Rishi Sunak hopes a “blueprint” inspired by the coronavirus vaccine rollout will help tackle the NHS’s four “healthcare missions” of cancer, obesity, mental health and addiction.
The prime minister has announced more than £113m in funding for research into new treatments and technologies with the aim of encouraging breakthroughs.
Ministers believe tackling the key challenges could save the health service and the economy billions, with obesity alone estimated to cost £6.1bn a year.
But the NHS is also struggling with a record treatment backlog and staffing crisis, with nurses preparing to strike next monthover pay and patient safety.
The British Medical Association welcomed the “injection of funding” for research but warned it must be coupled with further investment in the NHS and in the welfare system.
Medical academic staff committee chairman Professor David Strain said: “Doctors are already struggling to pick up the pieces of a broken social safety net.
“A stronger social safety net, backed by well-funded public services, would save thousands from needing the NHS’s services at all.”
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Prof Strain said the government needs to invest more in the NHS “here and now” – saying the extra £3.3bn of funding announced in the autumn statement was an “effective pay cut to the health service’s budget”.
“This is impeding the NHS from getting on top of the backlog and providing treatment to patients who desperately need it, causing untold suffering across the country.”
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Chancellor’s pledge to increase NHS budget
In his autumn statement, Chancellor Jeremy Hunt promised an additional £3.3bn in funding for the NHS for each of the next two years.
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19% pay rise for nurses ‘unaffordable’, says Sunak
Mr Sunak, Health Secretary Steve Barclay and Business Secretary Grant Shapps will meet NHS leaders, global chief executives and key industry figures on Monday.
“The NHS faces real pressures, which is why we are investing over £100m in the technologies and medicines of the future to address some of the biggest public health challenges facing our country,” Mr Sunak said.
The government hopes to follow the vaccine approach with its “missions” by harnessing the best research expertise, removing unwarranted bureaucracy and strengthening partnerships with businesses.
Research into mental health will get £40.2m, addiction £30.5m, cancer £22.5m and obesity £20m.
Each mission will be led by an independent expert, who will be chosen by a panel that will include Dame Kate Bingham, who headed the vaccine taskforce.
Shadow health secretary Wes Streeting said: “It is welcome that NHS and life sciences leaders are being brought in to help fix the mess the Conservatives have made.”
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Nurse tells Sky why she’s striking
Liberal Democrat health spokeswoman Daisy Cooper said the “level of ambition for health research is long overdue”.
“But as health and care services prepare for one of the most difficult winters in memory, the government needs to urgently demonstrate this level of ambition when it comes to GP appointments, ambulance delays, discharges to social care and hospital beds,” she added.
“Our health and care services are stretched to the brink of collapse after years of mismanagement by this Conservative government.”
The bodies of two more Israeli hostages have been handed over to the Red Cross by Hamas – but uncertainty still hangs over the fate of the missing remains of others.
Under the ceasefire agreement, all remaining 48 hostages, dead and alive, were supposed to be returned by this Monday.
So far, only the 20 living hostages have been returned, as well as seven dead hostages, according to Israel’s count, with two further bodies still being verified.
Hamas has previously said recovering the remaining bodies could take time, as not all burial sites are known.
Its armed wing put out a statement on Wednesday, saying it has returned all the bodies it could reasonably recover, but would require special equipment to hand over the remaining ones.
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Meanwhile, the Gaza Health Ministry said it received 45 more bodies of Palestinians from Israel, another step in the implementation of the ceasefire agreement.
Image: Red Cross vehicles escort a truck transporting the bodies of Palestinian hostages. Pic: Reuters.
That brings to 90 the total number of bodies returned to Gaza for burial. The forensics team examining the remains claimed they showed signs of mistreatment.
Israel – which has freed around 2,000 Palestinian prisoners and detainees as part of the peace deal – had already threatened to keep the Rafah crossing between Gaza and Egypt closed on Wednesday, and limit aid entering Gaza, due to Hamas not returning all of the dead.
And in an interview with CNN on Wednesday, Mr Trump warned that Israel could resume the war if he feels Hamas is not upholding its end of the agreement.
“Israel will return to those streets as soon as I say the word,” he said.
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Trump: ‘If Hamas doesn’t disarm, we will disarm them’
Since the October 7 Hamas attacks on Israel in 2023 – in which around 1,200 people were killed and 251 taken hostage – the two sides have been at war.
Nearly 68,000 Palestinians have been killed since Israel’s subsequent offensive, according to the Health Ministry, which is part of the Hamas-run government in Gaza.
The ministry maintains detailed casualty records that are seen as generally reliable by UN agencies and independent experts – though the ministry does not say how many of those killed are combatants.
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Middle East correspondent Adam Parsons explains why tensions may begin to bubble
Similar incident in previous ceasefire
This is not the first time Hamas has returned a wrong body to Israel.
During a previous ceasefire, the group said it handed over the bodies of Shiri Bibas and her two sons, but testing in February 2025 showed that one of the bodies returned was identified as a Palestinian woman. Ms Bibas’ body was returned a day later.
Meanwhile, Hamas spokesperson Hazem Kassem accused Israel of violating the deal with shootings on Tuesday in eastern Gaza City and the southern city of Rafah.
