What does alcohol do to the body?

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2 years ago

January 10, 2023

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Most people who drink alcohol will be familiar with the short-term effects of alcohol intoxication. The mild state of euphoria and feelings of relaxation are among the main reasons why humans have been producing and drinking alcohol for thousands of years, according to “Alcohol: Science, Policy and Public Health” (Oxford University Press, 2013).

Similarly, most people are aware that excessive and chronic drinking can severely impact their physical and mental health. But the exact effects will depend on the amount of alcohol consumed and how frequently someone drinks it.

In the U.S., moderate drinking is limited to two drinks per day for men and one drink per day for women, according to the Centers for Disease Control and Prevention (opens in new tab) (CDC). One drink refers to an equivalent of 0.6 ounce (14 grams) of pure alcohol. That amount can be found in a bottle of beer (5% alcohol content), a small glass of wine (12% alcohol content) or a shot of distilled spirits (40% alcohol content).

According to the CDC (opens in new tab) , heavy drinking is defined as consuming eight or more drinks per week for women, and 15 or more drinks per week for a man. This is different to binge drinking, which the CDC defines as consuming five or more drinks on one occasion for men or four or more drinks on one occasion for women.What are the short-term effects of alcohol?

Short-term effects of alcohol consumption often include feelings of mild euphoria and a state of relaxation. This state is caused by temporary changes to brain signaling, said Sarah Boss (opens in new tab) , a psychiatrist in Spain and clinical director of The Balance Luxury Rehab, who specializes in addiction.

“Alcohol can interfere with neurotransmitters, which are chemicals that help relay messages between neurons in the brain, leading to changes in mood, behavior and thinking,” she told Live Science.

According to the American Addiction Centers (opens in new tab) , short-term effects of moderate alcohol consumption may range from skin flushing and trouble concentrating to more severe symptoms, such as vomiting and passing out. Other effects of short-term alcohol use include loss of coordination, mood swings, raised blood pressure, dull vision and lowered inhibitions.

(Image credit: Getty Images)

Then comes the effects of alcohol withdrawal, commonly referred to as a hangover. Hangover symptoms usually begin within several hours of a person’s last drink and they tend to vary from person to person. These can include headaches, exhaustion, nausea and dehydration, said Dr. Kathryn Basford (opens in new tab) , a medical doctor at ZAVA online doctor service in England.

“Alcohol inhibits the body’s production of vasopressin, a hormone which tells the body to retain water in the kidneys,” Basford (opens in new tab) told Live Science. “Without this, water goes directly to the bladder and leaves the body dehydrated. The headache is the brain’s reaction to this loss of fluid, while the nausea and lack of energy is the body’s response to low blood sugar levels and the loss of the minerals and electrolytes which help the body to function properly.”

The more a person drinks, Basford said, the more likely it is that they are going to feel these effects, and the longer a person might take to recover. Related: What is ‘hangxiety’ and why do some people experience it?

Hangover symptoms tend to pass within 24 hours of a person’s last drink and do not tend to produce lasting health problems.What are the long-term effects of alcohol consumption?

Long-term alcohol consumption can affect many aspects of physical and mental health. According to the American Addiction Centers (opens in new tab) , the main areas affected include the brain, digestive system, cardiovascular system and musculoskeletal system.

(Image credit: Getty Images) Brain

According to Boss, there’s a lot of scientific evidence to show that alcohol impacts the proper functioning of the brain, namely by affecting levels of neurotransmitters — chemical messengers in the brain. ALCOHOL GUIDANCE AND SUPPORT—Substance Abuse and Mental Health Services Administration

—Secular Organizations for Sobriety

—Moderation Management

“You may notice alcohol can cause wild mood swings,” she said. “This is because alcohol interacts with GABA, a neurotransmitter that helps to regulate mood and anxiety.”

Alcohol also works as a central nervous system depressant, Boss said, which means it slows down the communication between the brain and the body. This can lead to impaired coordination, slurred speech, slowed reflexes and blackouts. Heavy drinking can also lead to other problems such as sleep disturbances.

Long-term alcohol use may even lead to changes in the brain’s structure. “Heavy drinking can kill brain cells,” Boss said. “This damage can lead to problems with memory, learning and coordination, as well as increases in anxiety [disorder] and depression.”

