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A cure for motor neurone disease (MND) could be “possible”, according to an expert, as a charity launched by a rugby legend unveils its five-year research strategy to give hope to those diagnosed with the condition.

The My Name’5 Doddie Foundation (MNDF), first set up in 2017 by the late Scottish rugby player Doddie Weir, will invest millions of pounds into research for treatments.

Mr Weir died in November 2022, following a six-year-long battle with MND.

The charity’s aim will be to effectively deliver treatments to slow the progress of MND, while also working towards the goal of finding a complete cure.

And Professor Ammar Al-Chalabi, director of the MND Research Centre at King’s College London, said finding a cure is now a real possibility.

He said: “When I started MND research almost 30 years ago it seemed ridiculous that an effective treatment might be possible.

“Now a cure is a possibility, although a treatment that dramatically slows MND is more likely. Both are still somewhat in the future.”

The money provided by charities is vital to driving research into treatments and an eventual cure, the professor added.

He said: “Research is expensive, however, and My Name’5 Doddie Foundation and other MND charities are crucial in funding it.

“They drive the cutting-edge stuff that pushes the field forward as well as the important ‘slogging away at it’ work that is essential to keep everything going.

“We are only where we are because of MND charities and the people who fundraise so effectively.”

Effective treatments ‘aren’t too far away’

Doddie Weir was inspired to set up a charity because a diagnosis of MND seemed to be without hope.

MNDF’s new five-year strategy, known as the Catalysis a Cure strategy, aims to drive forward research over the next five years with a commitment by 2028 to have invested in developing new treatments and improving early diagnosis.

It will also improve biomarkers which indicate whether treatments are working or not.

The organisation has committed around £8.5m to research and was also one of several UK organisations to successfully campaign for a UK government commitment of £50m for MND research.

Jessica Lee, director of research at MNDF, said: “We believe that effective treatments to slow or stop disease progression aren’t too far away.

“By working closely with our remarkable research community and supporting the adoption of new approaches and ways of thinking, we will accelerate the journey towards making these treatments a reality.”

Sports broadcaster and chief executive of the charity, Jill Douglas, added: “Doddie’s greatest frustration when he was diagnosed with MND in 2016 was the lack of hope for people faced with such devastating news.

“He wanted the Foundation to relentlessly work towards a world where that is not the case, and we are beginning to see real progress.

“There is huge momentum in MND research, and backed by the thousands of fundraisers who support the Foundation, this bold and ambitious research strategy ensures we are in the best position possible to build on that and work with the MND research community to hopefully accelerate the development of new treatments.”

Read more:
‘Important new step’ in finding treatment, scientists reveal
‘Milestone’ treatment slows weakness – study

What is motor neurone disease?

According to the NHS, motor neurone disease (MND) is an uncommon condition affecting the brain and nerves – it can also cause weakness and gradually worsen over time.

The condition mainly affects people in their 60s and 70s but can also affect adults of all ages.

There is no cure as of yet, but there are treatments to help reduce the impact it has on someone’s day-to-day life.

Some people can live with the condition for many years but it can also be fatal.

The NHS says MND can happen gradually and may not be obvious initially. Here are some of the early symptoms:

• Weakness in ankle or leg, leading to difficulty climbing stairs

• Slurred speech, which may develop into difficulty swallowing some foods

• A weak grip

• Muscle cramps and twitches

• Weight loss

• Difficulty stopping yourself from crying or laughing in inappropriate situations

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Trump-Starmer talks could be landmark moment – and join pantheon of UK-US summits

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Trump-Starmer talks could be landmark moment - and join pantheon of UK-US summits

In years to come, it may become known simply as Chequers ’25.

But today’s summit between Sir Keir Starmer and Donald Trump, at the prime minister’s country retreat, has the potential to be a landmark moment in UK-US history.

There’s plenty of scope for it to go horribly wrong, of course: over Jeffrey Epstein, Sir Keir’s pledge to recognise Palestine, the president’s lukewarm support for Ukraine, the Chagos Islands sell-off, or free speech.

Trump state visit live – read the latest

But on the other hand, it could be a triumph for the so-called “special relationship” – as well as relations between these two unlikely allies – with deals on trade and tariffs and an improbably blossoming bromance.

Either way, this Chequers summit – on the president’s historic second state visit to the UK – could turn out to be one of the most notable one-to-one meetings between PM and president in 20th and 21st century history.

Sir Keir and Mr Trump have already met several times, most recently at The Donald’s golf courses in Scotland in late July and, before that, memorably at the White House in February.

