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A scientist in a race against time to find a cure for her daughter’s rare and deadly disease has said they are “finally in the driving seat”.

Dr Michelle Teng is trying to develop the world’s first treatment for TUBB4a leukodystrophy before it is too late for her 12-year-old daughter Sofia.

The life-threatening genetic condition affects the central nervous system and can lead to an inability to walk, talk and even swallow. Most young patients die before they reach adulthood.

Sofia started showing symptoms when she was a toddler and was eventually diagnosed with the disease aged four.

“When we Googled the condition, it was a terrifying experience,” Michelle remembers.

“If you read the worst-case scenarios, the children die within 12 months.

“In [Sofia’s] case, it’s a slow, neurodegenerative disease. Obviously, I didn’t know that, and I had no idea how long she was going to live for.

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“The doctors told us there’s nothing you can do, and I think it’s probably the most devastating news for any parent to hear.”

Sofia Teng

‘It’s a ticking time bomb’

But the diagnosis spurred Dr Teng into action. At first, she raised money for research because at that point, in 2014, the disease had only just been defined.

But as Sophia’s condition began to deteriorate, to the point where she is now unable to walk or talk, Michelle realised she needed to do more.

“Anyone who’s lived with a loved one with Parkinson’s, Alzheimer’s or anything that’s degenerative will see that it’s a ticking time bomb,” she said.

“It’s a steady decline, and as the years go by, you see the people you love start losing the ability to do certain things.

“We raised something like close to £200,000 in a short space of time, which was extremely encouraging, but to really find a treatment, and to bring that treatment to clinic, will take five to 10 million, and I realised that was not going to cut the mustard.”

Sofia Teng

‘You have to be an optimist’

So in April 2021, Dr Teng set up SynaptixBio, a biotech firm based in Oxford with the sole aim of finding a treatment for TUBB4a.

The company recently signed a global licensing deal with the Children’s Hospital of Philadelphia – the world’s leading TUBB4a leukodystrophy centre – in the US to accelerate the research process.

It aims to launch clinical trials for a treatment in 2024.

Dr Teng said: “I feel like because we’ve set up this company, we’re finally in the driving seat in finding a treatment for [Sofia], within those timelines that we believe will be on time for her.

“And when you work in biotech, you have to be an optimist.”

Sofia Teng

‘A game-changer’

Research suggests there are 1,650 babies worldwide who are born with TUBB4a every year. In the UK, it is thought to affect between 60-90 newborns.

But scientists fear the number of cases could be higher still, due to many patients being misdiagnosed with other conditions, such as cerebral palsy.

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Desperate parents ‘freezing’ to keep their disabled children ‘alive’

A varied combination of symptoms makes it incredibly difficult to spot. The only way to confirm the disease is by genome sequencing and an MRI scan.

Dr Dan Williams, SynaptixBio CEO and co-founder, called the treatment the company is developing a potential “game-changer”.

“One of the most horrible things is that a lot of these children don’t actually make it into late teenagers,” he said.

“Hopefully, by stopping the progression of this disease, it could offer them a better quality of life as well as an extension to their lives as well.”

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‘A constant game of cat and mouse’: Inside the crackdown on illegal moped delivery drivers

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'A constant game of cat and mouse': Inside the crackdown on illegal moped delivery drivers

The first thing you notice when immigration officers stop a possible illegal moped delivery driver is the speed in which the suspect quickly taps on their mobile.

“We’re in their WhatsApp groups – they’ll be telling thousands now that we’re here… so our cover is blown,” the lead immigration officer tells me.

“It’s like a constant game of cat and mouse.”

Twelve Immigration Enforcement officers, part of the Home Office, are joining colleagues from Avon and Somerset Police in a crackdown on road offences and migrants working illegally.

Police chase suspected illegal immigrant working as a delivery drivers

The West of England and Wales has seen the highest number of arrests over the last year for illegal workers outside of London.

“It is a problem… we’re tackling it,” Murad Mohammed, from Immigration Enforcement, says. He covers all the devolved nations.

“This is just one of the operations going on around the country, every day of the week, every month of the year.”

Murad Mohammed from Immigration Enforcement
Image:
Murad Mohammed, from Immigration Enforcement, says his team are attempting to tackle the issue

Just outside the Cabot Circus shopping complex, we stop a young Albanian man who arrived in the UK on the back of a truck.

