After the sudden deaths of two patients at a hospital in New Jersey, nobody could have guessed the crimes that were about to be uncovered.
And a key player in the investigation was Amy Loughren – the subject of the new Netflix film The Good Nurse – who would play a vital role in revealing the shocking truth about Charles Cullen, a colleague she called a friend.
Born in New Jersey in 1960, Cullen was the youngest of eight siblings.
His father was a bus driver who died before Cullen turned a year old, and his mother, a homemaker, died in a car accident when he was a teenager.
His first murders
After what has widely been reported as a miserable childhood, a brief stint in the Navy and numerous alleged suicide attempts, Cullen eventually became a nurse, graduating from nursing school in 1987 before getting married.
Cullen and his wife had two daughters before getting a divorce in 1993.
During that time, Cullen is believed to have killed his first victims.
Cullen would go on to work in several hospitals and nursing homes. Some jobs he quit after being investigated over allegations of misconduct – on one occasion because an elderly woman complained he kept coming into her room and giving her injections when he wasn’t the nurse assigned to her.
He was fired from one hospital for hiding heart medicine in a bin meant for disposing of needles.
He would bounce from different medical centres in New Jersey, and even worked for a time in Pennsylvania after getting a licence to practice there.
His weapon of choice: Digoxin
Between 1998 and 2002, he did some agency work and had some full-time jobs.
In this time, he is believed to have killed even more people.
His weapon of choice was a drug called digoxin – a medication routinely used to treat people with an irregular heartbeat or heart failure – but is lethal in large doses.
Cullen would also inject patients’ saline pouches with lethal doses of insulin and other drugs.
His crimes were committed over a period of 16 years – but it was in 2003 while he was working at Somerset Medical Centre in Somerville, New Jersey, that it would all finally unravel.
Florian Gall was a reverend being treated at the hospital.
After showing signs of improvement during his stay, Gall had a massive heart attack and died.
It was later determined that he had a lethal level of digoxin, and his death was caused by an unauthorised dose of the drug.
Cullen was finally arrested in December in 2003.
He told investigators that he administered the drug overdoses to put “very sick” patients out of their misery.
He admitted to 30-40 murders, but the true number is thought to be closer to 400 – which would make him the most prolific serial killer in US history.
The friendship that would ultimately bring him down
While working at what would become his last hospital, Cullen met a nurse – Loughren – and they formed a friendship.
She saw in him a kind man, someone she wanted to spend time with and be friends with.
But it was Loughren – described as “courageous” and “incredible” – who helped detectives build the case against him.
The single mother and cardiomyopathy sufferer was coping with night shifts in a New Jersey hospital in order to qualify for health insurance when the apparently highly-qualified Cullen was hired to help manage the workload.
The two quickly formed a close bond – Cullen even helping Loughren to cover up her illness and care for her two young daughters.
But following the sudden death of two patients, detectives became suspicious of Cullen.
When they gave her documents that showed the drugs Cullen was ordering, she “knew he was murdering people”, she previously said.
“There were so many withdrawals of lethal medications” that you wouldn’t order unless you wanted to kill someone,” she had told CBS at the time.
She began collecting evidence at the hospital and wore a wire at a meeting with him. She also admits to manipulating him to try to get him to confess.
In The Good Nurse, Loughren is played by Jessica Chastain, while Eddie Redmayne picks up the role of Cullen.
She says she was “proud” to see the film come together, although it acted as a “trigger” for so much of the time she spent with Cullen.
Loughren said: “I was pretty terrified every day and I held that together.
“The things that they don’t show in the film was that I was actually much more sick – and I was truly terrified of leaving my two girls behind.
“Watching Jessica play me – I allowed myself to feel proud of myself.”
‘My guilt about missing my friendship – because he’s a monster’
“It was triggering watching Charlie (played by Redmayne) because Eddie truly embodies who my friend Charlie was.
“The way that he moves, the way that he speaks, the interactions that we have, are so real. That part of it was extremely triggering.
