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2 years agoon
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adminThe new drug looked so promising except for that one warning sign.
This story also ran on Fortune. It can be republished for free.
At the American College of Rheumatologys annual meeting in 2008, Duke Universitys Dr. John Sundy proudly announced that pegloticase, a drug hed helped develop, was astoundingly effective at treating severe gout, which affects perhaps 50,000 Americans. In about half of those who had taken it, the drug melted away the crystalline uric acid deposits that encrusted their joints to cause years of pain, immobility, or disfigurement.
But Sundy also disclosed an unsettling detail: In one clinical trial, patients who got the drug were more likely to develop heart problems than those who didnt. The day after Sundys talk, the stock price of Savient Pharmaceuticals, which developed the drug with Duke scientists, plunged 75%.
That danger signal would disappear in later studies, and the FDA approved pegloticase, under the trade name Krystexxa, two years later. But the small biotech company never recovered. In 2013, Savient was sold at auction to Crealta, a private equity venture created for the purpose, for $120 million.
Two years later, a young company now called Horizon Therapeutics bought Crealta and its drug portfolio for $510 million.
Even at that price, it proved a good deal. Krystexxa brought in $716 million in 2022 and was expected to earn $1 billion annually in coming years.
Although Horizon says it now has 20 drugs under development, in its 15 years of existence it has yet to license a product it invented. Yet the company has managed to assemble a war chest of lucrative drugs, in the process writing a playbook for how to build a modern pharmaceutical colossus.
As the White House and both parties in Congress grapple with reining in prescription drug prices, Horizons approach reveals just how difficult this may be.
Horizons strategy has paid off handsomely. Krystexxa was just one of the many shiny objects that attracted Amgen, a pharmaceutical giant. Amgen announced in December that it intends to buy Horizon for $27.8 billion, in the biggest pharmaceutical industry deal announced in 2022.
Horizons CEO, Tim Walbert, who will reportedly get around $135 million when the deal closes, has mastered a particular kind of industry expertise: taking drugs invented and tested by other people, wrapping them expertly in hard-nosed marketing and warm-hued patient relations, raising their prices, and enjoying astounding revenues.
Hes done this with unusual finesse courting patients with concierge-like attention and engaging specialist clinicians with lunches, conferences, and research projects, all while touting his own experience as a patient with a rare inflammatory disease. Walberts company has been particularly adept at ensuring that insurers, rather than patients, bear the costly burdens of his drugs.
A federal prosecutor in 2015 began examining allegations that Horizons patient assistance program had worked with specialty pharmacies to evade insurers efforts to shun Horizons expensive drugs. A separate probe opened in 2019 over alleged kickbacks to pharmacy benefit managers, companies that negotiate to get Horizons drugs covered by insurers. Those investigations appear to be no longer active, Horizon spokesperson Catherine Riedel said. The company this year disclosed a third probe, concerning methods the company allegedly used to get prior authorization of its drugs. Justice officials did not respond to requests for comment on the investigations. Email Sign-Up
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An Injection of Marketing
To help sell its drugs, Horizon blankets specialist physicians with marketing and peer-to-peer appeals. Its payments to physicians for things like consulting, speeches, and meals totaled $8.7 million in 2021, compared with the $10 million it paid them for research, federal records show. By contrast, Seagen, a biotech company of roughly the same size, paid doctors a total of $116 million, with nearly $112 million of that pegged for research. Riedel said Horizons marketing and educational approaches were necessarily unique because of the challenges of treating rare and neglected diseases.
Walbert launched Horizon in 2008 in the Chicago area by combining and refashioning generic drugs into single pills. Duexis, Horizons first drug, is a mixture of generic Motrin and Pepcid. Its Vimovo combines generic Aleve and Nexium. In a 2017 article, a ProPublica reporter described being prescribed Vimovo for a shoulder injury. It cost him nothing, but his insurer was billed $3,252 for pills that together cost about $40 for a months supply in generic form. Horizon sold more than $57 million worth of Vimovo that year.
