The reigning National League MVP led off the game with a double to right-center field off Martin Perez. With Marcell Ozuna at the plate, Acuna started toward third on a stolen base attempt and his left knee appeared to buckle. He remained down for several minutes while being treated, pointing at his left leg before walking off under his own power.
Acuna, a 26-year-old outfielder, is batting .250 with four home runs and 15 RBIs in 49 games. The four-time All-Star hit a career-best .337 last season with 41 homers and 106 RBIs.
Adam Duvall shifted from left to right in the bottom half, and Jarred Kelenic entered the game in place of Acuna and played left.