“And allowing myself to understand that I missed him for a while – and my guilt about actually missing my friendship, because he’s a monster.
“But I didn’t know the murderer. I only met the murderer a couple of times and he played this part of my friend.
“I missed that friendship, so it was very triggering. And then it was like, ‘let’s get him’.”
Image: Amy Loughren, left, and Jessica Chastain at the Toronto International Film Festival. Pic: Evan Agostini/Invision/AP
Making a film ‘was laughable at first’
Film producers found the relationship between the single mother and Cullen as the most “compelling” part of the narrative.
Loughren, who retired 18 months ago, added: “It was laughable at first because I’m thinking how would anybody really want to see a film? And truly, (the investigation) was such a small part.
“Darren Aronofsky was the one who initially picked it up and decided to make it into a movie.
“He said the most compelling part of Charles Graeber’s absolutely brilliant book was the friendship and that it was compelling to him.
“Something that I had actually been embarrassed about and felt so much guilt about was all of a sudden going to be up on a big screen.
“I didn’t really know how to feel. I didn’t want anyone to know who I was 20 years ago.
Image: Eddie Redmayne and Jessica Chastain in The Good Nurse. Pic: JoJo Whilden/Netflix
“I didn’t want anyone to be judging me from the 20 years ago that I was.
“It was scary. I didn’t want my name on it at first. Then I realised it’s going to happen with or without me – I might as well give myself a voice.”
Chastain, who met Loughren for the first time during a Zoom call, highlighted learning how complicated life was for the former nurse.
‘What she stumbles into is quite shocking’
Chastain told Sky News: “To be able to talk to Amy and understand what her life was like and what she had at stake, it really helped me to realise how courageous she was and what an incredible person she is.
“All the things that she was juggling at the time. Being a single mother, two girls, not having health insurance, working on a night shift so you’re not really getting proper sleep.
“And also, at the same time, needing a heart transplant. That’s what we walk in with at the beginning of this film.
“What she then stumbles into is quite shocking.”
Director Tobias Lindholm said what he “loved” about the story was how it focused on “a hardworking woman whose superpower was her humanity”.
He added: “I remember coming across the script a few years ago and it mirrored Charles Graeber’s book a bit more closely in that it focused on the killer, but it was Amy Loughren’s role in this story that I found to be most interesting.”
Sean “Diddy” Combs has been sentenced to more than four years in prison over prostitution charges relating to his former girlfriends and male sex workers.
Judge Arun Subramanian handed down his 50-month sentence – including a $500,000 fine – at the end of a long and emotional full-day hearing, which saw the hip-hop mogul speak out for the first time in court.
Combs, 55, admitted his past behaviour was “disgusting, shameful and sick”, and apologised personally to Cassie Ventura and “Jane”, another former girlfriend who testified anonymously during the trial.
Image: Sean Diddy Combs broke down and cried at one point during the sentencing hearing. Pic: AP/ Elizabeth Williams
But despite his plea for “mercy” and expressions of remorse, the judge told him he had abused his “power and control” with women he professed to love – and rejected the defence’s characterisation that “freak off” sexual encounters were consensual experiences, that his was just a “sex, drugs and rock’n’roll story”.
Addressing Cassie and “the other brave survivors who came forward”, the judge said. “We heard you… I can only say your families are proud of you and your children will be proud of you.
“You weren’t just talking to the jury you were talking to the women who feel powerless – you gave them a voice, you stood up to power, it’s not easy.”
Combs showed no visible change of emotion as his sentence was delivered, looking straight ahead as the judge spoke. Afterwards, he seemed subdued – with no sign of the enthusiasm or feeling showed earlier in the day.
Image: Six of Combs’s children, including Chance, right, and twins Jessie and D’Lila Star, addressed the judge in support of their father. Pic: AP/Richard Drew
Ahead of his own speech, the court heard from six of his seven children – causing the rapper to break down in tears as they spoke about how much they loved him, how he has changed, and how much they and their younger two-year-old sister need him.
