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A decades-old drug for urinary tract infections may also work for “brain-eating” amoeba infections, which kill the vast majority of people who contract them, Science magazine reported (opens in new tab) .

The drug’s promise was demonstrated in a recent case report, published in January in the journal Emerging Infectious Diseases (opens in new tab) , which describes a 54-year-old man whose brain was infiltrated by the amoeba Balamuthia mandrillaris. The single-celled organism lives in dust, soil and water, and can enter the body through skin wounds and cuts or through the lungs, when it’s inhaled, according to the Centers for Disease Control and Prevention (opens in new tab) (CDC). The amoeba can then infiltrate the bloodstream and travel to the brain, triggering a very rare infection called “granulomatous amebic encephalitis” that kills around 90% of people affected. 

“The disease might appear mild at first but can become more severe over weeks to several months,” the CDC notes.

The man in the case report initially received treatment at a Northern California hospital for an unexplained seizure. Magnetic resonance imaging (MRI) revealed a mass on the left side of his brain, surrounded by swelling. At this point, the man was transferred to the University of California San Francisco (UCSF) Medical Center, where doctors took samples of the patient’s brain tissue and the clear fluid surrounding the brain and spinal cord. This analysis revealed B. mandrillaris in the man’s brain.  

Related: Boy dies from rare ‘brain-eating’ amoeba found in splash pad at Texas park 

After consulting the CDC, the patient’s doctors prescribed an aggressive regimen of antiparasitic, antibacterial and antifungal drugs. “It’s what’s recommended because it was what happened to be used in patients who survived,” Dr. Natasha Spottiswoode (opens in new tab) , an infectious disease physician-scientist at UCSF and first author of the case report, told Science. Unfortunately, the treatment triggered severe side effects, including kidney failure, and the patient wasn’t yet amoeba-free. RELATED STORIES—5 key facts about brain-eating amoeba

—Deadly ‘brain-eating amoeba’ has expanded its range northward

—Nebraska child likely died of a brain-eating-amoeba infection

In search of another solution, Spottiswoode dug up a 2018 report, published in the journal mBio (opens in new tab) , in which UCSF scientists found evidence that an antibiotic called nitroxoline can kill B. mandrillaris in laboratory settings. The drug is approved in Europe, but not the U.S., so the medical team sought permission from the Food and Drug Administration to use it; they received approval, started the patient on nitroxoline and observed rapid improvement, within a week.

The patient was soon discharged from the hospital and he continued to take nitroxoline at home, along with other medications; his clinicians plan to eventually discontinue his use of the drugs. In the meantime, UCSF doctors are overseeing the case of a second B. mandrillaris-infected patient who’s started receiving nitroxoline. They are seeing similar improvements, Science reported. 

Read more in Science (opens in new tab) .  

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Zilisch to miss Xfinity race in Texas after wreck

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Zilisch to miss Xfinity race in Texas after wreck

FORT WORTH, Texas — Connor Zilisch, the 18-year-old driver already with two NASCAR Xfinity Series race wins, will miss Saturday’s race at Texas because of lower back injuries sustained in a last-lap wreck at Talladega.

Trackhouse Racing said Wednesday that its development driver will return as soon as possible to the No. 88 JR Motorsports Chevrolet. The team didn’t provide any additional details about Zilisch’s injuries.

Cup Series regular Kyle Larson will drive the No. 88 in Texas. After that, the Xfinity Series has a two-week break before racing again May 24 at Charlotte.

Zilisch, sixth in points through the first 11 races, was driving for the win at Talladega Superspeedway when contact on the backstretch sent his car spinning, and head-on into inside wall.

Zilisch won in his Xfinity debut at Watkins Glen last Sept. 14. He added another win this year at Austin, the same weekend that he made his Cup Series debut. He has six top-10 finishes in his 15 Xfinity races.

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23XI, Front Row ask judge to toss NASCAR claim

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23XI, Front Row ask judge to toss NASCAR claim

CHARLOTTE, N.C. — The two teams suing NASCAR asked a judge to dismiss the sanctioning body’s counterclaim in court Wednesday.

In a 20-page filing in district court in North Carolina, 23XI Racing and Front Row Motorsports opposed NASCAR’s motion to amend its original counterclaim. The teams argued that the need to amend the counterclaim further demonstrates the weakness of NASCAR’s arguments, calling them an attempt by NASCAR to distract and shift attention away from its own unlawful, monopolistic actions.

NASCAR’s counterclaim singled out Michael Jordan’s longtime business manager, Curtis Polk. Jordan is co-owner of 23XI Racing.

