DEL MAR, Calif. — Knicks Go burst into the lead out of the starting gate and kicked away to a 2¾-length victory in the $6 million Breeders’ Cup Classic on Saturday at Del Mar.

No one seriously pressed the colt, who earned his fourth straight victory and in the process solidified a bid to win the Eclipse Award as Horse of the Year.

“Speed is very dangerous,” winning trainer Brad Cox said.

Ridden by Joel Rosario, 5-year-old Knicks Go squared off against a trio of top 3-year-olds — controversial Kentucky Derby winner Medina Spirit, Belmont Stakes winner Essential Quality and hometown hero Hot Rod Charlie, whose ownership has San Diego ties.

“He broke really sharp,” Rosario said. “He looked like he was really enjoying what he was doing. I could see his ears, he was so relaxed.”

Sent off at 3-1 odds, Knicks Go paid $8.40 to win. Cox also saddled 9-5 favorite Essential Quality, who finished third.

Medina Spirit was second for embattled trainer Bob Baffert. The colt failed a postrace drug test after the Derby and the Kentucky Horse Racing Commission has yet to make a final ruling based on its investigation.

Baffert was allowed to enter horses in the season-ending world championships, but the event’s money-leading trainer had to meet certain conditions, including stricter out-of-competition testing of his horses and greater security at his barn. He agreed to the extra scrutiny and was required to pay for it out of his own pocket. He won the $2 million Juvenile with Corniche on Friday.

Hot Rod Charlie, second to Essential Quality in the Belmont, was fourth. Fans chanted “Let’s go Chuck!” before the race.

The Classic field was reduced to eight when Express Train was scratched in the morning with swelling in his right hock, similar to an ankle.

In other races:

— Japan snapped an 0-for-13 skid in the Breeders’ Cup with a stunning 45-1 upset in the $2 million Distaff and a victory in the $2 million Filly and Mare Turf.

Marche Lorraine edged Dunbar Road by a nose after a photo finish in the Distaff. The 5-year-old mare ran 1⅛ miles in 1:47.67 and paid $101.80 to win under Irish jockey Oisín Murphy.

Letruska, the 8-5 favorite with ties to Mexico, finished 10th among 11 horses.

Yoshito Yahagi trained both of Japan’s champions. Loves Only You won the Filly & Mare Turf by a half-length under Yuga Kawada. She covered 1⅜ miles in 2:13.87 and paid $10.60 to win.

“I’d like to say thank you to my horse. She did a great job,” Yahagi said through a translator. “It’s a dream come true for the Japanese horse racing industry. I’d love to come back Breeders’ Cup at Keeneland next year and do the same thing.”

• Britain-bred Yibir won the $4 million Turf by a half-length, giving trainer Charlie Appleby, jockey William Buick and owner Godolphin Stables their third win of the weekend. Godolphin is the racing outfit for Sheikh Mohammed bin Rashid Al Maktoum, the ruler of Dubai. Yibir ran 1½ miles in 2:25.90 and paid $19 to win at 8-1 odds. The 3-year-old gelding had one horse beat turning for home before charging on the outside and reeling in Broome, who finished second. Tarnawa, the 2-1 favorite, was 11th.

The trio earlier teamed to win the $2 million Mile with 2-1 favorite Space Blues and the $1 million Juvenile Turf on Friday with Modern Games.

• In the Mile, Ireland-bred Space Blues won by a half-length. He ran the distance on the turf in 1:34.01 and paid $6.20 to win as the 2-1 favorite in his last race before retiring. Appleby’s other horse, Master of the Seas, was scratched at the starting gate after acting up in the No. 1 post. Neither horse nor jockey James Doyle was hurt. It was similar to what occurred Friday, when Modern Games was mistakenly scratched by the veterinarians before being reinstated to run in the Juvenile Turf for purse money only. Modern Games won.

• Aloha West scored a nose upset in the $2 million Sprint. The 4-year-old colt, who began his racing career this year, was sixth at the top of the stretch and edged Dr. Schivel at the wire under Jose Ortiz, who won his second Cup race of the weekend. Trained by Wayne Catalano, Aloha West ran six furlongs in 1:08.49 and paid $24.60 to win.

• Ce Ce won the $1 million Filly & Mare Sprint by 2½ lengths in an upset. The 6-1 shot paid $14.40 to win. Defending champion Gamine, the 2-5 favorite trained by Baffert, finished third. Victor Espinoza, who is 49, rode the winner. She ran seven furlongs in 1:21.

• Life Is Good cruised to a 5¾-length victory in the $1 million Dirt Mile, giving jockey Irad Ortiz Jr. his third Cup victory of the weekend. The 3-year-old colt ran the distance in 1:34.12 and paid $3.40 to win as the 3-5 favorite. Todd Pletcher trains Life Is Good and earned his 12th Cup win. Ortiz has 14 career Cup victories.

• Golden Pal rocketed to the front in the $1 million Turf Sprint and won by 1¼ lengths under Irad Ortiz Jr. The 5-2 favorite ran 1¼ miles in 54.75 seconds and paid $7 to win. Ortiz and trainer Wesley Ward combined to take the Juvenile Turf on Friday with Twilight Gleaming.

• Jockey E.T. Baird was fined $5,000 by the Del Mar stewards for violating California’s whip rules in the Juvenile Turf Sprint on Friday. He was cited for using the whip more than six times during a race. His mount, One Timer, finished ninth.