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SpaceX’s Dragon cargo ship is scheduled to launch Tuesday (March 14) evening, carrying nearly 6,300 pounds (2,860 kilograms) of cargo to the International Space Station (ISS). But among the spacewalk equipment, vehicle hardware and fresh fruit for the crew, there will be several small devices that contain something a little more unusual: beating human heart tissue. 

The tissue will be used in two experiments — Cardinal Heart 2.0 and Engineered Heart Tissues-2 — which will test whether existing drugs can help prevent or reverse spaceflight’s negative effects on the heart.

Research indicates that spaceflight can shrink the heart, because in microgravity, the heart muscles don’t need to work as hard to pump blood through the upper parts of the body. In addition, the heart may change shape under the influence of microgravity, as blood shifts upward, out of the legs and abdomen and into the head and torso, causing the heart to swell, according to NASA (opens in new tab) . 

Studies suggest that the heart also undergoes cellular changes associated with aging during spaceflight. Therefore, this research is not only critical to future space exploration but could also lead to improved treatments for age-related heart dysfunction and disease on Earth, Devin Mair (opens in new tab) , a doctoral candidate at Johns Hopkins University who’s involved in Engineered Heart Tissues-2, said during a NASA news conference Tuesday.  

Related: Tiny ‘hearts’ self-assemble in lab dishes and even beat like the real thing 

The experiments are part of the Tissue Chips in Space initiative, a joint project of the National Institutes of Health and the International Space Station National Laboratory aimed at understanding the effects of spaceflight and microgravity on the human body, according to NASA (opens in new tab) . 

The Engineered Heart Tissues-2 (opens in new tab) experiment involves two devices that carry cardiomyocytes — the heart muscle cells that contract — in small, fluid-filled chambers. The muscle cells were grown from stem cells and coaxed into 3D shapes in the lab. They were then strung between two posts within each chamber, similar to how tennis nets are suspended between a pair of posts. One post contains a magnet that moves each time the muscle cells contract. A sensor tracks the magnet’s movement, allowing the researchers to monitor muscle contractions in real time. RELATED STORIES—Lab-grown miniplacentas resemble the real thing so much, they fooled a pregnancy test

—Scientists grew human tear ducts in a lab and taught them to cry

—What are ‘minibrains’? Everything to know about brain organoids 

Mair and his colleagues previously sent heart tissue to space in March 2020, and in that experiment, they observed signs that cells’ mitochondria were malfunctioning, he said at the NASA news conference. Mitochondria provide power to cells and thus fuel the pumping of the heart, and their dysfunction has been tied to a variety of heart problems, including irregular heartbeat and heart failure. In an experiment launched on this trip to the ISS, the team will continue to study mitochondrial dysfunction, as well as test several existing drugs to see if they prevent or reverse the problems, Mair said.  

“These drugs specifically target mitochondrial dysfunction and upstream mechanisms that lead to this dysfunction,” Mair told Live Science in an email.

Similarly, the Cardinal Heart 2.0 (opens in new tab) experiment will use tiny, 3D clumps of heart tissue, known as heart organoids, to test whether already-approved drugs can protect heart cells from the stress of microgravity. The organoids will be treated prior to Dragon’s launch, with the goal of preventing the negative effects of microgravity from setting in, Dilip Thomas (opens in new tab) , a postdoctoral researcher at the Stanford Cardiovascular Institute who’s involved in Cardinal Heart 2.0, said at the news conference. These drugs include a statin and an anti-hypertensive drug used for heart failure, Thomas told Live Science in an email.

The organoids, grown from stem cells, are tiny models of full-size hearts that mimic key features of the organ’s structure and function. They contain cardiomyocytes, as well as cells that provide physical scaffolding for heart muscles (cardiac fibroblasts), and ones that line blood vessels (endothelial cells). 

The Dragon spacecraft is set to launch at 8:30 p.m. EDT Tuesday (0030 GMT Wednesday) from NASA’s Kennedy Space Center in Florida. Here’s how to watch it live (opens in new tab) .

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Business

‘It shouldn’t be like this’: Full-time workers relying on food handouts amid cost of living crisis

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'It shouldn't be like this': Full-time workers turning to food banks

At a community food table in Staffordshire, produce is being handed out for free.

“I need to come here otherwise we’d be living on bread,” Rebecca Flynn told Sky News.

The 51-year-old said: “I’m earning pretty decent money, but it’s not enough.”

Rebecca Flynn
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Rebecca Flynn

It gives you an insight into just how deeply the cost of living crisis is biting – because Rebecca is working full-time as an office manager for a day service for people with learning difficulties.

On top of that, she has a second job going door-to-door on evenings and weekends, selling cosmetics and homeware.

“There’s nothing more I can do. Unless I win the lottery or get another job. It should be noticed that people are in this state,” she says.