The sentencing brings to an end a sordid case that featured harrowing testimony – not just from Cassie and Jane, but also from former employees and associates of Combs.
He was convicted in July of flying people around the US and abroad for sexual encounters, including his then girlfriends and male sex workers, in violation of prostitution laws.
However, he was cleared of more serious charges of racketeering conspiracy and sex-trafficking that could have put him in jail for life.
‘I hate myself right now’
Image: Diddy cried as his children read impact statements. Pic: Reuters/Jane Rosenberg
He expanded on this in court, saying he wanted to “personally apologise” to Cassie for “any harm” he caused her “emotionally or physically”, and to Jane – and all victims of domestic violence.
He told the court he got “lost in my excess and lost in my ego”, but since his time in prison he has been “humbled and broken to my core”.
Combs continued: “I hate myself right now… I am truly sorry for it all.”
Image: Janice Combs supported her son in court. Pic: AP Photo/Eduardo Munoz Alvarez
Once one of the most influential hip-hop producers of the 1990s and 2000s – the founder of Bad Boy Records and a Grammy-winning artist in his own right – he has led a very different life since his high-profile arrest.
He was facing a maximum of 20 years in prison for the prostitution-related charges, so the sentence is towards the lower end of the scale.
Prosecutors had argued he should spend at least 11 years behind bars, while Combs’s lawyers were calling for him to be freed almost immediately due to time already served since his arrest just over a year ago.
Christy Slavik, for the prosecution, told the judge sparing the rapper serious prison time would excuse years of violence.
‘Make the most of that second chance’
Image: Judge Arun Subramanian told Combs he will still have a life after prison if he takes his second chance. Pic: Elizabeth Williams via AP
The judge, who had rejected bail for the rapper several times before sentencing, told him that he would get through his time in prison. It will be hard, he said, but he will still “have a life afterwards”.
Combs has “a chance for renewal and redemption”, he added. “What went wrong can be made right… I am counting on you to make the most of that second chance.”
Outside the courthouse, journalists and onlookers swarmed the pavements as TV crews stood in a long row across the street, echoing scenes from the two-month high-profile trial.
It included four days of testimony from Cassie, now Cassie Ventura Fine, who told the court she was coerced and sometimes blackmailed into sexual encounters with male sex workers, referred to as “freak offs”.
Cassie responds
Image: Diddy and Cassie at the premiere for a film she starred in, just days after the 2016 hotel incident. Pic: zz/Galaxy/STAR MAX/IPx/ AP
Jurors were also shown video clips of Combs dragging and beating her in a Los Angeles hotel hallway after one of those sessions in 2016.
Combs referred to this in court, saying it was a “heavy burden” that he will forever carry, and that he was “sick from drugs” and “out of control” at the time, “lost in my excess and lost in my ego”.
Ahead of the sentencing, Cassie also submitted a letter to the judge, calling Combs a “manipulator” and saying she would fear for her safety should he be immediately released.
Responding to the sentence, her lawyers Douglas Wigdor and Meredith Firetog (Wigdor LLP), said: “While nothing can undo the trauma caused by Combs, the sentence imposed today recognises the impact of the serious offences he committed.
“We are confident that with the support of her family and friends, Ms Ventura will continue healing knowing that her bravery and fortitude have been an inspiration to so many.”
Sean “Diddy” Combs has apologised and taken “full responsibility” for “all of the hurt and pain” he has caused others in a letter to the court, less than 24 hours before he is due to be sentenced.
The hip-hop mogul did not give evidence during his trial earlier this year, so this is the first time he has addressed Judge Arun Subramanian.
In the letter, the 55-year-old admits “past wrongs” but says he is no longer running from his “many mistakes”.
He also addresses the infamous CCTV footage from an LA hotel in 2016, which showed him attacking his former girlfriend Cassie Ventura.
“First and foremost, I want to apologise and say how sincerely sorry I am for all of the hurt and pain that I have caused others by my conduct,” Combs writes. “I take full responsibility and accountability for my past wrongs.”
