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A cure for motor neurone disease (MND) could be “possible”, according to an expert, as a charity launched by a rugby legend unveils its five-year research strategy to give hope to those diagnosed with the condition.

The My Name’5 Doddie Foundation (MNDF), first set up in 2017 by the late Scottish rugby player Doddie Weir, will invest millions of pounds into research for treatments.

Mr Weir died in November 2022, following a six-year-long battle with MND.

The charity’s aim will be to effectively deliver treatments to slow the progress of MND, while also working towards the goal of finding a complete cure.

And Professor Ammar Al-Chalabi, director of the MND Research Centre at King’s College London, said finding a cure is now a real possibility.

He said: “When I started MND research almost 30 years ago it seemed ridiculous that an effective treatment might be possible.

“Now a cure is a possibility, although a treatment that dramatically slows MND is more likely. Both are still somewhat in the future.”

The money provided by charities is vital to driving research into treatments and an eventual cure, the professor added.

He said: “Research is expensive, however, and My Name’5 Doddie Foundation and other MND charities are crucial in funding it.

“They drive the cutting-edge stuff that pushes the field forward as well as the important ‘slogging away at it’ work that is essential to keep everything going.

“We are only where we are because of MND charities and the people who fundraise so effectively.”

Effective treatments ‘aren’t too far away’

Doddie Weir was inspired to set up a charity because a diagnosis of MND seemed to be without hope.

MNDF’s new five-year strategy, known as the Catalysis a Cure strategy, aims to drive forward research over the next five years with a commitment by 2028 to have invested in developing new treatments and improving early diagnosis.

It will also improve biomarkers which indicate whether treatments are working or not.

The organisation has committed around £8.5m to research and was also one of several UK organisations to successfully campaign for a UK government commitment of £50m for MND research.

Jessica Lee, director of research at MNDF, said: “We believe that effective treatments to slow or stop disease progression aren’t too far away.

“By working closely with our remarkable research community and supporting the adoption of new approaches and ways of thinking, we will accelerate the journey towards making these treatments a reality.”

Sports broadcaster and chief executive of the charity, Jill Douglas, added: “Doddie’s greatest frustration when he was diagnosed with MND in 2016 was the lack of hope for people faced with such devastating news.

“He wanted the Foundation to relentlessly work towards a world where that is not the case, and we are beginning to see real progress.

“There is huge momentum in MND research, and backed by the thousands of fundraisers who support the Foundation, this bold and ambitious research strategy ensures we are in the best position possible to build on that and work with the MND research community to hopefully accelerate the development of new treatments.”

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What is motor neurone disease?

According to the NHS, motor neurone disease (MND) is an uncommon condition affecting the brain and nerves – it can also cause weakness and gradually worsen over time.

The condition mainly affects people in their 60s and 70s but can also affect adults of all ages.

There is no cure as of yet, but there are treatments to help reduce the impact it has on someone’s day-to-day life.

Some people can live with the condition for many years but it can also be fatal.

The NHS says MND can happen gradually and may not be obvious initially. Here are some of the early symptoms:

• Weakness in ankle or leg, leading to difficulty climbing stairs

• Slurred speech, which may develop into difficulty swallowing some foods

• A weak grip

• Muscle cramps and twitches

• Weight loss

• Difficulty stopping yourself from crying or laughing in inappropriate situations

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Masked burglars ‘raid’ Windsor Castle grounds ‘while William, Kate and children slept at home on estate’

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Masked burglars 'raid' Windsor Castle grounds 'while William, Kate and children slept at home on estate'

Masked burglars have stolen farm vehicles from the Windsor Castle estate while members of the Royal Family are believed to have been asleep nearby.

Two men scaled a 6ft fence on the night of 13 October and used a stolen truck to break through a security gate, The Sun first reported.

The pair then fled with a pick-up and a quad bike that were stored in a barn.

The King and Queen were not in residence.

But the Prince and Princess of Wales, along with their three children George, 11, Charlotte, nine, and six-year-old Louis were believed to have been in their home, Adelaide Cottage, on the estate, according to The Sun.

The family moved there in 2022.

In a statement, Thames Valley Police said: “At around 11.45pm on Sunday 13 October, we received a report of burglary at a property on Crown Estate land near to the A308 in Windsor.

“Offenders entered a farm building and made off with a black Isuzu pick-up and a red quad bike. They then made off towards the Old Windsor/Datchet area.

“No arrests have been made at this stage and an investigation is ongoing.”

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On Christmas Day 2021, a man climbed a fence at Windsor Castle armed with a crossbow and claimed he wanted to kill Queen Elizabeth II.

Jaswant Singh Chail was handed a nine-year custodial sentence for treason, possession of an offensive weapon and making threats to kill.

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UK told to expect ‘disruptive snow’ as warnings cover large parts of country

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UK told to expect 'disruptive snow' as warnings cover large parts of country

The UK is braced for “disruptive snow” as yellow weather warnings cover large parts of the country until Tuesday – with the Met Office saying there is the “potential” for the alerts to be “escalated”.

