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Most people who drink alcohol will be familiar with the short-term effects of alcohol intoxication. The mild state of euphoria and feelings of relaxation are among the main reasons why humans have been producing and drinking alcohol for thousands of years, according to “Alcohol: Science, Policy and Public Health” (Oxford University Press, 2013). 

Similarly, most people are aware that excessive and chronic drinking can severely impact their physical and mental health. But the exact effects will depend on the amount of alcohol consumed and how frequently someone drinks it.

In the U.S., moderate drinking is limited to two drinks per day for men and one drink per day for women, according to the Centers for Disease Control and Prevention (opens in new tab) (CDC). One drink refers to an equivalent of 0.6 ounce (14 grams) of pure alcohol. That amount can be found in a bottle of beer (5% alcohol content), a small glass of wine (12% alcohol content) or a shot of distilled spirits (40% alcohol content).      

According to the CDC (opens in new tab) , heavy drinking is defined as consuming eight or more drinks per week for women, and 15 or more drinks per week for a man. This is different to binge drinking, which the CDC defines as consuming five or more drinks on one occasion for men or four or more drinks on one occasion for women.What are the short-term effects of alcohol?

Short-term effects of alcohol consumption often include feelings of mild euphoria and a state of relaxation. This state is caused by temporary changes to brain signaling, said Sarah Boss (opens in new tab) , a psychiatrist in Spain and clinical director of The Balance Luxury Rehab, who specializes in addiction. 

“Alcohol can interfere with neurotransmitters, which are chemicals that help relay messages between neurons in the brain, leading to changes in mood, behavior and thinking,” she told Live Science.

According to the American Addiction Centers (opens in new tab) , short-term effects of moderate alcohol consumption may range from skin flushing and trouble concentrating to more severe symptoms, such as vomiting and passing out. Other effects of short-term alcohol use include loss of coordination, mood swings, raised blood pressure, dull vision and lowered inhibitions. 

(Image credit: Getty Images)

Then comes the effects of alcohol withdrawal, commonly referred to as a hangover. Hangover symptoms usually begin within several hours of a person’s last drink and they tend to vary from person to person. These can include headaches, exhaustion, nausea and dehydration, said Dr. Kathryn Basford (opens in new tab) , a medical doctor at ZAVA online doctor service in England. 

“Alcohol inhibits the body’s production of vasopressin, a hormone which tells the body to retain water in the kidneys,” Basford (opens in new tab) told Live Science. “Without this, water goes directly to the bladder and leaves the body dehydrated. The headache is the brain’s reaction to this loss of fluid, while the nausea and lack of energy is the body’s response to low blood sugar levels and the loss of the minerals and electrolytes which help the body to function properly.”

The more a person drinks, Basford said, the more likely it is that they are going to feel these effects, and the longer a person might take to recover. Related: What is ‘hangxiety’ and why do some people experience it? 

Hangover symptoms tend to pass within 24 hours of a person’s last drink and do not tend to produce lasting health problems.What are the long-term effects of alcohol consumption?

Long-term alcohol consumption can affect many aspects of physical and mental health. According to the American Addiction Centers (opens in new tab) , the main areas affected include the brain, digestive system, cardiovascular system and musculoskeletal system.    

(Image credit: Getty Images) Brain

According to Boss, there’s a lot of  scientific evidence to show that alcohol impacts the proper functioning of the brain, namely by affecting levels of neurotransmitters — chemical messengers in the brain. ALCOHOL GUIDANCE AND SUPPORT—Substance Abuse and Mental Health Services Administration

—Secular Organizations for Sobriety 

—Moderation Management 

“You may notice alcohol can cause wild mood swings,” she said. “This is because alcohol interacts with GABA, a neurotransmitter that helps to regulate mood and anxiety.” 

Alcohol also works as a central nervous system depressant, Boss said, which means it slows down the communication between the brain and the body. This can lead to impaired coordination, slurred speech, slowed reflexes and blackouts. Heavy drinking can also lead to other problems such as sleep disturbances.

Long-term alcohol use may even lead to changes in the brain’s structure. “Heavy drinking can kill brain cells,” Boss said. “This damage can lead to problems with memory, learning and coordination, as well as increases in anxiety [disorder] and depression.” 

