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A new and more infectious version of the Delta variant now accounts for 15% of coronavirus cases in the UK, according to the latest government data.

AY.4.2 is an evolutionary spin-off of the original Delta variant first found in India.

The UK Health and Security Agency (UKHSA) designated it a ‘variant under investigation’ on 20 October.

Data shows it made up 14.7% of sequenced cases in the week ending 6 November and is continuing to grow.

But as AY.4.2 starts to take over, Sky News looks at how the new variant could affect people’s COVID immunity in the run-up to Christmas.

What do we know about AY.4.2?

AY.4.2 is a sub-lineage of the Delta variant.

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There are currently nine versions of Delta present in the UK.

But government experts have classified AY.4.2 as a ‘variant under investigation’ because it has accounted for a “slowly increasing proportion of cases in the UK” since September.

Imperial College London’s REACT-1 study suggested it could be up to 10% more infectious than Delta, first found in Kent in late 2020. Delta was around 60% more transmissible than Alpha.

Scientists are not sure why it appears to spread more easily.

But the latest UKHSA data suggests vaccines are just as effective against it as they are against Delta – and it could carry a slightly lesser risk of hospitalisation.

The REACT-1 study of 100,000 people between 19 and 5 November also showed only a third of people with AY.4.2 had the classic COVID symptoms of a cough, fever, loss or change in taste and smell – compared to 46% who had the original Delta variant.

Authors of the study said people with the new variant were less likely to show any other symptoms as well.

If I’ve had COVID recently, does a new variant mean I could get it again?

Both vaccines and natural infection offer varying levels of immunity from getting reinfected with COVID-19.

Previous studies have shown getting COVID gives people around 80% protection from getting reinfected within five months.

But there is not yet enough data on AY.4.2 to know how long natural immunity from the new variant might last.

This means that if you have been recently infected with AY.4.2 it is not clear whether you are largely protected from contracting the original Delta variant within the following months.

But if the vaccines are just as effective against it, catching it naturally could offer similar levels of protection, Dr Raghib Ali, of the University of Cambridge’s epidemiology unit, tells Sky News.

“We don’t have reinfection data yet,” he says.

“But what we do have is data that shows no real difference in vaccine effectiveness between AY.4.2 and Delta.

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“Getting a vaccine induces an immune response that is based on the spike protein.

“And when you get infected naturally you also produce an immune response – so there shouldn’t be much difference.”

But he claims this only applies to people who have been vaccinated with two or three doses.

“In general, if you’ve been infected with Delta and you’ve had both vaccines, you should have good protection from AY.4.2 and vice versa,” he says.

A Harvard study has also showed that people who have had a combination of vaccines and natural infection have “substantially higher antibody responses” than people who have only been vaccinated.

“They have very good levels of protection,” Dr Ali adds.

“Because each time you are exposed to the vaccine or the virus, you develop an immune response.”

‘It’s not a hard shield’

Although most people develop some level of immunity from getting the virus naturally, it is not guaranteed, Dr Deepti Gurdasani warns.

“Neither natural infection nor vaccination should be seen as a hard shield,” the clinical epidemiologist at Queen Mary University tells Sky News.

“You get more varying levels of immune response from natural infection than you do from vaccination.

“Not everyone who gets infected naturally seroconverts [produces an immune response].”

She also says lower immune responses are more common in people who get no or mild symptoms, as well as children and young people.

“Some don’t produce immune responses at all,” she adds.

“If you have had two doses and a natural infection – you have got some boosted immunity, but the protection you get from both is just a layer – it’s not absolute.”

Boosters, tests and hand washing important for Christmas

As Christmas approaches, with more socialising and case rates still considerably high, experts have warned the UK is facing a tough winter – and the NHS being overwhelmed.

And with immunity waning a few months after getting a second vaccine, both scientists are urging people to get booster jabs if they are eligible.

“There is more and more evidence that this [coronavirus] is a three-dose vaccine,” Dr Gurdasani says.

“Lots of people are at the stage now where they’re three or four-months post-vaccination and are getting breakthrough infections.

“It highlights the importance of boosters and of seeing each thing you do, whether that be a test, wearing a mask or recovering from infection, as a layer of protection – not absolute protection.”

Dr Ali adds: “The most important thing is still to have the vaccine, but it’s also true that the vaccine isn’t 100% effective.

“So if you’re mixing with vulnerable or elderly relatives over Christmas, basic interventions like taking a lateral flow test and washing your hands regularly are still important.”

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About 100 sub-postmaster convictions separate to Post Office cases may be ‘tainted’

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About 100 sub-postmaster convictions separate to Post Office cases may be 'tainted'

Prosecutions of sub postmasters by the Department for Work and Pensions could be “tainted” as Sky News reveals officials worked with now discredited Post Office investigators to secure convictions.

Around 100 prosecutions of Post Office staff were led by the Department for Work and Pensions (DWP) between 2001 and 2006.

It is understood that these usually involved the cashing in of stolen order books.