Donald Trump and Keir Starmer wave as they board Air Force One on a previous trip. Pic: AP
Image:
Donald Trump and Keir Starmer wave as they board Air Force One on a previous trip. Pic: AP

It was then that the PM theatrically pulled King Charles’s invitation for this week’s visit out of his inside pocket in a spectacular stunt surely masterminded by the “Prince of Darkness”, spin doctor-turned-ambassador (until last week, anyway) Peter Mandelson.

And over the years, there have been some remarkable and historic meetings and relationships, good and bad, between UK prime ministers and American presidents.

From Churchill and Roosevelt to Eden and Eisenhower, from Macmillan and JFK to Wilson and Johnson, from Thatcher and Reagan, to Blair and Bush, and from Cameron and Obama… to Starmer and Trump, perhaps?

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‘History’ that binds the UK and US

A brief history of relationships between PMs and presidents

Throughout UK-US history, there have been many examples of a good relationship and close bond between a Labour prime minister and a Republican president. And vice versa.

Also, it has not always been rosy between prime ministers and presidents of the two sister parties. There have been big fallings out: over Suez, Vietnam and the Caribbean island of Grenada.

Leading up to this Chequers summit, the omens have not been good.

First, the PM was forced to sack his vital link between Downing Street and the Oval Office, Lord Mandelson, over his friendship with Epstein.

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Trump meets Starmer: What can we expect?

Second, the president arrived in the UK to a barrage of criticism from London mayor Sir Sadiq Khan, who accused him of doing more than anyone else to encourage the intolerant far right across the globe.

And third, in a video-link to the “Unite the Kingdom” march in London last weekend, one-time Trump ally Elon Musk called for a dissolution of parliament and a change of government and appeared to encourage violent protest.

Churchill and FDR

Churchill and FDR at the White House in 1941. Pic: AP
Image:
Churchill and FDR at the White House in 1941. Pic: AP

Back in the mid-20th century, the godfather of the “special relationship” was wartime leader Sir Winston Churchill, though it was 1946 before he first coined the phrase in a speech in the US, in which he also spoke of the “iron curtain”.

It was in 1941 that Churchill held one of the most significant meetings with a US president, Franklin D Roosevelt, at a Washington conference to plot the defeat of Germany after Japan’s attack on Pearl Harbour.

Churchill arrived in Washington in December after a rough 10-day voyage on a Royal Navy battleship and stayed three weeks, spending Christmas in the White House and on Boxing Day becoming the first UK PM to address Congress.

The close bond between Churchill and Roosevelt was described as a friendship that saved the world. It was even claimed one reason the pair got on famously was that they were both renowned cigar smokers.

Churchill and Truman

Churchill and Truman catch a train from Washington in 1946. Pic: AP
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Churchill and Truman catch a train from Washington in 1946. Pic: AP

After the war ended, Churchill’s “special relationship” speech, describing the alliance between the UK and US, was delivered at Westminster College, in Fulton, Missouri in March 1946.

The speech was introduced by president Harry Truman, a Democrat, with whom Churchill had attended the Potsdam Conference in 1945 to negotiate the terms of ending the war.

These two were also close friends and would write handwritten letters to each other and address one another as Harry and Winston. Mr Truman was also the only US president to visit Churchill at Chartwell, his family home.

Eden and Eisenhower

Eden and Eisenhower shake hands at the conclusion of their three-day conference in 1956. Pic: AP
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Eden and Eisenhower shake hands at the conclusion of their three-day conference in 1956. Pic: AP

But the transatlantic cosiness came to an abrupt end in the 1950s, when Churchill’s Conservative successor Anthony Eden fell out badly with the Republican president Dwight Eisenhower over the Suez Crisis.

Mr Eden did visit Mr Eisenhower in Washington in January 1956, and the official record of the meeting describes the discussion as focussing on “policy differences and Cold War problems”.

Macmillan and JFK

Harold Macmillan and John F Kennedy at Andrews Air Force Base. Pic: AP
Image:
Harold Macmillan and John F Kennedy at Andrews Air Force Base. Pic: AP

But in the early 1960s, a Conservative prime minister and a Democrat president with seemingly nothing in common, the stuffy and diffident Harold Macmillan, and the charismatic John F Kennedy, repaired the damage.

They were credited with rescuing the special relationship after the rupture of the Suez Crisis, at a time of high tensions around the world: the Berlin Wall, the Cuban missile crisis, and the threat of nuclear weapons.

