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Elon Musk’s Neuralink, a medical device company, is under federal investigation for potential animal-welfare violations amid internal staff complaints that its animal testing is being rushed, causing needless suffering and deaths, according to documents reviewed by Reuters and sources familiar with the investigation and company operations.

Neuralink is developing a brain implant it hopes will help paralysed people walk again and cure other neurological ailments. The federal probe, which has not been previously reported, was opened in recent months by the US Department of Agriculture’s Inspector General at the request of a federal prosecutor, according to two sources with knowledge of the investigation. The probe, one of the sources said, focuses on violations of the Animal Welfare Act, which governs how researchers treat and test some animals.

The investigation has come at a time of growing employee dissent about Neuralink’s animal testing, including complaints that pressure from CEO Musk to accelerate development has resulted in botched experiments, according to a Reuters review of dozens of Neuralink documents and interviews with more than 20 current and former employees. Such failed tests have had to be repeated, increasing the number of animals being tested and killed, the employees say. The company documents include previously unreported messages, audio recordings, emails, presentations and reports.

Musk and other Neuralink executives did not respond to requests for comment.

Reuters could not determine the full scope of the federal investigation or whether it involved the same alleged problems with animal testing identified by employees in Reuters interviews. A spokesperson for the USDA inspector general declined to comment. US regulations don’t specify how many animals companies can use for research, and they give significant leeway to scientists to determine when and how to use animals in experiments. Neuralink has passed all USDA inspections of its facilities, regulatory filings show.

In all, the company has killed about 1,500 animals, including more than 280 sheep, pigs and monkeys, following experiments since 2018, according to records reviewed by Reuters and sources with direct knowledge of the company’s animal-testing operations. The sources characterised that figure as a rough estimate because the company does not keep precise records on the number of animals tested and killed. Neuralink has also conducted research using rats and mice.

The total number of animal deaths does not necessarily indicate that Neuralink is violating regulations or standard research practices. Many companies routinely use animals in experiments to advance human health care, and they face financial pressure to quickly bring products to market. The animals are typically killed when experiments are completed, often so they can be examined post-mortem for research purposes.

But current and former Neuralink employees say the number of animal deaths is higher than it needs to be for reasons related to Musk’s demands to speed research. Through company discussions and documents spanning several years, along with employee interviews, Reuters identified four experiments involving 86 pigs and two monkeys that were marred in recent years by human errors. The mistakes weakened the experiments’ research value and required the tests to be repeated, leading to more animals being killed, three of the current and former staffers said. The three people attributed the mistakes to a lack of preparation by a testing staff working in a pressure-cooker environment.

One employee, in a message seen by Reuters, wrote an angry missive earlier this year to colleagues about the need to overhaul how the company organises animal surgeries to prevent “hack jobs.” The rushed schedule, the employee wrote, resulted in under-prepared and over-stressed staffers scrambling to meet deadlines and making last-minute changes before surgeries, raising risks to the animals.

Musk has pushed hard to accelerate Neuralink’s progress, which depends heavily on animal testing, current and former employees said. Earlier this year, the chief executive sent staffers a news article about Swiss researchers who developed an electrical implant that helped a paralyzed man to walk again. “We could enable people to use their hands and walk again in daily life!” he wrote to staff at 6:37 a.m. Pacific Time on Feb. 8. Ten minutes later, he followed up: “In general, we are simply not moving fast enough. It is driving me nuts!”

On several occasions over the years, Musk has told employees to imagine they had a bomb strapped to their heads in an effort to get them to move faster, according to three sources who repeatedly heard the comment. On one occasion a few years ago, Musk told employees he would trigger a “market failure” at Neuralink unless they made more progress, a comment perceived by some employees as a threat to shut down operations, according to a former staffer who heard his comment.

Five people who’ve worked on Neuralink’s animal experiments told Reuters they had raised concerns internally. They said they had advocated for a more traditional testing approach, in which researchers would test one element at a time in an animal study and draw relevant conclusions before moving on to more animal tests. Instead, these people said, Neuralink launches tests in quick succession before fixing issues in earlier tests or drawing complete conclusions. The result: More animals overall are tested and killed, in part because the approach leads to repeated tests.