The Post Office itself wrongly prosecuted hundreds of sub-postmasters between 1999 and 2015 – based on evidence from the faulty Horizon accounting system.

The role of government

A Sky News investigation, however, has discovered that information was shared between Post Office investigation teams and the DWP.

Chair of the Justice Select Committee, Sir Robert Neill KC, said as a result DWP convictions “need to be looked at”.

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“I hadn’t been aware of that, for example, there may have been material in the DWP case as a result of joint investigations – which suggests a disclosure failure,” he added.

“I think that’s the area they need to look at if we are saying their approach was tainted from the beginning – in the way the investigators adopted things – then joint operations I suspect would be just as tainted arguably as something where it has been the Post Office on its own.”

What was known?

A 2003 DWP report into fraud describes “joint working” and the “sharing of information” with the Post Office.

It also outlines a “Fraud Prevention Board” established by the DWP and Royal Mail Group plc which includes “the exchange of information that directly assists fraud prevention and investigations”.

In addition, separately, a 2003 letter seen by Sky News also indicates a connection between DWP and Post Office investigations.

The letter, from the then post affairs minister Stephen Timms, references the case of Roger Allen, a sub-postmaster from Norwich.

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It states: “Subsequent investigations by the police, the Post Office Investigation Department and the Department for Work and Pensions (DWP) led to a prosecution by DWP…”

Roger Allen was convicted in 2004 of stealing pension payments and was sentenced to six months in prison. He died in March of this year.

Mr Allen had pleaded guilty to spare his wife – after his lawyer told him in a letter that there had been “an indication from the Crown that they may discontinue the proceedings against Mrs Allen were you minded to plead guilty”.

Despite the Criminal Cases Review Commission deciding Mr Allen had grounds to appeal against his conviction – it was upheld by the Court of Appeal in 2021.

DWP prosecutions are not covered in upcoming government legislation that will overturn Post Office convictions.

Roger Allen. Pic: Keren Simpson
Image:
Roger Allen. Pic: Keren Simpson

Fighting to clear names

Keren Simpson, Roger’s daughter, has vowed to fight to clear his name posthumously.

She describes her father as a “proud” and “honest” man who “couldn’t face or deal” with the fact his conviction would not be overturned.

She says “in the end he obviously gave up” and there is “very little surviving evidence” because of the passage of time.

“He’s the innocent one,” Keren states. “I don’t see why he’s got to try and prove it. They have got to try and prove it, and show what evidence they actually had on my dad.

“Because the Department of Work and Pensions have put a statement out saying there was surveillance and witness testimonies and physical evidence to show it.

“Show me it.”

Roger Allen. Pic: Keren Simpson
Image:
Roger Allen. Pic: Keren Simpson

Investigation failures?

Sky News has also seen documents that suggest failures by DWP investigators in a different case in the 2000s.

It involved a sub-postmaster who decided to plead not guilty and was acquitted of stealing by a jury.

In one extract it says a “senior investigating officer” was “willing to admit in open court that (they) had been neglectful in (their) duty in securing evidence”.

Another document appears to show a failure to review transaction logs used as evidence against the sub-postmaster.

Some logs appear to show that the accused did not cash the “dockets”, used to collect pension payments.

Other transaction logs indicate the sub-postmaster was not present at a particular branch when the theft was alleged to have occurred.

Christopher Head
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Christopher Head

Chris Head, former sub-postmaster and a campaigner for others, has also seen the documents and says they point to a “deeply flawed” DWP investigation.

“…they failed to obtain all transaction logs for the entirety of this case, but the ones that they have, they have they clearly haven’t looked at.”

He believes there are “more cases out there” which could be “part of a miscarriage of justice”.

A Department for Work and Pensions spokesperson said: “We do not recognise these claims.

“DWP investigates offences against the welfare system to protect taxpayers’ money, and between 2001 and 2006 a small number of Post Office staff were convicted for welfare-related fraud.

“These cases involved complex investigations and were backed by evidence including filmed surveillance, stolen benefit books and witness statements – they did not rely on Horizon evidence, and this has been accepted by the Court of Appeal.”

The Post Office says it “continues to help other prosecuting authorities to ensure that they have every assistance in taking their work forward”.

“This includes sharing all the information we have in relation to prosecutions which have been brought by other prosecutors.”

Meanwhile, Lord Sikka has tabled an amendment in the House of Lords to the Post Office (Horizon System) Offences Bill to include all DWP convictions.

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What is cryptosporidium? The diarrhoea-causing parasite found in Devon drinking water

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What is cryptosporidium? The diarrhoea-causing parasite found in Devon drinking water

An outbreak of a waterborne disease in Devon has prompted urgent warnings for residents to boil their tap water. 

At least 22 cases of cryptosporidiosis disease have been confirmed in and around the town of Brixham in South West England.

But what is the parasite that is making people sick, what are the symptoms of being infected with it and how serious can it be?

What is cryptosporidiosis disease?

Cryptosporidiosis is the disease caused by the parasite cryptosporidium.

Often shortened to crypto, infections can be caused by drinking contaminated water or swallowing contaminated water in swimming pools or streams.