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Israel’s defence minister, Israel Katz, said the military is operating along the deployment lines troops withdrew to under the deal, and he warned that anyone approaching the lines will be targeted, as happened on Tuesday with several militants.
Aid trickling in
The World Food Programme said its trucks began arriving in Gaza after the entrance of humanitarian aid was paused for two days due to the exchange on Monday and a Jewish holiday on Tuesday.
The timing of the scaled-up deliveries – which are also part of the ceasefire deal – had been called into question after Israel said on Tuesday that it would cut the number of trucks allowed into Gaza, saying Hamas was too slow to return the hostages’ bodies.
Image: Trucks carrying humanitarian aid and fuel enter Khan Yunis, a city in the southern Gaza Strip. Pic: AP
Abeer Etefa, spokesperson for the World Food Programme, lauded the trucks’ passage but said the situation remained unpredictable.
“We’re hopeful that access will improve in the coming days,” she said.
The Egyptian Red Crescent said 400 trucks carrying food, fuel and medical supplies were bound for Gaza on Wednesday.
Fifteen UK charities have launched a fresh appeal for donations to Gaza to address “catastrophic levels of need” in the devastated region.
The charities make up the Disasters Emergency Committee (DEC), which has been raising millions for Gaza – where tens of thousands have been killed over the past two years of war – and the wider Middle East.
After the initial stage of a much-sought ceasefire deal aimed at ending the conflict in Gaza was agreed on by Israel and Hamas, aid has begun to trickle into the devastated region again.
According to the DEC, its charities and local partners have been scaling up their work in the Gaza Strip since the agreement took effect last week.
Image: Palestinians walk past the rubble of destroyed buildings in Gaza City. Pic: Reuters
It said lorries carrying food and other aid began to enter Gaza on Sunday, with the British Red Cross and Plan International UK among those confirming supplies had made it in.
After raising more than £50m since the Middle East Humanitarian Appeal was launched last October, the DEC is renewing calls for donations, saying £10 could provide blankets for two people, while £50 could provide emergency food for five families for one week.
As goods are returning to Gaza’s markets, the DEC said, they are increasing cash assistance to help people buy essentials as they become more affordable.
They’re also distributing clean water, medicine, food, and nutrition support.
Donald Trump has refused to say if the CIA has the authority to assassinate Venezuela’s president, after approving covert operations in the country to tackle alleged drug trafficking.
Mr Trump said large amounts of drugs were entering the US from Venezuela, much of it trafficked by sea.
“We are looking at land now, because we’ve got the sea very well under control,” he said.
When asked why the coastguard wasn’t asked to intercept suspected drug trafficking boats, which has been a longstanding US practice, Mr Trump said the approach had been ineffective.
“I think Venezuela is feeling heat,” he said.
He declined to answer whether the CIA has the authority to execute Mr Maduro.
The US has offered a $50m (£37m) reward for information leading to his arrest, accusing him of connections to drug trafficking and criminal organisations – claims he denies.
Image: President Nicolas Maduro. Pic: Reuters
Image: Donald Trump at the White House on Wednesday evening. Pic: Reuters
US targets ‘drug boats’
Mr Trump also alleged Venezuela had sent a significant number of prisoners, including individuals from mental health facilities, into the US, though he did not specify the border through which they reportedly entered.
On Tuesday, he announced America had targeted a small boat suspected of drug trafficking in waters off the Venezuelan coast, resulting in the deaths of six people.
According to the president’s post on social media, all those killed were aboard the vessel.
Image: Footage of the strike was released by Donald Trump on social media. Pic: Truth Social
The incident marked the fifth such fatal strike in the Caribbean, as the Trump administration continues to classify suspected drug traffickers as unlawful combatants to be confronted with military force.
War secretary Pete Hegseth authorised the strike, according to Mr Trump, who released a video of the operation.
The black-and-white footage showed a small boat seemingly stationary on the water. It is struck by a projectile from above and explodes, then drifts while burning for several seconds.
Mr Trump said the “lethal kinetic strike” was in international waters and targeted a boat travelling along a well-known smuggling route.
There has also been a significant increase in US military presence in the southern Caribbean, with at least eight warships, a submarine, and F-35 jets stationed in Puerto Rico.
‘Bomb the boats’: Bold move or dangerous overreach?
It’s a dramatic – and risky – escalation of US strategy for countering narcotics.
Having carried out strikes on Venezuelan “drug boats” at sea, Trump says he’s “looking a” targeting cartels on land.
He claims the attacks, which have claimed 27 lives, have saved up to 50,000 Americans.
By framing bombings as a blow against “narcoterrorists”, he’s attempting to justify them as self-defence – but the administration has veered into murky territory.
Under international law, such strikes require proof of imminent threat – something the White House has yet to substantiate.
Strategically, Trump’ss militarised approach could backfire, forcing traffickers to adapt, and inflaming tensions with Venezuela and allies wary of US intervention.
Without transparent evidence or congressional oversight, some will view the move less like counterterrorism and more like vigilantism on the seas.
The president’s “bomb the boats” rhetoric signals a shift back to shock and awe tactics in foreign policy, under the banner of fighting drugs.
Supporters will hail it as a bold, decisive move, but to critics it’s reckless posturing that undermines international law.
The strikes send a message of strength, but the legal, moral and geopolitical costs are still being calculated.