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A cure for motor neurone disease (MND) could be “possible”, according to an expert, as a charity launched by a rugby legend unveils its five-year research strategy to give hope to those diagnosed with the condition.

The My Name’5 Doddie Foundation (MNDF), first set up in 2017 by the late Scottish rugby player Doddie Weir, will invest millions of pounds into research for treatments.

Mr Weir died in November 2022, following a six-year-long battle with MND.

The charity’s aim will be to effectively deliver treatments to slow the progress of MND, while also working towards the goal of finding a complete cure.

And Professor Ammar Al-Chalabi, director of the MND Research Centre at King’s College London, said finding a cure is now a real possibility.

He said: “When I started MND research almost 30 years ago it seemed ridiculous that an effective treatment might be possible.

“Now a cure is a possibility, although a treatment that dramatically slows MND is more likely. Both are still somewhat in the future.”

The money provided by charities is vital to driving research into treatments and an eventual cure, the professor added.

He said: “Research is expensive, however, and My Name’5 Doddie Foundation and other MND charities are crucial in funding it.

“They drive the cutting-edge stuff that pushes the field forward as well as the important ‘slogging away at it’ work that is essential to keep everything going.

“We are only where we are because of MND charities and the people who fundraise so effectively.”

Effective treatments ‘aren’t too far away’

Doddie Weir was inspired to set up a charity because a diagnosis of MND seemed to be without hope.

MNDF’s new five-year strategy, known as the Catalysis a Cure strategy, aims to drive forward research over the next five years with a commitment by 2028 to have invested in developing new treatments and improving early diagnosis.

It will also improve biomarkers which indicate whether treatments are working or not.

The organisation has committed around £8.5m to research and was also one of several UK organisations to successfully campaign for a UK government commitment of £50m for MND research.

Jessica Lee, director of research at MNDF, said: “We believe that effective treatments to slow or stop disease progression aren’t too far away.

“By working closely with our remarkable research community and supporting the adoption of new approaches and ways of thinking, we will accelerate the journey towards making these treatments a reality.”

Sports broadcaster and chief executive of the charity, Jill Douglas, added: “Doddie’s greatest frustration when he was diagnosed with MND in 2016 was the lack of hope for people faced with such devastating news.

“He wanted the Foundation to relentlessly work towards a world where that is not the case, and we are beginning to see real progress.

“There is huge momentum in MND research, and backed by the thousands of fundraisers who support the Foundation, this bold and ambitious research strategy ensures we are in the best position possible to build on that and work with the MND research community to hopefully accelerate the development of new treatments.”

Read more:
‘Important new step’ in finding treatment, scientists reveal
‘Milestone’ treatment slows weakness – study

What is motor neurone disease?

According to the NHS, motor neurone disease (MND) is an uncommon condition affecting the brain and nerves – it can also cause weakness and gradually worsen over time.

The condition mainly affects people in their 60s and 70s but can also affect adults of all ages.

There is no cure as of yet, but there are treatments to help reduce the impact it has on someone’s day-to-day life.

Some people can live with the condition for many years but it can also be fatal.

The NHS says MND can happen gradually and may not be obvious initially. Here are some of the early symptoms:

• Weakness in ankle or leg, leading to difficulty climbing stairs

• Slurred speech, which may develop into difficulty swallowing some foods

• A weak grip

• Muscle cramps and twitches

• Weight loss

• Difficulty stopping yourself from crying or laughing in inappropriate situations

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What do dolphins get up to beneath the waves? Their poo has the answers

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What do dolphins get up to beneath the waves? Their poo has the answers

Scientists are turning detective to work out what British dolphins are up to beneath the waves – by using forensic-style DNA techniques on their poo.

Conservationists have been studying the 250 or so bottlenose dolphins living in Cardigan Bay, west Wales, over many decades.

Up to now, they have only been able to observe the dolphins as they surface to breathe or play, identifying the animals from the unique marks on their dorsal fins to establish which animals were hanging out together and where.

Dolphins in Cardigan Bay. Pic: Sarah Perry/WTSWW
Image:
Dolphins in Cardigan Bay. Pic: Sarah Perry/WTSWW

But now for the first time scientists are using DNA excreted by the dolphins in their poo to build a more complete picture of their lives.

It allows them to identify the sex of individuals and how they are related to other animals. Signficantly, it also shows what the dolphins have been eating.

Dolphin poo. Pic: Sarah Perry/WTSWW
Image:
Dolphin poo. Pic: Sarah Perry/WTSWW

Dr Sarah Perry, marine conservation manager at The Wildlife Trust of South and West Wales, said: “In order to be able to conserve them, we need to know why they’re here and a big a missing part of that is, what they’re feeding on.

“Is that changing at different times of the year? Are certain species of fish more important to them early on in the year, in the spring, and the summer months, and then does that change over the autumn and winter months?

“Are certain species important for younger animals? We don’t know that, so that kind of information, we need to find out.”

Dr Sarah Perry
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Dr Sarah Perry

Catching dolphin poo involves a large element of luck.

The animals occasionally eject a cloud of waste material as they swim.

But it quickly sinks, so the scientists’ boat needs to be close enough for them to scoop it out of the sea with a fine-meshed net.

A sample is then sent to a lab at the University of Aberystwyth, where DNA is extracted for analysis.

More from Sky News:
PM could scrap divisive policy
Bates attacks Post Office scheme

Scientists on the hunt for dolphin poo.
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Scientists on the hunt for dolphin poo

Dolphins adapting to effects of climate change

Results so far suggest the dolphins are having to adapt to a change in fish species as the water warms.