“Local councils, local governments, they need to see what’s going on, come to ground level. It’s 2025. It shouldn’t be like this.”

But it’s not just Rebecca working all hours and needing food handouts to survive.

Alex Chapman is the co-founder of the Norton Canes Community Food Table, and says a third of the people who use it are working full-time.

“It’s mad that you’re working a good job and you think you’d be able to afford everything and go on holiday and everything like that, but in reality they’re struggling to put food on the table,” he says.

“We’re seeing a massive increase in the people that are using the food table. We see them in their work outfits. Professionals, nurses – you don’t expect them to be struggling because they’re working full-time. People who aren’t working – you expect them to be struggling. But it’s across the board.”

Cannock Chase
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Cannock Chase

The food table is in Cannock Chase.

Sky News analysis of local authorities gives an insight into why people are feeling dissatisfied their salaries are no longer delivering the comfortable lifestyles they thought hard work and a good job would deliver.

Over the past few years, Cannock Chase has gone from being a middle-class part of Britain to one of the lowest-earning areas in the UK.

In 2021, UK average annual salaries were just short of £26,000 – Cannock Chase was almost identical, according to Sky News analysis of Annual Survey of Hours and Earnings data from the Office for National Statistics (ONS).

Since then, the UK average wage has increased by 21.6% – or more than £5,000 a year – keeping pace with high inflation.

But in Cannock Chase, salaries have only risen by 8.4% – meaning on average people are now £300 worse off per month than the average worker across the UK.

SEE HOW YOUR AREA HAS COPED WITH THE COST OF LIVING CRISIS

It won’t have escaped your attention that prices have gone up, by a lot – by a fifth since 2021, the highest sustained rate since the 1990s – with some of the biggest rises among essentials like energy and food.

But, across the whole country, wages have actually done a pretty good job at keeping up with inflation. The problem is that the wage increase is an average, made up of highs and lows, while the price rises affect us more uniformly.

That means if you haven’t had a pay-rise, you will quite quickly find that you can’t afford as many of the things you used to.

People in places like Brentwood in Essex, the Cotswolds in rural Gloucestershire, and Melton in Leicestershire, have seen their wages increase at twice the rate of prices in the last few years, on average.

But on the other end of the scale are places like Cannock Chase, where inflation has been more than double the rate of wage increases.

It used to be a place where average earnings pretty much exactly reflected the UK midpoint. Now, people in Cannock are about £300 worse-off every month than the average person.

See how your area compares with our look-up.

Louise Schwartz, who has two children, describes herself as middle-class. After 20 years in the classroom she now has three jobs, working 50 hours a week as a teaching coach, at a software firm and giving private music lessons.

Her husband is an estate agent. They have a mortgage and three cars and together earn around £80,000 a year.

She says the family loves travelling together but can’t afford to go on holiday this year: “It makes me feel sad for my kids, more than anything, that we can’t give them a week away.

“We have food on the table, we’ve got heating, we’ve got cars to drive. But there are definitely some luxuries that we’ve cut back on recently.

“We don’t do expensive supermarkets. We don’t do expensive brands. We do whatever’s on offer for that particular week. My eldest son has started driving, which has then had an impact on my daughter’s horse-riding lessons.”

Louise Schwartz
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Louise Schwartz

Louise adds that the family have a hot tub in the garden that they bought years ago, but because of the cost of electricity, they don’t use it.

I ask her: “What does it say that a teacher and an estate agent both working full time can’t afford to go on holiday this year?”

She replies: “I think a lot of people might not be surprised by that because I think people are probably in a similar position but maybe we just don’t talk about it.”

Full-time workers tell us again and again they thought their lifestyles would be more comfortable – that the work ethic would be delivering more than it is.

Heidi Boot
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Heidi Boot

It seems the dissatisfaction is not only what one person described as “robbing Peter to pay Paul”, but also the lack of what people refer to as “pleasure money”.

Heidi Boot is what you might call the backbone of the middle classes – running a small business full-time called HB Aesthetics, a salon that does eyebrows, eyelashes and nails.

“I feel like everybody is stretching their appointments. People are working so hard for their money and they’ve got nothing to show for it. They’ve paid all their bills and now they’ve got nothing left to spend on themselves,” she says.

“It shouldn’t be that way. But because I see it all the time I feel like it’s just the normal now.”

Read more UK news:
Hitler-inspired boy plotted terror attack at mosque
Prince Harry considering whether to start new charity

The constituency of Cannock Chase has always voted the way of the country – and at the last election showed significant support for Reform.

The financial woes will worry the government, which insists it’s taking action to give workers more money in their pockets.

But there’s no denying the despairing mood of middle England in the political battlegrounds that brought Labour to power.

