What is frontotemporal dementia and how does it affect people?
Bruce Willis has been diagnosed with frontotemporal dementia, one of the rarer types of dementia.
His family said difficulties with communication are “just one of the challenges” the 67-year-old actor faces.
So what is frontotemporal dementia and what are people diagnosed with it likely to experience?
Frontotemporal dementia and its symptoms
Frontotemporal dementia (FTD) is thought to account for less than one in 20 of all dementia cases.
It is named for the parts of the brain it affects: the frontal and temporal lobes. It is sometimes called Pick’s disease or frontal lobe dementia.
There are different types of frontotemporal dementia. Behaviour variant FTD is the most common and mainly causes changes in someone’s personality and behaviour.
People with behavioural variant FTD may lose motivation; struggle to focus on tasks, make plans and decisions; lose their inhibitions; show repetitive behaviours and become less considerate of others.
The other main type of FTD is primary progressive aphasia (PPA) which has two sub-types: semantic variant PPA and non-fluent variant PPA.
Semantic variant PPA causes a person to forget the meaning of words.
The person is likely to lose their vocabulary over time and forget what familiar objects are used for.
Non-fluent variant PPA causes a person to have problems with speaking.
Over time, the person will find it more difficult to get their words out and may start to put words in the wrong order, miss out words and say the opposite of what they mean.
Last year, the Die Hard star retired from acting after being diagnosed with aphasia.
Bruce Willis in 1999
How is it different to other types of dementia?
The first noticeable symptoms of FTD are different to other types of dementia.
While people with Alzheimer’s disease often have early problems with day-to-day memory, many people in the early stages of FTD can still remember recent events.
By contrast, the early symptoms of FTD are changes to personality and behaviour and/or difficulties with language.
Who does it affect?
FTD typically affects people between the ages of 45 and 64 but can affect people younger or older than this.
How is it treated?
There’s currently no cure for frontotemporal dementia or any treatment that will slow it down, according to the NHS.
However, treatments such as medicines, therapies and memory activities can help control some of the symptoms.
There’s also a glimmer of hope for people with FTD thanks to researchers at Durham University working on developing treatments.
Professor Andy Whiting said they had conducted some “promising” research that “directly addresses the reasons why there is nerve cell loss”.
He said he was “hopeful” the current lack of treatment could change over the next few years.
Brain scans from a study targeting the earliest brain changes in dementia. Pic: Matt York/AP
Read more:
Celebrities send messages to ‘legend’ Bruce Willis
What is the outlook for people with FTD?
As FTD progresses, the differences between behavioural variant FTD and primary progressive aphasia become less obvious.
People who started with language difficulties often develop changes in their behaviour and vice versa.
People may eventually lose all speech.
The later stages of all types of FTD bring a greater range of symptoms, which are similar to the later stages of other types of dementia.
The person may become forgetful, have delusions or hallucinations, get agitated easily and no longer recognise family and friends. They may require full-time care.
How quickly FTD progresses and the person’s life expectancy will depend on the individual.
The average survival time after symptoms start is 8 to 10 years, according to the NHS.
How is FTD caused?
FTD is caused by damage to cells in areas of the brain called the frontal and temporal lobes.
There is a build up of proteins which clump together and damage the brain cells, eventually causing them to die.
It’s not fully understood why this happens, but there’s often a genetic link according to the NHS.
Around 1 in 8 people who get frontotemporal dementia will have relatives who also experienced the condition.
Virginia Giuffre, who accused Prince Andrew of sexual assault, has died aged 41.
In a statement to Sky’s US partner network NBC News on Friday, her family said she took her own life in the Perth suburb of Neergabby, Australia, where she had been living for several years.
“It is with utterly broken hearts that we announce that Virginia passed away last night at her farm in Western Australia,” her family said.
“She lost her life to suicide, after being a lifelong victim of sexual abuse and sex trafficking.
“Virginia was a fierce warrior in the fight against sexual abuse and sex trafficking. She was the light that lifted so many survivors.
“In the end, the toll of abuse is so heavy that it became unbearable for Virginia to handle its weight.”
Pic: AP
Police said emergency services received reports of an unresponsive woman at a property in Neergabby on Friday night.