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4:43
How the Diddy trial unfolded
The rapper describes the last two years – which started with a civil lawsuit filed by Cassie in November 2023 – as the “hardest” of his life, but admits: “I have no one to blame for my current reality and situation but myself.”
Since his arrest in September 2024 and subsequent time in prison, the rapper says he has “had to look in the mirror like never before” and admits his “downfall was rooted in my selfishness”.
Prosecutors have called for at least 11 years, while his defence team argues he should serve no more than 14 months. The latter would see him walk free almost immediately after time already served.
His letter comes after several filed by witnesses who testified during the trial, including Cassie, who has urged the judge not to be lenient and expressed fears for her safety.
She alleged on the witness stand that she was coerced and sometimes blackmailed into taking part in sex sessions with male escorts. Combs has strenuously denied allegations of sexual abuse, and jurors cleared him of sex trafficking, only finding him guilty of the charges relating to hiring the sex workers.
However, his legal team admitted from the beginning that he had been violent in the past.
Image: Cassie Ventura gave evidence during the trial. Pic: Reuters/Jane Rosenberg
‘I could not forgive anyone putting a hand on one of my daughters’
Talking about the 2016 CCTV footage – which showed Combs, wearing only a towel and socks, attacking Cassie in a hallway – he says in his letter: “The scene and images of me assaulting Cassie play over and over in my head daily.
“I literally lost my mind. I was dead wrong for putting my hands on the woman that I loved. I’m sorry for that and always will be. My domestic violence will always be a heavy burden that I will have to forever carry. The remorse, the sorrow, the regret, the disappointment, the shame.”
He goes on to say he feels sorry “for something that I couldn’t forgive someone else for: if they put their hands on one of my daughters.”
The footage was played several times during his trial after first being made public by CNN in May 2024.
The hip-hop mogul also references “Jane”, another former girlfriend who testified against him in court, who did not give her real name.
“I thought I was providing for Jane concerning her and her child, but after hearing her testimony, I realised that I hurt her,” he writes. “For this I am deeply sorry. I lost my way … Lost in the drugs and the excess.”
Image: Combs fell to his knees when the verdict was delivered. Pic: Reuters/Jane Rosenberg
‘The old me died in jail’
Combs goes on to describe his time in prison, saying he has been “humbled and broken to my core” and that there “have been so many times that I wanted to give up”.
“The old me died in jail and a new version of me was reborn. Prison will change you or kill you – I choose to live.”
Combs says he has had therapy and has been “working diligently to become the best version” of himself, and that there has been some good to come out of his time in prison.
“For starters, I am now sober for the first time in 25 years. I have been trying my best to deal with my drug abuse and anger issues and take accountability as well as positive steps towards healing.”
Asking Judge Subramanian for “mercy” for himself, his seven children and his 84-year-old mother, he says: “I have failed my children as a father. My father was murdered when I was three years old so I know first-hand what it is to not have a father. More than anything, I just want the opportunity to return home and be the father that they need and deserve.”
Combs goes on to say he is “scared to death” at the thought of spending more time away from his family, and that he no longer cares “about the money or the fame”.
And as previously detailed by his lawyers, he describes conditions at the Metropolitan Detention Centre in Brooklyn as inhumane – but says he is not looking for “pity or sympathy”, and that his time there has “changed me forever!”.
Combs concludes by vowing to never commit another crime again: “I can’t change the past, but I can change the future … I’m committed to the journey of remaining a drug free, non-violent and peaceful person.
“Today, I humbly ask you for another chance – another chance to be a better father, another chance to be a better son, another chance to be a better leader in my community, and another chance to live a better life.”
Sean “Diddy” Combs has apologised and taken “full responsibility” for “all of the hurt and pain” he has caused others in a letter to the court, less than 24 hours before he is due to be sentenced.
The hip-hop mogul did not give evidence during his trial earlier this year, so this is the first time he has addressed Judge Arun Subramanian.
In the letter, the 55-year-old admits “past wrongs” but says he is no longer running from his “many mistakes”.