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Environment

Elon Musk’s Tesla launches bid to supply electricity to British households

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Elon Musk's Tesla launches bid to supply electricity to British households

A photo shows the logo on US electric carmaker Tesla’s European headquarters in Amsterdam on May 2, 2025.

Ramon Van Flymen | Afp | Getty Images

Elon Musk’s electric vehicle manufacturer and energy company Tesla is preparing to supply electricity to British households and businesses.

The Texas-based company formally submitted its request for an electricity license to the British energy regulator Ofgem at the end of last month, according to a notice on the watchdog’s website.

If approved, the move could pave the way for Tesla to compete with the big firms that dominate the U.K. energy market from as soon as next year.

The application, first reported by the Sunday Telegraph, came from Tesla Energy Ventures and was signed by Andrew Payne, who runs the firm’s European energy operations.

Tesla, which is best known as one of the world’s leading EV manufacturers, also develops solar energy generation systems and battery energy storage products.

Musk’s company already has an electricity supplier in Texas, called Tesla Electric. The service, which was launched in 2022, allows customers to optimize energy consumption and pays them for selling excess energy back to the grid.

Tesla’s push for a license to supply electricity to British households comes as the company endures a protracted European sales slump.

Data published last week by the U.K.’s Society of Motor Manufacturers and Traders (SMMT) showed Tesla’s new car sales dropped by nearly 60% to 987 units last month, down from 2,462 a year ago.

In Germany, meanwhile, Tesla car sales fell to 1,110 units in July, down 55.1% from the same month in 2024.

The latest sales figures underscored some of the challenges facing the company, which continues to face stiff competition, particularly from Chinese EV manufacturers, and reputational damage from Musk’s incendiary rhetoric and relationship with U.S. President Donald Trump’s administration.

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Politics

‘Deport now, appeal later’ scheme for foreign criminals expanded to 23 countries

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'Deport now, appeal later' scheme for foreign criminals expanded to 23 countries

A hostile environment era deportation policy for criminals is being expanded by the Labour government as it continues its migration crackdown.

The government wants to go further in extraditing foreign offenders before they have a chance to appeal by including more countries in the existing scheme.

Offenders that have a human right appeal rejected will get offshored, and further appeals will then get heard from abroad.

It follows the government announcing on Saturday that it wants to deport criminals as soon as they are sentenced.

The “deport now, appeal later” policy was first introduced when Baroness Theresa May was home secretary in 2014 as part of the Conservative government’s hostile environment policy to try and reduce migration.

It saw hundreds of people returned to a handful of countries like Kenya and Jamaica under Section 94B of the Nationality, Immigration and Asylum Act 2002, added in via amendment.

In 2017, a Supreme Court effectively stopped the policy from being used after it was challenged on the grounds that appealing from abroad was not compliant with human rights.

More on Theresa May

However, in 2023, then home secretary Suella Braverman announced she was restarting the policy after providing more facilities abroad for people to lodge their appeals.

Now, the current government says it is expanding the partnership from eight countries to 23.

Previously, offenders were being returned to Finland, Nigeria, Estonia, Albania, Belize, Mauritius, Tanzania and Kosovo for remote hearings.

Angola, Australia, Botswana, Brunei, Bulgaria, Canada, Guyana, India, Indonesia, Kenya, Latvia, Lebanon, Malaysia, Uganda and Zambia are the countries being added – with the government wanting to include more.

Read more:
Govt vows to deport foreign criminals immediately
First migrants detained under returns deal with France

Theresa May's hostile environment policy proved controversial. Pic: PA
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Theresa May’s hostile environment policy proved controversial. Pic: PA

The Home Office claims this is the “the government’s latest tool in its comprehensive approach to scaling up our ability to remove foreign criminals”, touting 5,200 removals of foreign offenders since July 2024 – an increase of 14% compared with the year before.

Home Secretary Yvette Cooper said: “Those who commit crimes in our country cannot be allowed to manipulate the system, which is why we are restoring control and sending a clear message that our laws must be respected and will be enforced.”

Foreign Secretary David Lammy said: “We are leading diplomatic efforts to increase the number of countries where foreign criminals can be swiftly returned, and if they want to appeal, they can do so safely from their home country.

“Under this scheme, we’re investing in international partnerships that uphold our security and make our streets safer.”

Both ministers opposed the hostile environment policy when in opposition.

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In 2015, Sir Keir Starmer had questioned whether such a policy was workable – saying in-person appeals were the norm for 200 years and had been a “highly effective way of resolving differences”.

He also raised concerns about the impact on children if parents were deported and then returned after a successful appeal.

In today’s announcement, the prime minister’s administration said it wanted to prevent people from “gaming the system” and clamp down on people staying in the UK for “months or years” while appeals are heard.

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