Many of these changes in the brain happen on a molecular level. According to a 2021 review published in the journal Trends in Neurosciences (opens in new tab) , excessive drinking can disrupt gene expression in neurons, a process in which brain cells develop and connect with each other. These adaptations may be a key factor for developing alcohol use disorder, the researchers said.Heart 

Long-term alcohol use will also have an impact on cardiovascular health. According to a 2016 review published in the Journal of the American College of Cardiology (opens in new tab) , even modest amounts of alcohol may predispose someone to atrial fibrillation — a condition that causes an irregular heartbeat, dizziness and shortness of breath. 

How drinking affects heart health may depend on the amount of alcohol consumed, though the evidence is far from conclusive. Some studies indicate that low-to-moderate drinking may actually lower your risk of heart disease and stroke, according to a 2021 review published in the journal Nutrients (opens in new tab) . However, this is not well understood. A 2017 review published in the journal Alcohol Research (opens in new tab) suggests that low-to-moderate alcohol consumption may indirectly reduce atherosclerosis — a buildup of fatty plaques in and on the artery walls — and inflammation, as well as mitigate the effects of psychological stress on the cardiovascular system. 

Certain compounds found in alcoholic drinks could also play a role. For example, polyphenols found in red wine may protect against atherosclerosis, hypertension and heart failure, a 2016 review published in the journal Nutrients (opens in new tab) reported. Digestive health 

Excessive drinking can lead to liver damage and alcohol-related liver disease, according to a 2021 review published in the journal Alcohol Research (opens in new tab) . 

Alcohol affects other parts of the digestive system too. A 2014 review in the World Journal of Gastroenterology (opens in new tab) found that consuming more than five drinks a day can damage the pancreas, esophagus, stomach and intestinal tract. 

(Image credit: Getty Images)

Long-term alcohol consumption may also lead to poor gut health. According to a 2021 review published in the International Journal of Molecular Sciences (opens in new tab) , excessive drinking may lead to changes in the gut microbiome,  by reducing diversity of microbes and causing an overgrowth of bacteria that promote inflammation, such as Proteobacteria. These alterations may lead to intestinal inflammation and leaky gut — a condition in which the intestinal walls become porous, enabling toxins and harmful pathogens to enter the bloodstream. 

Caitlin Hall, chief dietitian and head of clinical research at myota (opens in new tab) , said that these changes may be harmful to our general health. “One of the most important functions of the gut microbiome is to ferment dietary fibers and produce anti-inflammatory molecules called short chain fatty acids [SCFAs],” she told Live Science. “SCFAs are essential for our immune health, mental wellbeing and for reversing and preventing chronic diseases including diabetes and cancers. Cutting down on alcohol helps ensure that the microbiome can produce enough of these vital molecules.”  Immunity 

The immune system may also be affected by long-term alcohol use. According to a 2015 review published in the journal Alcohol Research (opens in new tab) , chronic heavy drinking may lead to a significant drop in the number of white blood cells responsible for combating infections and preventing cancers.  

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‘I have nightmares of dead bodies’: Patients dying and undiscovered for hours in hospital corridors

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'I have nightmares of dead bodies': Patients dying and undiscovered for hours in hospital corridors

Patients are dying in corridors and going undiscovered for hours while the sick are left to soil themselves, nurses have said, revealing the scale of the corridor crisis inside the UK’s hospitals.

In a “harrowing” report built from the experiences of more than 5,000 NHS nursing staff, the Royal College of Nursing (RCN) found almost seven in 10 (66.81%) say they are delivering care in overcrowded or unsuitable places, including converted cupboards, corridors and even car parks, on a daily basis.

Demoralised staff are looking after as many as 40 patients in a single corridor, unable to access oxygen, cardiac monitors, suction and other lifesaving equipment.

Women are miscarrying in corridors, while some nurses report being unable to carry out adequate CPR on patients having heart attacks.

Sara (not her real name) said she was on shift when a doctor told her there was a dying patient who had been waiting in the hospital’s corridor for six hours.

“It took a further two hours to get her into an adequate care space to make her clean and comfortable,” she told Sky News.

“That’s a human being, someone in the last hours of their life in the middle of a corridor with a detoxing patient vomiting and being abusive behind them and a very poorly patient in front of them, who was confused, screaming in pain. It was awful on the family, and it was awful on the patient.”

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Dead patients ‘not found for hours’

A nurse working in the southeast of England quit her job after witnessing an elderly lady in “animal-like conditions”.

