Connect with us

Published

on

NEW DELHI – India has been taking measures to wean off dependence on China for ingredients that go into making a variety of drugs, including antibiotics.

But three years after the Covid-19 pandemic disrupted supply chains from China, India is still a long way off from reducing imports of active pharmaceutical ingredients (APIs) chemicals responsible for the therapeutic effect of drugs, noted industry experts.

Instead, India imported APIs and drugs worth 352.49 billion rupees (S$5.7 billion) in 2021-22, up from 285.29 billion rupees the previous year, according to government figures.

In the northern state of Himachal Pradesh, construction has started on a pharmaceutical park spread over 362 ha, while in the western state of Gujarat, work has started on a similar park spread over 809 ha.

Land for a third park is being acquired in the southern state of Andhra Pradesh.

The parks, which are expected to be ready in two years time, are in addition to the government giving Production Linked Incentives (PLIs) worth US$2 billion (S$2.6 billion) for manufacturing 53 APIs such as levofloxacin, an antibiotic used to treat pneumonia, for which India is heavily dependent on China.

Manufacturing has already started for about three dozen APIs like para-aminophenol, a raw material for paracetamol, but volumes have yet to reach a point where imports can be cut, noted industry experts.

The realisation of the benefit of the (PLI) scheme will take time as the incubation time is high, said Mr Sudarshan Jain, secretary general of the Indian Pharmaceutical Alliance.

Under the PLI scheme, different incentives are given for different products over a period of time. For instance, products that require fermentation, a process to create microorganisms for antibiotics and others, will get 20 per cent of the total cost to push up manufacturing between FY24-27.

On the pharmaceutical parks, Mr Jain said: India aims to create clusters for developing an ecosystem for bulk drug manufacturers. These clusters will be of great help as they facilitate faster clearance, efficiency and product development initiatives.

India is the biggest supplier of generic drugs in the world, meeting more than half of global demand for many vaccines. Still, the US$42 billion sector is heavily dependent on China for APIs.

According to a government report, India imports about 68 per cent of its APIs from China as it is a cheaper option than manufacturing them domestically.

And the dependence on China for certain life-saving antibiotics such as penicillin and azithromycin, used to treat bacterial infections such as bronchitis, is about 80 per cent to 90 per cent, according to industry data. More On This Topic India ready to export fever drugs to China amid Covid-19 surge India probes Uzbekistans claim that 18 children died after taking India-made cough syrup Mr Deepak Jotwani, assistant vice-president and sector head of corporate ratings at ICRA, an India-based credit rating agency, assessed that dependence will go down only over a four- to five-year period.

He noted that for some drugs like the entire requirement of certain fermentation-based APIs like penicillin and erythromycin are being sourced from China.

And then there are some APIs that are made only in China like Penicillin Gand 7-aminocephalosporanic acid, the key raw materials required for manufacturing cephalosporins, used for making certain antibiotics.

For real impact on reducing imports from China, industryexperts said the requirement was to get middle-level pharma firms to increase manufacturing and push innovation.

A majority of firms that have applied for incentives under the PLI scheme are major companies like Sun Pharmaceutical Industries and Dr. Reddys Laboratories.

The volume drivers from the middle-tier players are still not very well engaged, said Mr Naveen Kulkarni, chief executive of biotransformation company Quantumzyme, on the PLI scheme.

One of the primary reasons could be that the high-value products requiring fermentation capabilities are received sceptically by mid-level players, who are not willing to move out of their comfort zone, he said.

He noted that the governments incentive scheme, which runs for six years, could also be a deterrent and perceived as risky by the mid-level players, who are enjoying a better bottom line with extremely low risk. More On This Topic Critical tuberculosis drug set to be cheaper after India removes J&Js patent protection India awaits WHO information on any cough syrup link to Gambia deaths Import dependence is expected to remain high in the interim because domestic demand is expected to increase, even as India is set to overtake China as the nation with the worlds largest population at 1.4 billion people

It will, however, take time for these local manufacturing capacities to develop large-scale outputs. In the meantime, rising domestic demand for drug intermediates is likely to preserve the import dependence on China, said Dr Amitendu Palit, a senior research fellow and research lead (trade and economics) at the Institute of South Asian Studies in Singapore.

Firms that have started increasing capacity include biopharmaceutical company Biocon.

Our immunosuppressant facility in Visakhapatnam and peptides facility in Bengaluru… are expected to go live in FY24, with more projects in the pipeline, said Mr Siddharth Mittal, managing director and chief executive of Biocon.

Without going into details, a spokesman for pharmaceutical firm Glenmark, said: As a beneficiary, we have enhanced our development efforts on complex products as well as towards increasing our manufacturing capacity under the (PLI) scheme.

