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By Pooja Toshniwal Paharia Mar 17 2023 Reviewed by Danielle Ellis, B.Sc.

In a recent study published in JAMA Network Open, researchers assessed the relationship between coronavirus disease 2019 (COVID-19)-associated stress in the antenatal period and the mental well-being of mothers and their infants in the postpartum period. Study: Association of Antenatal COVID-19–Related Stress With Postpartum Maternal Mental Health and Negative Affectivity in Infants. Image Credit: GrooveZ/Shutterstock Background

Studies have reported that antenatal stressors significantly increase the risk of adverse postpartum outcomes regarding mental well-being, such as cognitive and behavioral problems among infants. Cases of anxiety and depression during pregnancy have significantly increased during the severe acute respiratory coronavirus 2 (SARS-CoV-2) pandemic, with lowered positive affectivity, worsened orienting behavior, and higher surgency among infants.

However, the association between COVID-19-associated stress and postpartum maternal and infant outcomes is not completely understood. Previous studies evaluating the effects of antenatal stressors on maternal and infantile health outcomes were largely cross-sectional, single-center, retrospective, with small sample populations, and often utilized unvalidated assessment measures with no documentation of psychometric properties. About the study

In the present longitudinal survey-based study, researchers evaluated the impact of antenatal SARS-CoV-2 infection-associated stress on postpartum maternal and infant mental health outcomes.

The study comprised 318 individuals aged ≥11.0 years who participated in the coronavirus disease 2019 risks across lifespan (CORAL) study conducted in the United Kingdom (UK), United States (US), and Australia. Females who were expecting at the initial evaluation between 5 May and 30 September 2020 and completed two follow-up evaluations between 28 October 2021 and 24 April 2022 at three-month intervals were considered for the analysis.

In addition, the participants were invited to fill out a fourth survey on maternal mental well-being and infant temperament in the follow-up period. COVID-19-associated stress levels were evaluated using the pandemic anxiety measurement scale. The team used the eight-component patient health questionnaire to assess depression among mothers and the seven-component general anxiety disorder (GAD) scale to assess generalized anxiety levels.

During follow-ups, postpartum distress levels were evaluated using the 10.0-component postpartum distress assessment measure, and health outcomes among infants were assessed using the Infant Behavior questionnaire. Individuals were recruited for the study through paid advertising, social media, mothers' group newsletters, mental well-being organizations, and web-based pregnancy forums. Related StoriesHyperinflammation triggers long COVID headachesWhat is the gastrointestinal impact of Long Covid?Early outpatient treatment of COVID-19 with metformin could reduce the risk of developing long COVID

Linear mixed-effects modeling was performed for the analysis. Sensitivity analyses were performed controlling for maternal mental health at initial evaluation and COVID-19 risks experienced during pregnancy and the age of the infants during follow-up assessments. The study participants were provided Amazon gift vouchers of A$100 for the initial survey and A$20 for follow-up surveys. Results

The mean age of the study participants was 32 years, and among the study participants, 28% (n=88), 30% (n=94), and 43% (n=136) resided in Australia, the United States, and the United Kingdom, respectively, among whom, 87% (n=276) were White, and 81% (n=256) had university degrees. A history of psychiatric disorders was reported by 36% (n=114) of the study participants.

Other races and ethnicities included in the sample population were Aboriginal or Torres Strait Islander, Asian, Hispanic, mixed, or other, among two, 12, eight, seven, and 10 participants, respectively. High school education was attained by 19 women and professional or vocational training by 41 women.

At the initial evaluation, the mean values for the number of children and the gestational age (in months) were 1.20 and 5.80, respectively. At the final evaluation, the mean infant age was 14 months. COVID-19-associated stress in the antenatal period showed significant associations with distress, anxiety, and depression among mothers and negative affectivity among infants in the postpartum period. Sensitivity analyses yielded similar findings.

At the initial evaluation, three women showed mild GAD and depression (mean scores on the GAD-7 scale and Patient Health questionnaire of 6.70 and 7.80, respectively), and symptoms remained elevated for 17.0 months postpartum. There were no interactive associations between the age of the infants and antenatal SARS-CoV-2 infection-associated stress with infant health outcomes. Conclusions

Overall, the study findings showed that antenatal pandemic-associated stressors must be targeted to improve mothers' and infants' postpartum outcomes. Expecting women must be considered vulnerable and prioritized during COVID-19 and other pandemics and provided appropriate care for physical and mental well-being.

