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In a first for India, Chimeric Antigen Receptor T-cell (CAR-T) therapy, a type of gene therapy for blood cancer treatment, was successfully conducted last Friday at the Bone Marrow Transplant unit at the Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Hostpital in Mumbai in collaboration with IIT Bombay. The Central government has now allocated Rs 19.15 crore to conduct first-in-human phase-I/ II clinical trials of the CAR-T cells, the Department of Biotechnology (DBT), part of the Ministry of Science and Technology, said on Thursday. The CAR-T therapy has emerged as a breakthrough in cancer treatment, and clinical trials across the globe have shown promising results in end-stage patients, particularly the ones suffering from acute lymphocytic leukemia.

Despite a proven therapeutic potential for cancer patients, this gene therapy is still not available in India. A patient’s CAR-T cell therapy costs Rs. 3-4 crore and, therefore, the challenge lies in not just developing the technology at scale but also bring the cost down. And last Friday’s success may just be the first step in that direction. The CAR-T cells were designed and manufactured at IIT Bombay’s Bioscience and Bioengineering (BSBE) department.

Subhasis Chaudhuri, the director of IIT Bombay, said: “Our scientists along with Tata Memorial Hospital have come out with the most sophisticated therapy in cancer treatment. If the trials are successful, it may save millions of lives by making the treatment available in India at an affordable cost.”

The clinical trials for the “first in India” gene therapy are being conducted by Dr. (Surg Cdr) Gaurav Narula, Professor of Paediatric Oncology and Health Sciences, and his team from TMC, Mumbai. The novel CAR-T cells that will act as drugs were manufactured by Professor Rahul Purwar, Bioscience and Bioengineering (BSBE) department, and his team at IIT Bombay. The design, development, and extensive pre-clinical testing were carried out by IIT-B as a collaborative project with Tata Memorial Center, Mumbai by the two investigators, DBT said via a press release.

The work is partly supported by Biotechnology Industry Research Assistance Council (BIRAC). The National Biopharma Mission, under DBT-BIRAC, is also supporting the TMC-IIT Bombay in the Phase I/II trial of their CAR-T product.

Besides this, the National Biopharma Mission is also supporting the development of a Lentiviral vector manufacturing facility for packaging plasmids used to transfer the modified T cell inside the body, a cGMP facility for T-cell transduction, and the expansion for CAR T-cell manufacturing to two other organisations.


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NASA’s X-59 Moves Closer to First Flight with Advanced Taxi Tests and Augmented Vision

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NASA’s X-59 Moves Closer to First Flight with Advanced Taxi Tests and Augmented Vision

X-59 of NASA has been designed from the ground to fly at a faster speed of sound without making thunderous sonic booms, which are usually associated with supersonic flight. This 99-foot aircraft, which features a logically elongated design, jettisons the front windscreen and is now heading towards the runway. Pilots can see what is at the front through an augmented reality (AR) enabled closed-circuit camera system, which is termed by NASA as the External Vision System (XVS). NASA took control of an experimental aircraft and performed taxi tests on it during this month.

X-59’s Futuristic Design: Eliminating Sonic Booms with External Vision System

According to As per NASA, the test pilot Nils Larson, during the test, drove the X-59 at the runway by keeping a low speed. This is done to ensure the working of the steering and braking systems of the jet. Lockheed Martina and NASA would perform the taxi tests at high speed, in which the X-59 will move faster to make it to the speed at which it will go for takeoff.

Taxi tests are held at the U.S. Air Force’s Plant 42 facility in Palmdale, California. The contractors and the Air Force utilise the plant for manufacturing and testing the aircraft. Lockheed Martin has developed this aircraft, whose Skunk Works is found in Plant 42.

Taxi Tests at Plant 42: NASA and Lockheed Martin Prepare X-59 for First Flight

Some advanced aircraft of the U.S. military were developed to a certain extent at Plant 42, together with the B-2 Spirit, the F-22 Raptor, and the uncrewed RQ-170 Sentinel spy drone.

SOFIA airborne observatory aircraft, which is a flying telescope called Plant 42, home recently retired. The space shuttle of the agency is the world’s first reusable spacecraft; these were assembled and tested at the facility.

Such taxi tests have started over the last months. NASA worked in collaboration with the Japan Aerospace Exploration Agency for testing a scale model of the X-59 in the supersonic wind tunnel to measure the noise created under the aircraft.