One former employee who asked management several years ago for more deliberate testing was told by a senior executive it wasn’t possible given Musk’s demands for speed, the employee said. Two people told Reuters they left the company over concerns about animal research.

The problems with Neuralink’s testing have raised questions internally about the quality of the resulting data, three current or former employees said. Such problems could potentially delay the company’s bid to start human trials, which Musk has said the company wants to do within the next six months. They also add to a growing list of headaches for Musk, who is facing criticism of his management of Twitter, which he recently acquired for $44 billion. Musk also continues to run electric carmaker Tesla Inc and rocket company SpaceX.

The US Food and Drug Administration is in charge of reviewing the company’s applications for approval of its medical device and associated trials. The company’s treatment of animals during research, however, is regulated by the USDA under the Animal Welfare Act. The FDA didn’t immediately comment.

Missed deadlines, botched experiments

Musk’s impatience with Neuralink has grown as the company, which launched in 2016, has missed his deadlines on several occasions to win regulatory approval to start clinical trials in humans, according to company documents and interviews with eight current and former employees.

Some Neuralink rivals are having more success. Synchron, which was launched in 2016 and is developing a different implant with less ambitious goals for medical advances, received FDA approval to start human trials in 2021. The company’s device has allowed paralyzed people to text and type by thinking alone. Synchron has also conducted tests on animals, but it has killed only about 80 sheep as part of its research, according to studies of the Synchron implant reviewed by Reuters. Musk approached Synchron about a potential investment, Reuters reported in August.

Synchron declined to comment.

In some ways, Neuralink treats animals quite well compared to other research facilities, employees said in interviews, echoing public statements by Musk and other executives. Company leaders have boasted internally of building a “Monkey Disneyland” in the company’s Austin, Texas facility where lab animals can roam, a former employee said. In the company’s early years, Musk told employees he wanted the monkeys at his San Francisco Bay Area operation to live in a “monkey Taj Mahal,” said a former employee who heard the comment. Another former employee recalled Musk saying he disliked using animals for research but wanted to make sure they were “the happiest animals” while alive.

The animals have fared less well, however, when used in the company’s research, current and former employees say.

The first complaints about the company’s testing involved its initial partnership with University of California, Davis, to conduct the experiments. In February, an animal rights group, the Physicians Committee for Responsible Medicine, filed a complaint with the USDA accusing the Neuralink-UC Davis project of botching surgeries that killed monkeys and publicly released its findings. The group alleged that surgeons used the wrong surgical glue twice, which led to two monkeys suffering and ultimately dying, while other monkeys had different complications from the implants.

The company has acknowledged it killed six monkeys, on the advice of USC Davis veterinary staff, because of health problems caused by experiments. It called the issue with the glue a “complication” from the use of an “FDA-approved product.” In response to a Reuters inquiry, a USC Davis spokesperson shared a previous public statement defending its research with Neuralink and saying it followed all laws and regulations.

A federal prosecutor in the Northern District of California referred the animal rights group’s complaint to the USDA Inspector General, which has since launched a formal probe, according to a source with direct knowledge of the investigation. USDA investigators then inquired about the allegations involving the UC Davis monkey research, according to two sources familiar with the matter and emails and messages reviewed by Reuters.

The probe is concerned with the testing and treatment of animals in Neuralink’s own facilities, one of the sources said, without elaborating. In 2020, Neuralink brought the program in-house, and has since built its extensive facilities in California and Texas.

A spokesperson for the US attorney’s office for the Northern District of California declined to comment.

Delcianna Winders, director of the Animal Law and Policy Institute at the Vermont Law and Graduate School, said it is “very unusual” for the USDA inspector general to investigate animal research facilities. Winders, an animal-testing opponent who has criticised Neuralink, said the inspector general has primarily focused in recent years on dog fighting and cockfighting actions when applying the Animal Welfare Act.

It’s hard on the little piggies

The mistakes leading to unnecessary animal deaths included one instance in 2021, when 25 out of 60 pigs in a study had devices that were the wrong size implanted in their heads, an error that could have been avoided with more preparation, according to a person with knowledge of the situation and company documents and communications reviewed by Reuters.

The mistake raised alarms among Neuralink’s researchers. In May 2021, Viktor Kharazia, a scientist, wrote to colleagues that the mistake could be a “red flag” to FDA reviewers of the study, which the company planned to submit as part of its application to begin human trials. His colleagues agreed, and the experiment was repeated with 36 sheep, according to the person with knowledge of the situation. All the animals, both the pigs and the sheep, were killed after the procedures, the person said.

