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A team of researchers at the Perelman School of Medicine at the University of Pennsylvania has discovered that obese mice, treated with the cytokine (a category of proteins) known as TSLP, reported significant fat and weight loss. Described as an “unforeseen finding,” researchers also said that the fat loss was in no way related to decreased food intake or faster metabolism. The treatment revealed, “TSLP prompted the immune system to release lipids through the skin’s oil-producing sebaceous glands.” 

The study is led by Taku Kambayashi, Associate Professor of Pathology and Laboratory Medicine at the University of Pennsylvania. He was joined by Ruth Choa, a fourth-year PhD medical student. Kambayashi said that despite being an unexpected discovery, the team has demonstrated that fat loss was possible by secreting calories from the skin in the form of energy-rich sebum. The professor added that the findings of the animal experiment also show that this could develop into a model for the treatment of obesity among people.  

Kambayashi said that they never thought the TSLP would have any impact on obesity itself. What they set out for was to find out if it impacted insulin resistance. “We thought that the cytokine could correct Type 2 diabetes, without actually causing the mice to lose any weight,” he said.

In order to see the effect of TSLP on Type 2 diabetes, the researchers administered on obese mice a viral vector to increase their bodies’ TSLP levels. Four weeks after the mice were administered injections, the team found that TSLP, besides affecting their diabetes risk, also reduced obesity in them. Compared to TSLP-treated mice, the control group continued to gain weight. The TSLP-treated mice lost 20 grams, going from 45 to just 25 grams in 28 days, the team said. 

Not just that, while the mice reported weight and fat loss, Kambayashi assumed that TSLP was perhaps sickening them. Upon further testing, the group realised that the mice receiving TSLP treatment were also eating 20 to 30 percent more. Besides, they also had similar energy expenditures, base metabolic rates, and activity levels compared to their non-treated counterparts.

Could this work on Humans?

The authors of the study said that in humans, shifting sebum release into “high gear” could feasibly lead to the “sweating of fat” and weight loss.

Kambayashi’s group next plans to test this hypothesis. He said that he doesn’t think humans naturally control their weight by regulating sebum production. “We may be able to hijack the process and increase sebum production to cause fat loss,” he said.


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Mice now use VR headsets to help scientists study brain activity and behaviour

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Mice now use VR headsets to help scientists study brain activity and behaviour

Innovative VR headsets have been designed for mice, enabling scientists to study brain activity in highly immersive environments. Using these headsets, researchers can observe neural responses during specific behaviours, potentially unlocking new understanding of human neurological disorders. Crafted from readily available components such as smartwatch screens and miniature lenses, these devices are seen as a breakthrough in neuroscience research, offering precise insights into how mammals interact with their surroundings.

Development and Functionality of the Headsets

According to a study published in Nature Methods, the VR headsets—known as “MouseGoggles”—are paired with a spherical treadmill that keeps the mice stationary while simulating movement. These goggles attach to the mice’s heads, displaying sharp, high-contrast visuals that mimic real-world experiences. Dr. Matthew Isaacson, a postdoctoral researcher at Cornell University, stated in a press release that prior methods using projector screens failed to engage mice effectively, but the new goggles produced significant behavioural responses, such as startled reactions to simulated predators.

Verification of the Technology

To confirm the efficacy of the MouseGoggles, researchers examined activity in two critical brain regions. The primary visual cortex revealed that the mice could perceive the projected images clearly, while the hippocampus indicated accurate mapping of virtual environments. These findings underline the potential for the technology to deepen understanding of how mammals navigate and interact with their surroundings.

Future Applications and Advancements

Dr. Chris Schaffer, Professor of Biomedical Engineering at Cornell, noted to phys.org that these headsets could transform neuroscience by enabling the study of naturalistic behaviours. Plans are underway to create lightweight versions for larger rodents like rats and to incorporate sensory elements such as smell and taste into the VR experience. This expanded capability could provide more comprehensive insights into complex decision-making processes and sensory integration.
The research team believes this technology could significantly enhance studies into conditions like Alzheimer’s, offering critical understanding of spatial navigation and memory deficits.