In 2014 and 2015, respectively, Horizon picked up two relatively new drugs that had no generic versions: the immunosuppressant Actimmune and Ravicti, which treats a rare genetic disorder. Soon Horizon was charging more than $50,000 a month for each, placing Actimmmune fourth and Ravicti second on GoodRxs 2020 list of the most expensive U.S. drugs.
Horizons net sales soared from $20 million in 2012 to $981 million in 2016; Walberts pay package followed suit, topping an astronomical $93.4 million in 2015 in salary and stock. Stock analysts questioned the long-term soundness of a strategy of simply selling old drugs for mind-boggling prices, but Walbert was using the cash to refashion the company as a rare-diseases franchise.
His approach would make Walbert a darling of pharmaceutical investors and his board, which lavished him with over $20 million in compensation each of the past three years. While most biotechs and startups borrow heavily from venture capital to do science and have no idea how to develop and market a drug, Walbert got cash coming in quickly. He did it backwards, said Annabel Samimy, an analyst at Stifel Financial Corp. Horizon built commercial platforms before they got into drug development.
Generating robust sales of what sounded like not very interesting drugs allowed Walbert to start a company on not very much, said Oppenheimer analyst Leland Gershell. All the while, Horizon funded and cultivated the patient advocacy groups that can help lobby for a drug to be approved by the FDA and placed on insurers formularies, the lists of drugs health plans cover for patients.
Capitalizing on His Own Illness?
As Walbert and his spokespeople often point out, Walbert and his youngest son suffer from a rare disease, and Walbert also has an autoimmune disease. Walbert wont name the diseases, but has said hes taken the anti-inflammatory injectable Humira since 2003 the year he led that drugs commercial launch as a vice president at Abbott Laboratories. Humira has become the bestselling drug in history, with about $200 billion in all-time global sales.
In 2014, Walbert moved Horizons headquarters to Ireland, which nearly halved its tax rate. A year later it gained control of Krystexxa, and in 2017 it bought, for $145 million, a failing company that produced Tepezza, a drug for thyroid eye disease, which causes unsightly eye bulging and pain.
Tepezza quickly became a blockbuster, with $3.6 billion in total sales in 2021 and 2022. The company conducted additional clinical research on both Tepezza and Krystexxa, but it also spent heavily promoting these and other drugs to specialists who could prescribe them.
All the while it steadily raised prices. Savient put Krystexxa on the market in 2011 at $2,300 per injection. Horizon charges roughly 10 times as much. Six months of Tepezza treatment can run more than $400,000.
Horizons publicity emphasized the companys sensitivity to patients, and its constant contact with disease advocates.
Our scientists are attuned to the unmet needs of patients, their diagnostic and therapeutic journey, Bill Rees, Horizons vice president for translational sciences, told KFF Health News. Its the marrying of the basic clinical science with a focus on the needs of the patient that differetiates us.
To make sure patients keep using its drugs, clinicians say, Horizon staffers negotiate with insurance carriers, and the company offers drug discounts to lower-income patients while swaddling them with attention from its medical staff.
Horizon has a nurse talk to each and every patient before every appointment, said Dr. Brigid Freyne, who treats around half a dozen patients each year with Krystexxa at her Murrieta, California, rheumatology clinic. The patients who come in here are highly motivated to get their IV. They get the message that its very important and they are fortunate to get the medicine.
None of the manufacturers of her other infusion drugs shower patients with this kind of attention, she said.
While at Abbott, Walbert pioneered direct-to-consumer advertising for specialty drugs like Humira, a trend that aggravated insurers, who anticipated, correctly, that they would soon be shelling out billions for expensive drugs.
Horizons marketing plan for Krystexxa includes direct-to-consumer ads aimed at driving patients to specialists. The drug is designed for recalcitrant gout patients, who often have large lumps on their fingers, feet, and kidneys. Many, though not all, are heavy drinkers of beer or soda sweetened with high-fructose corn syrup, which can increase the buildup of uric acid, the cause of gout, said Dr. Robert McLean of Yale University.
While Krystexxa can help patients with advanced gout, the American College of Rheumatology views it as a drug of last resort, with plenty of cheaper, early intervention alternatives available.
