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By Bhavana Kunkalikar Apr 27 2023 Reviewed by Lily Ramsey, LLM

In a recent study published in the American Journal of Preventive Cardiology, researchers explored the impact of ketogenic dieting on low-density lipoprotein (LDL) cholesterol levels.

Study:  Dramatic elevation of LDL cholesterol from ketogenic-dieting: A Case Series . Image Credit: SewCreamStudio/Shutterstock.com Background

Due to the escalating obesity levels, the ketogenic (keto) diet has been studied as a potential remedy for overweight patients' deteriorating weight gain, cardiovascular outcomes, and insulin resistance.

Though popular as a comparatively safe, non-pharmaceutical therapy, the long-term effects of the keto diet for weight loss are not fully understood, and most professional medical societies do not advise this regimen.

Some individuals on a ketogenic diet may experience a significant rise in low-density lipoprotein (LDL) cholesterol levels due to its high saturated fatty acid content. About the study

In the present study, researchers described a cohort of patients whose LDL-cholesterol levels rose to an unprecedented level after beginning a ketogenic diet.

The team evaluated medical records of patients who presented to Cardiology for a hyperlipidemia diagnosis after lipid panel blood work revealed an LDL cholesterol level of 190 mg/dL or more. The charts of these patients were cross-referenced to involve the words "keto" or "ketogenic".

The physician's notes were manually inspected for the patient's dietary routines to confirm that these terms were correctly applied. Almost 17 patients consuming a high-fat, low-carbohydrate diet (called the ketogenic diet) were detected and evaluated via chart review.  Results

Eleven patients were male, and six were female. The mean age at hyperlipidemia assessment was 46 years. The ethnicity of 14 patients was Caucasian, while one was Lebanese, one was Asian, and one was Hispanic.

Two patients reported a history of documented coronary artery disease, one had prior ST-elevation myocardial infarction (STEMI), and another reported coronary artery calcifications. Also, ten patients revealed a family history of hyperlipidemia and atherosclerotic coronary disease. Three patients fulfilled the criteria for familial hyperlipidemia established by the Dutch Lipid Clinic Network. Related StoriesNew VA Medical Center program to help veterans with atherosclerotic cardiovascular diseaseReversing infertility in sterile mice by reducing high-circulating cholesterol with a bacterial proteinLDL cholesterol levels reduced by oral PCSK9 inhibitor in phase 2 trial

The patient's body-mass index (BMI) ranged from 14.83 to 43.87 kg/m2, averaging 27 kg/m2. Only one patient had xanthelasmas, while the others did not. No patients displayed additional physical manifestations of hyperlipidemia, such as tendinous xanthomas or corneal arcus.

The cohort's average LDL cholesterol at baseline was 129 mg/dL. Almost three patients presented with no basal LDL cholesterol levels before recruitment. During an average of 12.3 months on a low-carbohydrate and high-fat diet, the mean LDL cholesterol was 316 mg/dL.

Thirteen patients who stopped dieting and received a lipid panel after almost nine months had an average LDL cholesterol level of 142.7 mg/dL. Seven of these thirteen patients who underwent follow-up laboratory testing could change their LDL cholesterol through dietary modification alone without altering their exercise routine. Statin medications were prescribed to eight patients. At follow-up, one of the patients continued the ketogenic regimen.

In seven and ten patients, Apolipoprotein A1 (Apo A1) and Apo B were collected, respectively. The mean Apo A1 concentration was 149.4 mg/dL, and the mean Apo B concentration was 191 mg/dL.

Furthermore, no acute atherosclerotic cardiovascular disease (ASCVD) events have been recorded while these patients were on the ketogenic diet. Five patients were evaluated genetically for familial hypercholesterolemia. Two patients were discovered to have an LDL-R gene mutation. Conclusion

The study findings showed patients who followed the ketogenic diet for 12.3 months displayed a mean elevation in LDL cholesterol of 187 mg/dL, accounting for a 245% increase.

When patients stopped consuming the ketogenic regimen, their LDL cholesterol levels were reduced by a mean of 174 mg/dL, or 220%. Further research is necessary to comprehend this heightened response's causes and long-term medical importance. Journal reference:

Schmidt, T. et al. (2023) "Dramatic elevation of LDL cholesterol from ketogenic-dieting: A Case Series", American Journal of Preventive Cardiology, 14, p. 100495. doi: 10.1016/j.ajpc.2023.100495.https://www.sciencedirect.com/science/article/pii/S2666667723000363?via%3Dihub

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Ecosystem health is the missing link to blockchain’s long-term success

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Ecosystem health is the missing link to blockchain’s long-term success

Ecosystem health is the key to blockchain’s long-term success. Cultivating transparency, strong developer tools and engaged communities, blockchain networks can grow securely and sustainably.

