As health care becomes increasingly digitized, scientists, doctors and researchers have to try and decipher unprecedented amounts of data to adequately personalize care. The excess of information available to these experts often outpaces their ability to consume and analyze it. Amazon‘s cloud unit has been working to close that gap.
Amazon Web Services recently launched general availability for Amazon Omics, which helps researchers store and analyze omic data like sequences of DNA, RNA and proteins. The service provides customers with the underlying infrastructure they need to make sense of large amounts of data so they can spend more time making new scientific discoveries.
AWS generates a substantial piece of Amazon’s revenue, pulling in $20.5 billion in the third quarter. The cloud-computing business has been expanding into health care, and while AWS doesn’t disclose revenue projections for particular services, the global genomic data analysis market size is expected to reach $2.15 billion by 2030, according to a report from Straits Research.
Dr. Taha Kass-Hout, chief medical officer at AWS, said the vast majority of health care data is unstructured in nature, which means that about 97% of it goes unused. Indexing and making sense of this information is a challenge, especially when researchers are collecting omic data from tens of thousands of patients.
Prior to his time at Amazon, Kass-Hout served two terms under President Barack Obama and was the first chief health information officer at the U.S. Food and Drug Administration.
Sequencing one human genome can require anywhere from 80 to 150 gigabytes of storage, Kass-Hout said, and some research projects deal with petabytes and exabytes of genomic information.
“You’re talking about almost nine Harry Potter’s worth if you want to print it on a printer,” Kass-Hout told CNBC. “And that’s just for one human being.”
Amazon Omics helps researchers sort through their data by providing them with three components that they can leverage individually or as a collective. Omics-aware object storage helps researchers store and share raw sequence data; Omics Workflows helps run workflows that process raw sequence data at scale; and Omics Analytics simplifies the output of the sequence processing.
More than a dozen customers and partners tested a beta version of the service and are already using Amazon Omics.
For Jeffrey Pennington, chief research informatics officer at the Children’s Hospital of Philadelphia, it’s already made a noticeable impact.
Pennington works in the department of biomedical and health informatics, which uses data and technology to solve issues in child health. He said the department spent five years expanding the infrastructure to analyze omics data, and now it’s no longer something they need to build or maintain themselves.
“We’re a big pediatric academic medical center, but we’re still not big enough to learn and build everything that is required to make productive use of omic data,” Pennington said. “Our time and energy, our effort, our financial wherewithal is much better spent putting the puzzle together rather than generating those pieces in the first place.”
Amazon Omics also encourages collaboration between large research groups, smaller clinical groups and intelligence and pharmaceutical companies, said Boris Oklander, co-founder and chief technology officer of C2i Genomics.
C2i is a biotechnology company that’s working to use genomic data to develop personalized treatments for cancer. Oklander said the company participated in the beta for Amazon Omics after trying to develop its own data-analysis technology.
He said Amazon Omics has created an ecosystem for collaboration that eliminates the need for researchers to build a complex technology from the ground up.
“We’re just democratizing,” he said. “This type of service is something that allows [us] to unlock the value in the investments that different players in this space are doing.”
Other major tech companies have developed similar tools. Microsoft‘s cloud-computing platform Azure launched Microsoft Genomics in 2018 to help researchers interpret data generated by genomic technologies. Google‘s Cloud Life Sciences technology also allows researchers to process biomedical data at a large scale.
Pennington said the Broad Institute and DNAnexus offer popular genomic data analysis services as well, but said they can be difficult to maintain and can analyze fewer data types than Amazon Omics.
Given the sensitive and deeply personal nature of omic data, Kass-Hout said privacy and patient data protection is “job zero” for AWS. He said AWS uses more than 300 security, compliance and governance services and supports 98 security standards and compliance certifications. In doing so, AWS goes “way beyond” regulatory compliance, Kass-Hout said, and it also provides best-practice resources and encryption tools to its customers.
Customers are also responsible for building secure applications on top of Amazon Omics’ services, which guards AWS from seeing or leveraging the data.
Kass-Hout said that ultimately, Amazon Omics serves as a way to efficiently index information so researchers can focus on making real advances in precision medicine.
“If the last decade was about the digitization the health and life science industry has gone through, I truly believe the next decade is about making sense of this data in ways now [where] we can find new therapeutics, new diagnostics, more targeted therapies,” he said.
Anne Wojcicki attends the WSJ Magazine Style & Tech Dinner in Atherton, California, on March 15, 2023.
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23andMe CEO Anne Wojcicki and New Mountain Capital have submitted a proposal to take the embattled genetic testing company private, according to a Friday filing with the U.S. Securities and Exchange Commission.
Wojcicki and New Mountain have offered to acquire all of 23andMe’s outstanding shares in cash for $2.53 per share, or an equity value of approximately $74.7 million. The company’s stock closed at $2.42 on Friday with a market cap of about $65 million.
The offer comes after a turbulent year for 23andMe, with the stock losing more than 80% of its value in 2024. In January, the company announced plans to explore strategic alternatives, which could include a sale of the company or its assets, a restructuring or a business combination.