Many of these changes in the brain happen on a molecular level. According to a 2021 review published in the journal Trends in Neurosciences (opens in new tab) , excessive drinking can disrupt gene expression in neurons, a process in which brain cells develop and connect with each other. These adaptations may be a key factor for developing alcohol use disorder, the researchers said.Heart

Long-term alcohol use will also have an impact on cardiovascular health. According to a 2016 review published in the Journal of the American College of Cardiology (opens in new tab) , even modest amounts of alcohol may predispose someone to atrial fibrillation — a condition that causes an irregular heartbeat, dizziness and shortness of breath.

How drinking affects heart health may depend on the amount of alcohol consumed, though the evidence is far from conclusive. Some studies indicate that low-to-moderate drinking may actually lower your risk of heart disease and stroke, according to a 2021 review published in the journal Nutrients (opens in new tab) . However, this is not well understood. A 2017 review published in the journal Alcohol Research (opens in new tab) suggests that low-to-moderate alcohol consumption may indirectly reduce atherosclerosis — a buildup of fatty plaques in and on the artery walls — and inflammation, as well as mitigate the effects of psychological stress on the cardiovascular system.

Certain compounds found in alcoholic drinks could also play a role. For example, polyphenols found in red wine may protect against atherosclerosis, hypertension and heart failure, a 2016 review published in the journal Nutrients (opens in new tab) reported. Digestive health

Excessive drinking can lead to liver damage and alcohol-related liver disease, according to a 2021 review published in the journal Alcohol Research (opens in new tab) .

Alcohol affects other parts of the digestive system too. A 2014 review in the World Journal of Gastroenterology (opens in new tab) found that consuming more than five drinks a day can damage the pancreas, esophagus, stomach and intestinal tract.

(Image credit: Getty Images)

Long-term alcohol consumption may also lead to poor gut health. According to a 2021 review published in the International Journal of Molecular Sciences (opens in new tab) , excessive drinking may lead to changes in the gut microbiome, by reducing diversity of microbes and causing an overgrowth of bacteria that promote inflammation, such as Proteobacteria. These alterations may lead to intestinal inflammation and leaky gut — a condition in which the intestinal walls become porous, enabling toxins and harmful pathogens to enter the bloodstream.

Caitlin Hall, chief dietitian and head of clinical research at myota (opens in new tab) , said that these changes may be harmful to our general health. “One of the most important functions of the gut microbiome is to ferment dietary fibers and produce anti-inflammatory molecules called short chain fatty acids [SCFAs],” she told Live Science. “SCFAs are essential for our immune health, mental wellbeing and for reversing and preventing chronic diseases including diabetes and cancers. Cutting down on alcohol helps ensure that the microbiome can produce enough of these vital molecules.” Immunity

The immune system may also be affected by long-term alcohol use. According to a 2015 review published in the journal Alcohol Research (opens in new tab) , chronic heavy drinking may lead to a significant drop in the number of white blood cells responsible for combating infections and preventing cancers.

UK

Virginia Giuffre, who accused Prince Andrew of sexual assault, has died, her family says

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2 hours ago

April 26, 2025

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Virginia Giuffre, who accused Prince Andrew of sexual assault, has died, her family says

Virginia Giuffre, who accused Prince Andrew of sexual assault, has died aged 41.

In a statement to Sky’s US partner network NBC News on Friday, her family said she took her own life in the Perth suburb of Neergabby, Australia, where she had been living for several years.

“It is with utterly broken hearts that we announce that Virginia passed away last night at her farm in Western Australia,” her family said.

“She lost her life to suicide, after being a lifelong victim of sexual abuse and sex trafficking.

“Virginia was a fierce warrior in the fight against sexual abuse and sex trafficking. She was the light that lifted so many survivors.

“In the end, the toll of abuse is so heavy that it became unbearable for Virginia to handle its weight.”

Police said emergency services received reports of an unresponsive woman at a property in Neergabby on Friday night.

“Police and St John Western Australia attended and provided emergency first aid. Sadly, the 41-year-old woman was declared deceased at the scene,” a police spokeswoman said.

“The death is being investigated by Major Crime detectives; early indication is the death is not suspicious.”

Sexual assault claims

Ms Giuffre sued the Duke of York for sexual abuse in August 2021, saying Andrew had sex with her when she was 17 and had been trafficked by his friend, the billionaire paedophile Jeffrey Epstein.

The duke has repeatedly denied the claims, and he has not been charged with any criminal offences.