“Police and St John Western Australia attended and provided emergency first aid. Sadly, the 41-year-old woman was declared deceased at the scene,” a police spokeswoman said.
“The death is being investigated by Major Crime detectives; early indication is the death is not suspicious.”
Sexual assault claims
Prince Andrew has denied all claims of wrongdoing. File pic: Reuters
Ms Giuffre sued the Duke of York for sexual abuse in August 2021, saying Andrew had sex with her when she was 17 and had been trafficked by his friend, the billionaire paedophile Jeffrey Epstein.
The duke has repeatedly denied the claims, and he has not been charged with any criminal offences.
In March 2022, it was announced Ms Giuffre and Andrew had reached an out-of-court settlement – believed to include a “substantial donation to Ms Giuffre’s charity in support of victims’ rights”.
‘An incredible champion’
Sigrid McCawley, Ms Giuffre’s attorney, said in a statement that she “was much more than a client to me; she was a dear friend and an incredible champion for other victims”.
“Her courage pushed me to fight harder, and her strength was awe-inspiring,” she said. “The world has lost an amazing human being today.”
“Rest in peace, my sweet angel,” she added.
Listen to The World with Richard Engel and Yalda Hakim every Wednesday
Dini von Mueffling, Ms Giuffre’s representative, also said that “Virginia was one of the most extraordinary human beings I have ever had the honour to know”.
“Deeply loving, wise, and funny, she was a beacon to other survivors and victims,” she added. “She adored her children and many animals.
“She was always more concerned with me than with herself. I will miss her beyond words.
“It was the privilege of a lifetime to represent her.”
Ms Giuffre said at the end of March she had four days to live after a car accident, posting on social media that “I’ve gone into kidney renal failure”. She was discharged from hospital eight days later.
Raised mainly in Florida, she said she was abused by a family friend early in life, which led to her living on the streets at times as a teenager.
She said that in 2000, she met Ghislaine Maxwell, a British socialite who was convicted in 2021 on federal sex trafficking and conspiracy charges and was sentenced to 20 years in prison.
Ghislaine Maxwell and Jeffrey Epstein. Pic: US Department of Justice
Ms Giuffre said Maxwell then introduced her to Epstein and hired her as his masseuse, and said she was sex trafficked and sexually abused by him and associates around the world.
‘A survivor’
After meeting her husband in 2002, while taking massage training in Thailand at what she said was Epstein’s behest, she moved to Australia and had a family.
She founded the sex trafficking victims’ advocacy charity SOAR in 2015, and is quoted on its website as saying: “I do this for victims everywhere.
“I am no longer the young and vulnerable girl who could be bullied. I am now a survivor, and nobody can ever take that away from me.”
:: Anyone feeling emotionally distressed or suicidal can call Samaritans for help on 116 123 or email jo@samaritans.org in the UK. In the US, call the Samaritans branch in your area or 1 (800) 273-TALK.
Donald Trump has met Volodymyr Zelenskyy ahead of the Pope’s funeral, Vatican sources have told Sky News.
The US and Ukrainian presidents had a “very productive discussion”, according to a White House Official, and have also agreed to hold further talks after the service.
They are among world leaders, including Sir Keir Starmer and Emmanuel Macron, who are attending the funeral of Pope Francis.
Follow live updates: Zelenskyy among world leaders joining thousands of mourners
There was applause from some of those gathered in St Peter’s Square when the Ukrainian leader walked out.
The former British ambassador to Russia Sir Tony Brenton said the event presents diplomatic opportunities, including the “biggest possible meeting” between Mr Trump and Mr Zelenskyy.
Trump and Zelenskyy meet for first time since Oval Office row. Pic: Reuters
He told Sky News it could mark “an important step” in starting the peace process between Russia and Ukraine, and is their first face-to-face meeting after a very public row between the presidents at the White House in February.
The bilateral meeting comes after Mr Trump’s peace negotiator Steve Witkoff held talks with Vladimir Putin at the Kremlin.
They discussed “the possibility of resuming direct negotiations between Russia and Ukraine”, Kremlin aide Yuri Ushakov said.