Kharazia did not comment in response to requests.

On another occasion, staff accidentally implanted Neuralink’s device on the wrong vertebra of two different pigs during two separate surgeries, according to two sources with knowledge of the matter and documents reviewed by Reuters. The incident frustrated several employees who said the mistakes – on two separate occasions – could have easily been avoided by carefully counting the vertebrae before inserting the device.

Company veterinarian Sam Baker advised his colleagues to immediately kill one of the pigs to end her suffering.

“Based on low chance of full recovery … and her current poor psychological well-being, it was decided that euthanasia was the only appropriate course of action,” Baker wrote colleagues about one of the pigs a day after the surgery, adding a broken heart emoji.

Baker did not comment on the incident.

Employees have sometimes pushed back on Musk’s demands to move fast. In a company discussion several months ago, some Neuralink employees protested after a manager said that Musk had encouraged them to do a complex surgery on pigs soon. The employees resisted on the grounds that the surgery’s complexity would lengthen the amount of time the pigs would be under anesthesia, risking their health and recovery. They argued they should first figure out how to cut down the time it would take to do the surgery.

“It’s hard on the little piggies,” one of the employees said, referring to the lengthy period under anesthesia.

In September, the company responded to employee concerns about its animal testing by holding a town hall to explain its processes. It soon after opened up the meetings to staff of its federally-mandated board that reviews the animal experiments.

Neuralink executives have said publicly that the company tests animals only when it has exhausted other research options, but documents and company messages suggest otherwise. During a November 30 presentation the company broadcast on YouTube, for example, Musk said surgeries were used at a later stage of the process to confirm that the device works rather than to test early hypotheses. “We’re extremely careful,” he said, to make sure that testing is “confirmatory, not exploratory,” using animal testing as a last resort after trying other methods.

In October, a month before Musk’s comments, Autumn Sorrells, the head of animal care, ordered employees to scrub “exploration” from study titles retroactively and stop using it in the future.

Sorrells did not comment in response to requests.

Neuralink records reviewed by Reuters contained numerous references over several years to exploratory surgeries, and three people with knowledge of the company’s research strongly rejected the assertion that Neuralink avoids exploratory tests on animals. Company discussions reviewed by Reuters showed several employees expressing concerns about Sorrells’ request to change exploratory study descriptions, saying it would be inaccurate and misleading.

One noted that the request seemed designed to provide “better optics” for Neuralink.

© Thomson Reuters 2022


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A Nearby Supernova May End Dark Matter Search, Claims New Study

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A Nearby Supernova May End Dark Matter Search, Claims New Study

The pursuit of understanding dark matter, which comprises 85 percent of the universe’s mass, could take a significant leap forward with a nearby supernova. Researchers at the University of California, Berkeley, led by Associate Professor of Physics Benjamin Safdi, have theorised that the elusive particle known as the axion might be detected within moments of gamma rays being emitted from such an event. Axions, predicted to emerge during the collapse of a massive star’s core into a neutron star, could transform into gamma rays in the presence of intense magnetic fields, offering a potential breakthrough in physics.

Potential Role of Gamma-Ray Telescopes

The study was published in Physical Review Letters and revealed that the gamma rays produced from axions could confirm the particle’s mass and properties if detected. The Fermi Gamma-ray Space Telescope, currently the only gamma-ray observatory in orbit, would need to be pointed directly at the supernova, with the likelihood of this alignment estimated at only 10 percent. A detection would revolutionise dark matter research, while the absence of gamma rays would constrain the range of axion masses, rendering many existing dark matter experiments redundant.

Challenges in Catching the Event

For detection, the supernova must occur within the Milky Way or its satellite galaxies—an event averaging once every few decades. The last such occurrence, supernova 1987A, lacked sensitive enough gamma-ray equipment. Safdi emphasised the need for preparedness, proposing a constellation of satellites, named GALAXIS, to ensure 24/7 sky coverage.

