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Using GLP-1s drug injections for weight loss has become one of the latest ways some big names in the market are shedding extra pounds. Elon Musk recently tweeted about how using Novo Nordisk’s Wegovy helped him lose weight. Fanatics CEO Michael Rubin recently told CNBC’s “Squawk Box” that using a different version of Novo Nordisk’s same drug, Ozempic, which is most commonly associated with diabetes care, made him much less hungry.

“The weekly shot is amazing. … I started this about a year ago, it’s been life changing for me,” Rubin said. 

Social media influencer Remi Bader said she was prescribed Ozempic after experiencing issues with insulin and weight gain.

GLP-1s — which stands for glucagon-like peptide-1 — are receptor agonists that work by imitating the effects of the GLP-1 hormone, activating GLP-1 receptors inside of the pancreas and producing more insulin inside the body. The insulin helps lower blood sugar levels, which can be helpful in managing Type 2 diabetes. GLP-1s also have been found to help with weight loss as they make individuals who use them feel fuller for a longer period of time.

It’s not only the GLP-1 drugs that are helping celebrities and the wealthy, but also their ability to receive high quality clinical and obesity care that helps them lose the weight, according to Zachariah Reitano, the co-founder and CEO of telehealth company Ro. That’s why his company has launched a program to offer GLP-1 drugs and corresponding medical care to individuals struggling with obesity or weight loss issues.

“I think what we’re able to do now is leverage all of the technology that we have to give everyone access to something that only a few people have access to now,” Reitano said in a recent interview with CNBC. 

Ro’s Body Program offers personalized treatment for GLP-1s and weight management. The year-long program uses a combination of GLP-1s and personal coaching. In clinical trials, these drugs have helped participants lose an average of 15% of their weight over a year.

Pairing personalized coaching with GLP-1s is the key to effective weight loss treatment, Reitano said, and helping patients maximize their results.

“I think what’s really important is, yes, it’s access to the medication … but once they have the medication, we want to hold their hand throughout the entire process, and we have built the technology to be able to do that at scale,” Reitano said.

With the Ro Body Program, participants are first diagnosed, entering information about their health history, any weight loss and obesity challenges, and lifestyle and diet, and then are sent an at-home lab test to obtain measures of A1C blood sugar test, cholesterol and kidney function, among other health metrics. Based on their test results and an initial consultation, a doctor may prescribe patients to start off with a low dosage of GLP-1s that is slowly ramped up over time to meet the desired dosage amount.

Diabetes, obesity and a nationwide drug controversy

Ozempic – the brand of semaglutide, a GLP-1 receptor agonist, marketed for Type 2 diabetes treatment – recently made headlines for a nationwide shortage as its use as a weight loss drug gained popularity. When Wegovy, the brand semaglutide marketed for weight management, began experiencing shortages, some using the medicine were prescribed off-brand Ozempic, makin the drug much harder to find. Many with Type 2 diabetes that relied on Ozempic to treat it have been left scrambling to find the medication. There have also been reports of people looking for weight loss help turning to multiple other drug solutions as a result of difficulty finding GLP-1 drugs.

Both obesity and Type 2 diabetes affect a large number of Americans. According to the CDC, the adult obesity rate in the United States was 41.9% in 2017, and about one in 10 people in the United States have Type 2 diabetes. Reitano said it is important to recognize both obesity and diabetes as diseases that deserve proper treatment.

“I think what we’re actually going to see over the next 5 to 10 years is a weight-centric approach to metabolic health,” Reitano said, who noted in a subsequent interview with CNBC’s “Mad Money” on Thursday night that his father’s personal experience with GLP-1 drugs was a motivating factor for his business decision. “I’ve seen GLPs have a tremendous impact on my dad,” he said.

He told CNBC’s Jim Cramer that the once a week injections do three “very, very important things” when comes to obesity. They help regulate sugar levels; they help regulate appetite; and they slow the passage of food from the stomach to the small intestine. This combination of controls has helped patients in clinical studies lose on average 15% of body weight over a year.

Novo Nordisk, Ozempic and Wegovy’s manufacturer, told NBC News last week the company is still experiencing supply chain issues that will last through the month, though access to some dosages of Ozempic for patients with Type 2 diabetes has improved.

The GLP-1 drug Wegovy for weight issues or obesity is approved for individuals with a BMI of 26-plus and co-morbidities, or those with a BMI of 30-plus.

A new real-time approach to weight management

Reitano said it should not be an either/or scenario involving diabetes management of weight loss and that will change over the next decade.

