Connect with us

Published

4 years ago

on

In a first for India, Chimeric Antigen Receptor T-cell (CAR-T) therapy, a type of gene therapy for blood cancer treatment, was successfully conducted last Friday at the Bone Marrow Transplant unit at the Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Hostpital in Mumbai in collaboration with IIT Bombay. The Central government has now allocated Rs 19.15 crore to conduct first-in-human phase-I/ II clinical trials of the CAR-T cells, the Department of Biotechnology (DBT), part of the Ministry of Science and Technology, said on Thursday. The CAR-T therapy has emerged as a breakthrough in cancer treatment, and clinical trials across the globe have shown promising results in end-stage patients, particularly the ones suffering from acute lymphocytic leukemia.

Despite a proven therapeutic potential for cancer patients, this gene therapy is still not available in India. A patient’s CAR-T cell therapy costs Rs. 3-4 crore and, therefore, the challenge lies in not just developing the technology at scale but also bring the cost down. And last Friday’s success may just be the first step in that direction. The CAR-T cells were designed and manufactured at IIT Bombay’s Bioscience and Bioengineering (BSBE) department.

Subhasis Chaudhuri, the director of IIT Bombay, said: “Our scientists along with Tata Memorial Hospital have come out with the most sophisticated therapy in cancer treatment. If the trials are successful, it may save millions of lives by making the treatment available in India at an affordable cost.”

The clinical trials for the “first in India” gene therapy are being conducted by Dr. (Surg Cdr) Gaurav Narula, Professor of Paediatric Oncology and Health Sciences, and his team from TMC, Mumbai. The novel CAR-T cells that will act as drugs were manufactured by Professor Rahul Purwar, Bioscience and Bioengineering (BSBE) department, and his team at IIT Bombay. The design, development, and extensive pre-clinical testing were carried out by IIT-B as a collaborative project with Tata Memorial Center, Mumbai by the two investigators, DBT said via a press release.

The work is partly supported by Biotechnology Industry Research Assistance Council (BIRAC). The National Biopharma Mission, under DBT-BIRAC, is also supporting the TMC-IIT Bombay in the Phase I/II trial of their CAR-T product.

Besides this, the National Biopharma Mission is also supporting the development of a Lentiviral vector manufacturing facility for packaging plasmids used to transfer the modified T cell inside the body, a cGMP facility for T-cell transduction, and the expansion for CAR T-cell manufacturing to two other organisations.

Interested in cryptocurrency? We discuss all things crypto with WazirX CEO Nischal Shetty and WeekendInvesting founder Alok Jain on Orbital, the Gadgets 360 podcast. Orbital is available on Apple Podcasts, Google Podcasts, Spotify, Amazon Music and wherever you get your podcasts.

Related Topics:
Continue Reading

Science

Rare Titan Shadow Transits Will Sweep Across Saturn in Summer 2025

Published

9 hours ago

on

June 30, 2025

By

Rare Titan Shadow Transits Will Sweep Across Saturn in Summer 2025

Saturn’s largest moon Titan will cast its shadow across the planet’s surface in a rare spectacle this summer. Over the coming months, observers on Earth may see a dark “hole” move across Saturn’s disk as Titan passes in front of the planet. This event is tied to a special alignment: roughly every 15 years, Saturn’s rings become edge-on to our view (a ring-plane crossing or equinox). Indeed, in March 2025 the rings briefly vanished as they lined up edge-on, setting the stage for Titan’s shadow to loom large on Saturn’s globe. After this year’s transit season, the configuration won’t recur until about 2040, making these transits uniquely unmissable.

Saturn’s Equinox and Titan’s Transits

According to Space.com, right now Saturn is near its equinox, meaning its tilted rings are edge-on to Earth. This geometry allows Titan’s shadow – a dark spot on Saturn – to sweep across the planet’s face, much like a lunar eclipse but on Saturn. Titan orbits Saturn about every 16 days, so during this alignment we can see its shadow cross Saturn’s disk repeatedly. In fact, roughly ten Titan shadow-transit events are expected during 2025. Three have already occurred (most recently on June 16), and seven more are forecast from July through early October 2025. When visible, each transit looks like a moving dark spot (a “hole”) on Saturn’s bright disk.

Viewing the Titan Shadow Transits

These transits are faint and require planning. A good telescope (at least 200× magnification) is needed to see Titan and its shadow. For viewers in North America, Saturn will be low in the pre-dawn sky during the event dates. According to Sky & Telescope, the remaining 2025 transit dates are July 2, July 18, August 3, August 19, September 4, September 20 and October 6 (local viewing times vary by location).

Early-season events last several hours, but the crossings shorten as the year goes on: by Oct. 6 the shadow is only visible briefly at the exact mid-transit moment. Observers should consult astronomy software and aim for clear skies on those dates, as any clouds or mist will obscure the subtle shadow.