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How Human Activity Fuels Pandemics: Climate Change and Biodiversity at the Core

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How Human Activity Fuels Pandemics: Climate Change and Biodiversity at the Core

The rise in pandemics has been attributed to disruptions caused by human activities to the planet’s ecosystems. Infectious diseases, which have historically resulted in significant loss of life, are appearing more frequently. This resurgence has raised concerns among experts about the factors driving this trend. Modern advancements in science, including vaccinations and antibiotics, initially seemed to have controlled these outbreaks. Yet, the occurrence of diseases such as HIV/AIDS, SARS, and COVID-19 highlights the ongoing challenges.

Ecosystem Disruption and Its Role

According to a study published by researchers from the University of Adelaide, the disruption of ecosystems is central to the emergence of pandemics. Healthy ecosystems regulate diseases by maintaining natural balances, including predator-prey dynamics and vegetation growth. However, activities such as deforestation, climate change, and biodiversity loss have altered these balances, enabling pathogens to spread more easily. For instance, changes in climate have allowed disease-carrying mosquitoes to expand their range into previously temperate regions.

The Impact of Biodiversity Loss

Reports have indicated that biodiversity loss has created opportunities for pathogens to move from wildlife to humans. The case of vampire bats in South America is often cited, where deforestation and agricultural expansion provided new feeding grounds, leading to the spread of rabies. Similarly, the HIV virus emerged through the hunting of apes for food, eventually spreading globally. These examples underscore the link between human activity and the rise of zoonotic diseases.

The Importance of Planetary Health

Experts advocate for a “planetary health” approach, emphasising the interdependence of human health and the natural environment. This strategy aims to address fundamental drivers like climate change while also tackling immediate causes such as wildlife-human interactions. Educational institutions are increasingly integrating planetary health into their curricula to equip future leaders with tools to mitigate pandemic risks effectively.

It is widely believed that without addressing the root causes, the likelihood of future pandemics remains significant. Efforts to balance human development with ecological preservation have been suggested as key to safeguarding global health.

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Parker Solar Probe to make record-breaking Sun flyby on Christmas Eve

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Parker Solar Probe to make record-breaking Sun flyby on Christmas Eve

The Parker Solar Probe, a mission by NASA, is set to make its closest approach to the Sun on Christmas Eve, December 24, 2024. This milestone flyby is expected to occur at precisely 6:53 a.m. EST, as reported by multiple sources. The spacecraft will reach an unprecedented proximity of 6.1 million kilometers from the Sun’s surface, marking the 22nd close encounter of its mission. This approach represents a record-breaking moment in space exploration, achieved through seven Venus flybys that incrementally brought the probe closer to the Sun.

Details of the Flyby

According to mission updates from NASA and the Johns Hopkins Applied Physics Laboratory (JHUAPL), the Parker Solar Probe will travel at a staggering speed of 692,000 kilometers per hour during its journey through the Sun’s outer atmosphere, or corona. This high-speed encounter aims to shed light on the corona’s extreme temperatures and its role in solar wind generation. The probe’s heat shield, built to endure temperatures up to 1,377 degrees Celsius, will ensure the spacecraft remains operational as it navigates the intense environment.

Updates and Tracking

While the event itself will not be broadcast live, updates will be provided through NASA’s official channels and the Parker Solar Probe mission blog. A status check from the spacecraft is expected on December 27, followed by the first telemetry data on January 1, 2025. The initial scientific findings, including data on solar activity, are anticipated by late January.

What Comes Next

This flyby is part of the probe’s seven-year mission, concluding in 2025 after a total of 24 solar encounters. Subsequent flybys in March and June 2025 will continue to gather valuable data, with decisions about the probe’s orbit to be made thereafter, as per the mission team’s updates.

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