Moderna says vaccines for cancer, heart disease could be ready by 2030

Published

2 years ago

April 9, 2023

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A pharmaceutical firm that produced a leading Covid-19 jab said vaccines against cancer as well as cardiovascular and autoimmune diseases can be ready by 2030, which could potentially save millions of lives.

Modernas chief medical officer Paul Burton believes the company will be able to offer vaccines for all sorts of disease areas in as little as five years.

Studies into the vaccines have shown tremendous promise, Dr Burton told British newspaper The Guardian, adding that his company is developing cancer vaccines that target different tumour types.

We will have that vaccine, and it will be highly effective, and it will save many hundreds of thousands, if not millions, of lives. I think we will be able to offer personalised cancer vaccines against multiple different tumour types to people around the world, he said.

Cardiovascular diseases and cancer are a leading cause of death worldwide, according to the World Health Organisation (WHO).

An estimated 17.9 million people died of cardiovascular diseases in 2019, said WHO, while cancer accounted for nearly 10 million deaths in 2020, or nearly one in six deaths.

Dr Burton also told The Guardian that multiple respiratory infections could be covered by a single injection.

This would allow vulnerable people to be protected against Covid-19, flu and respiratory syncytial virus a virus that causes mild, cold-like symptoms.

Meanwhile, Dr Burton said messenger ribonucleic acid (mRNA) therapies could be available for rare diseases for which there are currently no drugs.

I think we will have mRNA-based therapies for rare diseases that were previously undruggable, and I think that 10 years from now, we will be approaching a world where you truly can identify the genetic cause of a disease and, with relative simplicity, go and edit that out and repair it using mRNA-based technology.

Vaccines based on mRNA teach cells to make a protein to prompt an immune response.

Moderna and drugmaker Pfizer-BioNTech were the first to use the technology to create the mRNA vaccines used to fight Covid-19.

Dr Burton attributed the progress of the vaccines to advancement in the field of mRNA, with some experts saying that 15 years of progress are now in the final stretches due to the quick roll-out of the Covid-19 jabs.

I think what we have learnt in recent months is that if you ever thought that mRNA was just for infectious diseases, or just for Covid-19, the evidence now is that thats absolutely not the case, The Guardian quoted him as saying.

It can be applied to all sorts of disease areas; we are in cancer, infectious disease, cardiovascular disease, autoimmune diseases, rare disease. We have studies in all of those areas, and they have all shown tremendous promise. More On This Topic MOH supporting development of mRNA cancer vaccines in Singapore Moderna, Merck see positive results from skin cancer vaccine In December 2022, Moderna and pharmaceutical company MSD announced that an mRNA cancer vaccine they are jointly developing reduced cancer recurrence or death in melanoma patients by 44 per cent in a phase two clinical trial.

Scientists said a high level of investment is needed to maintain the progress.

Professor Andrew Pollard, a director of the Oxford Vaccine Group and chair of Britains Joint Committee on Vaccination and Immunisation, said it was important not to lose sight of the threat of a new pandemic.

If you take a step back to think about what we are prepared to invest in during peacetime, like having a substantial military for most countries… Pandemics are as much a threat, if not more, than a military threat because we know they are going to happen as a certainty from where we are today. But were not investing even the amount that it would cost to build one nuclear submarine, he told The Guardian.

Technology

European SpaceX rival raises $160 million for reusable capsule to carry astronauts, cargo to space

Published

1 hour ago

November 17, 2024

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European SpaceX rival raises 0 million for reusable capsule to carry astronauts, cargo to space

The Space Exploration develops a product called Nyx, a reusable capsule that can be launched from rockets into space carrying passengers and cargo.

The Exploration Company (TEC) announced Monday it has raised $160 million to fuel development of its capsule that is designed to take astronauts and cargo to space stations.

Venture capital firms Balderton Capital and Plural were the lead investors in the round which also included French government-backed investment vehicle French Tech Souveraineté and German government-backed fund DeepTech & Climate Fonds.

TEC’s core product is Nyx, a capsule that can be launched from rockets into space carrying passengers and cargo. Nyx is reusable so once it has dropped its payload, it can re-enter the Earth’s atmosphere and be used for the next mission.

“It’s a big market, and it’s growing about a bit more than 10% per year because more nations want to fly their astronauts and more nations want to go to the moon,” Hélène Huby, founder and CEO of TEC, told CNBC in an interview.

“So there is an increased demand for sending people to stations, sending cargo to stations,” she said.

This part of the market has very few players. Some of the biggest are SpaceX which has a capsule called Dragon. There are also rivals from China and Russia.

“We said, ‘okay, let’s build this capacity in Europe so that Europe can have its own capsule and also the world needs an alternative solution. [We] cannot only bet on SpaceX,” Huby said.

TEC is currently developing the second version of Nyx which it expects to launch next year, followed by a final version in 2028. This model will be partly financed by the European Space Agency.