“If we saw obesity as a disease, and we’re both focused on preventing it but once it happens treating it and treating it as a disease, I think we’re going to see an entirely different approach,” he said.

Reitano said the weight loss and obesity management program fits within his company’s broader goal of changing the way patients receive medical care and reach health goals, from doctor visits to pharmacy and ongoing health issue management.

“High-quality obesity care is an important part of it,” he told Cramer. “Patients can’t just receive these medications and be left to their own devices.”

In addition to shipping the GLP-1 drug to a patient’s home, the Ro Body program tracks patients in real-time with remote monitoring. That is facilitated by a cellular-connected smart scale also sent to the patient which tracks weight and sends data to an app so medical professionals can tweak dosages of the drugs to make sure the patient is receiving the right dose to achieve the weight loss results they want. Patients also receive one-to-one coaching with nurses over the year-long period and up to 24 telehealth visits with a doctor.

“The speed with which we can communicate with patients, update their plans and really be there for them and guide them through this experience, and have that serve as a really strong compliment to their overall primary care, is one of the things I think we’re really excited about,” Reitano said in a recent phone interview with CNBC.

Price of these drugs, though, is an issue, with Wegovy costing as much as $1,700 a month without insurance. Reitano said Ro helps guide individuals through the insurance process and to get these drugs at the lowest price, but he conceded in his “Mad Money” interview that pricing in this pharmaceutical niche “can be challenging for patients.”

The Ro Body Program is the latest addition to Ro’s health care offerings. The company, which ranked No. 38 on the 2022 CNBC Disruptor 50 list, started off selling men’s health care products, helping to treat issues such as erectile dysfunction and hair loss, and has since expanded to provide multiple at-home services including pharmaceutical and fertility treatments. 

CNBC is now accepting nominations for the 2023 Disruptor 50 list – our 11th annual look at the most innovative venture-backed companies. Learn more about eligibility and how to submit an application by Friday, Feb. 17.

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Tesla launches refreshed Model Y in China to fend off domestic rivals

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Tesla launches refreshed Model Y in China to fend off domestic rivals

Tesla launched a revamped version of its Model Y in China.

Tesla

Tesla on Friday announced a revamped version of its popular Model Y in China, as the U.S. electric car giant looks to fend off challenges from domestic rivals.

The Model Y will start at 263,500 Chinese yuan ($35,935), with deliveries set to begin in March. That is 5.4% more expensive than the starting price of the previous Model Y.

A spokesperson for Tesla China said that the new Model Y is only open for pre-sale in the Chinese market, rather than being launched globally.

Tesla’s Model Y refresh comes after the auto giant this month reported its first ever annual decline in overall deliveries for 2024.

Elon Musk’s electric vehicle firm is facing heightened competition around the world, from startups and traditional carmakers in Europe. In China, the company continues to face an onslaught of rivals from BYD to newer players like Xpeng and Nio.

Jason Low, principal analyst at Canalys, notes that the Tesla Model Y was the best-selling EV in China in 2024 and that the popularity of the car “remains high.” However, he noted that the competition in the sports utility vehicle (SUV) segment with vehicles priced between 250,000 yuan and 350,000 yuan “has been fierce.”

“Tesla must showcase compelling smart features, particularly a unique but well localized cockpit and services ecosystem,” as well as “effective” semi-autonomous driver assistance features “to ensure its competitiveness in the market,” Low added.

Tesla is offering a number of incentives for customers to buy the Model Y including a five-year 0% interest financing plan.

The new Model Y can accelerate from 0 kilometers per hour to 100 kilometers per hour in 4.3 seconds, Tesla said, exceeding the speed capabilities of the previous vehicle. The Model Y Long Range has a further driving range on a single charge versus its predecessor.

Tesla has not introduced a new model since it began delivering the Cybertruck in late 2023, which starts at nearly $80,000.

Investors have been yearning for a new mass-market model to reinvigorate sales. Tesla has previously hinted that that a new affordable model could be launched in the first half of 2025.

Despite Tesla’s headwinds, the company’s stock is up nearly 70% over the last 12 months, partly due to CEO Musk’s close relationship with U.S. President-elect Donald Trump.

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World’s biggest chipmaker TSMC posts record 2024 revenue as AI boost continues

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World's biggest chipmaker TSMC posts record 2024 revenue as AI boost continues

The logo for Taiwan Semiconductor Manufacturing Company is displayed on a screen on the floor of the New York Stock Exchange on Sept. 26, 2023.