Russia and Ukraine have not held direct talks since the early weeks of the war, which began in February 2022.
Mr Trump has claimed a deal to end the war is “very close” and has urged Mr Zelenskyy to “get it done” in a post on his Truth Social platform.
He has previously warned both sides his administration would walk away from its efforts to achieve a peace if the two sides do not agree a deal soon.
Meanwhile, the Polish Armed Forces said a Russian military helicopter violated its airspace over the Baltic Sea on Friday evening, in a post on X.
This breaking news story is being updated and more details will be published shortly.
Please refresh the page for the fullest version.
You can receive breaking news alerts on a smartphone or tablet via the Sky News app. You can also follow us on WhatsApp and subscribe to our YouTube channel to keep up with the latest news.
US
Donald Trump says Russia and Ukraine are ‘very close to a deal’ – and says ‘two sides should now meet’
Donald Trump has said Russia and Ukraine are “very close to a deal” with “most of the major points agreed” – as he called for the two sides to meet.
Shortly after arriving in Rome for Pope Francis’s funeral, the US president said high-level officials should now meet to “finish [the deal] off”.
“A good day in talks and meetings with Russia and Ukraine,” Mr Trump wrote on his Truth Social platform.
“They are very close to a deal, and the two sides should now meet, at very high levels, to ‘finish it off’.
“Most of the major points are agreed to. Stop the bloodshed, NOW. We will be wherever is necessary to help facilitate the END to this cruel and senseless war!”
Please use Chrome browser for a more accessible video player
Ukraine-Russia peace talks explained
Throughout the week, the US president has criticised both Ukraine and Russia for failing to agree to a peace deal.
On Wednesday, he accused Mr Zelenskyy of harming talks on Truth Social, saying “the man with ‘no cards to play’ should now, finally, GET IT DONE”.
A day later, after nine people were killed in Kyiv after a Russian missile and drone strike, Mr Trump said: “Vladimir, STOP! 5000 soldiers a week are dying. Let’s get the Peace Deal DONE!”
The president and other officials have also threatened to withdraw from negotiations if no progress is made toward a deal.
It comes after Mr Trump’s envoy Steve Witkoff met Vladimir Putin in Moscow to discuss a US-brokered peace plan for Ukraine.
Please use Chrome browser for a more accessible video player
Putin-Witkoff meeting
The talks allowed Russia and the United States to “further bring their positions closer together” on “a number of international issues”, a Kremlin aide said.
Speaking earlier on the flight to Italy, Mr Trump said he hadn’t been fully briefed on Mr Witkoff and Mr Putin’s meeting – but added it was a “pretty good meeting”.
Read more:
US and Russia talks moving in ‘right direction’, top diplomat says
A ‘barbaric’ 24 hours in a ‘horrendous’ war
Russia and Ukraine have not held direct talks since the early weeks of the war, which began in February 2022.
Ukraine has repeatedly said it would not accept a deal conceding land or handing over sovereignty to Russia.
However, Mr Trump said in an interview with TIME magazine that “Crimea will stay with Russia,” describing the region as a place where Moscow has “had their submarines” and “the people speak largely Russian”.
“Zelenskyy understands that, and everybody understands that it’s been with them for a long time,” he added. “It’s been with them long before Trump came along.”
When asked on Friday about Mr Trump’s comments, Mr Zelenskyy did not want to comment but repeated that recognising occupied Ukrainian territory as Russian is a red line.
-
Sports3 years ago‘Storybook stuff’: Inside the night Bryce Harper sent the Phillies to the World Series
-
Sports1 year agoStory injured on diving stop, exits Red Sox game
-
Sports1 year agoGame 1 of WS least-watched in recorded history
-
Sports2 years agoMLB Rank 2023: Ranking baseball’s top 100 players
-
Sports4 years ago
Team Europe easily wins 4th straight Laver Cup
-
Environment2 years agoJapan and South Korea have a lot at stake in a free and open South China Sea
-
Environment2 years agoGame-changing Lectric XPedition launched as affordable electric cargo bike
-
Business3 years agoBank of England’s extraordinary response to government policy is almost unthinkable | Ed Conway