Axion’s Theoretical Importance

The axion, supported by theories like quantum chromodynamics (QCD) and string theory, bridges gaps in physics, potentially linking gravity with quantum mechanics. Unlike neutrinos, axions could convert into photons in strong magnetic fields, providing unique signals. Laboratory experiments like ABRACADABRA and ALPHA are also probing for axions, but their sensitivity is limited compared to the scenario of a nearby supernova. Safdi expressed urgency, noting that missing such an event could delay axion detection by decades, underscoring the high stakes of this astrophysical endeavour.

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Fastest-Moving Stars in the Galaxy May be Piloted by Aliens, New Study Suggests

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Fastest-Moving Stars in the Galaxy May be Piloted by Aliens, New Study Suggests

Intelligent extraterrestrial civilisations might be utilising stars as massive interstellar vehicles to explore the galaxy, according to a theory proposed by Clement Vidal, a philosopher at Vrije Universiteit Brussel in Belgium. His research suggests that alien species could potentially accelerate their binary star systems to traverse vast cosmic distances. While such a concept is purely hypothetical and unproven, Vidal’s recent paper, which has not undergone peer review, raises intriguing possibilities about advanced extraterrestrial engineering.

Concept of Moving Star Systems

The study was published in the Journal of the British Interplanetary Society. As per a report by LiveScience, the idea revolves around the notion that alien civilisations, instead of building spacecraft for interstellar travel, might manipulate entire star systems to travel across the galaxy. Vidal highlights binary star systems, particularly those involving neutron stars and smaller companion stars, as ideal candidates. Neutron stars, due to their immense gravitational energy, could serve as anchors for devices designed to propel the system by selectively ejecting stellar material.

Vidal explained in the paper that uneven heating or manipulation of magnetic fields on a star’s surface could cause it to eject material in one direction. This process would create a reactionary thrust, propelling the binary system in the opposite direction. The concept provides a way to travel while preserving planetary ecosystems, making it a theoretically viable method for species reliant on their home systems.

Known Examples with High Velocities

Astronomers have identified hypervelocity stars, such as the pulsars PSR J0610-2100 and PSR J2043+1711, which exhibit high accelerations. While their movements are believed to be natural phenomena, Vidal suggests they could be worth further investigation to rule out potential artificial influences.

This theory adds an unconventional angle to the search for intelligent life, expanding possibilities beyond traditional methods of exploration like searching for signals or probes. The research underscores the importance of considering advanced and unconventional methods aliens might employ to navigate the galaxy.

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Hubble Telescope Finds Unexpectedly Hot Accretion Disk in FU Orionis

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Hubble Telescope Finds Unexpectedly Hot Accretion Disk in FU Orionis

NASA’s Hubble Space Telescope has provided new insights into the young star FU Orionis, located in the constellation Orion. Observations have uncovered extreme temperatures in the inner region of its accretion disk, challenging current models of stellar accretion. Using Hubble’s Cosmic Origins Spectrograph and Space Telescope Imaging Spectrograph, astronomers captured far-ultraviolet and near-ultraviolet spectra, revealing the disk’s inner edge to be unexpectedly hot, with temperatures reaching 16,000 kelvins—almost three times the Sun’s surface temperature.

A Star’s Bright Outburst Explained

First observed in 1936, FU Orionis became a hundred times brighter in months and has remained a unique object of study. Unlike typical T Tauri stars, its accretion disk touches the stellar surface due to instabilities. These are caused by the disk’s large mass, interactions with companion stars, or material falling inwards. Lynne Hillenbrand, a co-author from Caltech, in a statement said that the ultraviolet brightness seen exceeded predictions, revealing a highly dynamic interface between the star and its disk.

Implications for Planet Formation

As per a report by NASA, the study holds significant implications for planetary systems forming around such stars. The report further quoted Adolfo Carvalho, lead author of the study, saying that while distant planets in the disk may experience altered chemical compositions due to outbursts, planets forming close to the star could face disruption or destruction. This revised model provides critical insights into the survival of rocky planets in young star systems, he further added.

Future Investigations on FU Orionis

The research team continues to examine spectral emission lines in the collected data, aiming to map gas movement in the star’s inner regions. Hillenbrand noted that FU Orionis offers a unique opportunity to study the mechanisms at play in eruptive young stars. These findings, published in The Astrophysical Journal Letters, showcase the ongoing value of Hubble’s ultraviolet capabilities in advancing stellar science.

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