He’s on an expensive and fast-looking e-bike, with a new-looking Just Eat delivery bag.

He says he just uses it for “groceries” – but the officer isn’t buying it. He’s arrested, but then bailed instantly.

A man inspects the Just Eat food delivery bag of a suspected illegal immigrant working as a delivery driver

We don’t know the specifics of his case, but one officer tells me this suspected offence won’t count against his asylum claim.

Such is the scale of the problem – the backlog, loopholes and the complexity of cases – that trying to keep on top of it feels impossible.

This is one of many raids happening across the UK as part of what the government says is a “blitz” targeting illegal working hotspots.

Angela Eagle, the border security and asylum minister, joins the team for an hour at one of Bristol’s retail parks, scattered with fast food chains and, therefore, delivery bikes.

Angela Eagle, Minister for Border Security and Asylum
Image:
Border security and asylum minister, Angela Eagle, speaks to Sky News

She says arrests for illegal working are up over the last year by 51% from the year before, to more than 7,000.

“If we find you working, you can lose access to the hotel or the support you have [been] given under false pretences,” she said.

“We are cracking down on that abuse, and we intend to keep doing so.”

A suspected illegal immigrant working as a delivery driver being arrested

There are reports that asylum seekers can rent legitimate delivery-driver accounts within hours of arriving in the country – skipping employment legality checks.

Uber Eats, Deliveroo, and Just Eat all told Sky News they’re continuing to strengthen the technology they use to remove anyone working illegally.

But a new Border Security Bill, working its way through Parliament, could see companies fined £60,000 for each illegal worker discovered, director disqualifications and potential prison sentences of up to five years.

“I had them all in to see me last week and I told them in no uncertain terms that we take a very tough line on this kind of abuse and they’ve got to change their systems so they can drive it out and off their platforms,” the minister tells me.

Read more:
Welfare bill passes final Commons stage after another concession
Ex-Tory chairman defects to Reform
Wealth tax could be coming to the UK – what is it?

The gig economy – so prevalent in every city – creates another incentive for those wanting to risk their lives coming to the UK illegally.

More than 20,000 migrants have crossed the English Channel to the UK in 2025 – a record number at this point of the year.

A suspected illegal immigrant working as a delivery driver holds his helmet

For some of those who arrive, a bike and a phone provide a way to repay debts to gang masters.

There were eight arrests today in Bristol, one or two taken into custody, but it was 12 hours of hard work by a dozen immigration officers and the support of the police.

As two mopeds are pushed onto a low-loader, you can’t help but feel, despite the best intentions, that at the moment, this is a losing battle.

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This flimsy vessel carrying migrants could reach British waters in a few hours’ time

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This flimsy vessel carrying migrants could reach British waters in a few hours' time

We see the boat from a distance – the orange of the life jackets reflected in the rising sun.

And as we draw closer, we can make out dozens of people crowded on board as it sets off from the shore, from a beach near Dunkirk.

There is no sign of any police activity on the shore, and there are no police vessels in the water.

Instead, the migrants crammed into an inflatable dinghy are being watched by us, on board a private boat, and the looming figure of the Minck, a French search and rescue ship that soon arrives.

Picture to go with Adam Parsons' eyewitness of migrants crossing on 10/07/25
Image:
Minck, a French search and rescue ship, shadows the boat

The dinghy meanders. It’s not heading towards Britain but rather hugging the coast.

A few of the passengers wave at us cheerfully, but then the boat starts to head back towards the shore.

Picture to go with Adam Parsons' eyewitness of migrants crossing on 10/07/25
Image:
Sky’s Adam Parsons at the scene

As it nears a different beach, we see a police vehicle – a dune buggy – heading down to meet it.

Normal practice is for French police officers to slice through the material of any of these small boats that end up back on shore.

Two police officers get out of the buggy and wait. A police helicopter arrives and circles above, performing a tight circle over the heads of the migrants.

The police think they might be about to go back on to the beach; in fact, these passengers know that most of them are staying put.

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The boat stops a short distance from the shore and four people jump out. As they wade towards the beach, the boat turns and starts to head back out to sea.

We see the two police officers approach these four men and have a brief conversation.

They don’t appear to check the bags they are carrying and, if they do question them about why they left the boat, it is the most cursory of conversations.

In reality, these people probably don’t speak French but they were almost certainly involved in arranging this crossing, which is against the law. But all four walk away, disappearing into the dunes at the back of the beach.