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Mabli Hall: Woman jailed for four years for causing eight-month-old baby’s death

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Mabli Hall: Woman jailed for four years for causing eight-month-old baby's death

A woman has been sentenced to four years in prison for causing the death of an eight-month-old baby by dangerous driving.

Bridget Curtis, 71, had previously pleaded guilty to causing the death of Mabli Cariad Hall outside Withybush Hospital in Haverfordwest, Pembrokeshire.

Mabli was airlifted to the University Hospital of Wales in Cardiff after she was hit by a white BMW on Wednesday 21 June 2023.

She was later moved to Bristol Royal Hospital for Children where she died four days later.

Mabli Cariad Hall died after a crash outside Withybush Hospital in Pembrokeshire. Pic: Family handout
Image:
Pic: Family handout

‘Entirely tragic’

Swansea Crown Court heard Mabli and her family were visiting her grandmother, who was receiving end-of-life care at the hospital, when the crash happened.

Prosecuting, Craig Jones said it was an “entirely tragic” case.

He said Mabli was “very nearly nine months” when she died, a day when the weather conditions were “fine and dry”.

Mabli was with her father in a grassed area under some trees opposite the hospital’s entrance.

“Mr Hall put Mabli back into her pushchair and was adjusting the straps when he heard the sound of an approaching vehicle,” Mr Jones said.

Bridget Curtis. File pic: Rex
Image:
Bridget Curtis. File pic: Rex

The court heard that Curtis had given her daughter a lift to the hospital for an appointment and had stopped the car outside the main entrance.

After she was dropped off, her daughter went to retrieve her handbag from the back of the car but was “unable to see the bag and tapped the window to attract her mother’s attention”.

“With the engine running, [the defendant] turned around from her seat to look in the back,” he said.

“The defendant had failed to switch off the vehicle and had failed to place the car, which was an automatic-geared vehicle, into a parked setting.”

In a period of four and a half seconds, the vehicle reached a top speed of 29 miles per hour and travelled a distance of 28 metres.

‘So beautiful’

In a victim impact statement, Rob Hall told the court he remembered Mabli “smiling at [him], making her cute noises”.

He said the “violent revving, screeching tyres” of the car was something he saw and heard “daily”.

Mr Hall said that after Mabli’s death, his family “were numb, felt helpless and destroyed”.

“This struggle continues to this day, and will always be there. Life from then until now has been horrendous. It’s been so hard to live this life,” he said.

“It’s exhausting, we’re drained, and I just don’t know how we recover from such trauma.”

Mabli Cariad Hall died after a crash outside Withybush Hospital in Pembrokeshire. Pic: Family handout
Image:
Pic: Family handout

Mabli’s mother, Gwen Hall, also read a victim impact statement from the witness box, telling the court the day Mabli died was the day her life “irreversibly changed for the worse”.

“She had said ‘Mamma’ for the first time only the day before,” she said.

Ms Hall said the family was “heartbroken”, but that the word “does not do justice to how broken and destroyed we are as a family”.

“Everyone needs to remember that Mabli was eight months old, she was so bright, so beautiful and so full of love and life. She was the apple of all our eye,” Ms Hall added.

“She was my best friend, my shadow, my second skin.”

‘Devastation of their lives’

In mitigation, Mr John Dye said the defendant had “led a blameless, law-abiding life”.

He said she had shown “extremely genuine remorse” and had written a letter to Mabli’s family.

The court heard Curtis had “ongoing mobility issues” and had caring responsibilities for her adult daughter.

Handing down his sentence of four years in prison, Judge Geraint Walters said “loving parents, siblings and a wider extended family suffered the devastation of their lives”.

“That is because that day, they suffered that which each parent dreads, the loss of a much-cherished child, then just eight months old,” he said.

“Her life was taken from her senselessly, and indeed needlessly, as a result of your actions.”

The judge said the case was aggravated by the fact that others were struck by the vehicle, namely Mabli’s father and uncle.

As well as the custodial sentence, Curtis was also disqualified from driving for eight years and would have to undergo a driving test before she could re-apply for a licence.