It can also be acquired through contact with the faeces of infected animals or humans.

What are the symptoms?

The symptoms of cryptosporidiosis include:

• profuse watery diarrhoea
• stomach pains
• nausea or vomiting
• low-grade fever
• loss of appetite

How long does it last?

Most people develop symptoms within one to 12 days of picking up the parasite.

Symptoms usually last for about two weeks, but can last up to six weeks or longer when the immune system is not working properly.

During the illness, you might think you are getting better but the illness returns a couple of days later before you fully recover.

How serious is it?

Most people recover, but in people with severely weakened immune systems it can cause severe disease and can be fatal.

Serious cases and death used to be more common, according to Paul Hunter, professor in medicine at the University of East Anglia (UEA).

This is because before effective antiretroviral treatments were introduced for HIV/AIDS, people living with these illnesses would not recover if they picked up cryptosporidiosis.

Who is most at risk of serious illness?

People with weak immune systems are at greater risk of serious illness. This includes:

• people on some immunosuppressive drugs, for example cancer or transplant patients
• people with untreated HIV/AIDS
• malnourished children

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Residents ‘worried’ over water parasite

Does it need treatment?

There is no specific treatment for cryptosporidiosis.

It important to drink plenty of fluids as diarrhoea or vomiting can lead to dehydration, according to advice from the UK Health Security Agency (UKHSA).

You might also want to talk to a pharmacist about oral rehydration sachets to help replace the sugar, salts and minerals the body has lost.

Dr Lincoln Sargeant, Torbay’s Director of Public Health, said anyone with “severe symptoms like bloody diarrhoea” should contact NHS 111 or their GP.

Severe cases may require hospital treatment.

How do you know if you have crypto?

The symptoms of crypto are similar to other stomach bugs, so the only way to know for sure if you have it is for your doctor to send a sample of your faeces to be tested in a laboratory.

Read more:
Water disease outbreak may last a week, expert says
Sickness outbreak forces farm to cancel animal cuddling

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How can you stop the illness spreading?

If you are ill, stay away from nursery, school or work while you have symptoms, and for at least 48 hours after they stop.

You should also avoid swimming for two weeks after being unwell.

You should not prepare food for anyone else until 48 hours after diarrhoea has stopped.

Make sure you’re using good handwashing practices too, washing your hands thoroughly when handling food and after using the toilet.

The UKHSA also advises washing bedding and towels on the hottest possible cycle.

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Lucy Letby: Families of victims want inquiry live streamed to stop ‘grossly offensive’ conspiracy theories

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Lucy Letby: Families of victims want inquiry live streamed to stop 'grossly offensive' conspiracy theories

The inquiry into how nurse Lucy Letby was able to murder babies at a hospital in Chester will begin to hear evidence in September. 

Lawyers for the families of Letby’s victims told a preliminary hearing that the inquiry should be live streamed to the public to prevent the spread of “grossly offensive” conspiracy theories.

Letby was sentenced to 14 whole-life orders after she was convicted of murdering seven babies and attempting to murder six others while working on the neo-natal unit at the Countess of Chester Hospital in 2015 and 2016.

At the preliminary hearing, inquiry chair Lady Justice Thirlwall heard submissions on whether the hearings should be publicly broadcast.

Peter Skelton KC, on behalf of the families of six babies, said Letby’s crimes continued to be the subject of conspiracy theories online.

“One of the most effective antidotes to those theories and the damage they cause will be to see and to hear the people involved in the hospital give a true and comprehensive account of the facts,” he said.

But Andrew Kennedy KC, representing the Countess of Chester, said there was a “high level of anxiety” from staff at the prospect of giving evidence which was live streamed.

He said: “If a witness is concerned about live-streaming then if we can remove that concern we can, we would suggest, encourage candour, frankness and openness.”

Serial child killer Lucy Letby
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Letby was given multiple whole-life terms and will be re-tried on one charge next month

Richard Baker KC, representing some of the other families, said: “Their desire in this case is for change and so that others do not experience what they have experienced.”

They were “saddened” and “concerned” at the suggestion the lack of transparency might continue, he said.

Lady Justice Thirlwall will give her decision on whether the hearings will be broadcast at a later date.

She had begun the proceedings with a pause for reflection on the “lives lost”, “injuries sustained” and “suffering” of the families.

Read more from Sky News:
Boy dies after falling from apartment block in east London
Top midwife slams progress two years after key report

The hearing was told 188 requests for information had been made to individuals including midwives, nurses, doctors, managers and members of the hospital board.

The inquiry hearings are scheduled to begin on 10 September at Liverpool Town Hall.

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The parents of the babies will be among the first to give evidence.

Counsel to the inquiry Rachel Langdale KC told the hearing: “There are no sides. It is a search for the truth.”

Last month Letby asked the Court of Appeal for permission to mount a full legal challenge to her conviction. Judges are due to rule on this at a later date.

The former nurse is due to face a re-trial next month on one charge of the attempted murder of a baby in February 2016.

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