Continue Reading

World

Donald Trump’s Middle East envoy pushes for Gaza ceasefire deal ahead of US inauguration

Published

on

By

Donald Trump's Middle East envoy pushes for Gaza ceasefire deal ahead of US inauguration

Donald Trump’s Middle East envoy has met Israel’s prime minister in an effort to secure a ceasefire deal in Gaza before the president-elect takes office on 20 January.

Benjamin Netanyahu’s office confirmed details of the meeting with Steve Witkoff on Saturday, adding that the head of the Israeli Mossad intelligence agency has been deployed to Qatar in order to “advance” talks.

It was not immediately clear when David Barnea would travel to Doha for the latest round of indirect discussions between Israel and Hamas.

Earlier on Saturday, an Israeli official said some progress had been made, mediated by Egypt, Qatar and the United States, to reach a deal in Gaza.

Israel's Chief of the Mossad David Barnea and Security Agency director Ronen Bar attend a memorial ceremony of the Hamas attack on October 7 last year that sparked the ongoing war in Gaza, at the Mount Herzl military cemetery in Jerusalem on October 27, 2024. GIL COHEN-MAGEN/Pool via REUTERS
Image:
Ronen Bar (left), director of Israel’s security agency, and David Barnea (right), head of Mossad, at a ceremony marking the 7 October Hamas attack. File pic: Reuters

The mediators are making renewed efforts to halt fighting in Gaza and free the remaining Israeli hostages held there before Mr Trump takes office.

A deal would also involve the release of some Palestinian prisoners held in Israeli jails.

Families of Israeli hostages welcomed Mr Netanyahu’s decision to dispatch the officials, with the Hostages and Missing Families Forum Headquarters describing it as a “historic opportunity”.

Mr Witkoff arrived in Doha on Friday and met the Qatari Prime Minister Sheikh Mohammed bin Abdulrahman Al Thani, Qatar’s foreign ministry said.

Egyptian and Qatari mediators received reassurances from Mr Witkoff that the US would continue to work towards a fair deal to end the war soon, Egyptian security sources said, though no further details were released.

Read more from Sky News:
Why does Donald Trump want Greenland?
Trump says Vladimir Putin wants to meet
A guide to Donald Trump’s inauguration

Israel launched its assault on Gaza after Hamas fighters stormed across its borders in October 2023, killing 1,200 people and taking more than 250 hostages, according to Israeli figures.

Families of the roughly 100 hostages still held in Gaza are pressing Mr Netanyahu to reach a deal to bring their loved ones home.

Since then, more than 46,000 people have been killed in Gaza, according to Palestinian health officials, with much of the area destroyed and gripped by a humanitarian crisis, with most of its population displaced.

Continue Reading

World

Pope Francis honoured by Joe Biden with Presidential Medal of Freedom with Distinction

Published

on

By

Pope Francis honoured by Joe Biden with Presidential Medal of Freedom with Distinction

Pope Francis has been honoured with America’s highest civilian award by President Joe Biden, who has described the pontiff as “a light of faith, hope, and love that shines brightly across the world”.

It is the first time Mr Biden, 82, has given the Presidential Medal of Freedom with Distinction during his four years in office.

In a statement, the White House said the award is “presented to individuals who have made exemplary contributions to the prosperity, values, or security of the United States, world peace, or other significant societal, public or private endeavours”.

Mr Biden had been scheduled to present the medal to Pope Francis, 88, in person on Saturday in Rome on what was to be the final overseas trip of his presidency. But the president cancelled his visit to monitor the California wildfires.

The White House said Mr Biden bestowed the award during a phone call in which they also discussed efforts to promote peace and alleviate suffering around the world.

President Joe Biden presents Bono with the Presidential Medal of Freedom. Pic: AP
Image:
President Joe Biden presented Bono with the Presidential Medal of Freedom. Pic: AP

President Joe Biden presents the Presidential Medal of Freedom to Denzel Washington. Pic: AP
Image:
Denzel Washington was also recognised. Pic: AP

President Joe Biden presents the Presidential Medal of Freedom to Michael J Fox. Pic: AP
Image:
Michael J Fox was bestowed with the honour. Pic: AP

The award can be presented with or without distinction.

Mr Biden presented the medal of freedom – without distinction – on 5 January to several people including fellow Democrat Hillary Clinton, humanitarian and U2 singer Bono, fashion designer Ralph Lauren and actors Michael J Fox and Denzel Washington.

Please use Chrome browser for a more accessible video player

‘I could have beaten Trump’

Read more from Sky News:
Gay men can become priests
Search widened for missing sisters
Carrie Johnson left ‘struggling to breathe’

Mr Biden himself is a recipient of the award with distinction, recognised when he was vice president by then president Barack Obama in a surprise ceremony eight years ago.

President Barack Obama presents Vice President Joe Biden with the Presidential Medal of Freedom during a ceremony in the State Dining Room of the White House in Washington, Jan. 12, 2017. (AP Photo/Susan Walsh)
Image:
Barack Obama presented Joe Biden with the Presidential Medal of Freedom with Distinction in 2017. File pic: AP

The citation for the pope’s honour said his “mission of serving the poor has never ceased”.

