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In a first for India, Chimeric Antigen Receptor T-cell (CAR-T) therapy, a type of gene therapy for blood cancer treatment, was successfully conducted last Friday at the Bone Marrow Transplant unit at the Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Hostpital in Mumbai in collaboration with IIT Bombay. The Central government has now allocated Rs 19.15 crore to conduct first-in-human phase-I/ II clinical trials of the CAR-T cells, the Department of Biotechnology (DBT), part of the Ministry of Science and Technology, said on Thursday. The CAR-T therapy has emerged as a breakthrough in cancer treatment, and clinical trials across the globe have shown promising results in end-stage patients, particularly the ones suffering from acute lymphocytic leukemia.

Despite a proven therapeutic potential for cancer patients, this gene therapy is still not available in India. A patient’s CAR-T cell therapy costs Rs. 3-4 crore and, therefore, the challenge lies in not just developing the technology at scale but also bring the cost down. And last Friday’s success may just be the first step in that direction. The CAR-T cells were designed and manufactured at IIT Bombay’s Bioscience and Bioengineering (BSBE) department.

Subhasis Chaudhuri, the director of IIT Bombay, said: “Our scientists along with Tata Memorial Hospital have come out with the most sophisticated therapy in cancer treatment. If the trials are successful, it may save millions of lives by making the treatment available in India at an affordable cost.”

The clinical trials for the “first in India” gene therapy are being conducted by Dr. (Surg Cdr) Gaurav Narula, Professor of Paediatric Oncology and Health Sciences, and his team from TMC, Mumbai. The novel CAR-T cells that will act as drugs were manufactured by Professor Rahul Purwar, Bioscience and Bioengineering (BSBE) department, and his team at IIT Bombay. The design, development, and extensive pre-clinical testing were carried out by IIT-B as a collaborative project with Tata Memorial Center, Mumbai by the two investigators, DBT said via a press release.

The work is partly supported by Biotechnology Industry Research Assistance Council (BIRAC). The National Biopharma Mission, under DBT-BIRAC, is also supporting the TMC-IIT Bombay in the Phase I/II trial of their CAR-T product.

Besides this, the National Biopharma Mission is also supporting the development of a Lentiviral vector manufacturing facility for packaging plasmids used to transfer the modified T cell inside the body, a cGMP facility for T-cell transduction, and the expansion for CAR T-cell manufacturing to two other organisations.

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Solar System’s Journey Through Orion Complex May Have Altered Earth’s Climate

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March 3, 2025

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Solar System’s Journey Through Orion Complex May Have Altered Earth’s Climate

The movement of the solar system through the Orion star-forming complex around 14 million years ago may have influenced Earth’s climate, according to scientists. This dense region of space, part of the Radcliffe Wave galactic structure, could have compressed the heliosphere—the protective shield surrounding the solar system—while increasing interstellar dust reaching Earth. Researchers suggest that this influx of cosmic dust might have left traces in geological records, potentially linking galactic activity to past climate changes.

Solar System’s Passage Through the Radcliffe Wave

According to the study published in Astronomy & Astrophysics, an international research team led by the University of Vienna used data from the European Space Agency’s Gaia mission and spectroscopic observations to determine that the solar system moved through the Radcliffe Wave in the Orion constellation between 18.2 and 11.5 million years ago. The most probable period was estimated between 14.8 and 12.4 million years ago. João Alves, Professor of Astrophysics at the University of Vienna and co-author of the study, stated to Phys.org, that this research builds on prior findings regarding the Radcliffe Wave. This structure, made up of interconnected star-forming regions, includes the Orion complex, which the sun is believed to have passed through.

Potential Impact on Earth’s Climate

The study suggests that the increased presence of interstellar dust may have influenced Earth’s atmosphere. Efrem Maconi, lead author and doctoral student at the University of Vienna, said that this dust might have contained traces of radioactive elements from supernovae, which could be detected in geological records using advanced technology in the future.

The solar system’s passage aligns with the Middle Miocene Climate Transition, a period marked by a shift from a warmer, variable climate to a cooler one, leading to the development of Antarctic ice sheets. Scientists highlight that while interstellar dust could have played a role, the dominant factor in this climate change was a long-term decrease in atmospheric carbon dioxide levels.