He also addresses the infamous CCTV footage from an LA hotel in 2016, which showed him attacking his former girlfriend Cassie Ventura.
“First and foremost, I want to apologise and say how sincerely sorry I am for all of the hurt and pain that I have caused others by my conduct,” Combs writes. “I take full responsibility and accountability for my past wrongs.”
Please use Chrome browser for a more accessible video player
4:43
How the Diddy trial unfolded
The rapper describes the last two years – which started with a civil lawsuit filed by Cassie in November 2023 – as the “hardest” of his life, but admits: “I have no one to blame for my current reality and situation but myself.”
Since his arrest in September 2024 and subsequent time in prison, the rapper says he has “had to look in the mirror like never before” and admits his “downfall was rooted in my selfishness”.
Prosecutors have called for at least 11 years, while his defence team argues he should serve no more than 14 months. The latter would see him walk free almost immediately after time already served.
His letter comes after several filed by witnesses who testified during the trial, including Cassie, who has urged the judge not to be lenient and expressed fears for her safety.
She alleged on the witness stand that she was coerced and sometimes blackmailed into taking part in sex sessions with male escorts. Combs has strenuously denied allegations of sexual abuse, and jurors cleared him of sex trafficking, only finding him guilty of the charges relating to hiring the sex workers.
However, his legal team admitted from the beginning that he had been violent in the past.
Image: Cassie Ventura gave evidence during the trial. Pic: Reuters/Jane Rosenberg
‘I could not forgive anyone putting a hand on one of my daughters’
Talking about the 2016 CCTV footage – which showed Combs, wearing only a towel and socks, attacking Cassie in a hallway – he says in his letter: “The scene and images of me assaulting Cassie play over and over in my head daily.
“I literally lost my mind. I was dead wrong for putting my hands on the woman that I loved. I’m sorry for that and always will be. My domestic violence will always be a heavy burden that I will have to forever carry. The remorse, the sorrow, the regret, the disappointment, the shame.”
He goes on to say he feels sorry “for something that I couldn’t forgive someone else for: if they put their hands on one of my daughters.”
The footage was played several times during his trial after first being made public by CNN in May 2024.
The hip-hop mogul also references “Jane”, another former girlfriend who testified against him in court, who did not give her real name.
“I thought I was providing for Jane concerning her and her child, but after hearing her testimony, I realised that I hurt her,” he writes. “For this I am deeply sorry. I lost my way … Lost in the drugs and the excess.”
Image: Combs fell to his knees when the verdict was delivered. Pic: Reuters/Jane Rosenberg
‘The old me died in jail’
Combs goes on to describe his time in prison, saying he has been “humbled and broken to my core” and that there “have been so many times that I wanted to give up”.
“The old me died in jail and a new version of me was reborn. Prison will change you or kill you – I choose to live.”
Combs says he has had therapy and has been “working diligently to become the best version” of himself, and that there has been some good to come out of his time in prison.
“For starters, I am now sober for the first time in 25 years. I have been trying my best to deal with my drug abuse and anger issues and take accountability as well as positive steps towards healing.”
Asking Judge Subramanian for “mercy” for himself, his seven children and his 84-year-old mother, he says: “I have failed my children as a father. My father was murdered when I was three years old so I know first-hand what it is to not have a father. More than anything, I just want the opportunity to return home and be the father that they need and deserve.”
Combs goes on to say he is “scared to death” at the thought of spending more time away from his family, and that he no longer cares “about the money or the fame”.
And as previously detailed by his lawyers, he describes conditions at the Metropolitan Detention Centre in Brooklyn as inhumane – but says he is not looking for “pity or sympathy”, and that his time there has “changed me forever!”.
Combs concludes by vowing to never commit another crime again: “I can’t change the past, but I can change the future … I’m committed to the journey of remaining a drug free, non-violent and peaceful person.
“Today, I humbly ask you for another chance – another chance to be a better father, another chance to be a better son, another chance to be a better leader in my community, and another chance to live a better life.”