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23andMe has a special committee of independent directors in place to evaluate potential paths forward. The company appointed three new independent directors to its board in October after all seven of its previous directors abruptly resigned the prior month. The special committee has to approve Wojcicki and New Mountain’s proposal.
“We believe that our Proposal provides compelling value and immediate liquidity to the Company’s public stockholders,” Wojcicki and Matthew Holt, managing director and president of private equity at New Mountain, wrote in a letter to the special committee on Thursday.
Wojcicki previously submitted a proposal to take the company private for 40 cents per share in July, but it was rejected by the special committee, in part because the members said it lacked committed financing and did not provide a premium to the closing price at the time.
Wojcicki and New Mountain are willing to provide secured debt financing to fund 23andMe’s operations through the transaction’s closing, the filing said. New Mountain is based in New York and has $55 billion of assets under management, according to its website.
Shares of Hims & Hers Health tumbled more than 23% on Friday after the U.S. Food and Drug Administration announced that the shortage of semaglutide injection products has been resolved.
Semaglutide is the active ingredient in Novo Nordisk‘s blockbuster weight loss drug Wegovy and diabetes treatment Ozempic. Those medications are part of a class of drugs called GLP-1s, and demand for the treatments has exploded in recent years. As a result, digital health companies such as Hims & Hers have been prescribing compounded semaglutide as an alternative for patients who are navigating volatile supply hurdles and insurance obstacles.
Compounded drugs are custom-made alternatives to brand-name drugs designed to meet a specific patient’s needs, and compounders are allowed to produce them when brand-name treatments are in shortage. The FDA doesn’t review the safety and efficacy of compounded products.
Hims & Hers began offering compounded semaglutide to patients in May, and it owns compounding pharmacies that produce the medications.
Compounded medications are typically much cheaper than their branded counterparts. Hims & Hers sells compounded semaglutide for less than $200 per month, while Ozempic and Wegovy both cost around $1,000 per month without insurance.
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The FDA said Friday that it will start taking action against compounders for violations in the next 60 to 90 days, depending on the type of facility, in order to “avoid unnecessary disruption to patient treatment.”
“Now that the FDA has determined the drug shortage for semaglutide has been resolved, we will continue to offer access to personalized treatments as allowed by law to meet patient needs,” Hims & Hers CEO Andrew Dudum posted Friday on X. “We’re also closely monitoring potential future shortages, as Novo Nordisk stated two weeks ago that it would continue to have ‘capacity limitations’ and ‘expected continued periodic supply constraints and related drug shortage notifications.'”
Him & Hers’ weight loss offerings have been a massive hit with investors. Shares of the company climbed more than 200% last year, and the stock is already up more than 100% this year despite Friday’s move.
Even before it added compounded GLP-1s to its portfolio, the company said in its 2023 fourth-quarter earnings call that it expects its weight loss program to bring in more than $100 million in revenue by the end of 2025.
Despite the turbulent regulatory landscape, Hims & Hers has showed no signs of slowing down.
On Friday, the company announced it has acquired a U.S.-based peptide facility that will “further verticalize the company’s long-term ability to deliver personalized medications.” Hims & Hers will explore advances across metabolic optimization, recovery science, biological resistances, cognitive performance and preventative health through the acquisition, the company said.
That move comes just days after Hims & Hers also bought Trybe Labs, the New Jersey-based at-home lab testing facility. Trybe Labs will allow Hims & Hers to perform at-home blood draws and more comprehensive pretreatment testing.
Hims & Hers did not disclose the terms of either deal.
Tesla models Y and 3 are displayed at a Tesla dealership in Corte Madera, California, on Dec. 20, 2024.
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Tesla is voluntarily recalling 376,241vehicles in the U.S. to correct an issue with failing power-assisted steering systems, according to records posted to the website of the U.S. National Highway Traffic Safety Administration.
In a safety recall report posted on the NHTSA website, Tesla said the recall includes Model 3 and Model Y vehicles that were manufactured for sale in the U.S. from Feb. 28, 2023, to October 11, 2023, and that were equipped with a certain older software release.
The records said printed circuit boards in the steering systems in affected vehicles could become overstressed, causing the power-assist steering to fail in some cases when a Tesla vehicle rolled to a stop and then accelerated.
When electronic power-assist steering systems fail in a Tesla, drivers need to exert more force to steer their cars, which can increase the risk of a collision.
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Tesla told the vehicle safety regulator that it was not aware of any crashes, injuries or deaths related to the power steering failures, and that it was offering an over-the-air software update as a remedy.
The recall follows an earlier related probe and voluntary recall in China concerning the same systems.
President Donald Trump has appointed Tesla CEO Elon Musk to lead a team that is slashing the federal government workforce, and in some cases, regulations and entire agencies. Those cuts already affected the NHTSA, an agency Musk has long seen as standing in the way of some of his ambitions at Tesla.
The regulator has been engaged in a yearslong investigation into safety defects in the systems that Tesla markets currently as its Autopilot and Full Self-Driving (Supervised) options. The features do not make Tesla cars into robotaxis. They require a human driver ready to steer or brake at any time.
The Washington Post reported on Thursday that Musk’s team has led mass firings at the NHTSA, reducing the agency’s workforce and capacity to investigate companies including Tesla by about 10%.