The forecaster has warned up to 20cm of snow may accumulate in the worst affected areas as the country experiences its “first taste of winter”.

The Met Office has also told people to expect ice, cold temperatures and wintry showers this week.

Check the forecast in your area

A yellow warning for snow and ice is in place for much of the north of the country – covering areas in the East Midlands, Yorkshire, Wales and the north of England – from 7pm on Monday night to 10am on Tuesday morning.

Those in the impacted areas have been told power cuts are possible and mobile phone coverage might be affected.

The Met Office has said there is a “slight chance” some rural communities could be cut off and that bus and train services may be delayed or cancelled.

People are also warned to be careful not to slip or fall on icy surfaces.

The Met Office has said there will be bright spells across northern and eastern areas throughout today, but rain in the south and west will gradually spread northeastwards and turn to snow over northern hills.

Snow in Leeds.
File pic: PA.
Image:
Parts of the UK are experiencing their ‘first taste of winter’, says the Met Office. File pic: PA

Tom Morgan, Met Office meteorologist, said: “We could see some disruptive snow in the Pennine regions, in particular, the Peak District as well, especially Monday night, but we could well see some impacts lasting on until Tuesday morning’s rush hour.

“Even down to lower levels, we could well see some snow as well, so quite a bit of disruption possible by Tuesday morning, and then the week ahead is likely to stay cold nationwide, a windy day on Tuesday, and then winter showers through the week ahead.”

Mr Morgan said that despite a “mild” start to the month, the cold conditions are more typical of “mid-winter to late-winter”.

“What we can say is that it’s going to be very cold for the time of year, there will be widespread overnight frosts, and a few locations where there’s snow on the ground,” he continued.

The yellow weather warnings in place across the UK
Image:
The yellow weather warnings in place across the UK

Meanwhile, a yellow snow and ice weather warning that came into force at 4pm on Sunday will end at 11am this morning.

The warning covers the northern tip of Scotland and people there have been told there may be icy patches on some untreated roads, pavements and cycle paths.

The Met Office has said there is “potential” for both yellow warnings to be “escalated”.

In southern England, a typical maximum temperature for this time of year is 11C (52F), but daytime highs for the week ahead are forecast to be around 5C (41F), while some parts of Scotland will reach “only just above freezing”, Mr Morgan said.

The meteorologist said the public can best prepare for the wintry weather by checking their cars are suitable for icy and potentially snowy conditions and to take extra supplies including food, blankets and a fully charged mobile phone with them on journeys.

He added there were “likely” to be changes to the weather warnings in the coming days, and that “winter flurries” could be seen in the south of England later in the week.

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Despite the cold conditions, the “whole of the UK” will enjoy more sunshine this week, the meteorologist added.

He said: “There’ll be some snow showers in the peripheries of the UK, particularly northern Scotland, and down the east and the west coast, but if you live inland and you live in the south, there’ll be lots of sparkly blue skies on the most days through Tuesday to Friday.”

It comes as a cold weather alert issued by the UK Health Security Agency, which was introduced at 9am on Sunday, will be in place until 9am on Thursday.

It covers a large area of England, north of Northhampton. The alert is triggered when there is a risk that healthcare services might face extra pressure and is designed to prepare those who are “particularly vulnerable” and “likely to struggle to cope”.

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Man pleads guilty to being owner of dangerously out of control XL bully which killed his neighbour near Sunderland

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Man pleads guilty to being owner of dangerously out of control XL bully which killed his neighbour near Sunderland

A man has pleaded guilty to being the owner of a dangerously out of control XL bully dog which killed his neighbour.

Christopher Bell, 45, admitted to the offence at Newcastle Crown Court.

The XL bully killed Ian Langley in Shiney Row near Sunderland on 3 October last year.

The 54-year-old suffered fatal neck injuries when he was attacked while walking his puppy.

Bell, formerly of Maple Terrace, Shiney Row, pleaded guilty to being the owner of a dog which caused injury leading to death while dangerously out of control in a public place.

Bell, now living in Coltman Street, Hull, was granted bail and will be sentenced on 27 January.

The charge named his dog as Titan – “an American bully XL”.

Police shot the dog at the scene to protect the public.

Neighbours said Mr Langley, who was originally from Liverpool, was walking his patterdale puppy called Bow when he was attacked.

His puppy bolted and managed to escape and was being looked after by a neighbour in the aftermath of the attack which horrified residents living on the estate.

Read more on Sky News:
UK told to expect ‘disruptive snow’
Schools shut in world’s most polluted city

At the time, Michael Kennedy, also from Shiney Row, said he had known Mr Langley for more than 20 years, and said many people knew him simply as “Scouse”.

He said: “He was a really nice lad, he came from Liverpool, he was a lovable rogue you might say.

“He never did any harm, he was not a violent person, he wasn’t a hard man, he wasn’t the type to go looking for trouble.

“He was really thin, he would have no chance against a big dog.”

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