Further research must be conducted to determine methods of reducing pandemic-associated stress to promote maternal and neonatal well-being in the postpartum period. The long-term relationships between SARS-CoV-2 infection-associated stress and maternal and neonatal health must be assessed.

Psychological and biological vulnerability markers among a more diverse group of pregnant women belonging to different ethnicities and residing in different geographical regions must be identified to personalize antenatal healthcare. Journal reference: Schweizer, S. et al. (2023) "Association of Antenatal COVID-19–Related Stress With Postpartum Maternal Mental Health and Negative Affectivity in Infants", JAMA Network Open, 6(3), p. e232969. doi: 10.1001/jamanetworkopen.2023.2969. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2802388

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Advertising mogul Sorrell approached about S4 Capital deal

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Advertising mogul Sorrell approached about S4 Capital deal

Sir Martin Sorrell, the advertising mogul, has received a number of merger approaches for S4 Capital, the London-listed marketing services group he founded seven years ago.

Sky News can reveal that Sir Martin has been contacted in recent weeks by potential suitors including One Equity Partners, a US-based private equity firm which focuses on acquiring companies in the healthcare, industrials, and technology sectors.

This weekend, analysts suggested that One Equity would seek to combine S4 Capital with MSQ, a creative and technology agency group it bought in 2023.

Further details of the possible tie-up were unclear on Saturday, including whether a formal proposal had been made or whether S4 Capital might remain listed on the London Stock Exchange if a deal were to be completed.

S4 Capital is also understood to have attracted recent interest from other parties, the identities of which could not be immediately established.

In March 2024, the Wall Street Journal reported that Sir Martin had rebuffed several offers from Stagwell, an advertising group led by Mark Penn, a former adviser to President Bill Clinton.

New Mountain Capital, another American private equity firm, was also said at the time to have held talks about buying parts or all of S4 Capital.

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News of One Equity’s approach puts the venture founded by one of Britain’s most prominent business figures firmly in play after a torrid period in which it has been buffeted by macroeconomic headwinds and a number of accounting issues.

Sir Martin founded S4 Capital in 2018, months after his unexpected and acrimonious departure from WPP, the group he transformed from a manufacturer of wire baskets into the world’s largest provider of marketing services.

The businessman, who has voting control at S4 Capital, used his deep network of institutional relationships to raise money for an acquisition spree at S4, which included technology-focused agencies such as MediaMonks and MightyHive.

S4’s clients now include Alphabet, Amazon, General Motors, Meta, T-Mobile, and Walmart.

Sir Martin’s decision to target acquisitions in the digital content and programmatic media arenas reflected the priorities of what he described as a marketing services group for a new era.

At WPP, he was the architect of a now-widely replicated strategy to assemble hundreds of agency brands under one holding company.

By the time he stepped down, WPP was the owner of creative agency networks such as JWT and Ogilvy, while its media-buying muscle was channelled through the global subsidiary GroupM.

The latest approaches for S4 Capital come during a period of profound change in the global marketing services industry, as artificial intelligence dismantles practices and creative processes that had evolved over decades.

Sir Martin has spurned few opportunities to criticise his successor at WPP, Mark Read, as well as the wider advertising industry, in the seven years since he established S4 Capital.

Last month, WPP announced that Mr Read would be replaced by Cindy Rose, a senior Microsoft executive who has sat on the company’s board as a non-executive director since 2019.

“Cindy has supported the digital transformation of large enterprises around the world – including embracing AI to create new customer experiences, business models and revenue streams,” the WPP chairman, Philip Jansen, said.

“Her expertise in this landscape will be hugely valuable to WPP as the industry navigates fundamental changes and macroeconomic uncertainty.”

WPP has also forfeited its status as the world’s largest marketing services empire to Publicis, and will be shunted even further behind the sector’s biggest players once Omnicom Group’s $13.25bn (£9.85bn) takeover of Interpublic Group is completed.

At the time of Sir Martin’s exit from WPP in April 2018, the company had a market capitalisation of more than £16bn.

On Friday, its market value at its closing share price of 367.5p was just £4.23bn.

Last month, the advertising industry news outlet Campaign reported that WPP had held tentative discussions with the consulting firm Accenture about a potential combination or partnership, underscoring the pressure on legacy marketing services groups.

This weekend, it remained unclear how likely it was that Sir Martin would consummate a deal to combine S4 Capital with another industry player such as One Equity-owned MSQ.

