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Most people who drink alcohol will be familiar with the short-term effects of alcohol intoxication. The mild state of euphoria and feelings of relaxation are among the main reasons why humans have been producing and drinking alcohol for thousands of years, according to “Alcohol: Science, Policy and Public Health” (Oxford University Press, 2013). 

Similarly, most people are aware that excessive and chronic drinking can severely impact their physical and mental health. But the exact effects will depend on the amount of alcohol consumed and how frequently someone drinks it.

In the U.S., moderate drinking is limited to two drinks per day for men and one drink per day for women, according to the Centers for Disease Control and Prevention (opens in new tab) (CDC). One drink refers to an equivalent of 0.6 ounce (14 grams) of pure alcohol. That amount can be found in a bottle of beer (5% alcohol content), a small glass of wine (12% alcohol content) or a shot of distilled spirits (40% alcohol content).      

According to the CDC (opens in new tab) , heavy drinking is defined as consuming eight or more drinks per week for women, and 15 or more drinks per week for a man. This is different to binge drinking, which the CDC defines as consuming five or more drinks on one occasion for men or four or more drinks on one occasion for women.What are the short-term effects of alcohol?

Short-term effects of alcohol consumption often include feelings of mild euphoria and a state of relaxation. This state is caused by temporary changes to brain signaling, said Sarah Boss (opens in new tab) , a psychiatrist in Spain and clinical director of The Balance Luxury Rehab, who specializes in addiction. 

“Alcohol can interfere with neurotransmitters, which are chemicals that help relay messages between neurons in the brain, leading to changes in mood, behavior and thinking,” she told Live Science.

According to the American Addiction Centers (opens in new tab) , short-term effects of moderate alcohol consumption may range from skin flushing and trouble concentrating to more severe symptoms, such as vomiting and passing out. Other effects of short-term alcohol use include loss of coordination, mood swings, raised blood pressure, dull vision and lowered inhibitions. 

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Then comes the effects of alcohol withdrawal, commonly referred to as a hangover. Hangover symptoms usually begin within several hours of a person’s last drink and they tend to vary from person to person. These can include headaches, exhaustion, nausea and dehydration, said Dr. Kathryn Basford (opens in new tab) , a medical doctor at ZAVA online doctor service in England. 

“Alcohol inhibits the body’s production of vasopressin, a hormone which tells the body to retain water in the kidneys,” Basford (opens in new tab) told Live Science. “Without this, water goes directly to the bladder and leaves the body dehydrated. The headache is the brain’s reaction to this loss of fluid, while the nausea and lack of energy is the body’s response to low blood sugar levels and the loss of the minerals and electrolytes which help the body to function properly.”

The more a person drinks, Basford said, the more likely it is that they are going to feel these effects, and the longer a person might take to recover. Related: What is ‘hangxiety’ and why do some people experience it? 

Hangover symptoms tend to pass within 24 hours of a person’s last drink and do not tend to produce lasting health problems.What are the long-term effects of alcohol consumption?

Long-term alcohol consumption can affect many aspects of physical and mental health. According to the American Addiction Centers (opens in new tab) , the main areas affected include the brain, digestive system, cardiovascular system and musculoskeletal system.    

(Image credit: Getty Images) Brain

According to Boss, there’s a lot of  scientific evidence to show that alcohol impacts the proper functioning of the brain, namely by affecting levels of neurotransmitters — chemical messengers in the brain. ALCOHOL GUIDANCE AND SUPPORT—Substance Abuse and Mental Health Services Administration

—Secular Organizations for Sobriety 

—Moderation Management 

“You may notice alcohol can cause wild mood swings,” she said. “This is because alcohol interacts with GABA, a neurotransmitter that helps to regulate mood and anxiety.” 

Alcohol also works as a central nervous system depressant, Boss said, which means it slows down the communication between the brain and the body. This can lead to impaired coordination, slurred speech, slowed reflexes and blackouts. Heavy drinking can also lead to other problems such as sleep disturbances.

Long-term alcohol use may even lead to changes in the brain’s structure. “Heavy drinking can kill brain cells,” Boss said. “This damage can lead to problems with memory, learning and coordination, as well as increases in anxiety [disorder] and depression.” 

