Four amateur astronauts are due to spend about three days in orbit in a world first, after they blasted off from the Kennedy Space Centre in Florida on Wednesday evening.
The Inspiration4 mission, backed by SpaceX, was organised by entrepreneur Jared Isaacman, who is also one of the passengers.
They are the first all-civilian crew ever to circle the Earth from space.
During their trip, those on board will carry out a series of science experiments before returning home.
So who are the four crew members, how did they get there and what will happen in the next 72 hours or so.
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A giant leap in commercial space travel
Who are the amateur astronauts?
The four people aboard the Dragon capsule are Jared Isaacman, Hayley Arceneaux, Chris Sembroski, and Dr Sian Proctor.
Mr Isaacman is the man behind the mission, and paid an undisclosed sum to get the project off the ground.
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The 38-year-old made his money with a payment processing company – like SpaceX head Elon Musk – and now also operates a private air force.
An experienced pilot, he wants the journey to raise awareness for St Jude’s Children’s Research Hospital in Memphis, Tennessee.
The other three members of the crew were selected according to Mr Isaacman’s conditions.
Hayley Arceneaux, 29, is an employee of St Jude’s, and had cancer during her childhood.
Taking someone from the hospital was a condition from Mr Isaacman.
Ms Arceneaux, a physician’s assistant, is the first person to travel to space with a prosthesis – part of her right femur was replaced by a metal rod during a bone cancer battle at the age of 10.
Dr Proctor, 51, is an entrepreneur and trained pilot herself.
She won her seat through a competition based on a set of business-related tasks.
The scientist previously applied for NASA‘s astronaut programme but was unsuccessful – but is now in space.
Last up is Chris Sembroski, 42, a US Air Force veteran who now works for Lockheed Martin.
He was selected from a lottery of people who donated to St Jude’s – a competition which received around 72,000 entries.
What are their roles?
The four space tourists have defined roles, according to their backgrounds.
They have been branded leadership, hope, prosperity and generosity.
Mr Isaacman is leadership, and he will be the mission commander in charge of the operation.
Hope is Ms Arceneaux, who will act as medical officer and will help with experiments being carried out – many of which are medically based.
Dr Proctor is prosperity and the mission pilot. She will support Mr Isaacman.
Generosity is represented by Mr Sembroski, who is the mission specialist and will help “manage payload, science experiments, communications to mission control and more”.
What will they do?
Most of the experiments being carried out by the crew are “to increase humanity’s knowledge on the impact of spaceflight on the human body”.
SpaceX, the Translational Research Institute for Space Health (TRISH) at Baylor College of Medicine in Houston, Texas, and the Weill Cornell Medicine in New York City will analyse the data collected.
What experiments will they do
Collecting “research-grade ECG activity, movement, sleep, heart rate and rhythm, blood oxygen saturation, cabin noise and light intensity”
Test behavioural and cognitive function using computer software
Ultrasound scans for organs to see if non-experts can get good quality image and see how spaceflight affects the body
Draw and test blood to see how the immune system functions in space
Testing motor function before and after the flight
How is the ship controlled?
The crew are aboard a Dragon capsule, a reusable pod developed by SpaceX.
It can seat up to seven people, and has been to the International Space Station 25 times – 10 of which were repeat journeys.
It is capable of carrying 365lbs (166kg) of cargo, which is being used for scientific equipment and crew essentials on this journey.
Solar panels on the outside of the craft are used to generate power for the capsule and crew.
The vessel is largely automatically controlled, with a set of large touch screens instead of the traditional-looking dashboard of buttons, levers and toggles for the pilots to observe.
The pilots can also take control of the capsule with the touchscreens.
Sixteen Draco thrusters are used to direct the vehicle after it separates from the take-off rocket, and it has a set of parachutes for landing.
How are they getting back?
After the orbiting is complete, the capsule will head back to Earth.
According to the official plan, this will culminate in a “soft water landing” off the coast of Florida.
After re-entering our planet’s atmosphere, two “drogue” parachutes are deployed, before four main canopies are released.
The crew and vessel will then be retrieved from the water.
Voters across 50 states are preparing to cast their ballots after a bitterly contested US election campaign, which will see Donald Trump or Kamala Harris become president.
In the last few hours, both candidates have been giving their final pitches. “The momentum is on our side,” Ms Harris told a crowd in Philadelphia that chanted back, “We will win”.
“Tonight, then, we finish as we started: with optimism, with energy, with joy,” she said, while enjoying the support of celebrity endorsements on the day from Katy Perry, Lady Gaga and Jon Bon Jovi.
In contrast, Mr Trump ended his campaign in Michigan, repeating key messages about the economy and immigration.
A handful of states will play a crucial role in determining the outcome of the election. Arizona, Georgia, Michigan, Nevada, North Carolina, Pennsylvania and Wisconsin hold the keys to the White House.
To become president, the winning candidate needs 270 electoral votes or more, with each state carrying a different number of votes.
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But the focus has been on Pennsylvania which carries 19 electoral votes, the most of all the swing states.