She told the RCN: “A 90-year-old lady with dementia was scared, crying and urinating in the bed after asking several times for help to the toilet. Seeing that lady, frightened and subjected to animal-like conditions is what broke me.

“At the end of that shift, I handed in my notice with no job to go to. I will not work where this is a normal day-to-day occurrence.”

Another nurse in the South East said a patient died in a corridor and “wasn’t discovered for hours”.

Sara told Sky another woman needed resuscitating after the oxygen underneath her trolley ran out. Sara was one of just two nurses caring for more than 30 patients on that corridor.

“I have had nightmares – I have a nightmare that I walk out in the corridor and there are dead bodies in body bags on the trolleys,” she said, growing visibly emotional.

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No electricity to plug in computers

One nurse, who spoke to Sky News, said the conditions were “undignified” and “inhumane”.

“It’s not just corridors – we utilise chairs, cupboards, whatever space is available in the hospital to be repurposed into a care space, in the loosest sense of that term. These spaces are unsafe.”

Some spaces, she said, don’t even have basic electricity for nurses to plug in their computers.

The nurse, who spoke to Sky on the condition of anonymity, said she has experienced burnout multiple times over the state of her workplace.

“I have come to the conclusion this week I don’t think I can continue working in the NHS or as a nurse,” she said.

“It breaks my soul; I love what I do when I am able to do it in the right way. I like caring for people, I like making people better, I also like providing a dignified death.”

She added: “I want to look after the institution I was born into, but for the sake of my family and my mental health, I don’t know how much more I can give.”

With 32,000 nursing vacancies in England alone, data also shows around one in eight nurses leave the profession within five years of qualifying.

Nurses are being forced to provide care in hospital corridors and car parks. Pic: PA
Image:
Nurses are being forced to provide care in hospital corridors and car parks. Pic: PA

Staff ‘not proud of the care they are giving’

The Royal College of Nursing (RCN) says the testimony, which runs to over 400 pages, must mark a “moment in time”. In May 2024, the RCN declared a “national emergency” over corridor care in NHS services.

Professor Nicola Ranger, RCN general secretary and chief executive, said: “At the moment, [nursing staff] are not proud of the care they are giving.”

“We hear stories of escalation areas and temporary beds that have been open for two years,” she added. “That is no longer escalation, it’s understaffed and underfunded capacity that is pretty shocking care for patients. We have to get a grip on that.”

Read more: Hospital advertises for corridor nurse amid NHS winter crisis

She called the situation “a disgrace”, citing abuse of staff as another reason for people leaving the profession in droves.

Last week, a nurse was left with “life-changing injuries” after being stabbed by a man while at work.

“The NHS used to be the envy of the world and we need to take a long hard look at ourselves and say ‘what needs to change?’

“The biggest concern for us is that the public Is starting to lose a little faith in their care, and that has to stop. We absolutely have to sort this out.”

Commenting on the RCN’s report, Duncan Burton, chief nursing officer for England, said the NHS had experienced one of the “toughest winters” in recent months, and the report “should never be considered the standard to which the NHS aspires”.

“Despite the challenges the NHS faces, we are seeing extraordinary efforts from staff who are doing everything they can to provide safe, compassionate care every day,” he added. “As a nurse, I know how distressing it can be when you are unable to provide the very best standards of care for patients.”

Have you experienced corridor care in an NHS hospital? Get in touch on NHSstories@sky.uk

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Tesla is offering Cybertruck discounts as EV market gets crowded

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Tesla is offering Cybertruck discounts as EV market gets crowded

A soldier walks next to a Tesla Cybertruck, which was donated to the National Guard, after powerful winds fueling devastating wildfires in the Los Angeles area forced people to evacuate, in the Pacific Palisades neighborhood on the west side of Los Angeles, California, U.S. Jan. 13, 2025. 

Daniel Cole | Reuters

Tesla started offering discounts on new Cybertruck vehicles in its inventory this week, according to listings on the company’s website.

Discounts are as high as $1,600 off new Cybertrucks, with the reduced price depending on configuration, and up to around $2,600 for demo versions of the trucks in inventory, the listings show. Production of the angular, unpainted steel pickups has reportedly slowed in recent weeks at Tesla’s factory in Austin, Texas.

Deliveries of the unconventional pickup began reaching customers in 2023. CEO Elon Musk originally unveiled the Cybertruck in 2019 and said it would cost around $40,000, but its base price in the U.S. was closer to $80,000 over the course of 2024.