I prescribe it maybe once a year, McLean said. From a cost-effectiveness standpoint, it warrants questioning.
Horizon recently started a publicity campaign addressed to all gout sufferers, urging them to see a rheumatologist or a nephrologist the specialists it has targeted with Krystexxa educational materials before the disease does too much harm.
Horizon would like you to say, Everyone with serious gout should be started on Krystexxa, said Dr. James ODell, a rheumatologist at the University of Nebraska Medical Center. The Horizon pitchmen he deals with are nice guys, but we dont believe thats the best way.
The company defends its marketing practices. We learn what matters most to patient communities and act. This approach has been validated by independent third-party research, said Riedel.
The Federal Trade Commission said in January it was seeking more information on the Amgen-Horizon merger. Sen. Elizabeth Warren (D-Mass.), citing high prices for Horizon and Amgen drugs, urged the agency to nix the deal.
Arthur Allen: ArthurA@kff.org, @ArthurAllen202 Related Topics Health Care Costs Health Industry Pharmaceuticals Drug Costs Prescription Drugs Contact Us Submit a Story Tip

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Business
The 40 jobs ‘most at risk of AI’ – and 40 it can’t touch
Published
3 hours agoon
October 11, 2025By
admin
AI has stolen £120,000 from Joe Turner.
The 38-year-old writer lost 70% of his clients to chatbots in two years.
His is one of 40 job roles that AI is fast replacing, according to conversations the Money team had with industry experts, researchers, and affected workers.
Read all the latest Money news here
“It’s a betrayal,” says Turner, who earned six figures as a freelancer before the rise of generative AI.
“You’ve put your heart and soul into it for so long, and then you get replaced by a machine.”
He adds: “You always think ‘it’s never going to happen to me’.”

Joe Turner
Around 85% of the tasks involved in Turner’s job could be performed by AI, according to research published by Microsoft in July that has gone largely unnoticed.
The tech giant’s analysis of 200,000 conversations with its Co-Pilot chatbot concluded it could complete at least 90% of the work carried out by historians and coders, 80% of salespeople and journalists, and 75% of DJs and data scientists.
Also in the top 40 most exposed jobs were customer service assistants (72%), financial advisers (69%) and product promoters (62%). Search the table below to see how your role fares…
Speaking to the Money team, senior Microsoft researcher Kiran Tomlinson insists the study “explores which job categories can productively use AI chatbots, not take away or replace jobs”.
Turner for one doesn’t buy this. “That’s what they want to market it as,” he says.
Experts we spoke with were just as sceptical of Microsoft’s optimism.
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‘Replaced entirely by the tool’
“If you were to look at these jobs in three to five years, there’s a very good chance they’ve been replaced entirely,” says an AI consultant with more than a decade of experience deploying the tech in nearly 40 companies.
“Except in areas where they are either relationship-driven or very judgmental,” they add, speaking on condition of anonymity due to their commercial relationships with a range of SMEs, multibillion-pound funds and public bodies.
“These types of jobs are by nature most likely to be replaced entirely by the tool,” agrees AI researcher Xinrong Zhu, an assistant professor at Imperial College London.
“We’re living in a world where we’re witnessing a very important turning point.”

Xinrong Zhu
It’s a verdict echoing job cuts announced by major companies over the summer.
Buy now, pay later firm Klarna shrunk its headcount by 40% due to investments in AI and a hiring freeze, while boasting its chatbot was doing the work of 700 employees.
Microsoft itself said it was laying off 15,000 employees while investing £69bn in data centres to train AI models and reportedly using AI to save $500m in its call centres.
Amazon chief executive Andy Jassy said he expected to “reduce our total corporate workforce as we get efficiency gains from using AI extensively”.
But don’t take this at face value, says the AI consultant. Just because AI will take jobs doesn’t mean it can right now: “I wouldn’t say AI is in a position that you can then generate layoffs immediately: What you tend to see in most businesses is hiring freezes.”