Brendan Mcdermid | Reuters

Taiwan Semiconductor Manufacturing Co. posted December quarter revenue that topped analyst estimates, as the company continues to get a boost from the AI boom.

The world’s largest chip manufacturer reported fourth-quarter revenue of 868.5 billion New Taiwan dollars ($26.3 billion), according to CNBC calculations, up 38.8% year-on-year.

That beat Refinitiv consensus estimates of 850.1 billion New Taiwan dollars.

For 2024, TSMC’s revenue totaled 2.9 trillion New Taiwan Dollars, its highest annual sales since going public in 1994.

TSMC manufacturers semiconductors for some of the world’s biggest companies, including Apple and Nvidia.

TSMC is seen as the most advanced chipmaker in the world, given its ability to manufacture leading-edge semiconductors. The company has been helped along by the strong demand for AI chips, particularly from Nvidia, as well as ever-improving smartphone semiconductors.

“TSMC has benefited significantly from the strong demand for AI,” Brady Wang, associate director at Counterpoint Research told CNBC.

Wang said “capacity utilization” for TSMC’s 3 nanometer and 5 nanometer processes — the most advanced chips — “has consistently exceeded 100%.”

AI graphics processing units (GPUs), such as those designed by Nvidia, and other artificial intelligence chips are driving this demand, Wang said.

Taiwan-listed shares of TSMC have risen 88% over the last 12 months.

TSMC’s latest sales figures may also give hope to investors that the the demand for artificial intelligence chips and services may continue into 2025.

Foxconn, which assembles Apple’s iPhones, reported its highest-ever fourth quarter revenue this week, as it notched strong demand for AI servers.

Meanwhile, Microsoft this month said that it plans to spend $80 billion in its fiscal year to June on the construction of data centers that can handle artificial intelligence workloads.

CNBC’s Jordan Novet contributed to this report.

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Supreme Court set to hear oral arguments on challenge to TikTok ban

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Supreme Court set to hear oral arguments on challenge to TikTok ban

Tik Tok creators gather before a press conference to voice their opposition to the “Protecting Americans from Foreign Adversary Controlled Applications Act,” pending crackdown legislation on TikTok in the House of Representatives, on Capitol Hill in Washington, U.S., March 12, 2024.

Craig Hudson | Reuters

The Supreme Court on Friday will hear oral arguments in the case involving the future of TikTok in the U.S., which could ban the popular app as soon as next week.

The justices will consider whether the Protecting Americans from Foreign Adversary Controlled Applications Act, the law that targets TikTok’s ban and imposes harsh civil penalties for app “entities” that continue to carry the service after Jan.19, violates the U.S. Constitution’s free speech protections.

It’s unclear when the court will hand down a decision, and if China’s ByteDance continues to refuse to divest TikTok to an American company, it faces a complete ban nationwide.

What will change about the user experience?

The roughly 115 million U.S. TikTok monthly active users could face a range of scenarios depending on when the Supreme Court hands down a decision.

If no word comes before the law takes effect on Jan. 19 and the ban goes through, it’s possible that users would still be able to post or engage with the app if they already have it downloaded. However, those users would likely be unable to update or redownload the app after that date, multiple legal experts said.

Thousands of short-form video creators who generate income from TikTok through ad revenue, paid partnerships, merchandise and more will likely need to transition their businesses to other platforms, like YouTube or Instagram.

“Shutting down TikTok, even for a single day, would be a big deal, not just for people who create content on TikTok, but everyone who shares or views content,” said George Wang, a staff attorney at the Knight First Amendment Institute who helped write the institute’s amicus briefs on the case. 

“It sets a really dangerous precedent for how we regulate speech online,” Wang said.

Who supports and opposes the ban?

Dozens of high-profile amicus briefs from organizations, members of Congress and President-elect Donald Trump were filed supporting both the government and ByteDance.

The government, led by Attorney General Merrick Garland, alleges that until ByteDance divests TikTok, the app remains a “powerful tool for espionage” and a “potent weapon for covert influence operations.”

Trump’s brief did not voice support for either side, but it did ask the court to oppose banning the platform and allow him to find a political resolution that allows the service to continue while addressing national security concerns. 

The short-form video app played a notable role in both Trump and Democratic nominee Kamala Harris’ presidential campaigns in 2024, and it’s one of the most common news sources for younger voters.

In a September Truth Social post, Trump wrote in all caps Americans who want to save TikTok should vote for him. The post was quoted in his amicus brief. 

What comes next?

It appears TikTok could really get shut down, says Jim Cramer

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