Ms Truss said she was “incredibly sorry” to lose her good friend Mr Kwarteng, and confirmed that she had appointed Jeremy Hunt in his place.
She said Mr Hunt would deliver the medium-term fiscal plan at the end of the month.
Ms Truss also confirmed the government would raise corporation tax next April to 25% from 19%, despite pledging not to do so in the mini-budget.
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The PM spoke for just three and a half minutes and answered only four questions from journalists, for which she has received much criticism, with some Tory MPs saying the news conference only made things worse.
Ms Truss said Mr Hunt is “one of the most experienced and widely respected government ministers and parliamentarians, and he shares my convictions and ambitions for our country”.
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But she refused to take responsibility for any of the economic turmoil the mini-budget caused, saying: “It is clear that parts of our mini-budget went further and faster than markets were expecting, so the way we are delivering our mission now has to change.”
Determined to remain as prime minister, she said she “acted decisively” and in the national interest.
“I am determined to see through what I’ve promised – deliver higher growth, a more prosperous United Kingdom,” she insisted.
“I have to act in the national interest as prime minister.”
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Moment PM abruptly ends news conference
And asked if she would apologise after former Tory chancellor Philip Hammond said she had trashed the party’s winning reputation for economic competence, she refused.
“Well, I am determined to deliver on what I set out when I campaigned to be party leader,” she said.
“We need to have a high growth economy, but we have to recognise that we are facing very difficult issues as a country.”
Image: Jeremy Hunt has replaced Kwasi Kwarteng as chancellor
The PM sacked Mr Kwarteng this afternoon, shortly after he landed in London after leaving International Monetary Fund meetings in Washington DC early.
He was sacked three weeks after unveiling £45bn of unfunded tax cuts in the mini-budget, which pushed the pound to a record low against the dollar, sent the cost of government borrowing and mortgage rates up and led to an unprecedented intervention by the Bank of England.
The economic turmoil forced the government into two U-turns of major policies in the mini-budget: abolishing the 45p rate of income tax for higher earners and axing the planned rise in corporation tax from 19% to 25% next April.
Worldwide stock markets have plummeted for the second day running as the fallout from Donald Trump’s global tariffs continues.
While European and Asian markets suffered notable falls, American indexes were the worst hit, with Wall Street closing to a sea of red on Friday following Thursday’s rout – the worst day in US markets since the COVID-19 pandemic.
All three of the US’s major indexes were down by more than 5% at market close; The Dow Jones Industrial Average plummeted 5.5%, the S&P 500 was 5.97% lower, and the Nasdaq Composite slipped 5.82%.
The Nasdaq was also 22% below its record-high set in December, which indicates a bear market.
Ever since the US president announced the tariffs on Wednesday evening, analysts estimate that around $4.9trn (£3.8trn) has been wiped off the value of the global stock market.
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Mr Trump has remained unapologetic as the markets struggle, posting in all-caps on Truth Social before the markets closed that “only the weak will fail”.
The UK’s leading stock market, the FTSE 100, also suffered its worst daily drop in more than five years, closing 4.95% down, a level not seen since March 2020.
And the Japanese exchange Nikkei 225 dropped by 2.75% at end of trading, down 20% from its recent peak in July last year.
Image: US indexes had the worst day of trading since the COVID-19 pandemic. Pic: Reuters
Trump holds trade deal talks – reports
It comes as a source told CNN that Mr Trump has been in discussions with Vietnamese, Indianand Israelirepresentatives to negotiate bespoke trade deals that could alleviate proposed tariffs on those countries before a deadline next week.
The source told the US broadcaster the talks were being held in advance of the reciprocal levies going into effect next week.
Vietnam faced one of the highest reciprocal tariffs announced by the US president this week, with 46% rates on imports. Israeli imports face a 17% rate, and Indian goods will be subject to 26% tariffs.
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China – hit with 34% tariffs on imported goods – has also announced it will issue its own levy of the same rate on US imports.
Mr Trump said China “played it wrong” and “panicked – the one thing they cannot afford to do” in another all-caps Truth Social post earlier on Friday.
Later, on Air Force One, the US president told reporters that “the beauty” of the tariffs is that they allow for negotiations, referencing talks with Chinese company ByteDance on the sale of social media app TikTok.
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Tariffs: Xi hits back at Trump
He said: “We have a situation with TikTok where China will probably say, ‘We’ll approve a deal, but will you do something on the tariffs?’
“The tariffs give us great power to negotiate. They always have.”
Global financial markets gave a clear vote of no-confidence in President Trump’s economic policy.
The damage it will do is obvious: costs for companies will rise, hitting their earnings.
The consequences will ripple throughout the global economy, with economists now raising their expectations for a recession, not only in the US, but across the world.
The court ruled to uphold the impeachment saying the conservative leader “violated his duty as commander-in-chief by mobilising troops” when he declared martial law.
The president was also said to have taken actions “beyond the powers provided in the constitution”.
Image: Demonstrators stayed overnight near the constitutional court. Pic: AP
Supporters and opponents of the president gathered in their thousands in central Seoul as they awaited the ruling.
The 64-year-old shocked MPs, the public and international allies in early December when he declared martial law, meaning all existing laws regarding civilians were suspended in place of military law.
Image: The court was under heavy police security guard ahead of the announcement. Pic: AP
After suddenly declaring martial law, Mr Yoon sent hundreds of soldiers and police officers to the National Assembly.
He has argued that he sought to maintain order, but some senior military and police officers sent there have told hearings and investigators that Mr Yoon ordered them to drag out politicians to prevent an assembly vote on his decree.
His presidential powers were suspended when the opposition-dominated assembly voted to impeach him on 14 December, accusing him of rebellion.
The unanimous verdict to uphold parliament’s impeachment and remove Mr Yoon from office required the support of at least six of the court’s eight justices.
South Korea must hold a national election within two months to find a new leader.
Lee Jae-myung, leader of the main liberal opposition Democratic Party, is the early favourite to become the country’s next president, according to surveys.