“A loving pastor, he joyfully answers children’s questions about God. A challenging teacher, he commands us to fight for peace and protect the planet. A welcoming leader, he reaches out to different faiths,” it added.

Continue Reading

World

As the AfD elects its chancellor candidate, the far-right party looms large over German politics

Published

on

By

As the AfD elects its chancellor candidate, the far-right party looms large over German politics

And so now it is certain. Alice Weidel will lead her far-right party into Germany’s general election next month.

She was overwhelmingly backed at the Alternative for Germany (AfD) conference and was greeted with a standing ovation.

Weidel will fight the election with a manifesto that follows a familiar pattern from other successful populist campaigns in Europe and beyond – contempt for mainstream politicians, anger over levels of irregular immigration, a desire to rein in the power of the European Union and dismay over the spread of so-called woke values.

Alice Weidel looks on after she was elected as top candidate for chancellor of the AfD.
Pic: Reuters/Matthias Rietschel
Image:
Alice Weidel looks on after she was elected as top candidate for chancellor of the AfD.
Pic: Reuters/Matthias Rietschel

A participant at the AfD national party conference.
Pic: AP/Sebastian Kahnert/picture-alliance/dpa
Image:
A participant at the AfD national party conference.
Pic: AP/Sebastian Kahnert/picture-alliance/dpa

“Thank you for your trust,” she told the audience.

“I am excited to lead our campaign. For our people, for our future.”

Who is Weidel?

Weidel is an unusual figure to lead a German hard right-wing party – a gay woman with a PhD in economics, a Sri Lankan partner, two children and a home in another country – she commutes from Switzerland.

More on Far-right

Admittedly there is an awkward history – her grandfather was a Nazi judge appointed to the job personally by Adolf Hitler, but she has maintained that she did not know that fact growing up and has angrily distanced herself from accusations of racism.

Indeed, Ms Weidel maintains that her party is not on the far right, but is simply conservative.

Pic: AP/Sebastian Kahnert/picture-alliance/dpa/
Image:
Pic: AP/Sebastian Kahnert/picture-alliance/dpa/

And that is part of her attraction – she is perceived as uncompromising on the things that the AfD’s supporters hold dear – migration, Euroscepticism, the greatness of German culture – but she’s also perceived as more palatable to the wider public.

Or, at least, that’s the idea.

Thousands of protesters

Outside the sports centre, where the AfD’s convention was being held, thousands of protesters gathered to raise their fears that the country was going back to the politics of the past.

“They are fascists,” said a man called Gabriel, who was helping to blockade the road that ran past the venue.

“I don’t know if we have learnt anything in the past hundred years but now we do have to stand against fascism.”

Protestors against the AfD during their national conference.
Pic: AP/Jan Woitas/picture-alliance/dpa/
Image:
Protesters against the AfD during their national conference.
Pic: AP/Jan Woitas/picture-alliance/dpa/

Many of the delegates would angrily decry that label.

However, there was a rousing reception for Bjorn Hocke, a long-standing AfD politician who is from the right wing of this right-wing party.

His grouping, Der Flugel, was declared a suspected extremist organisation but he remained the party’s leader in Thuringia.

In 2019, a court ruled that it was not libellous to refer to Hocke as a fascist.

He has twice been found guilty of using Nazi slogans but last year, under his leadership, the AfD won the state election.

Emotions often run high when the AfD is involved. The protests here were, at times, heated.

Police officers during the protest that blocked a road near the venue for the AfD party congress.
Pic: Reuters/Thilo Schmuelgen
Image:
Police officers during the protest that blocked a road near the venue for the AfD party congress.
Pic: Reuters/Thilo Schmuelgen

Police had to clear the road in front of Ms Weidel’s car as some protesters sat down and others began to surround it.

Later, the party’s MPs were called to gather together for a sudden security briefing.

The sports centre where this meeting was held once hosted the World Sumo Wrestling Championship.

Here, the heavyweights were political, and the prize at stake was far more consequential.

Barring a quite astonishing movement in the polls, the AfD is unlikely to win the election next month, but the party may well come second with more than 20% of the vote.

Read more from Sky News:
Harry and Meghan visit LA fires evacuees
Ukraine says it captured North Korean soldiers
Sudanese army retakes city from rebels

That probably won’t equate to power – Germany’s major parties have all said they won’t go into coalition with the AfD – but it will mean momentum.

It will mean a loud voice in the Bundestag, the German federal parliament, and the ability to pressure the next chancellor into reflecting the opinions of the millions who vote for Ms Weidel’s vision.

Long term, if Ms Weidel can prove that her party is palatable, as well as popular, then she knows the political dam will one day break.

If enough people back the AfD, it will eventually become impossible to shun the party forever.

Continue Reading

Trending