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A pharmaceutical firm that produced a leading Covid-19 jab said vaccines against cancer as well as cardiovascular and autoimmune diseases can be ready by 2030, which could potentially save millions of lives.

Modernas chief medical officer Paul Burton believes the company will be able to offer vaccines for all sorts of disease areas in as little as five years.

Studies into the vaccines have shown tremendous promise, Dr Burton told British newspaper The Guardian, adding that his company is developing cancer vaccines that target different tumour types.

We will have that vaccine, and it will be highly effective, and it will save many hundreds of thousands, if not millions, of lives. I think we will be able to offer personalised cancer vaccines against multiple different tumour types to people around the world, he said.

Cardiovascular diseases and cancer are a leading cause of death worldwide, according to the World Health Organisation (WHO).

An estimated 17.9 million people died of cardiovascular diseases in 2019, said WHO, while cancer accounted for nearly 10 million deaths in 2020, or nearly one in six deaths.

Dr Burton also told The Guardian that multiple respiratory infections could be covered by a single injection.

This would allow vulnerable people to be protected against Covid-19, flu and respiratory syncytial virus a virus that causes mild, cold-like symptoms.

Meanwhile, Dr Burton said messenger ribonucleic acid (mRNA) therapies could be available for rare diseases for which there are currently no drugs.

I think we will have mRNA-based therapies for rare diseases that were previously undruggable, and I think that 10 years from now, we will be approaching a world where you truly can identify the genetic cause of a disease and, with relative simplicity, go and edit that out and repair it using mRNA-based technology.

Vaccines based on mRNA teach cells to make a protein to prompt an immune response.

Moderna and drugmaker Pfizer-BioNTech were the first to use the technology to create the mRNA vaccines used to fight Covid-19.

Dr Burton attributed the progress of the vaccines to advancement in the field of mRNA, with some experts saying that 15 years of progress are now in the final stretches due to the quick roll-out of the Covid-19 jabs.

I think what we have learnt in recent months is that if you ever thought that mRNA was just for infectious diseases, or just for Covid-19, the evidence now is that thats absolutely not the case, The Guardian quoted him as saying.

It can be applied to all sorts of disease areas; we are in cancer, infectious disease, cardiovascular disease, autoimmune diseases, rare disease. We have studies in all of those areas, and they have all shown tremendous promise. More On This Topic MOH supporting development of mRNA cancer vaccines in Singapore Moderna, Merck see positive results from skin cancer vaccine In December 2022, Moderna and pharmaceutical company MSD announced that an mRNA cancer vaccine they are jointly developing reduced cancer recurrence or death in melanoma patients by 44 per cent in a phase two clinical trial.

Scientists said a high level of investment is needed to maintain the progress.

Professor Andrew Pollard, a director of the Oxford Vaccine Group and chair of Britains Joint Committee on Vaccination and Immunisation, said it was important not to lose sight of the threat of a new pandemic.

If you take a step back to think about what we are prepared to invest in during peacetime, like having a substantial military for most countries… Pandemics are as much a threat, if not more, than a military threat because we know they are going to happen as a certainty from where we are today. But were not investing even the amount that it would cost to build one nuclear submarine, he told The Guardian.

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Tesla’s board members have reportedly started looking for Elon Musk’s successor as CEO

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Tesla's board members have reportedly started looking for Elon Musk's successor as CEO

Tesla’s board members have reportedly started a search for someone to replace Elon Musk as CEO.

Several executive search firms were approached to find a successor around a month ago, the Wall Street Journal reported.

But it added that the current status of the succession planning for the electric car-maker was not known.

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Musk jokes about attacks on Tesla cars

Tesla’s chair, Robyn Denholm, later reacted to the report by insisting that any suggestion of an active search was “absolutely false”.

She added that the board was highly confident in Musk’s ability to continue “executing on the exciting growth plan ahead”.

Musk’s net worth has plunged and Tesla stocks have fallen sharply amid a public backlash over his role in Donald Trump’s government. He owns just under 13% of Tesla stock and is the largest shareholder.

The world’s richest man has been leading the Department of Government Efficiency (DOGE), where he has overseen the firing of tens of thousands of government employees.

