A manhunt is under way after at least seven people were injured when a gunman opened fire on cars on a highway in Kentucky, causing scenes described as “a madhouse”.

Police said the suspect, who remains at large, should be considered “armed and dangerous” and people have been urged to stay in their homes.

The shooting happened near the small city of London, about 75 miles (120km) south of Lexington, at about 5.30pm local time on Saturday.

Deputy Gilbert Acciardo, of Laurel County Sheriff’s Office, told a news conference on Sunday: “When our first two units got to the scene there, they said it was a madhouse – people on the sides of the road, emergency flashers going, bullet holes, windows shot out, nine vehicles shot.

“Can you imagine that? Just chaotic.”

Five people were shot and are all in a stable condition, although some have “very serious” injuries, including one person who was hit in the face, Mr Acciardo said.

Two other people were hurt in a crash caused by the shooting.

A search of a remote wooded area by officers, suspended overnight because of darkness, was to resume at daybreak on Sunday, he said.

Mr Acciardo added: “We do have the area contained right now. It’s a very fluid investigation. Our people are still on the scene. Our special response team is there. We are trying to find a shooter there.”

The sheriff’s office said a “person of interest” has been identified in connection with the shooting and warned people not to approach him.

He was named as 32-year-old Joseph A Couch.

But Mr Acciardo cautioned the authorities “have not determined that this is the individual that fired the weapon”.

In a video statement, London Mayor Randall Weddle said: “There are no deceased at this time. No one was killed from this, thankfully, but we ask that you continue to pray.”

He added: “We’re asking folks please do not go outside your home shooting because we might have first responders in that area.

“It’s important to know you are safe.

“We have multiple agencies in this community, in the city of London and in Laurel County.”

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Trooper Scottie Pennington, of the Kentucky State Police, wrote on Facebook: “The suspect has not been caught at this time and we are urging people to stay inside.”

Kentucky governor Andy Beshear said in a post on the social media platform: “I am receiving initial reports from the Kentucky State Police and our Office of Homeland Security – together we are actively monitoring the situation and offering support in any way possible.

“Please pray for everyone involved.”

The highway, which was closed nine miles north of London following the shooting, reopened about three hours later, according to police.

Former vice president and longtime Republican Dick Cheney has said he will vote for Kamala Harris in this year’s US election.

The 83-year-old issued a statement announcing he will be backing the Democratic candidate because her Republican rival Donald Trump can “never be trusted with power again”.

Mr Cheney has been an outspoken critic of Mr Trump, most notably during his daughter Liz Cheney’s unsuccessful campaign to hold on to her Wyoming seat in Congress in 2022.

Ms Cheney, who said she would be voting for Ms Harris on Wednesday, was the first to announce her father’s endorsement when she spoke to Mark Leibovich from The Atlantic magazine in an onstage interview at The Texas Tribune Festival in Austin on Friday.

“Wow,” Mr Leibovich replied as the audience cheered.

In a statement issued later, Mr Cheney said that “in our nation’s 248-year history, there has never been an individual who is a greater threat to our republic than Donald Trump”.

“He can never be trusted with power again,” he adds.

“As citizens, we each have a duty to put country above partisanship to defend our Constitution. That is why I will be casting my vote for Vice President Kamala Harris.”

Asked for comment after Ms Cheney announced her father’s voting intention, Trump spokesperson Steven Cheung said: “Who is Liz Cheney?”

The campaign confirmed Mr Cheung was being sarcastic by also pointing to a comment Ms Cheney posted online four years ago in which she called Ms Harris a “radical liberal”.

Mr Cheney, who served as vice president under Republican President George W Bush from 2001 to 2009, has made few if any public appearances over the past year or more.

He has dealt with heart issues since his 40s and underwent a heart transplant in 2012.

His statement on Friday was similar to a 2022 campaign ad for his daughter as she sought a fourth term as Wyoming’s lone congressperson.

In reference to the 6 January Capitol riots in 2021, he called Mr Trump a “coward” for trying to “steal the last election using lies and violence to keep himself in power after the voters had rejected him”.