Dr Niall McKeown
Image:
Dr Niall McKeown

Dr Niall McKeown, a marine biologist at the university, said: “We are seeing large amounts of sardine, sprat, and anchovy.

“This is quite interesting because these are species that are known to have increased in abundance in Welsh waters in recent years in response, we believe, to climate change.”

A scientist analyses a sample
Image:
Dr Niall analyses a sample

Scientists unsure why dolphin numbers are falling

But questions remain about the dolphins.

The number in Cardigan Bay seems to be falling, but scientists are not sure whether that’s a natural cycle or a response to other factors.

Boat noise and disturbance from some fishing activities, such as scallop dredging, could impact the animals, which rely on sound to communicate.

Dr Parry said: “How lucky are we to have such an important population of dolphins here? It’s crazy that we really don’t know that much about them.”

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Sir Alan Bates attacks ‘kangaroo court’ Post Office scheme after ‘take it or leave it’ offer

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Sir Alan Bates attacks 'kangaroo court' Post Office scheme after 'take it or leave it' offer

Sir Alan Bates has accused the government of presiding over a “quasi kangaroo court” for Post Office compensation.

Writing in The Sunday Times, the campaigner, who led a years-long effort for justice for sub-postmasters, revealed he had been given a “take it or leave it” offer that was less than half of his original claim.

“The sub-postmaster compensation schemes have been turned into quasi-kangaroo courts in which the Department for Business and Trade sits in judgement of the claims and alters the goal posts as and when it chooses,” he said.

“Claims are, and have been, knocked back on the basis that legally you would not be able to make them, or that the parameters of the scheme do not extend to certain items.”

More than 900 sub-postmasters were prosecuted between 1999 and 2015 after faulty Horizon accounting software made it look as if money was missing from their accounts.

Many are still waiting for compensation despite the previous government saying those who had their convictions quashed were eligible for £600,000 payouts.

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‘It still gives me nightmares’

After the Post Office terminated his contract over a false shortfall in 2003, Sir Alan began seeking out other sub-postmasters and eventually took the Post Office to court.

More on Post Office Scandal

A group litigation order (GLO) scheme was set up to achieve redress for 555 claimants who took the Post Office to the High Court between 2017 and 2019.

Sir Alan, who was portrayed by actor Toby Jones in ITV drama Mr Bates Vs The Post Office, has called for an independent body to be created to deliver compensation.

He added that promises the compensation schemes would be “non-legalistic” had turned out to be “worthless”.

It is understood around 80% of postmasters in Sir Alan’s group have accepted a full and final redress, or been paid most of their offer.

Read more:
Post Office scandal explained

Who are the key figures in the scandal?

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‘Lives were destroyed’

A Department for Business and Trade spokesperson told Sky News: “We pay tribute to all the postmasters who’ve suffered from this scandal, including Sir Alan for his tireless campaign for justice, and we have quadrupled the total amount paid to postmasters since entering government.

“We recognise there will be an absence of evidence given the length of time which has passed, and we therefore aim to give the benefit of the doubt to postmasters as far as possible.

“Anyone unhappy with their offer can have their case reviewed by a panel of experts, which is independent of the government.”

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PM could lift controversial benefit cap in budget – as Farage makes two big election promises

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PM could lift controversial benefit cap in budget - as Farage makes two big election promises

Sir Keir Starmer could decide to lift the two-child benefit cap in the autumn budget, amid further pressure from Nigel Farage to appeal to traditional Labour voters.

The Reform leader will use a speech this week to commit his party to scrapping the two-child cap, as well as reinstating winter fuel payments in full.

The prime minister – who took Westminster by surprise at PMQs by revealing his intention to row back on the winter fuel cut – has previously said he would like to lift the two-child cap if the government could afford it.

There are now mounting suggestions an easing of the controversial benefit restriction may be unveiled when the chancellor delivers the budget later this year.

According to The Observer, Sir Keir told cabinet ministers he wanted to axe the measure – and asked the Treasury to look for ways to fund the move.

It comes after the government delayed the release of its child poverty strategy, which is expected to recommend the divisive cap – introduced by former Tory chancellor George Osborne – is scrapped.

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Why did Labour delay their child poverty strategy?

Ministers have already said any changes to winter fuel payments, triggered by mounting political pressure, would only be made when the government’s next fiscal event rolls round.

The Financial Times reported it may be done by restoring the benefit to all pensioners, with the cash needed being clawed back from the wealthy through the tax system.

The payment was taken from more than 10 million pensioners this winter after it became means-tested, and its unpopularity was a big factor in Labour’s battering at recent elections.

Before Wednesday’s PMQs, the prime minister and chancellor had insisted there would be no U-turn.

More from Sky News:
PM’s winter fuel claim ‘not credible’
Starmer vs Reeves – the ‘rift’ in Downing Street

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Will winter fuel U-turn happen?

Many Labour MPs have called for the government to do more to help the poorest in society, amid mounting concern over the impact of wider benefit reforms.

Former prime minister Gordon Brown this week told Sky News the two-child cap was “pretty discriminatory” and could be scrapped by raising money through a tax on the gambling industry.

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Brown questioned over winter fuel U-turn

Mr Farage, who believes Reform UK can win the next election, will this week accuse Sir Keir of being “out of touch with working people”.

In a speech first reported by The Sunday Telegraph, he is expected to say: “It’s going to be these very same working people that will vote Reform at the next election and kick Labour out of government.”

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