In March 2022, it was announced Ms Giuffre and Andrew had reached an out-of-court settlement – believed to include a “substantial donation to Ms Giuffre’s charity in support of victims’ rights”.

She stuck by her version of events until the end

Of the many dozens of victims of Jeffrey Epstein, it was Virginia Giuffre who became the most high-profile.

She was among the loudest and most compelling voices, urging criminal charges to be brought against Epstein, waving her right to anonymity in 2015.

She told how he and Ghislaine Maxwell groomed her and “passed around like a platter of fruit” to be used by rich and powerful men.

But her name and face became known around the world after she accused Prince Andrew of sexually abusing her when she was 17 years old.

The picture of her together with the prince and Maxwell at the top of a staircase, his hand around her waist, is the defining image of the whole scandal.

Prince Andrew said he had no memory of the occasion. But Giuffre stuck by her version of events until the end.

‘An incredible champion’

Sigrid McCawley, Ms Giuffre’s attorney, said in a statement that she “was much more than a client to me; she was a dear friend and an incredible champion for other victims”.

“Her courage pushed me to fight harder, and her strength was awe-inspiring,” she said. “The world has lost an amazing human being today.”

“Rest in peace, my sweet angel,” she added.

Dini von Mueffling, Ms Giuffre’s representative, also said that “Virginia was one of the most extraordinary human beings I have ever had the honour to know”.

“Deeply loving, wise, and funny, she was a beacon to other survivors and victims,” she added. “She adored her children and many animals.

“She was always more concerned with me than with herself. I will miss her beyond words.

“It was the privilege of a lifetime to represent her.”

Ms Giuffre said at the end of March she had four days to live after a car accident, posting on social media that “I’ve gone into kidney renal failure”. She was discharged from hospital eight days later.

Raised mainly in Florida, she said she was abused by a family friend early in life, which led to her living on the streets at times as a teenager.

She said that in 2000, she met Ghislaine Maxwell, a British socialite who was convicted in 2021 on federal sex trafficking and conspiracy charges and was sentenced to 20 years in prison.

Ms Giuffre said Maxwell then introduced her to Epstein and hired her as his masseuse, and said she was sex trafficked and sexually abused by him and associates around the world.

‘A survivor’

After meeting her husband in 2002, while taking massage training in Thailand at what she said was Epstein’s behest, she moved to Australia and had a family.

She founded the sex trafficking victims’ advocacy charity SOAR in 2015, and is quoted on its website as saying: “I do this for victims everywhere.

“I am no longer the young and vulnerable girl who could be bullied. I am now a survivor, and nobody can ever take that away from me.”

:: Anyone feeling emotionally distressed or suicidal can call Samaritans for help on 116 123 or email jo@samaritans.org in the UK. In the US, call the Samaritans branch in your area or 1 (800) 273-TALK.

UK

Who will be at the Pope’s funeral – and who won’t be

Published

2 hours ago

April 26, 2025

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Who will be at the Pope's funeral - and who won't be

The Pope’s funeral will take place today at St Peter’s Basilica at the Vatican.

A pope’s funeral traditionally brings world leaders together, and some have already revealed they are attending.

Watch full coverage of the Pope’s funeral live on Sky News from 8am

Here’s a look at the list.

Prince William

The Prince of Wales will attend the funeral of Pope Francis on behalf of the King, Kensington Palace has said.

The King was in Rome with Queen Camilla earlier this month, and met the pontiff at the Vatican.

The trip came just a week-and-a-half after Buckingham Palace confirmed the King had been taken to hospital following side effects related to his ongoing cancer treatment.

Sir Keir Starmer

Number 10 has confirmed the prime minister received an invite and will attend the ceremony.

Speaking on Tuesday, Sir Keir said there had been “an outpouring of grief and love” for the Pope.

He added: “I think it reflects the high esteem in which he was held, not just by millions and millions of Catholics, but by many others, across the world, myself included.”

Donald Trump

The US president was one of the first to confirm he would be flying to Rome, adding he would be joined by first lady Melania Trump.

Writing on his social media platform Truth Social on Monday, he said: “Melania and I will be going to the funeral of Pope Francis, in Rome. We look forward to being there!”

The Pope had been critical of Mr Trump at times during his tenure.

In January, he said it would be a “disgrace” if the president went ahead with his crackdown on immigration, telling an Italian television station: “It would make the migrants, who have nothing, pay the unpaid bill.