The UK hasn’t had a sharp decline in postings for the jobs most threatened by AI, but they grew four times slower than the least threatened jobs between 2019 and 2024, according to PwC’s AI jobs barometer.
“AI is being used as an excuse,” the consultant says.
“There’s a load of macroeconomic effects that are actually causing [job cuts].”
It’s the Money blog’s usual suspects: Increases to employer national insurance, the cost of hiring and the cost of energy – not an AI takeover.
But, they say, “that’s not to say it won’t happen next year.”
Some 78% of global businesses anticipate increasing their overall AI spending this fiscal year, a Deloitte survey found.
Approximately 40% of employers expect to reduce their workforce where AI can automate tasks, according to a World Economic Forum survey.
An email that changed everything
Freelancers may, then, be the canary in the coal mine.
Demand for gigs related to writing and coding fell by 21% within eight months of the release of ChatGPT, according to a study conducted last year by Zhu.
“The magnitude really surprised us,” she says.
It wouldn’t have surprised Turner.
A few months earlier, in December 2023, he received an email from a website where he’d worked for a decade.
“Do you ever use AI?” it read. “No,” he replied.
That was the last time he heard from them. Overnight, £30,000 was wiped from his annual income.
“I went on their website and I realised they had started using AI instead of me,” he says.
One by one, most of his other clients followed suit.
“It was just a complete desert,” he says of the job landscape.
If you listen to the heads of some leading AI companies, you’d be forgiven for thinking this desert is just one apocalyptic vista at the end of the working world as we know it.
Dario Amodei, chief executive of Anthropic, has warned AI could “wipe out half of all entry-level white-collar jobs”, while OpenAI boss Sam Altman said entire job categories would be “totally, totally gone”.
“They want to glorify the models,” says Dr Fabian Stephany, a Labour economist at the University of Oxford and fellow at Microsoft’s independent AI Economy Institute.
Impersonating a big tech boss, he continues: “‘Oh wow, look, if we can automate away 50,000 people, then that technology must be really tremendous – so you should be investing in our company!’
“I would advocate to have a bit of more of a cooled down, pragmatic approach.
“Think about it as a technology and look at how technology has been interacting with the labour market in the past.”

Fabian Stephany
Inventions that revolutionised the workplace
Take Richard Arkwright’s invention of the Spinning Jenny in 1769, which churned out huge quantities of yarn to make cloth in some of the first factories at the start of the industrial revolution.
While putting home weavers out of a job, it increased the need for mill workers hundreds of times over, says Stephany.
Henry Ford’s invention of the assembly line in 1913 had a similar impact when it reduced the time taken to make a car from 12.5 hours to 1.5 hours.
Speed lowered production costs and forecourt prices, increasing demand, sales and the number of staff hired to fulfil them.
For the same reason, the invention of the ATM in 1967 led to more bank teller jobs despite automating one of their key functions – something Microsoft was keen to point out.
“Our research shows that AI supports many tasks, particularly those involving research, writing and communication, but does not indicate it can fully perform any single occupation,” Microsoft’s Tomlinson says.
Indeed, the study shows 40 jobs where AI can perform just 10% or fewer tasks.
Tradespeople feature heavily, like painter-decorators (4%), cleaners (3%) and roofers (2%).
Surgical assistants (3%), ship engineers (5%) and nursing assistants (7%) also make the list.
But history also includes a list of the losers of technological innovation.
Replacing horses with tractors wiped 3.4 billion man hours from American farmwork annually by 1960, according to research by economic historian Professor Alan Olmstead.
Spare a thought, too, for the pinsetters once responsible for stacking bowling alleys, who were more or less eliminated by the Automatic Pinspotter unveiled in 1946.
Quantity does not mean quality, either: Arkwright’s millers faced exhausting and repetitive 13-hour shifts in extreme noise, heat and dust.
How fulfilling would working with an AI be?
“Sterile and just not interesting, uniform and bleak and surface-level and hollow” is how Turner described its work after trying AI at the request of a client.
“Cars were a solution – a car was a horse that never got tired. But if you look at AI the same way, it’s basically saying: ‘There aren’t enough rubbish books out there, we need to make more.'”