The ad did little good for his daughter in a deep-red state that once held the Cheney family dear but is now thoroughly in Mr Trump’s corner.

Mr Cheney has been friends with Democrats over the years, but never supported one for president.

Both Cheneys backed Mr Trump during his successful 2016 presidential bid.

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However, their support for him waned with Ms Cheney criticising Mr Trump’s foreign policy decisions while he was in office.

She later criticised him over the 6 January Capitol riots.

Meanwhile, while in office, Mr Trump had criticised the “endless wars” in Afghanistan and Iraq launched when Mr Cheney was vice president.

If either Cheney supported Mr Trump in 2020, they were quiet about it.

Several other top Republicans have also come out in support of Ms Harris ahead of this year’s election while some, including Senator Mitt Romney and former vice president Mike Pence, say they will not be voting for Mr Trump.

Of them, only Mr Romney, who is not seeking re-election, is still in office.

Sir Keir Starmer will travel to Washington this coming week for a bilateral meeting with President Biden.

The trip to the White House, on Friday, will be the prime minister’s second visit since he was elected in July.

In a statement, the White House said the leaders would focus on “global issues of mutual interest”.

“The leaders will have an in-depth discussion… including continuing robust support to Ukraine in its defence against Russian aggression, securing a hostage release and ceasefire deal to end the war in Gaza, protecting international shipping in the Red Sea from Iranian-backed Houthi threats, and advancing a free and open Indo-Pacific,” the White House statement said.

It continued: “They will also discuss opportunities to strengthen US-UK cooperation to secure supply chains and increase climate resilience. President Biden will underscore the importance of continuing to strengthen the special relationship between the United States and the United Kingdom.”

The UK is heavily invested in several live geopolitical challenges which all predate Sir Keir’s premiership.

The hope, according to sources, is that mutual progress can be made on the various challenges with the outgoing Biden administration.

Britain and the US have cooperated closely on Ukraine, leading a Western alliance that has, at times, shown some reluctance in its continued support against Russian aggression.

On protecting international shipping in the Red Sea against continued Houthi attacks from Yemen, the UK has been a key partner for the US in a mission that’s shown limited success.

The potential for some divergence between the two leaders could come over Gaza.

Last week, the UK announced that it would suspend the export of some arms to Israel because of the risk that they could be used in non-compliance with international humanitarian law.

US government lawyers have not come to the same conclusions about how Israel is using weapons in Gaza but this week a State Department spokesman said the UK was making a sovereign decision that it was entirely entitled to make.

Notably, however, a foreign policy advisor to Republican presidential candidate Donald Trump struck a different tone.

Robert O’Brien – who is likely to be in a Trump White House if he wins in November – said that a UK-US special relationship would be under strain if the UK restricted weapons sales to Israel.

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The relationship between Mr Biden and Sir Keir reflects their political alignment. During his first visit to the White House, just days after taking office, President Biden, who was then the Democratic candidate for November’s election, spoke warmly of the much coveted “special relationship”.

“I kind of see you guys as the knot tying the transatlantic alliance together, the closer you are with Europe. We know where you are, you know where we are,” Mr Biden told Sir Keir.

No meetings have been announced between Sir Keir and vice president Kamala Harris, the new Democratic Party candidate for the November election, though it’s possible she will be part of the bilateral meetings with President Biden.

A significant moment would be a meeting between Sir Keir and Mr Trump.

No plans have been announced but such a meeting would be seen as diplomatically savvy, especially if a Harris meeting materialises, and it would not be without precedent.

Former prime minister David Cameron met Republican nominee Mitt Romney in July 2012 and Gordon Brown met Barack Obama when he was the Democratic Party candidate in 2008.

Sir Keir’s visit comes at the end of a week in which US secretary of state Antony Blinken will meet Foreign Secretary David Lammy in London.

Gaza will be a key focus but Mr Blinken will travel with ambassador Katherine Tai, the US trade representative.

Trade and technology are set to be on the agenda too.

The UK is still seeking to formalise a post-Brexit trade partnership with the US.