“It doesn’t work. You don’t resolve problems this way.”

Volodymyr Zelenskyy

The Ukrainian president, who met the Pope three times, is expected to attend, according to officials in Ukraine.

In his tribute, Mr Zelenskyy said his country was grieving the Pope and recalled how he often prayed for peace in Ukraine.

Emmanuel Macron

The French president told local reporters he would be going to the funeral.

In his tribute on Monday, Mr Macron said of the Pope: “In this time of war and brutality, he had a sense for the other, for the most fragile.”

Javier Milei

The president of Pope Francis’s native Argentina will attend, despite having launched insults at Francis in recent years.

Before taking office in December 2023, the far-right politician called him “an imbecile, the representative of evil on Earth”.

Mr Milei alluded to their “differences” in his tribute to the late Pope, writing: “It is with profound sorrow that I learned this sad morning that Pope Francis, Jorge Bergoglio, passed away today and is now resting in peace.

“Despite differences that seem minor today, having been able to know him in his goodness and wisdom was a true honour for me.”

Lula da Silva

The Brazilian president and first lady Janja Lula da Silva will be at the funeral, the country’s government announced.

Brazil has also declared a seven-day mourning period for the Pope.

“Humanity is today losing a voice of respect and welcome for others,” the president said in his tribute.

“Pope Francis lived and propagated in his daily life the love, tolerance and solidarity that are the basis of Christian
teachings.”

Ursula von der Leyen

The EU Commission President confirmed she would be attending after calling Francis a worldwide inspiration.

“He inspired millions, far beyond the Catholic Church, with his humility and love so pure for the less fortunate,” she said in her tribute.

Council President Antonio Costa, Parliament President Roberta Metsola are also expected to attend.

Here are some of the other notable attendees:

• Ireland’s taoiseach Micheal Martin
• Spain’s King Felipe and Queen Letizia
• Albanian president Bajram Begaj
• Angola’s president Joao Lourenco
• Austrian president Alexander Van der Bellen
• Bangladesh’s chief adviser and interim leader Muhammad Yunus
• Belgium’s King Philippe and Queen Mathilde, along with prime minister Bart De Wever
• Canada’s governor general Mary Simon
• Cape Verde president Jose Maria Neves
• Croatia’s president Zoran Milanovic
• Cyprian president Nikos Christodoulides
• Czech Republic’s prime minister Petr Fiala
• Democratic Republic of Congo president Felix Tshisekedi
• Dominican Republic’s president Luis Abinader
• East Timor’s president Jose Ramos-Horta
• Ecuador’s president Daniel Noboa
• Estonia’s president Alar Karis
• Finland’s president Alexander Stubb
• Gabon’s president Brice Oligui Nguema
• German president Frank-Walter Steinmeier and outgoing chancellor Olaf Scholz
• Greece’s prime minister Kyriakos Mitsotakis
• Honduras president Xiomara Castro
• Hungary’s president Tamas Sulyok
• Italy’s president Sergio Mattarella and prime minister Giorgia Meloni
• Latvian president Edgars Rinkevics
• Lithuanian president Gitanas Nauseda
• Moldova’s president Maia Sandu
• Netherlands’ prime minister Dick Schoof
• New Zealand’s prime minister Christopher Luxon
• Norway’s Crown Prince Haakon and Crown Princess Mette-Marit
• The Philippines’ president Ferdinand Marcos Jr
• Poland’s president Andrzej Duda
• Portugal’s president Marcelo Rebelo de Sousa and prime minister Luis Montenegro
• Romania’s interim president Ilie Bolojan
• Sweden’s King Carl XVI Gustaf, Queen Silvia and prime minister Ulf Kristersson
• Switzerland’s president Karin Keller-Sutter

Who won’t be there?

Vladimir Putin

The Russian president will not be attending the funeral, the Kremlin has confirmed.

But the controversial leader paid tribute to the Pope, writing a message to Cardinal Kevin Farrell, who is interim chief of the Catholic Church.

“Please accept my most sincere condolences on the passing of His Holiness Pope Francis,” Mr Putin said.

“Throughout the years of his pontificate, he actively promoted the development of dialogue between the Russian
Orthodox and Roman Catholic churches, as well as constructive cooperation between Russia and the Holy See.”

Benjamin Netanyahu

The Israeli prime minister is not expected to attend, with the country’s ambassador Yaron Sideman going instead.