More human work, not less?
That’s not what it’s for, though, says the AI consultant.
“I don’t see an AI right now coming up with wonderful ideas for creative writing authors,” they say.
But what it’s good at is taking an author’s idea and making a first draft extremely quickly, they explain.
“Now, does that mean we have fewer authors or does that mean we have more?”
The consultant’s optimism comes from seeing AI create extra human work at some of the companies that hired them.
A landscaping firm used ChatGPT to generate personalised services to upsell to existing customers.
At a pension provider with 350,000 scheme members, AI saved “literally thousands of hours” by scanning millions of notes, PDF documents and email chains for spousal support agreements.
That might seem like work stolen from a law firm at first glance, but it likely wouldn’t have been undertaken at all without AI due to the extreme cost of manual labour, says the consultant.
The cost of starting a digital business has also shrunk dramatically, he adds, if you use AI to organise a website, workflow, marketing and employment contracts.
“You end up in a world where you could have thousands more small start-ups because the cost of failure is so much lower.”

Pic: iStock
The ‘losers of technological change’
Such a positive attitude would do little to convince veteran audio producer Christian Allen, who has lost gigs worth £7,000 to AI in the past year.
“Hasn’t anyone seen Terminator, for Christ’s sake?” says Allen, 53, whose work over the past two decades has been played on major radio stations like Classic FM and Heart FM.
“I think it could very easily take over.”
AI started by depleting requests for voiceovers in company training videos, but Allen recently lost a potential radio client who instead bought the first AI advert he’s ever heard that’s good enough for broadcast.
“It was scarily good,” says Allen, who lives near Birmingham. “No one would know.”
The cost to the client? £11.99. Voice actors would expect £1,000.
“There’s no way anybody can compete.”

Pic: iStock
Shifting sands forming another job desert?
Not according to Oxford’s Labour economist Fabian Stephany, who was keen to “challenge the dystopian narrative”.
“It is very rare for a new technology to completely replace an entire profession,” says Stephany.
The only exceptions are jobs defined by a single task without any complexity, like bowling alley pinsetters or the translators at the top of Microsoft’s table, he says.
There’s complexity in Allen’s job, like creating video and TV soundtracks and mixing audio, but he’s still nervous.
“The AI subscription can mix for you too, so that’s production houses everywhere – we’re no longer needed. That’s quite scary.”
He adds: “I won’t be doing this in 10 years’ time.”
Microsoft researcher Kiran Tomlinson says AI “may prove to be a useful tool for many occupations” and “the right balance lies in finding how to use the technology in a way that leverages its abilities while complementing human strengths and accounting for people’s preferences”.
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Alexa, tell me what the government is doing
In January, Sir Keir Starmer said there was “barely an aspect of our society that will remain untouched” by AI in the coming years.
The technology is mentioned at least 126 times in the government’s industrial strategy for the tech sector, focusing heavily on its potential benefits.
Insufficient attention is being paid to its disruption, says Zhu. Why is Microsoft publishing reports on job exposure, but not the government? Where is the guidance on how employers and employees should adapt?
“The government should play some important role here, and they’re not,” she says.
Recalling how laid-off steelworkers were left to fend for themselves in the 20th century, Stephany warns it is “crucial to not make the mistakes of the past again”.
Allen couldn’t agree more: “All jobs under threat of AI need to be protected. Because otherwise, how the hell do people earn money?”
The government says it is putting people “at the heart” of its AI plans.
“That includes partnerships with leading tech firms to help us deliver AI skills training to 7.5 million workers, and initiatives to bring digital skills and AI learning into classrooms and communities,” a spokesperson says.
“This will provide training to people of all ages and backgrounds and is backed by £187m.”
They say “thousands of jobs” will be created by AI Growth Zones, areas earmarked for AI data centres where the state will support big tech companies with access to power and planning.

Keir Starmer announces the TechFirst programme teaching school pupils AI in June. Pic: PA
What can you do for yourself?
Workers should be concerned if they’re not trying to use AI, says the consultant.
