A coronavirus infection presents a much higher risk of developing a blood clot than a first dose of either the AstraZeneca or the Pfizer jab, a study has found.
The research used findings from more than 29 million people who were vaccinated with first doses of either jab.
The study showed although there was an increased risk of having a blood clot after having the first doses of either vaccine, it was much greater in someone who had tested positive for COVID-19.
The researchers are fully independent from the University of Oxford team that worked with AstraZeneca to develop that particular vaccine.
Fears over blood clots have led to the restricted use of the Oxford AstraZeneca vaccine in a number of countries.
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The researchers, writing in the British Medical Journal, found for short time intervals after the first does there are increased risks of some blood, or blood-vessel, related events leading to hospitalisation or death.
However, they also wrote that that the risk of these adverse events is substantially higher and for a longer period of time, following infection from coronavirus.
More on Covid-19
Julia Hippisley-Cox, professor of clinical epidemiology and general practice at the University of Oxford, lead author of the paper, said: “People should be aware of these increased risks after COVID-19 vaccination and seek medical attention promptly if they develop symptoms, but also be aware that the risks are considerably higher and over longer periods of time if they become infected with SARS-CoV-2.”
All of the coronavirus vaccines currently in use have been tested in randomised clinical trials, which are unlikely to be large enough to detect very rare adverse events.
When rare events are uncovered, regulators perform a risk-benefit analysis of the medicine to compare the risk of the adverse reaction, such as a blood clot, against the benefits of avoiding the disease – in this case COVID-19.
For this paper, the researchers used routinely collected electronic health records to evaluate the short-term risks (within 28 days) of hospital admission from blood clots.
They used data collected from across England between 1 December 2020 and 24 April 2021.
Professor Hippisley-Cox said: “This research is important as many other studies, while useful, have been limited by small numbers and potential biases. Electronic healthcare records, which contain detailed recording of vaccinations, infections, outcomes and confounders, have provided us with a rich source of data with which to perform a robust evaluation of these vaccines, and compare to risks associated with COVID-19 infection.”
The research was carried out by a team from the University of Oxford, University of Leicester, Guys and St Thomas’ NHS Foundation Trust, the Intensive Care National Audit & Research Centre, the London School of Hygiene and Tropical Medicine, the University of Cambridge, the University of Edinburgh and the University of Nottingham.
The family of a nine-year-old girl stabbed to death have said she was a “beautiful soul” who was brave, kind-hearted and “always put a smile on people’s faces”.
Police were called to Lime Close in Weston-super-Mare, Somerset, just before 6.10pm on Monday, where Aria Thorpe had suffered a single stab wound.
The child was pronounced dead at the scene.
In a tribute released by Avon and Somerset Police on Friday, the girl’s family on her mother’s side said: “For those who didn’t have the privilege of knowing Aria, she was the most beautiful little soul – happy-go-lucky, full of light, and joy.
“She loved to sing and dance, and she took such pride in dressing up, always wanting to look just like her mummy.”
Tom Thorpe, the girl’s father, said: “It’s hard to put into words how devastating it is, our little Aria, that you’re up there with the angels looking over us.”
It comes as a 15-year-old boy charged with Aria’s murder appeared in court.
Image: Pic: Avon and Somerset Police
Aria was a ‘precious girl’
In their statement, Aria’s family on her mother’s side said her death “has devastated us beyond words”.
“Our hearts are broken in a way we never imagined possible,” they added.
“As a family, we are holding one another close and doing everything we can to support each other through this unimaginable time.”
They said they were “truly touched by the lovely messages we have received”, before asking “that our privacy is respected, as we try to come to terms with the terrible loss of our precious girl”.
Image: Flowers laid in memory of the young girl
‘Wacky ways and outright madness’
Mr Thorpe said: “How sad it’s going to be not hearing ‘Dad, how long left?’ on our long journeys back and forth at weekends.
He then said that Aria was “such a brave, kind-hearted and a beautiful innocent soul”, and “always put a smile on people’s faces with your wacky ways and just outright madness”.
Mr Thorpe added: “Your other little family down here in Portsmouth will forever miss you.
“We’ll miss you begging to go outside, even in the pouring rain just to have as much fun as possible in the little time we had at weekends.
“You will be greatly missed, you special little angel. A life gone far too early but I hope a life lived well. We all love you dearly. Goodnight darling.”
Teenager in court
Meanwhile, a 15-year-old boy charged with Aria’s murder appeared at Bristol Crown Court on Friday, where he was remanded.
The teenager, who cannot be named because of his age, was arrested in the Somerset village of Worle at 6.19pm on Monday.
He is next due in court on 16 March 2026. Appearing via video link from youth detention accommodation, he spoke only to confirm his name.
Judge Peter Blair KC set a provisional trial date for 15 June during the hearing.
David Walliams has been dropped by his publisher HarperCollins UK.
A spokesperson for the company said that “after careful consideration, and under the leadership of its new CEO, HarperCollins UK has decided not to publish any new titles” from Walliams.
“HarperCollins takes employee well-being extremely seriously and has processes in place for reporting and investigating concerns,” the spokesperson added.
“To respect the privacy of individuals, we do not comment on internal matters.”
The publisher announced in October that it had appointed Kate Elton as its new chief executive, following the departure of former boss Charlie Redmayne.
The 54-year-old, who shot to fame with the BBC sketch show Little Britain, is one of the country’s best-selling children’s authors.
He has written more than 40 books, which have sold more than 60 million copies worldwide and been translated into 55 languages, according to his website.
His first children’s book, The Boy in the Dress, was published by HarperCollins in 2008.
Walliams is also known for Come Fly With Me, another BBC sketch show, and was formerly part of the judging panel for Britain’s Got Talent.
He was awarded an OBE in 2017 for services to charity and the arts.
Walliams has been contacted for comment.
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A teenager charged with the murder of nine-year-old Aria Thorpe will stand trial in June next year.
The 15-year-old boy, who cannot be named because of his age, appeared at Bristol Crown Court on Friday.
The defendant, who appeared via video link from youth detention accommodation, spoke only to confirm his name.
During a brief hearing, Judge Peter Blair KC, the Recorder of Bristol, set a provisional trial date for 15 June 2026.
The trial is expected to last two weeks.
Avon and Somerset Police were called to Lime Close in Weston-super-Mare just before 6.10pm on Monday, where nine-year-old Aria had suffered a single stab wound.
Image: Flowers laid in memory of the young girl
The boy was arrested in nearby Worle a short time later.
His father was among those attending in the public gallery.
The teenager is next expected to appear in court on 16 March.