Holmes, had been on bail, living in the San Diego area.
She was put under investigation in 2017 for the collapse of Theranos, a start-up she founded after dropping out of Stanford University when she was just 19.
Holmes became a Silicon Valley sensation when she promised that Theranos would revolutionise health care, thanks to a technology that could quickly scan for diseases and other problems with a few drops of blood taken with a finger prick.
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Forbes dubbed Holmes the world’s youngest female self-made billionaire in 2014, when she was 30 and her stake in Theranos was worth $4.5bn.
Theranos raised nearly $1bn from investors, but it all blew up after The Wall Street Journal published a series of articles exposing serious flaws in Theranos’ technology.
While she was building up Theranos, Holmes grew closer to Ramesh, ‘Sunny’ Balwani, who would become her romantic partner as well as an investor and fellow executive in the Palo Alto, California, company.
Holmes and Balwani, who had been secretly living together while running Theranos, broke up after the Journal’s revelations and the company collapsed.
In 2018, the US Justice Department charged both with a litany of white-collar crimes in a case aimed at putting a stop to the Silicon Valley practice of overselling the capabilities of a still-developing technology – a technique that became known as “fake it ’til you make it”.
Holmes admitted making mistakes at Theranos, but steadfastly denied committing crimes during seven days on the witness stand during her trial.
As she begins her sentence, Holmes leaves behind two young children – a son born in July 2021 a few weeks before the start of her trial and a three-month-old daughter.
Holmes met the children’s father, William ‘Billy’ Evans, in 2017 around the same time she was under investigation for the collapse of Theranos.