Many of these changes in the brain happen on a molecular level. According to a 2021 review published in the journal Trends in Neurosciences (opens in new tab) , excessive drinking can disrupt gene expression in neurons, a process in which brain cells develop and connect with each other. These adaptations may be a key factor for developing alcohol use disorder, the researchers said.Heart 

Long-term alcohol use will also have an impact on cardiovascular health. According to a 2016 review published in the Journal of the American College of Cardiology (opens in new tab) , even modest amounts of alcohol may predispose someone to atrial fibrillation — a condition that causes an irregular heartbeat, dizziness and shortness of breath. 

How drinking affects heart health may depend on the amount of alcohol consumed, though the evidence is far from conclusive. Some studies indicate that low-to-moderate drinking may actually lower your risk of heart disease and stroke, according to a 2021 review published in the journal Nutrients (opens in new tab) . However, this is not well understood. A 2017 review published in the journal Alcohol Research (opens in new tab) suggests that low-to-moderate alcohol consumption may indirectly reduce atherosclerosis — a buildup of fatty plaques in and on the artery walls — and inflammation, as well as mitigate the effects of psychological stress on the cardiovascular system. 

Certain compounds found in alcoholic drinks could also play a role. For example, polyphenols found in red wine may protect against atherosclerosis, hypertension and heart failure, a 2016 review published in the journal Nutrients (opens in new tab) reported. Digestive health 

Excessive drinking can lead to liver damage and alcohol-related liver disease, according to a 2021 review published in the journal Alcohol Research (opens in new tab) . 

Alcohol affects other parts of the digestive system too. A 2014 review in the World Journal of Gastroenterology (opens in new tab) found that consuming more than five drinks a day can damage the pancreas, esophagus, stomach and intestinal tract. 

(Image credit: Getty Images)

Long-term alcohol consumption may also lead to poor gut health. According to a 2021 review published in the International Journal of Molecular Sciences (opens in new tab) , excessive drinking may lead to changes in the gut microbiome,  by reducing diversity of microbes and causing an overgrowth of bacteria that promote inflammation, such as Proteobacteria. These alterations may lead to intestinal inflammation and leaky gut — a condition in which the intestinal walls become porous, enabling toxins and harmful pathogens to enter the bloodstream. 

Caitlin Hall, chief dietitian and head of clinical research at myota (opens in new tab) , said that these changes may be harmful to our general health. “One of the most important functions of the gut microbiome is to ferment dietary fibers and produce anti-inflammatory molecules called short chain fatty acids [SCFAs],” she told Live Science. “SCFAs are essential for our immune health, mental wellbeing and for reversing and preventing chronic diseases including diabetes and cancers. Cutting down on alcohol helps ensure that the microbiome can produce enough of these vital molecules.”  Immunity 

The immune system may also be affected by long-term alcohol use. According to a 2015 review published in the journal Alcohol Research (opens in new tab) , chronic heavy drinking may lead to a significant drop in the number of white blood cells responsible for combating infections and preventing cancers.  

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Ryanair raises fares after profits hit by lower ticket prices

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Ryanair raises fares after profits hit by lower ticket prices

Europe’s largest airline has seen annual earnings drop by 16% after cutting air fares – but revealed a price hike as it seeks to return to growth.

Ryanair reported profits after tax fell to €1.61bn (£1.35bn) for the year to 31 March, down from €1.92bn (£1.61bn) in 2024, still the second highest on record.

On average, plane tickets were 7% cheaper during this period than the 12 months before, it said.

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There had been a 21% rise in fares in the year up to March 2024, which bosses had signalled was due to end.

Higher-for-longer interest rates and inflation in the first half of the year meant ticket prices had to come down, the budget carrier said.

But fares are already back on the rise, Ryanair’s chief executive Michael O’Leary said.

The airline “cautiously” expects to recover “most, but not all” of the fare decline, which he said will boost profits.

Demand for summer flights is “strong”, Mr O’Leary said, with peak fares “modestly” ahead of last year.

In recent months, that rebound has already been under way. Fares since April are on track to be “a mid-high teen per cent ahead” by the end of next month, compared with the same period last year.