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Unusual Plasma Waves Above Jupiter’s North Pole Can Possibly Be Explained

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Unusual Plasma Waves Above Jupiter’s North Pole Can Possibly Be Explained

In recent observations, NASA’s Juno spacecraft has significantly detected the presence of a variety of plasma waves. The emergence of these waves on Jupiter’s powerful magnetic field is projected to be surprising, as their existence was never marked in the planetary magnetospheres. However, scientists might have come out with an explanation. Furthermore, the current studies have been questioned by scientists surfacing the activity at the North Pole. The article below will exemplify the findings and shed light on the plasmas. 

Uncovering Mystery at Jupiter’s North Pole 

According to a paper published in the Physical Review Letters, the scientists have uncovered the explanation behind the presence of these strange waves. They mainly suspect that the formation of these waves lies behind their evolution as a plasma, which later transforms into something different. 

Inside Jupiter’s Plasmas and Their Variants 

Plasmas are best referred to as the waves that pass through the amalgamation of the charged particles in the planet’s magnetosphere.These plasma waves come across in two forms: One, Langmuir waves, which are high-pitched lights crafted with electrons, while the other, Alfven waves, are slower, formed by ions (heavy particles). 

About Juno’s Findings

As unveiled by the Juno, the findings turned out to be questionable after the scientists noted that in Jupiter’s far northern region, the plasma waves were relatively slower. The magnetic field is about 40 times stronger than the Earth’s, but scientists were shocked to witness the results as the waves were slower. To analyse this further, a team from the University of Minnesota, led by Robert Lysak, identified the possibility of Alfven waves transforming into Langmuir waves. Post studying the data extracted from the Juno, the researchers then began to compare the relationship between the plasma wave frequency and number. 

According to Lysak’s research team, near Jupiter’s north pole, there might be a potential pathway of Alfven waves, which are massive in numbers, transforming into Langmuir waves. Scientists are also predicting that the reason behind evolution might be strong electrons that are shooting upwards at a very high energy. This discovery was made in the year 2016. Considering the current findings, the researchers indicate that Jupiter’s magnetosphere may comprise a new type of plasma wave mode that occurs during high magnetic field strength. 

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Russia Expands Space Weather Network, Launches Iran’s Nahid-2 in Joint Mission

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Russia Expands Space Weather Network, Launches Iran’s Nahid-2 in Joint Mission

Russia sent two new Ionosfera-M satellites into orbit on a Soyuz-2 on July 25, 2025. Rocket 1b from the Vostochny Cosmodrome in Siberia. The mission also placed Iran’s Nahid-2 communications satellite in orbit. These satellites will complement a four-satellite constellation aimed at keeping track of Earth’s upper atmosphere and space weather conditions, particularly the solar wind that can knock satellites and communications systems offline. The flight indicates Russia’s scientific ambitions and collaboration with Iran’s space program, showing Russia’s function in launching Tehran’s orbital assets. Both countries gain from the collaborative mission.

Russian Space Weather Satellites

According to official sources, Russia’s new Ionosfera-M probes, 3 and 4, follow two identical satellites launched in November 2024. Together the four craft form a mini-constellation orbiting about 820 kilometers above Earth. The network is explicitly designed to study space weather in the ionosphere, the charged upper atmosphere.

It will track solar wind and related phenomena that can disturb communications and navigation systems. The latest pair is being inserted into an orbital plane perpendicular to the first two, greatly expanding three-dimensional coverage of near-Earth space. They also carry a new Ozonometr-TM instrument to measure upper-atmosphere ozone for the first time in this mission.

Iranian Payload and International Implications

An Iranian communications satellite, Nahid-2, was also aboard the Soyuz mission.Nahid-2 is intended to bolster Iran’s civilian communications in space, an important capability given Iran’s limited homegrown launch capabilities. Russia’s role in the delivery of the payload reflects cooperation between the countries in space technology.

With the help of Russia, Iran can continue its satellite building efforts, even though these are restricted by the international community from also involving rocket export limitations. That Moscow has such a product even while Iran is under sanctions underscores the depth of their two-nation space partnership. This mission represents Russia’s support for ally’s space aspirations and the broader geopolitical implications of such collaborative efforts.

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