Mabli Hall, eight months, died after a crash outside Withybush Hospital. Pic: GoFundMe
Image:
Pic: GoFundMe

Addressing the media outside court, Mabli’s grandfather, Paul Sambrook, thanked “everyone who [had] been part of the process to secure justice for Mabli Cariad”.

“We’ve waited over 18 months for this day and finally this nightmarish chapter has come to an end,” he said.

“We’ll go home now and start to live our lives without Mabli. She was the sunshine who lit up our lives in so many ways, but now we have to focus on helping the other children of the family to cope with the loss and find a new way forward.

“If there is anything to learn from the pain and bereavement, this is what it is. Take care every time you sit behind the wheel of your car, think carefully about your own safety as well as the safety of others.”

Read more from Sky News:
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Iwan Jenkins from CPS Wales told Sky News that nothing could change “the tragic events of that day”.

“Although the criminal case has concluded, our thoughts remain with Mabli’s family over their heart-breaking loss and with everybody who received injuries on that day,” he added.

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Meet Cadillac’s new $80,000 Lyriq-V, the quickest Caddie (EV or gas-powered) so far

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Meet Cadillac's new ,000 Lyriq-V, the quickest Caddie (EV or gas-powered) so far

With 615 horsepower, the Cadillac Lyriq-V is the quickest Caddie to date. Cadillac’s first V-Series EV will outsprint a CT5-V Blackwing, and it can be yours for under $80,000.

The 2026 Lyriq-V EV is the fastest Cadillac ever

We knew it was coming soon. Cadillac teased the Lyriq-V for the first time in late October, giving a sneak peek at its first electric V-Series vehicle.

Cadillac’s performance brand is known for iconic sports cars like the CT5-V Blackwing, but the new EV pushes the “V-Series sub-brand to new heights,” boasted John Roth, vice president of Global Cadillac.

As the first EV to wear the V-Series badge, Cadillac promised the Lyriq-V would be powerful, but we didn’t know it would be this fast.

Cadillac officially introduced the 2026 Lyriq-V on Thursday, revealing additional specs, prices, and more. With an estimated 615 hp and 650 lb-ft of torque and a standard dual motor AWD powertrain, the EV is expected to accelerate from 0 to 60 mph in just 3.3 seconds, making it the quickest Cadillac to date.

Cadillac-Lyriq-V-EV
2026 Cadillac Lyriq-V (Source: GM)

At that speed, it would outrun the Cadillac CT5-V Blackwing with a 0 to 60 mph sprint time in 3.4 seconds. Although the CT-5 packs slightly more horsepower (668 hp), the Lyriq-V’s EV powertrain unlocks more powerful, instant acceleration.

The added power is enabled by an added Velocity Max feature, which “unleashes the vehicle’s full performance capability” with a surge of power and acceleration.

Cadillac-Lyriq-V-EV
2026 Cadillac Lyriq-V (Source: GM)

Interior and exterior design, prices, and features

The V-Series model differs from the traditional Lyriq with a lower center of gravity and custom front and rear bumpers. It also features V-Series badging on the rear doors and tailgate, V-pattern mesh on the lower grille, and 22″ wheels with the logo etched into the side.

Inside, the performance EV borrows features from the Lyriq, such as a panoramic fixed glass roof, a 23-speaker AKG sound system, and a massive 33″ LED display screen.

Cadillac distinguishes the V-Series from the traditional Lyriq by adding the V-Series logo, a V-mode button, and a sports rim with hand grips. Other unique features include a custom infotainment experience with a “V-Series persona,” a signature V-Series illuminated sill plate and V-pattern detailing on the seatbacks.

A 102 kWh battery pack is expected to provide a range of up to 285 miles. The 2026 Cadillac Lyriq-V starts at $79,990, including the destination fee.

Cadillac-Lyriq-V-EV
2026 Cadillac Lyriq-V (Source: GM)

In comparison, the Tesla Model Y Performance starts at $51,490 and has an EPA-estimated range of up to 277 miles. It also includes AWD and can accelerate from 0 to 60 mph in 3.5 seconds.

Cadillac’s new performance EV will be sold in the US, Canada, Australia, and New Zealand. Other markets will be announced closer to launch. GM will begin producing the new Lyriq-V at its Spring Hill, TN, manufacturing plant in early 2025.

What do you think of the Cadillac’s new performance EV? Would you buy one for $80,000? Or are you sticking with the Model Y Performance? Drop us a comment below to let us know.

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