Wall Street previously viewed the Cybertruck as an important driver of growth for Tesla’s core automotive sales.

While the Cybertruck outsold the Ford Lightning F-150 last year in the U.S. and became the fifth best-selling EV domestically, according to data tracked by Cox Automotive, its high price, repeat recalls and production issues in Austin hampered growth. In November, Tesla initiated its sixth recall in a year  to replace defective drive inverters.

As CNBC previously reported, Tesla’s deliveries declined slightly year-over-year in 2024, even as EV demand worldwide reached a record. A slew of new competitive models from a wide range of automakers eroded Tesla’s market share.

According to Cox data, full-year EV sales reached an estimated 1.3 million in 2024 in the U.S., an increase of 7.3% from the prior year. But Tesla’s sales for the year declined by about 37,000 vehicles.

The Tesla Model Y SUV and Model 3 sedan ranked as the top two best-selling EVs by a wide margin. But both older, more affordable Tesla models saw sales drop from the previous year. Cox estimated Tesla sold around 38,965 Cybertrucks in the U.S. last year.

In recent days, Musk apologized to customers in California for delays in delivering their Cybertrucks. He said the trucks are now being used to bring supplies and wireless internet service to people in Los Angeles impacted by devastating wildfires.

“Apologies to those expecting Cybertruck deliveries in California over the next few days,” Musk wrote on X. “We need to use those trucks as mobile base stations to provide power to Starlink Internet terminals in areas of LA without connectivity. A new truck will be delivered end of week.”

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Goldman Sachs CEO Solomon says IPO market is ‘going to pick up’ along with dealmaking

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Goldman Sachs CEO Solomon says IPO market is 'going to pick up' along with dealmaking

David Solomon, CEO of Goldman Sachs, speaks during the Reuters NEXT conference, in New York City, U.S., December 10, 2024. 

Mike Segar | Reuters

Goldman Sachs CEO David Solomon says there’s an end in sight to the multi-year IPO drought.

“It’s going to pick up,” Solomon said on Wednesday, in an on-stage interview with Cisco CEO Chuck Robbins at a summit hosted by the computer networking company in Silicon Valley. “It’s been slow, it’s been turned off.”

Solomon, who flew to California for the event just after his Wall Street bank reported fourth-quarter results that blew past analysts’ estimates, said the capital markets broadly are showing signs of life ahead of President-elect Donald Trump’s inauguration next week.

The tech IPO market has largely been dormant since the end of 2021, when tech stocks started falling out of favor due to soaring inflation and rising interest rates. Mergers and acquisitions have been difficult in technology because of hefty regulation that’s restricted the ability for the biggest companies to grow through dealmaking.

Solomon said the mood is changing, and he expects momentum M&A as well as in IPOs.

“We have a more constructive kind of optimism, which always helps,” Solomon said. He later added that, “broadly speaking, I think it’s an improved business environment.”

Earlier in the day, Solomon said on his company’s earnings call that Trump’s election and a swing back to Republican power in Washington is already starting to make an impact in the business world. He noted on the call that “there is a significant backlog from sponsors and an overall increased appetite for dealmaking supported by an improved regulatory backdrop.”

Solomon’s comments on the call and at the Cisco event came on a day when the S&P 500 posted his biggest gain since November, helped by a tame inflation report and Goldman’s results. Goldman’s stock popped 6% on Wednesday.

While the stock market has had a strong two-year run and the S&P 500 and Nasdaq hit fresh records last month, IPOs have yet to see a resurgence. Cloud software vendor ServiceTitan debuted on the Nasdaq in December, marking the first significant venture-backed IPO in the U.S. since Rubrik in April.

“The values came down after 2021, people are growing back into those values,” Solomon said at the Cisco summit.

Some companies have said they’re ready. Chipmaker Cerebras filed to go public in September, but the process was slowed down due to a review by the Treasury Department’s Committee on Foreign Investment in the U.S., or CFIUS. In November, online lender Klarna said it had confidentially filed IPO paperwork with the SEC.

Though he’s bullish about what’s coming, Solomon said that there are structural reasons not to go public. He said 25 years ago there were roughly 13,000 public companies in the U.S., and today that number has come down to 3,800. There are higher standards around disclosure for being public, and there’s now tons of private capital available “at scale.”

“It’s not fun being a public company,” Solomon acknowledged. “Who would want to be a public company?”

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