The legal battle began after more than two years of negotiations on new charter agreements — NASCAR’s equivalent of a franchise model — and the 30-page filing contends that Polk “willfully” violated antitrust laws by orchestrating anticompetitive collective conduct in connection with the most recent charter agreements.

23XI and Front Row were the only two organizations out of 15 that refused to sign the new agreements, which were presented to the teams last September in a take-it-or-leave-it offer a mere 48 hours before the start of NASCAR’s playoffs.

The charters were fought for by the teams ahead of the 2016 season and twice have been extended. The latest extension is for seven years to match the current media rights deal and guarantee 36 of the 40 spots in each week’s field to the teams that hold the charters, as well as other financial incentives. 23XI and Front Row refused to sign and sued, alleging NASCAR and the France family that owns the stock car series are a monopoly.

NASCAR already has lost one round in court in which the two teams have been recognized as chartered organizations for the 2025 season as the legal dispute winds through the courts. NASCAR has also appealed a judge’s rejection of its motion to dismiss the case.

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Logano throws fastball back at Jones: Ever drive?

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Logano throws fastball back at Jones: Ever drive?

CHARLOTTE, N.C. — Joey Logano wondered Tuesday if Baseball Hall of Famer Chipper Jones ever had driven a race car at Talladega after the former Atlanta Braves slugger criticized the NASCAR champion in a series of social media posts.

Jones was defending Austin Cindric, the winner of Sunday’s race at Talladega Superspeedway, after Team Penske teammate Logano unleashed an expletive-laden rant about Cindric around the halfway mark of the race. Logano was furious he did not receive the help he needed from Cindric, which allowed rival Toyota driver Bubba Wallace to win the second stage and earn valuable bonus points.

“Way to go, Austin. Way to go. You dumb f—. Way to f—ing go,” Logano said on his team radio. “What a stupid s—. He just gave it to him. Gave Toyota a stage win. Nice job. Way to go. What a dumbass.”

Jones was angered by Logano’s rant and in six social media posts congratulated Cindric, called Logano selfish and celebrated Logano being disqualified for failing postrace inspection.

“Good teammates are hard to come by, Boss! Remember that one of urs MFed u on national tv, when in all actuality, u did everything possible to keep from wrecking him,” Jones wrote. “Some people are ‘hooray for our team as long as I’m the star’ as every team has them. Hendrick, RCR, JGR, Penske, etc. Sometimes karma is glorious.”

When told of Jones’ comments on a Tuesday appearance of SiriusXM NASCAR Radio’s “The Morning Drive,” Logano said he was unaware of them. Once he was told, Logano asked: “Has Chipper Jones ever driven a race car at Talladega? That would be my first question. I’m pretty certain he hasn’t.”

“That’s like me saying something about baseball. I know nothing about baseball,” Logano said. “That’s like me saying something that he did something in baseball that was wrong. That doesn’t matter.”

“Chipper Jones, he seems like a cool dude, he’s done a lot, right? He’s a pretty popular, good baseball player, but he’s not a race car driver, and I know he wasn’t in the room with us when we set in place the way things are supposed to go.”

Joey Logano on SiriusXM

Logano continued by saying that as a former professional athlete, Jones should understand there was more to the situation than what he saw on television. Jones grew up outside Daytona International Speedway and was once the grand marshal for the Daytona 500.

“Chipper Jones, he seems like a cool dude, he’s done a lot, right? He’s a pretty popular, good baseball player, but he’s not a race car driver, and I know he wasn’t in the room with us when we set in place the way things are supposed to go,” Logano said. “You would think somebody that has been in professional sports and has been in meetings like that would probably take a step back and say, ‘Man, there’s probably more to the story here than what there is.’ I’m surprised it went that way. Maybe he was just bored. I don’t know what his situation is. I tell you I don’t care.”

Logano said he and Cindric cleared the air in Penske’s Monday meeting.

“Austin and I talked about it. We’ve got to move forward. That’s what it is,” he said. “I explained my side. He understood. We move on. There’s no sense in airing our dirty laundry and airing out what the actual rules are because that’s private information that doesn’t need to be out to everybody. But the facts are that what we set in place wasn’t happening and that’s why I got frustrated. Like I said, we talked about it and we moved on.”

Logano did acknowledge that he probably should not have hit the radio button and “spouted off so much.”

“Probably blew up into a little bigger situation than it needed to, but the conversation, either way, needed to happen. Just more people are talking about it now,” he added.

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