That trend is expected to continue to July, August and September, Mr O’Leary said.

“While we cautiously expect to recover most, but not all of last year’s 7% fare decline, which should lead to reasonable net profit growth in 2025-26, it is far too early to provide any meaningful guidance,” he said.

“The final 2025-26 outcome remains heavily exposed to adverse external developments, including the risk of tariff wars, macro-economic shocks, conflict escalation in Ukraine and the Middle East and European air traffic control mismanagement/short staffing.”

Read more from Sky News:
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Passenger numbers grew to a record 200 million on the back of cheaper fares, hitting a target that had been reduced due to delays in delivering new Boeing planes.

The US manufacturer has struggled with increased regulatory oversight after a door panel blew off an Alaska Airlines plane mid-flight in January last year. Strike action by staff had added to the delays.

The forecast for passenger numbers has been reduced again. Ryanair now aims to transport 206 million passengers in this financial year.

It hopes to reach 300 million passengers by 2034 and on Monday said it still expects to receive 300 new Boeing planes by 2033.

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World

Israel to allow ‘basic quantity of food’ into Gaza to avoid ‘starvation crisis’

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Israel to allow 'basic quantity of food' into Gaza to avoid 'starvation crisis'

Israel has said it will allow a “basic quantity of food” into the besieged enclave of Gaza to avoid a “starvation crisis” following a near three-month blockade.

Israeli Prime Minister Benjamin Netanyahu’s office said the decision was “based on the operational need to enable the expansion of the military operation to defeat Hamas“.

Gaza, where local authorities say more than 53,000 people have died in Israel’s 19-month campaign, has been under a complete blockade on humanitarian aid since 2 March.

It comes as global food security experts warn of famine across the territory and after a UN-backed report from last Monday which warned one in five people in Gaza were facing starvation.

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Israel ramps up bombing in Gaza

The statement from the prime minister’s office said it would “allow a basic quantity of food to be brought in for the population in order to make certain that no starvation crisis develops in the Gaza Strip”.

“Such a crisis would endanger the continuation of Operation ‘Gideon’s Chariots’ to defeat Hamas,” it added.

“Israel will act to deny Hamas’s ability to take control of the distribution of humanitarian assistance in order to ensure that the assistance does not reach the Hamas terrorists.”

More on Gaza

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Gaza is ‘a slaughterhouse’ says surgeon

It comes after a British surgeon working in Gaza said in a video to Sky News the enclave is now “a slaughterhouse” amid Israeli bombardment.

Israel has just ramped up its offensive in Gaza where it’s been conducting a military campaign in retaliation for 1,200 people killed and 251 taken hostage by Hamas on 7 October 2023 – with Palestinian health officials reporting at least 130 people were killed overnight into Sunday.

Israel Defence Forces (IDF) confirmed troops had begun “extensive ground operations throughout the northern and southern Gaza Strip”.

The Hamas-run health ministry in Gaza said 464 people had died in Israeli military strikes in the week to Sunday.

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In a statement on Sunday, IDF said its air force struck “over 670 Hamas terror targets throughout the Gaza Strip to disrupt enemy preparations and support ground operations” over the past week.

Israel has launched an escalation to increase pressure on Hamas, seize territory, displace Palestinians to the south and take greater control over the distribution of aid.

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UK

Easing trade and signing a defence pact would be manifesto promises delivered – and Starmer could use a win

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Easing trade and signing a defence pact would be manifesto promises delivered - and Starmer could use a win

This EU-UK summit has for months been openly billed by Sir Keir Starmer’s Downing Street as a hugely significant moment for this government.

The Labour leader promised in his 2024 election manifesto that the UK would sign a new security pact with the EU to strengthen cooperation and improve the UK’s trading relationship with the continent.

Since winning power in July, he has embarked on a charm offensive across European capitals in a bid to secure that better post-Brexit deal.

Monday is when the PM makes good on those promises at a historic summit at Lancaster House in London.

Read more: What exactly could the UK-EU reset look like?

There, the EU and UK are expected to sign a security and defence partnership, which has taken on a new sense of urgency since the arrival of President Trump in the White House.