Not Comparable to Human-Induced Climate Change

Maconi noted that while interstellar dust could have contributed to past climate shifts, the amount required for significant change would need to be much greater than current data suggests. The Middle Miocene Climate Transition unfolded over hundreds of thousands of years, unlike modern climate change, which is occurring rapidly due to human activities

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Ancient DNA Sheds Light on the Diverse Genetic Origins of the European Huns

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March 3, 2025

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Ancient DNA Sheds Light on the Diverse Genetic Origins of the European Huns

The origins of the Huns, a nomadic group that played a crucial role in the decline of the Roman Empire, have long remained uncertain. Recent DNA analysis of ancient skeletal remains has provided fresh insights into their ancestry, revealing a diverse genetic makeup rather than a singular point of origin. According to reports, researchers examined remains from individuals buried between the fourth and sixth centuries and found genetic links spanning Central Asia and Eastern Europe. These findings indicate that the Huns were not a homogenous group but a population shaped by centuries of migration and cultural interactions.

Genetic Analysis Reveals Diverse Ancestry

According to the study published in PNAS, a team led by Guido Gnecchi-Ruscone, an archaeogeneticist at the Max Planck Institute for Evolutionary Anthropology, analysed the genomes of 370 individuals. The research aimed to trace connections between European Huns and earlier nomadic groups, including the Xiongnu, whose empire thrived in Mongolia between 200 B.C. and A.D. 100. While certain Hun individuals exhibited direct genetic links to the Xiongnu elite, most carried varying degrees of Northeast Asian ancestry, underscoring a complex history of intermingling.

Connections Across the Eurasian Steppe

Using a technique called identity by descent (IBD) segment sharing, the researchers identified genetic ties across multiple regions over several centuries. Their findings suggested that trans-Eurasian relationships were maintained across generations. While high-status Xiongnu burials in Mongolia showed direct descendants among the European Huns, the study concluded that no large-scale migration of Xiongnu populations into Europe took place.

Insights from an Elite Hun Burial

A burial site in Pusztataskony, Hungary, yielded the remains of a Hun woman with an elongated skull, buried alongside gold earrings. Gnecchi-Ruscone told Live Science that this individual carried genetic markers linking her to the Xiongnu elite, suggesting that skull modification, a notable cultural practice, may have been passed down through generations. The study reinforces the view that the European Huns were a culturally and genetically diverse group shaped by centuries of movement and integration rather than a single migratory event.

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NASA’s IM-2 Mission Brings Ice Mining, Mobile Robots, and More on Moon



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NASA’s IM-2 Mission Brings Ice Mining, Mobile Robots, and More on Moon

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March 3, 2025

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NASA’s IM-2 Mission Brings Ice Mining, Mobile Robots, and More on Moon

NASA is preparing to send advanced technologies to the Moon through Intuitive Machines’ second lunar delivery under the Commercial Lunar Payload Services (CLPS) initiative. The mission, part of the Artemis programme, aims to establish a sustainable human presence on the Moon. A range of scientific instruments and communication systems will be tested on the lunar surface. The launch window for Intuitive Machines’ second CLPS mission, IM-2, is scheduled to open on 26 February from Launch Complex 39A at NASA’s Kennedy Space Center. The Nova-C class lander will carry key technology payloads, including a drill, mass spectrometer, a cellular network, and a drone for terrain exploration.

Lunar South Pole Exploration

As reported, the landing site for IM-2 has been selected based on data from NASA’s Lunar Reconnaissance Orbiter. Located in the South Pole region, the site offers a relatively flat terrain, meeting the criteria for a safe landing. The area is of particular interest due to its potential for in-situ resource utilisation, which could support future lunar missions.

Demonstration of New Technologies

According to NASA’s Space Technology Mission Directorate, the Polar Resources Ice Mining Experiment-1 (PRIME-1) will be tested as part of the mission. PRIME-1 includes a drill and a mass spectrometer designed to search for water ice and other resources beneath the lunar surface. Data gathered from this experiment will assist in future space exploration efforts by providing insight into potential resource extraction for fuel and oxygen production.

Mobile Robotics on the Moon

Two technology demonstrations will be deployed near the lander under NASA’s Tipping Point initiative. Intuitive Machines has developed a small drone, named Grace, which will conduct high-resolution surveys of the lunar terrain. The drone is designed to navigate steep inclines, craters, and other challenging obstacles, helping scientists study permanently shadowed regions that cannot be accessed by traditional rovers.

Lunar Surface Communication System

A communication system developed by Nokia Bell Labs will be tested to establish a lunar cellular network. The system will enable communication between the lander, a Lunar Outpost rover, and the Grace drone. It will be the first demonstration of cellular-based connectivity on the Moon, with potential applications for future crewed missions and robotic exploration.

Collaboration for Lunar Exploration

NASA is working alongside several U.S. companies to deliver scientific and technological advancements to the lunar surface. The Space Technology Mission Directorate has integrated multiple research and development efforts to support future Moon missions. The combination of CLPS and Tipping Point initiatives aims to advance exploration capabilities, benefiting NASA and the broader space industry.

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