It has been a remarkable journey for both candidates – with Mr Trump surviving two assassination attempts and Ms Harris not even originally in the running.
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For more than a year, the 2024 presidential race seemed destined for a rematch between Joe Biden and Mr Trump – but a disastrous TV debate by Mr Biden eventually forced him to withdraw from the ticket.
The Democratic party’s decision to replace Mr Biden with his vice president transformed the race and shifted polls in Ms Harris’s favour. But only just.
Many polls are too tight to call and, with a large margin of error, most experts are refusing to predict the outcome.
Later, attention will turn to those battleground states including Georgia, which is among the first polls to close at 7pm local time (midnight UK time).
State election officials told Sky News they could have a result as early as 10pm (3am UK time).
Even so, it could be several days before the US has a definitive result.
Voters are not just selecting a president. In addition, 10 states will hold abortion-related ballots, half of which would overturn existing restrictions.
Predict who you think will win in each swing state and we’ll tell you who the president will be if you’re right.
Tonight, Sky News will have access to the most comprehensive exit poll and vote-counting results from every state, county and demographic across America through its US-partner network NBC.
You can find out more about Sky News’ coverage here.
Up to 4,000 people voting overseas in the US election are having their ballots challenged in Pennsylvania, a key battleground state, according to the American Civil Liberties Union (ACLU).
They include Selma Aldi, 47, from Camden in north London who received a letter on Sunday explaining that her ballot in the US presidential election is at risk of being rejected.
“It was a shock,” she said. “It was terrifying to be targeted, to potentially lose a right that I hold as very important. It’s even a feeling that someone is questioning my identity.”
The trainee GP, who grew up in Hershey, Pennsylvania left America in 2000 but has voted via absentee ballot in every US presidential election since.
A letter from election officials in Dauphin County outlines the legal challenge. It reads: “The applicant is not registered to vote and therefore is not eligible to vote in Pennsylvania.
“Under Pennsylvania law, it is a felony to permit any person to vote who is not registered.”
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A hearing on the legal challenge is scheduled for Friday, in which Ms Aldi can respond.
Around 2.8 million US citizens living abroad are entitled to vote in the election, no matter where they are on polling day.
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But each state has different procedures and rules on how election paperwork can be sent and received.
But Ari Savitzky, senior staff Attorney at the ACLU said “any attempt to challenge [voters] eligibility is a clear violation of their rights”.
He told Sky News: “Between 3,000 and 4,000 challenges have been filed in Pennsylvania to the absentee ballots of US citizens living abroad.
“For decades, federal law has guaranteed the right of US citizens living abroad to vote in federal elections at their last US residence.
“In addition to being legally baseless, these challenges are an abuse to voters and to election administrators.”
Deborah Hinchey from another voting rights group, All Voting is Local, said: “Election deniers across Pennsylvania have submitted thousands of mass challenges to overseas voters.
“They want to block as many ballots as possible and silence our voices… but these baseless challenges have failed before and the proper checks and balances are in place to make sure they’ll fail again,” she added.
Tonight, Sky News will have access to the most comprehensive exit poll and vote-counting results from every state, county and demographic across America through its US-partner network NBC.
You can find out more about Sky News’ coverage here.
Elon Musk can keep giving away $1m to voters in battleground states, a judge has ruled – as a lawyer admitted the winners aren’t chosen randomly.
Musk – a supporter of Republican candidate Donald Trump – launched the giveaways last month via America PAC, his political action committee (PAC).
He has already handed out $16m in the scheme, which is open to registered voters in seven key battleground states – Arizona, Georgia, Michigan, Nevada, North Carolina, Pennsylvania and Wisconsin – who sign a petition pledging to support free speech and gun rights.
On Monday, Pennsylvania Judge Angelo Foglietta ruled the giveaways could carry on, rejecting a district attorney’s request that he shut it down because it allegedly violated state election law.
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Philadelphia District Attorney Larry Krasner, a Democrat, said it was “a political marketing masquerading as a lottery”, adding “That’s what it is. A grift.”
Judge Foglietta did not explain his ruling on the matter but Chris Gober, a lawyer for America PAC, had argued the winners are not chosen by chance and are instead hand-picked based on who would be the best spokespeople for the group – despite Musk’s assertion that they would be chosen randomly.
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Mr Gober said the final two winners before Tuesday’s presidential election will be in Arizona on Monday and Michigan on Tuesday.
He said the recipients “are not chosen by chance”, adding: “We know exactly who will be announced as the recipient today and tomorrow.”
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America PAC director Chris Young said recipients are vetted ahead of time to “feel out their personality, (and) make sure they were someone whose values aligned” with the group.
In closing arguments, Musk’s legal team said it was “core political speech” as anyone taking part had to sign a petition endorsing the US Constitution.
Given there will be no more Pennsylvania winners before the programme ends, Musk’s lawyers said any legal bid to stop it under Pennsylvania law was irrelevant.
Launching the plan in the state on 19 October, Musk said they would be “awarding a million dollars randomly to people who have signed the petition every day from now until the election.”