Helene has made landfall in northwestern Florida as a Category 4 hurricane, with forecasters warning of a “catastrophic” storm surge.
The National Hurricane Centre in Miami said Helene struck near the mouth of the Aucilla River in the Big Bend area of Florida’s Gulf Coast at around 11.10pm local time.
High winds, possibly in excess of 140mph (225kph), and flash floods are possible, the weather service said.
Florida Governor Ron DeSantis told reporters one person had died while driving on a motorway when a sign fell on to their car.
“When Floridians wake up tomorrow morning, we’re going to be waking up to a state where, very likely, there’s been additional loss of life. And certainly, there’s going to be loss of property,” Mr DeSantis said.
“You’re going to have people that are going to lose their homes because of this storm. So please keep those folks in mind, keep them in your prayers.”
Two other people are reported to have been killed in a possible tornado in neighbouring south Georgia as the storm approached, the Associated Press reported.
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More than one million homes and businesses were already without power shortly after the hurricane made landfall, according to tracking website poweroutage.
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States of emergency have been declared in Florida, Georgia, and the Carolinas, with hurricane and flash flood warnings in place as far away as south-central Georgia.
Officials pleaded with residents in the path of the storm to heed mandatory evacuation orders or face life-threatening conditions.
The surge caused by the hurricane – the wall of seawater pushed on land by hurricane-force winds – could rise as high as 20ft (6.1m) in some spots, as tall as a two-storey house, Michael Brennan, director of the hurricane centre, said in a video briefing.
“A really unsurvivable scenario is going to play out” in the coastal area, Mr Brennan said, with water capable of destroying buildings and carrying cars pushing inland. Millions of people are under the current flood watch.
Forecasters warned the storm surge could be particularly “catastrophic and unsurvivable” in Apalachee Bay.
‘It’s going to cause a lot of damage’
Residents in the city of Tallahassee told Sky’s US partner NBC News that they stocked up on sandbags, food and supplies, before leaving their homes.
The city’s mayor John Dailey urged people to take the evacuation warnings “extremely seriously”, calling Helene “the biggest storm in the history of the city to hit us head-on”.
Speaking to NBC News on Wednesday, Mr Dailey said though they are “very prepared”, he was also “very nervous, and I hope everyone is nervous”.
He added: “This is a big storm. It is going to cause a lot of damage.”
Jared Miller, sheriff of Wakulla County, went further – calling the storm “not a survivable event for those in coastal or low-lying areas”.
The county has issued a mandatory evacuation order, but one resident, Christine Nazworth from Crawfordville, which is located about 25 miles (40km) from Apalachee Bay, said her family would be sheltering in place.
She said: “I’m prayed up. Lord have mercy on us. And everybody else that might be in its path.”
Leslie Powell, from Quincy, a city a similar distance from Tallahassee, told NBC she was leaving her mobile home to go to a shelter with her eight-month-old baby and six-year-old daughter.
She said simply: “I’m scared. I’ve got a lot of trees around my home, so it’s not safe for me and my kids.”
Helene is expected to remain a full-fledged hurricane as it rolls through the Macon, Georgia, area on Friday, forecasters said.