Shares in S4 Capital closed on Friday at 21.2p, giving the company a market capitalisation of £140m.

The stock has fallen by nearly 60% during the last 12 months, and is more than 90% lower than its peak in 2022.

At one point, Sir Martin’s stake in S4 Capital was valued at close to £500m.

A spokeswoman for S4 declined to comment, while a spokesman for One Equity Partners said by email: “OEP is not commenting on this matter.”

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Lifting sanctions on Putin for Trump meeting is a massive victory for Moscow

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Lifting sanctions on Putin for Trump meeting is a massive victory for Moscow

The location of Alaska is unexpected.

Although close to Russia geographically – less than three miles away at the narrowest point – it’s a very long way from neutral ground.

The expectation was they would meet somewhere in the middle. Saudi Arabia perhaps, or the United Arab Emirates. But no, Vladimir Putin will be travelling to Donald Trump’s backyard.

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It’ll be the first time the Russian president has visited the US since September 2015, when he spoke at the UN General Assembly. Barack Obama was in the White House. How times have changed a decade on.

The US is not a member of the International Criminal Court, so there’s no threat of arrest for Vladimir Putin.

But to allow his visit to happen, the US Treasury Department will presumably have to lift sanctions on the Kremlin leader, as it did when his investment envoy Kirill Dmitriev flew to Washington in April.

And I think that points to one reason why Putin would agree to a summit in Alaska.

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Can Trump end the war in Ukraine?

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Instead of imposing sanctions on Russia, as Trump had threatened in recent days, the US would be removing one. Even if only temporary, it would be hugely symbolic and a massive victory for Moscow.

The American leader might think he owns the optics – the peace-making president ordering a belligerent aggressor to travel to his home turf – but the visuals more than work for Putin too.

Shunned by the West since his invasion, this would signal an emphatic end to his international isolation.

Donald Trump has said a ceasefire deal is close. The details are still unclear but there are reports it could involve Ukraine surrendering territory, something Volodymyr Zelenskyy has always adamantly opposed.

Either way, Putin will have what he wants – the chance to carve up his neighbour without Kyiv being at the table.

And that’s another reason why Putin would agree to a summit, regardless of location. Because it represents a real possibility of achieving his goals.

It’s not just about territory for Russia. It also wants permanent neutrality for Ukraine and limits to its armed forces – part of a geopolitical strategy to prevent NATO expansion.

In recent months, despite building US pressure, Moscow has shown no intention of stopping the war until those demands are met.

It may be that Vladimir Putin thinks a summit with Donald Trump offers the best chance of securing them.

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It’s been four years since a US president met Putin – and Trump will have a lot of ice to break

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It's been four years since a US president met Putin - and Trump will have a lot of ice to break

Donald Trump and Vladimir Putin will meet where their countries brush shoulders.

But why Alaska and why now?

A US-Russia summit in Alaska is geography as metaphor and message.

Alaska physically bridges both countries across the polar expanse.

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Choosing this location signals strategic parity – the US and Russian leaders face to face in a place where their interests literally meet.

Alaska has surged in geopolitical importance due to its untapped fossil fuels.

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Trump has aggressively pushed for more control in the Arctic, plans for Greenland and oil access.

Holding talks there centres the conversation where global energy and territorial stakes are high, and the US president thrives on spectacle.

Reuters file pic
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Reuters file pic

A dramatic summit in the rugged frontier of Alaska plays into his flair for the theatrical.

It is brand Trump – a stage that frames him as bold, unorthodox and in command.

It was 2021 when a US president last came face-to-face with a Russian president.

The leaders of the two countries haven’t met since Russia invaded Ukraine.

Pic: AP
Image:
Pic: AP

But Trump is in touch with all sides – Russia, Ukraine and European leaders – and says they all, including Putin, want “to see peace”.

He’s even talking up the potential shape of any deal and how it might involve the “swapping of territory”.

Volodymyr Zelenskyy has repeatedly insisted he will not concede territory annexed by Russia.

Moscow has sent the White House a list of demands in return for a ceasefire.

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‘I’m not against meeting Zelenskyy’

Trump is attempting to secure buy-in from Zelenskyy and other European leaders.

He styles himself as “peacemaker-in-chief” and claims credit for ending six wars since he returned to office 200 days ago.

There’s much ice to break if he’s to secure a coveted seventh one in Alaska.

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