Continue Reading

Science

NASA’s Chandra Reveals Stunning Multi-Wavelength Image of Andromeda Galaxy

Published

9 hours ago

on

June 30, 2025

By

NASA’s Chandra Reveals Stunning Multi-Wavelength Image of Andromeda Galaxy

NASA’s Chandra X-ray Observatory provides a new look at the Andromeda galaxy in this multi-wavelength image that includes X-ray, ultraviolet, optical, infrared, and radio images and illustrates the “collaboration of light” across the spectrum. The structure and future fate of the Milky Way are modelled with the help of Andromeda, which is 2.5 million light years away. This combined image not only shows high-energy radiation from a supermassive black hole but also provides a clear view of the arms and core of M31 in remarkable detail. The light is transformed into a sound with a sonification video, bringing another level of sensation.

Chandra X-ray Data Reveals Black Hole Flares and Dark Matter Legacy in New View of Andromeda

As per NASA’s Chandra team, the X-ray observations — alongside data from ESA’s XMM-Newton, NASA’s GALEX and Spitzer, Planck, IRAS, COBE, Herschel, and more — reveal distinct galactic features. Notably, a flare detected in 2013 from Andromeda’s supermassive black hole showed enhanced X-ray emission. The data also honours astronomer Vera Rubin, whose M31 rotation studies led to the first convincing evidence for dark matter. Rubin is now commemorated on a 2025 U.S. quarter.

Among the release features is a signature sonification, with different categories of light — X-ray, ultraviolet, optical, infrared, and radio — translated into sound tones. Volume is controlled by brightness, pitch by frequency position. The result is a sound map of the galaxy’s internal structure.

The Chandra programme for NASA’s Science Mission Directorate in Washington is managed by NASA’s Marshall Space Flight Centre in Huntsville, Alabama. Chandra’s overseer is the Smithsonian Astrophysical Observatory in Cambridge, Massachusetts.

With this updated M31 panorama in hand, astronomers are in for a beautiful sight, but the broader population is also treated to a sight and sound experience that transports us to our Milky Way’s closest galactic neighbour.

Continue Reading

Science

Could These Meteorites Be from Mercury? New Research Hints at Rare Discovery

Published

9 hours ago

on

June 30, 2025

By

Could These Meteorites Be from Mercury? New Research Hints at Rare Discovery

Scientists have observed whether the meteorites can reach Earth from Mercury. Over thousands of meteorites from Mars and the Moon have been observed, but none have been from Mercury, despite it being a nearby rocky planet. A new study revealed Icarus suggests two meteorites, Ksar Ghilane 022 and Northwest Africa 15915, could belong to Mercurian origin. Such a kind of meteorite can offer a realistic opportunity to study the material of the surface of the planet, if the technical challenges and the cost of sending a spacecraft to Mercury are met.

New Meteorite Samples Show Strong Similarities

As per the new studies reported to Physics.org , Meteorite NWA 7325 and aubrites in the past were considered to be possibly from Mercury. However, the mineral composition of their samples has inconsistencies with the known surface data from the Messenger mission of NASA. Aubrites formed on a planet similar in size to Mercury, lacking spectral and chemical similarities, and further weakened as Mercurian fragments.

Ksar Ghilane 022 and NWA 15915, the new samples, share many traits of Mercury crust, with olivine, oldhamite, pyroxene, and minor albitic plagioclase. The oxygen composition of these matched with the aubrites, signalling a similar planetary origin and putting them among strong Mercurian members.

Key Differences Raise Scientific Questions

There are key differences even after that, and the two meteorites contain very little plagioclase than on the Mercury surface, and are about 4,528 million years older than Mercury’s surface material. If they are from Mercury, there is a possibility that they can represent an ancient crust which is no longer visible on the planet.

Future Missions and Scientific Verification

Relating a meteorite to a particular planet is quite difficult without direct samples. BepiColombo missions are orbiting Mercury currently, and can offer valuable insights to confirm meteorites source. Mercurian meteorites can get valuable insights into the formation, composition and history of the planet. There are further findings to be presented at the Meteoritical Society Meeting 2025 in Australia.

For the latest tech news and reviews, follow Gadgets 360 on X, Facebook, WhatsApp, Threads and Google News. For the latest videos on gadgets and tech, subscribe to our YouTube channel. If you want to know everything about top influencers, follow our in-house Who’sThat360 on Instagram and YouTube.


Redmi K80 Ultra With Dimensity 9400+ SoC, 7,410mAh Battery Launched: Price, Specifications



Telegram Bot Reportedly Spotted Selling Sensitive Personal Data of Indian Users

Continue Reading

Trending