It is an agreement that will symbolise the post-Brexit reset, with the PM, European Commission president Ursula von der Leyen and European Council president Antonio Costa also signing off on a communique pledging deeper economic cooperation.

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But, rather like the torturous Brexit negotiations I covered for years in London and Brussels under Conservative prime ministers, Sir Keir’s post-Brexit reset went down to the wire.

Discussions continued over night as the two sides snared up over details around fisheries, food trade and youth mobility.

It’s not that both sides did not want the reset: the war in Ukraine and the spectre of the US becoming an unreliable partner have pushed London and Brussels closer together in their common defence interest.

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Fishing and youth mobility – the two snags

But the pressure for this deal weighed more heavily on our prime minister than his European colleagues. He’s been talking for months about securing a reset and better trading relationship with the EU to bolster the UK economy.

His need to demonstrate wins is why, suggests one continental source, the Europeans let talks go to the wire, with London and Brussels in a tangle over fishing rights – key demands of France and the Netherlands – and a youth mobility scheme, which is a particular focus for Berlin.

In the end, the UK allowed EU fishing boats access to British waters 12 years.

“The British came with 50 asks, we came with two – on fishing and the youth mobility scheme,” says one European source.

EU sources say Brussels had offered a time-limited deal to lift checks on animal products – replicating London’s offer on fisheries – but the UK is reluctant to do this as it leaves too much uncertainty for farmers and supermarkets.

Donald Tusk, Friedrich Merz, Emmanuel Macron and Keir Starmer talk to the press after their meeting.
Pic: Reuters
Image:
Poland’s Prime Minister Donald Tusk, Germany’s Chancellor Friedrich Merz, France’s President Emmanuel Macron and Sir Keir Starmer talk to the press after their meeting on May 16, 2025 Pic: Reuters

Scotland election weighing on talks

A deal on food products, known as sanitary and phytosanitary (SPS) goods, would be a boost for the economy, with potentially up to 80% of border checks disappearing, given the breadth of products – paint, fashion goods, leather as well as foods – with an animal component.

Any deal also means the UK would have to align with rules made in Brussels and make a financial contribution to the EU to fund work on food and animal standards.

Both elements will trigger accusations of Brexit “betrayal”, as the UK signs up as a “rule taker” and finds itself paying back into the EU for better access.

Government figures had been telling me how they are more than prepared to face down the criticisms thrown at them from the Conservatives.

But sensitivities around fishing, particularly in Scotland, where Labour is facing elections next year, weighed on talks.

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The other area of huge tension was over a youth mobility scheme, which would enable young adults from member states to study and work in the UK and vice versa.

Government sources familiar with the talks acknowledge some sort of scheme will be included, but want details to be vague – I’m told it might be “an agreement about a future agreement”, while the EU sees this a one of its two core demands.

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European leaders gather in Ukraine

In talks late on Sunday night, the UK government appeared to be softening on re-opening the pre-Brexit Erasmus student exchange scheme as perhaps a way to get around the impasse, according to one EU source.

The UK rejoining this scheme had been rebuffed by Sir Keir last year, but was raised again last night in talks, according to a source.

Common ground on defence and security

Wherever the economic horsetrading lands, the two sides have found common ground in recent months is on defence and security, with the UK working in lockstep with European allies over Ukraine and relationships deepening in recent months as Sir Keir Starmer has worked with President Macron and others to try to smooth tensions between Kyiv and Washington and work on a European peace deal for Ukraine.

The expectation is that the two sides will sign a security partnership that will reiterate the UK’s commitment to build up the continent’s defence capability and stand united against Russian aggression with its partners.

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Five years of Brexit explained

The deal should also mean British arms companies will be able to access the EU’s €150bn rearmament programme, which has been set up to create a massive surge in defence spending over the next five years as Europe prepares itself to better repel threats.

It is clearly in neither side’s interest for Monday to go wrong.

The EU and UK need to maintain a united front and, more importantly for Keir Starmer domestically, the PM needs to show an increasingly sceptical public he can deliver on his promises.

Easing trade barriers with Britain’s biggest trading partner and signing an EU defence pact would be two manifesto promises delivered.

And with his popularity sinking to a record low in recent days, he could really do with a win.

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