The two leaders exchanged handwritten notes, as well as Christmas and birthday cards. The Macmillans visited the Kennedys twice at the White House, in 1961 and 1962 – the second described in the US as a “momentous” meeting on the Cuban crisis.

The relationship was abruptly cut short in 1963 by Supermac’s demise prompted by the Profumo scandal, and JFK’s assassination in Dallas. But after her husband’s death, Jacqueline Kennedy was said to have had a father-daughter relationship with Macmillan, who was said to have been enchanted with her.

Wilson and LBJ

Johnson meeting with Wilson. Pic: Glasshouse Images/Shutterstock
Image:
Johnson meeting with Wilson. Pic: Glasshouse Images/Shutterstock

After JFK, the so-called special relationship cooled once again – and under a Labour prime minister and Democrat president – when Harold Wilson rejected pressure from Lyndon B Johnson to send British troops to Vietnam.

Mr Wilson became prime minister in 1964, just two months after LBJ sent US troops. His first overseas trip was to the White House, in December 1964, and the PM returned to tell his cabinet: “Lyndon Johnson is begging me even to send a bagpipe band to Vietnam.”

Thatcher and Reagan

Thatcher at Reagan's 83rd birthday celebrations. Pic: Reuters
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Thatcher at Reagan’s 83rd birthday celebrations. Pic: Reuters

And even though Margaret Thatcher and Ronald Reagan were ideological soulmates, Thatcher was furious when she wasn’t consulted before the Americans invaded Grenada in 1983 to topple a Marxist regime.

Even worse, according to Mrs Thatcher’s allies, a year earlier, Reagan had stayed neutral during the Falklands War. Reagan said he couldn’t understand why two US allies were arguing over “that little ice-cold bunch of land down there”.

Thatcher and Reagan became firm friends. Pic: Reuters
Image:
Thatcher and Reagan became firm friends. Pic: Reuters

But their relationship didn’t just survive, it flourished, including at one memorable visit to the presidential retreat at Camp David in 1984, where Reagan famously drove Mrs T around in a golf buggy.

They would also memorably dance together at White House balls.

Blair and Bush

Blair hosts Bush in Durham in 2003. Pic: PA
Image:
Blair hosts Bush in Durham in 2003. Pic: PA

Camp David was also where, in 2001, Republican president George W Bush and Labour’s Sir Tony Blair embarked on the defining mission of his premiership: the Iraq War. It was to prove to be an historic encounter.

The war was the turning point of Sir Tony’s decade in Number 10. He was branded a liar over claims about Saddam Hussein’s “weapons of mass destruction”, he was vilified by the Labour left, and it was the beginning of the end for him.

And to add to the suspicion among Sir Tony’s critics that he was Mr Bush’s poodle, in 2006 at a G8 summit in St Petersburg – that wouldn’t happen now – a rogue microphone picked up the president calling, “Yo, Blair! How are you doing?”

Cameron and Obama

Cameron and Obama serve food at a barbecue in the garden of 10 Downing Street. Pic: Reuters
Image:
Cameron and Obama serve food at a barbecue in the garden of 10 Downing Street. Pic: Reuters

Some years later, the Tory prime minister sometimes called the “heir to Blair”, David Cameron, bonded over burgers with the Democrat president Barack Obama, serving a BBQ lunch to military families in the Downing Street garden. They also played golf at the exclusive Grove resort in 2016.

They seemed unlikely allies: Obama, the first African-American president, and Cameron, the 19th old Etonian prime minister. It was claimed they had a “transatlantic bromance” in office. “Yes, he sometimes calls me bro,” Lord Cameron admitted.

But not everything went well.

The Tory PM persuaded Mr Obama to help the Remain campaign in the 2016 Brexit referendum, when he claimed the UK would be “at the back of the queue” on trade deals with the US, if it left the EU. It backfired, of course.

Now it’s Sir Keir Starmer’s turn to tread a delicate and potentially hazardous political tightrope as he entertains the latest – and most unconventional – US president.

The greatest dangers for Sir Keir will be a news conference in the afternoon, in the gardens, if the weather permits.

Good luck, as they say, with that.

Before then, there’s the potential for what the Americans call a “pool spray”, one of those impromptu, rambling and unpredictable Q&As we’ve seen so many times in the Oval Office.

For Sir Keir, what could possibly go wrong?

Chequers ’25 could be memorable and notable, like so many previous meetings between a PM and a president. But not necessarily for the right reasons for this UK prime minister.