Read more:
Why do so many from around the world try to cross the Channel?
Channel crossings rise by 50% in first six months of 2025

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Why do migrants want to come to the UK?

We follow the boat as it chugs off in the direction of Britain, carrying around 50 people.

The Minck returns to shadowing its progress, but its job is limited to offering help if the boat gets into trouble.

Otherwise, if the engine keeps working, then this flimsy vessel will reach British waters in a few hours’ time.

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UK

‘A constant game of cat and mouse’: Inside the police crackdown on illegal moped delivery drivers

Published

on

By

'A constant game of cat and mouse': Inside the crackdown on illegal moped delivery drivers

The first thing you notice when immigration officers stop a possible illegal moped delivery driver is the speed in which the suspect quickly taps on their mobile.

“We’re in their WhatsApp groups – they’ll be telling thousands now that we’re here… so our cover is blown,” the lead immigration officer tells me.

“It’s like a constant game of cat and mouse.”

Twelve Immigration Enforcement officers, part of the Home Office, are joining colleagues from Avon and Somerset Police in a crackdown on road offences and migrants working illegally.

Police chase suspected illegal immigrant working as a delivery drivers

The West of England and Wales has seen the highest number of arrests over the last year for illegal workers outside of London.

“It is a problem… we’re tackling it,” Murad Mohammed, from Immigration Enforcement, says. He covers all the devolved nations.

“This is just one of the operations going on around the country, every day of the week, every month of the year.”

Murad Mohammed from Immigration Enforcement
Image:
Murad Mohammed, from Immigration Enforcement, says his team are attempting to tackle the issue

Just outside the Cabot Circus shopping complex, we stop a young Albanian man who arrived in the UK on the back of a truck.

He’s on an expensive and fast-looking e-bike, with a new-looking Just Eat delivery bag.

He says he just uses it for “groceries” – but the officer isn’t buying it. He’s arrested, but then bailed instantly.

A man inspects the Just Eat food delivery bag of a suspected illegal immigrant working as a delivery driver

We don’t know the specifics of his case, but one officer tells me this suspected offence won’t count against his asylum claim.

Such is the scale of the problem – the backlog, loopholes and the complexity of cases – that trying to keep on top of it feels impossible.

This is one of many raids happening across the UK as part of what the government says is a “blitz” targeting illegal working hotspots.

Angela Eagle, the border security and asylum minister, joins the team for an hour at one of Bristol’s retail parks, scattered with fast food chains and, therefore, delivery bikes.

Angela Eagle, Minister for Border Security and Asylum
Image:
Border security and asylum minister, Angela Eagle, speaks to Sky News

She says arrests for illegal working are up over the last year by 51% from the year before, to more than 7,000.

“If we find you working, you can lose access to the hotel or the support you have [been] given under false pretences,” she said.

“We are cracking down on that abuse, and we intend to keep doing so.”

A suspected illegal immigrant working as a delivery driver being arrested

There are reports that asylum seekers can rent legitimate delivery-driver accounts within hours of arriving in the country – skipping employment legality checks.

Uber Eats, Deliveroo, and Just Eat all told Sky News they’re continuing to strengthen the technology they use to remove anyone working illegally.

But a new Border Security Bill, working its way through Parliament, could see companies fined £60,000 for each illegal worker discovered, director disqualifications and potential prison sentences of up to five years.

“I had them all in to see me last week and I told them in no uncertain terms that we take a very tough line on this kind of abuse and they’ve got to change their systems so they can drive it out and off their platforms,” the minister tells me.

Read more:
Welfare bill passes final Commons stage after another concession
Ex-Tory chairman defects to Reform
Wealth tax could be coming to the UK – what is it?

The gig economy – so prevalent in every city – creates another incentive for those wanting to risk their lives coming to the UK illegally.

More than 20,000 migrants have crossed the English Channel to the UK in 2025 – a record number at this point of the year.

A suspected illegal immigrant working as a delivery driver holds his helmet

For some of those who arrive, a bike and a phone provide a way to repay debts to gang masters.

There were eight arrests today in Bristol, one or two taken into custody, but it was 12 hours of hard work by a dozen immigration officers and the support of the police.

As two mopeds are pushed onto a low-loader, you can’t help but feel, despite the best intentions, that at the moment, this is a losing battle.

Continue Reading

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