The Jewish state and the Vatican have had strong relations in the past, with Israel sending a presidential delegation to the funeral of Pope John Paul II in 2005, and Pope Francis visiting Israel in 2014.

But their relationship has deteriorated since the start of the war in Gaza.

A month after the conflict started in 2023, a dispute broke out over whether Pope Francis had used the word “genocide” to describe events in Gaza. Palestinians who met with him said he did, but the Vatican said he did not.

The Pope met relatives of Israeli hostages on the same day.

Israeli officials have since lobbied the Vatican to be more forceful in its condemnation of Hamas.

In January, the Pope called the humanitarian situation in Gaza “shameful”, prompting criticism from Rome’s chief rabbi, Riccardo Di Segni, who accused Francis of “selective indignation”.

Rabbi Di Segni says he will be attending the funeral, despite it taking place on the Jewish sabbath.

Is there a seating plan?

The seats are assigned in advance, with the heads of state sitting in French alphabetical order based on their country’s name, rather than on the individual’s.

This applies to everyone apart from the presidents of Italy and Argentina, who get the best seats because the Pope lived in Italy and was an Argentinian native.

UK

Vincent Nichols: British cardinal who will be in the conclave says picking the next pope is ‘intimidating’

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2 hours ago

April 26, 2025

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Vincent Nichols: British cardinal who will be in the conclave says picking the next pope is 'intimidating'

The head of the Catholic Church in England and Wales has told Sky News it’s “intimidating” to be one of those responsible for choosing the next pope.

Vincent Nichols is among four UK cardinals in Rome for the Pope’s funeral on Saturday.

Following the funeral, and after nine days of mourning, cardinals from around the world will gather in the Vatican’s Sistine Chapel to cast their votes, with white smoke announcing to the world when a new pope has been elected.

Cardinal Nichols told Sky’s Anna Botting: “I hope nobody goes into this conclave, as it were, with the sole purpose of wanting to win. I think it’s very important that we go in wanting to listen to each other… It has to be together, trying to sense what God wants next. Not just for the church.”

He described the procession that took Pope Francis to lie in state as “the most moving thing I’ve ever attended here”.

Describing the Pope as a “master of the gesture and the phrase”, he also recalled the pontiff’s last journey away from the Vatican.

Cardinal Nichols said Pope Francis had visited the Regina Coeli prison, telling the inmates: “You know, except for the grace of God, it could well have been me … Don’t lose hope, God has you written in his heart.”

The Pope later told his doctor his last regret was not being able to wash the feet of the prisoners during that visit.

Becoming emotional, he also said the final message he would like to have given Pope Francis is “thank you”.

The 88-year-old died peacefully on Easter Monday, the Vatican confirmed.

Heads of state – including Sir Keir Starmer, Donald Trump and Emmanuel Macron – have all confirmed their attendance at his funeral, which takes place on Saturday at St Peter’s Square.

Prince William will attend on behalf of the King, Kensington Palace has said.

You can watch full coverage of the funeral live on Sky News on Saturday

Talking about the seating plan at the funeral, Cardinal Nichols said he understood it to be “royalty first, then heads of state, then political leaders”.

Cardinal Nichols explained event would be “exactly the same Catholic rite as everyone else – just on a grander scale”.

In a break from tradition, Pope Francis will be the first pope in a century to be interred outside the Vatican – and will instead be laid to rest at his favourite church, Santa Maria Maggiore Basilica in Rome’s Esquilino neighbourhood.

He will also be buried in just one simple wooden coffin, instead of the traditional three coffins which are usually used for pontiffs.

Born in Crosby near Liverpool, Cardinal Vincent Nichols hoped to be a lorry driver as a child – but as a teenager reportedly felt the calling to join the priesthood while watching Liverpool FC.

As cardinal, he is known for leading the church’s work tackling human trafficking and modern slavery, for which he received the UN Path to Peace Award.

He was criticised by the UK’s Independent Inquiry into Child Sexual Abuse, which said he “demonstrated a lack of understanding” of the impact of abuse and “seemingly put the reputation of the church first”.

Cardinal Nichols, responding to the findings, previously told Sky News he was “ashamed at what has happened in the context of the Catholic Church” and promised to improve the church’s response.

He has appeared to rule himself out of the running for pope, telling reporters he was “too old, not capable”.