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Sadiq Khan calls out Gaza ‘genocide’, as Starmer ‘delays’ recognising Palestinian state until end of Trump’s state visit

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Sadiq Khan calls out Gaza 'genocide', as Starmer 'delays' recognising Palestinian state until end of Trump's state visit

London’s mayor Sir Sadiq Khan has for the first time described the situation in Gaza as a “genocide”, becoming the most senior Labour figure to contradict the government’s official position.

Earlier this week, a UN Commission said a genocide was taking place in Gaza – something repeatedly denied by Israel.

Meanwhile, Sir Keir Starmer has been under pressure to raise Israel’s bombardment of the territory with Donald Trump during his state visit to the UK.

The prime minister is due to have discussions with the president today, but reports suggest he will delay formally recognising a Palestinian state until this weekend, after Mr Trump has left Britain.

It is claimed the government wants to avoid the issue dominating a news conference the two men plan to hold, according to The Times.

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Trump meets Starmer: What can we expect?

The prime minister has found himself at odds with the US administration over the move, which is opposed to official recognition of Palestine.

The mayor of London, who has engaged in a long-running spat with Mr Trump, has added to the political tension by contradicting official Labour policy at a people’s question time event on Wednesday.

“I think it’s inescapable to draw the conclusion in Gaza we are seeing before our very eyes a genocide,” said Sir Sadiq.

Sir Keir has previously pledged to recognise Palestinian statehood ahead of next week’s United Nations General Assembly in New York if Israel does not meet a series of conditions to improve the humanitarian situation in Gaza.

Other nations, including France, Australia and Canada, have said they plan to take the same step at the UN gathering.

Explainer: What does recognising a Palestinian state mean?

The UK has consistently argued that the issue of whether Israel has committed genocide was a matter for the courts. Israel is fighting a case at the International Court of Justice in The Hague in which the country is accused of genocide.

But some opposition leaders, including Zack Polanski for the Green Party, and the Liberal Democrats’ Sir Ed Davey have specifically referred to the situation in Gaza as genocide.

Read more from Sky News:
Watch: Israel’s Gaza City offensive
MPs denied entry into West Bank

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Is Israel committing genocide?

On Tuesday, the UN Independent International Commission of Inquiry on the Occupied Palestinian Territory released a report, claiming: “It is clear that there is an intent to destroy the Palestinians in Gaza”.

It said Israel’s actions meet the criteria set down for defining a genocide.

The UK government has said its official position was it “has not concluded that Israel is acting with that [genocidal] intent“.

Israel is currently undertaking a major ground offensive in Gaza, with thousands forced to flee from Gaza City in recent days.

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Man dies, woman injured, after London park shooting

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Man dies, woman injured, after London park shooting

A man has died and a woman has been taken to hospital after a shooting at a park in London.

The Metropolitan Police said officers attended Clissold Park in Hackney at 7.06pm on Wednesday.

A woman in her 40s was treated for gunshot wounds and treated by paramedics. There has been no update yet on her injuries or condition in hospital.

Police said a man in 40s also suffered gunshot wounds and was pronounced dead later in hospital.

A firearm, thought to have been involved in the shooting, has been recovered from the scene.

Forensic teams in blue boiler suits could be seen at the park on Wednesday night recovering items, including clothing, and placing them in evidence bags.

A blue forensic tent could be seen in the park with staff also taking pictures of the scene and logging evidence.

A blue forensic tent in the park
Image:
A blue forensic tent in the park

Police could be seen guarding several sites in and around the park, which had been cordoned off.

Numbered yellow evidence markers had also been placed on the ground at various locations.

Items are recovered by forensic teams and bagged
Image:
Items are recovered by forensic teams and bagged

Clothing appeared to be among the items being collected
Image:
Clothing appeared to be among the items being collected

In a statement, Detective Superintendent Oliver Richter said: “We are in the early stages of the investigation, but we believe the man and woman are known to one another.

“At this time, we are treating it as an isolated incident and there is no wider risk to the public.

“A crime scene remains in place for investigation with an increased police presence.”

Read more from Sky News:
Sadiq Khan calls out Gaza ‘genocide’
Trump speaks at state banquet
Overhaul needed for SEND support

Det Sup Richter added that officers were still working to establish what happened and did not elaborate on the circumstances surrounding the shooting or who fired the weapon.

Hackney Council said on social media that it was “supporting the police with their investigations”, adding the park would remain closed on Thursday morning.

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