: “The Sizemore family has been comforted by the hundreds of messages of support and love shown to their son, brother and father.
“They are asking for privacy during this difficult time and I am asking for those wishes to please be respected.”
There will be a private cremation service for the family with a larger “celebration of life event” planned in a few weeks, Mr Lago said.
A ‘spoiled movie star’ and an ‘arrogant fool’
Sizemore became a star in the films Natural Born Killers and Heat, before going on to blockbusters such as Saving Private Ryan and Black Hawk Down.
But he struggled with addiction during his acting career, having been arrested a number of times for driving under the influence and drug possession.
He was arrested a number of times for domestic violence, including against his girlfriend Heidi Fleiss for which he was convicted. He was also the subject of two workplace sexual harassment lawsuits related to the 2002 CBS show Robbery Homicide Division.
He wrote in a 2013 memoir that success had turned him into a “spoiled movie star”, an “arrogant fool” and “a hope-to-die addict”.
He also wrote: “I’ve led an interesting life, but I can’t tell you what I’d give to be the guy you didn’t know anything about.”