More on Elon Musk

He has also supported far-right parties in Europe, which has led to protests against Musk and Tesla, which have seen its showrooms and charging stations vandalised across the US and Europe.

President Trump has labelled the vandals “terrorists”.

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Musk pulls back from DOGE role

It comes after Musk said the time he spends with DOGE would “drop significantly” from May and he will dedicate more time to running his companies, such as Tesla, SpaceX and X.

The board members met with Musk and asked him to announce publicly he would spend more time at Tesla, the report said.

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It was unclear if Musk, who is a member of the board, was aware of any attempts to identify a successor, or if his pledge to spend more time at Tesla had affected succession planning, it added.

On Wednesday, Mr Trump said Musk could be part of his administration for as long as he wants.

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“You’re invited to stay as long as you want,” Mr Trump said.

He said Musk had been “treated unfairly” for his role in helping Mr Trump slash the size of the federal government, adding: “You really have sacrificed a lot.”

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Voting under way to decide thousands of councillors and Runcorn and Helsby by-election

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Voting under way to decide thousands of councillors and Runcorn and Helsby by-election

Voting is under way in local elections across England, as well as in the Runcorn and Helsby by-election.

Due to Ofcom rules, Sky News is limited on what it can report until polls close at 10pm.

The votes mark the first electoral test for the party leaders since last year’s general election.

In total, 23 of England’s 317 local authorities are holding elections, alongside the Isles of Scilly.

The make up of around 1,270 parish councils are also due to be decided.

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And six metro mayors are up for election.

The West of England, Cambridgeshire and Peterborough, Doncaster, and North Tyneside mayoralties already have a mayor in place – while Greater Lincolnshire and Hull and East Yorkshire are choosing a mayor for the first time.

Meanwhile, a by-election is being held in Runcorn and Helsby after previous Labour MP Mike Amesbury agreed to stand down following his conviction for punching a man in the street.

While this result is likely to come in overnight, most local election results won’t be known until Friday.

All voters in these elections must be over 18, and be registered.

Join Sky News presenter Jonathan Samuels and deputy political editor Sam Coates from midnight as the results start coming in. Lead politics presenter Sophy Ridge, political editor Beth Rigby, and data and economics editor Ed Conway will be taking over on Friday to report and explain what has happened.

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North Carolina House passes state crypto investment bill

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North Carolina House passes state crypto investment bill

North Carolina House passes state crypto investment bill

North Carolina’s House of Representatives has passed a bill allowing the state’s treasurer to invest public funds in approved cryptocurrencies, which will now head to the Senate.

The House passed the Digital Assets Investment Act, or House Bill 92, on its third reading on April 30 by a vote of 71 to 44.

Republican House Speaker Destin Hall introduced the bill in February, which would allow the treasurer to allocate 5% of the state’s investments into designated digital assets.

The investments can only be made after obtaining an independent third-party assessment confirming that the crypto holdings are maintained with a secure custody solution and risk oversight and regulatory compliance standards are met. 

New amendments allow the treasurer to examine the feasibility of allowing members of retirement and deferred compensation plans to elect to invest in digital assets held as exchange-traded products (ETPs).

The House also passed a related bill, the State Investment Modernization Act, or HB 506, with little discussion on April 30, in a 110 to 3 vote.

The bill aims to create the North Carolina Investment Authority (NCIA) to take over investment management from the treasurer.

If passed into law, authority to invest in digital assets would transfer from the treasurer to NICA, and it would require approval from its board of directors based on third-party assessments to make crypto investments.

Local news outlet NC Newsline reported that Treasurer Brad Briner supports both bills.

North Carolina House passes state crypto investment bill
Crypto legislation race. Source: Bitcoin Laws

Arizona leads the crypto bill race

North Carolina is second to Arizona in the state-level race to approve legislation allowing local governments to invest in cryptocurrencies. 

Related: New Hampshire Bitcoin reserve bill heads to full Senate vote

On April 28, Arizona’s House approved two bills, SB 1025 and SB 1373, proposing different methods for the state to establish a crypto reserve.

Arizona is the only state whose House and Senate have passed crypto-related bills, which are both awaiting Governor Katie Hobbs’ decision.

Magazine: ZK-proofs unlock trillions in Bitcoin for DeFi — BitcoinOS and Starknet

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