Huby said the company has signed $800 million in contracts to use its capsule. These include mission contracts with companies including Starlab, which is designing a new space station, and Axiom Space.

There is increasing activity in space among nations including China, the U.S. and India. One of the most ambitious projects is the NASA-led Gateway, which will be the first space station to orbit the moon.

“If you have more people, you also have a need for more cargo. So this is what is happening around the Earth and around the moon,” Huby said.

Huby sees TEC being a key player when it comes to developing the technology that is needed to return cargo to Earth once it has been in space.

“This is also where we where we believe our vehicle is going to play an important role,” Huby said.

UK

Harshita Brella: International manhunt under way for husband after woman’s body found in car boot

Published

1 hour ago

November 17, 2024

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Harshita Brella: International manhunt under way for husband after woman's body found in car boot

An international manhunt is under way for the husband of a murdered woman, whose body was found in the boot of a car.

The body of Harshita Brella was found in east London on Thursday, tens of miles away from her home in Corby.

On Sunday, Northamptonshire Police said they were looking for Pankaj Lamba – who they believe has left the country.

Sky News understands she had been under the protection of a court order designed for victims of domestic abuse.

“Our inquiries lead us to suspect that Harshita was murdered in Northamptonshire earlier this month by her husband Pankaj Lamba,” said chief inspector Paul Cash.

“We suspect Lamba transported Harshita’s body from Northamptonshire to Ilford by car.”

“Fast track” enquires were made after the force was contacted on Wednesday by someone concerned about Ms Brella’s welfare. After she failed to answer the door at her home in Skegness Walk, Corby, a missing person investigation was launched.

Her body was found inside the boot of a vehicle on Brisbane Road, Ilford, in the early hours of Thursday morning.

A post mortem – conducted at Leicester Royal Infirmary on Friday – established she had been murdered.

More than 60 detectives are working on the case, with lines of enquiry including going house to house and property searches, as well as looking at CCTV and ANPR.

“We are of course continuing to appeal for any information that will help us piece together exactly what happened as we work to get justice for Harshita,” said chief inspector Cash.

“I urge anyone listening to or reading this statement, that if you saw anything suspicious in the past week or have any information, no matter how small, please contact us. We would always rather receive well-meaning information that turns out to be nothing as opposed to not receiving it all.”

Force referred to police watchdog

On Saturday, Northamptonshire Police said it had made a mandatory referral to the Independent Office for Police Conduct due to previous contact between the force and the victim.

Northamptonshire Police previously said officers had been conducting investigations at three locations: Skegness Walk and Sturton Walk in Corby and Brisbane Road, Ilford, where Ms Brella’s body was found.

East Midlands Special Operations Major Crime Unit (EMSOU) and Northamptonshire Police said they were working “around the clock to establish the circumstances behind her death, including the exact location and timeframe in which it took place”.

UK

King Richard III given Yorkshire accent using state-of-the-art technology

Published

1 hour ago

November 17, 2024

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King Richard III given Yorkshire accent using state-of-the-art technology

State-of-the-art technology has been used to create a voice for King Richard III – giving him a Yorkshire accent.

A digital avatar of the medieval king’s head went on display in front of excited history fans at York Theatre Royal.

Richard III was king of England from 1483 until his death at the Battle of Bosworth in 1485, at the age of 32.

His remains were found in a car park in Leicester in 2012 by historian Philippa Langley.

Speaking about the recreation, she said: “We’ve got leading experts in their fields who have been working on this for 10 years and so everything has been meticulously researched, meticulously evidenced, so you are seeing the most accurate portrayal of Richard III”.

A team based at Face Lab at Liverpool John Moores University created the avatar based on the reconstruction of Richard III’s head with the help of a craniofacial expert.

Experts from various fields helped put the pieces of the puzzle together, including speech and language therapy, dentistry, forensic psychology and archaeology.

His voice has been created by Professor David Crystal, a leading linguist in 15th-century pronunciation. He admitted that it’s impossible to know exactly how he spoke, but this is as close as they will get.

The king was born in Northampton but spent a lot of his life in Yorkshire. His parents were also from the north of England.

Vocal coach Yvonne Morley-Chisholm spent a decade researching how the monarch would have sounded. She worked with the actor Thomas Dennis who was chosen as his body and face were such a good physical match.

Speaking to Sky News, she said people will be shocked at how different he sounded compared with traditional portrayals of the king on stage and screen.

The coach and actor also examined the king’s letters and diary so that “as you pronounced a word that’s how you would write it”.

The voice shows the change in pronunciation over the centuries – from regional variations to the Queen’s English.

History fans at the unveiling were delighted with the accent, with one telling Sky News: “Northerners are known to be happy, positive, all those lovely qualities.”

Born in Northampton but a northerner through and through, technology has brought the king’s speech back to life