CVs with AI skills have so far been consistently favoured by a group of 2,000 recruiters observed by Fabian Stephany in an ongoing study.
“If a worker is willing to invest in their skill set, in developing their profile, they should not be worried at all,” they say.
Almost half (45%) of global employers consider AI competency to be a core skill, according to the World Economic Forum.
LinkedIn data shows AI-related skills on member profiles rose 65% year-on-year in 2024.
Job postings on Indeed.com containing AI terms have risen by 170% since the end of June 2023 – albeit from a low starting point (1.7% to 4.6% by 31 August).
“If you’re willing to learn skills that allow you to integrate AI into the job that you’re currently doing, you will probably not only be doing fine, but you might actually have a big career boost ahead of you,” Stephany adds.
In a separate study of 10 million job vacancies in the UK, he found jobs asking for AI skills paid 23% more – a salary boost greater than that expected from a master’s degree (20%).
The best starting point is creating a free account with AI chatbots like ChatGPT, Claude or Gemini, says the AI consultant.
“Log into one of them, provide it a pretty detailed description of who you are, what you do day-to-day, both in your job and potentially in your personal life, and ask it how it can help.
“Right now, that can mean that you do your job better, which gets you promoted.”
Or maybe not.
In the past few months, writer Joe Turner has seen some clients make a sheepish return.
“I see an influx of new jobs coming in and people are now requesting no AI content at all,” he says.
Clients have found its hollow tropes and generic mannerisms carry the unmistakable mark of a “soulless machine”.
“It’s called AI, but it’s not artificial intelligence. It’s just a database of words with reasoning models,” he concludes.
“It puts the words in the right order, but at the end of the day, it means nothing.”
Politics
Corbyn and Sultana have ‘patched things up’ – but what really happened?
Published
3 hours agoon
October 11, 2025By
admin
For decades he was the dissident backbencher, then unlikely Labour leader. She was a firebrand left-wing Labour MP with a huge online presence. To the left – on paper – it looked like the perfect combination.
Coupled with the support of four other independent MPs, it held the blueprints of a credible party. But ever since the launch of Your Party (working title) the left-wing movement has faced mockery and exasperation over its inability to look organised.
First, we learned Jeremy Corbyn’s team had been unaware of the exact timing of Zarah Sultana’s announcement that she would quit the Labour Party. Then a much bigger row emerged when she launched a membership drive linking people to sign up to the party without the full consent of the team.
It laid bare the holes in the structure of the party and pulled focus away from its core values of trying to be a party to counter Labour and Reform UK, while also drawing out some pretty robust language from their only woman MP calling the grouping a “sexist boys club”. It gave the impression that she was being sidelined by the four other male MPs behind the scenes.
This week, they tried to come together for the first time at a rally I attended in Liverpool and then, in quick succession, another event at The World Transformed conference the day after. But not everyone I spoke to who turned up to see the two heroes of the left found them all that convincing.
Jeremy Corbyn admitted to me that “there were some errors made about announcements and that caused a problem”. He said he was disappointed but that “we’re past that”.

Jeremy Corbyn and Zarah Sultana take part in a discussion on Your Party at The World Transformed conference in Manchester. Pic: PA
Zarah Sultana said they were like Liam and Noel, who managed to “patch things up and have a very successful tour – we are doing the same”.
The problem is, it didn’t really explain what happened, or how they resolved things behind the scenes, and for some, it might have done too much damage already.
Layla signed up as a member when she first saw the link. It was the moment she had been waiting for after becoming frustrated with Labour. But she told me she found the ordeal “very unprofessional, very dishonest and messy”, and said she doesn’t want to be in a disorganised party and has lost trust in where her money will end up. She’s now thinking about the Greens. She said their leader, Zack Polanski “seemed like such a strong politician” with “a lot of charisma”.
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30:06
Jeremy Corbyn’s back – with Zarah Sultana and a new party. But is it a real threat to Labour, or just political theatre?
Since Polanski’s rise to power as leader, the Green Party has surged in popularity. According to a recent poll, they went up four points in just one week (following their conference). Voters, particularly on the left, seem to like his brand of “eco populism”.
While he has politely declined formally working in conjunction with Your Party publicly, he has said the “door is always open” to collaboration especially as he sees common goals between the two parties. Zarah Sultana said this weekend though that the Greens don’t describe themselves as socialists and that they support NATO which she has dubbed an “imperialist war machine”.
While newer coalitions may not be the problem for now, internal fissures might come sooner than they expect. Voters at the rally this weekend came with pretty clear concerns about some of the other independent MPs involved in Your Party.

The two heroes of the left fell out over a row over their party’s paid membership system
Read more on Sky News:
AI ‘distorting women online’
Pros and cons of digital IDs
Impact of new online safety rules
I asked Ayoub Khan if he considered himself left-wing. A question that would solicit a simple answer in a crowd like this. But he said his view was very simple, that he is interested in fighting for equality, fairness and justice: ‘We all know that different wards, different constituencies have different priorities and MPs should be allowed to represent the views of the communities they serve.” To him, that can sometimes mean voting against the private school tax and against decriminalising abortion.
The Your Party rally on Thursday night was packed, but the tone was subdued. People came full of optimism but they also wanted to make up their mind about the credibility of the new offering and to see the renewed reconciliation up close.
The organisers closed the evening off with John Lennon’s song, Imagine. That was apt, because until the party can get their act together, that’s all they’ll be doing.
Sports
M’s punch ALCS ticket in 15-inning instant classic
Published
6 hours agoon
October 11, 2025By
admin
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ESPN News Services
Oct 11, 2025, 01:19 AM ET
SEATTLE — Jorge Polanco hit a game-ending single in the 15th inning, and the Seattle Mariners advanced to the American League Championship Series by outlasting the Detroit Tigers for a 3-2 victory Friday night.
At 4 hours, 58 minutes, it was the longest winner-take-all postseason game in baseball history and featured 15 pitchers — eight for the Mariners and seven for the Tigers.
With one out and the bases loaded, Polanco drove in J.P. Crawford with a liner to right off Tommy Kahnle. Crawford hit a leadoff single, Randy Arozarena was hit by a pitch and Julio Rodriguez was intentionally walked before Polanco’s big swing on the 472nd pitch of an epic Game 5 in a tightly contested division series.
The Mariners left 12 runners on base and still advanced to the ALCS for the first time since 2001. Next up is a matchup with the AL East champion Blue Jays, beginning Sunday night in Toronto.
“We never give up,” Polanco said. “We just keep fighting. It doesn’t matter how many innings we play. We just stay ready and wait for the moment. It’s going to come. It was my time.”
Luis Castillo pitched 1⅓ innings for the win in his first major league relief appearance. Logan Gilbert, another member of Seattle’s rotation, worked two scoreless innings in his first relief outing since his college days at Stetson University in 2017.
“It was such a tough night,” Seattle catcher Cal Raleigh said. “Everyone put their other stuff aside and did everything for the team, including Logan and Luis.”
Detroit wasted a stellar performance by Tarik Skubal, who struck out 13 while pitching six innings of one-run ball. The Tigers went 1-for-9 with runners in scoring position and left 10 on base.
“We had an incredible game today that — unfortunately, somebody had to lose, and that somebody was us, and it hurts,” manager A.J. Hinch said.
Kerry Carpenter put Detroit in front when he hit a two-run homer off Gabe Speier in the sixth inning. Carpenter had four hits and walked twice, becoming the first player to reach five times and hit a home run in a winner-take-all postseason game since Babe Ruth in 1926.
The Mariners tied it at 2 on Leo Rivas‘ pinch-hit single off Tyler Holton in the seventh. Rivas celebrated his 28th birthday with his first postseason hit.
“He was up to the task tonight,” Seattle manager Dan Wilson said. “It was a huge hit.”
Friday’s win was the Mariners’ first series-clinching victory in extra innings since Game 5 of the 1995 ALDS, a 6-5 victory in 11 innings over the Yankees.
The Associated Press and ESPN Research contributed to this report.
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