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By Dr. Chinta Sidharthan Apr 28 2023 Reviewed by Lily Ramsey, LLM

In a recent study published in the PLOS ONE Journal, researchers reviewed existing studies on physical activity interventions for treating substance use disorders excluding studies that focused solely on tobacco use.

Study:  Characteristics and impact of physical activity interventions during substance use disorder treatment excluding tobacco: A systematic review. Image Credit: agny_illustration/Shutterstock.com Background

Substance use disorder is the problematic use of substances such as cannabis, alcohol, phencyclidine, hallucinogens, hypnotics, sedatives, inhalants, stimulants, opioids, anxiolytics, and other similar substances despite experiencing serious physical, behavioral, and cognitive symptoms.

The misuse of substances causing overdose or intoxication has short and long-term impacts on mental and physical health, including anxiety disorder, depression, asthma, heart disease, and cancer.

The treatment options for substance use disorders generally include residential and outpatient facilities that offer detoxification, but these have a significant relapse rate and low adherence.

Physical activity involving movement requiring energy expenditure has recently gained interest as a therapeutic tool in treating mental illnesses such as bipolar disorder, major depressive disorder, and schizophrenia.

Besides improving cardiovascular health and reducing depressive symptoms, physical activity has also decreased craving symptoms in tobacco users.

However, a shortage of reviews have focused on substance use disorders other than tobacco use, and many of the reviews have focused on a single substance. A large number of individuals with substance use disorders often misuse multiple substances.

Therefore, it is important to examine studies that include poly users of substances other than tobacco to understand the impact of physical activity in treating substance use disorder. About the study

In the present review, the researchers included studies involving adults above the age of 18 who were treated for substance use disorders related to various psychoactive substances such as cannabis, alcohol, phencyclidine, hallucinogens, opioids, inhalants, sedatives, stimulants, hypnotics, and anxiolytics, while excluding studies that focused on tobacco alone. Related StoriesResearchers examine impact of gamification on the effectiveness of digital health interventionsMore daily walking and moderate-to-vigorous physical activity reduced dementia, cognitive impairment riskBeing physically active at any time in adulthood linked to later life cognitive performance

The studies also involved chronic physical activity interventions offered during residential or detoxification treatments, including group or individual exercises and sports.

The examined outcomes included flexibility, aerobic capacity, other body composition and physical fitness outcomes, psychological outcomes such as changes in depressive symptoms, and life outcomes related to the social environment and behavior. The review only considered observational and experimental studies. Results

The results reported that 43 studies fit the eligibility criteria for the review and covered 3,135 participants. A large number (81%) of the studies were randomized controlled trials, followed by pre-post design and cohort studies (14% and 5%, respectively).

Physical activity of moderate intensity, spanning approximately 13 weeks with three sessions a week of about an hour each, was the most common intervention found in most studies.

The most examined outcome was the reduction or cessation of substance use, with 49% of the studies reporting a 75% reduction in substance use after the physical activity intervention.

The second most examined outcome was aerobic capacity, reported by 14 out of the 43 studies (33%), and 71% of these studies reported improvement in aerobic capacity after the intervention. Furthermore, 28% (12) of the studies also reported improvements in depressive symptoms.

The life outcomes examined by most studies covered quality of sleep and overall quality of life, and most studies reported improvements in both parameters after the initiation of physical activity interventions.

Cycling, walking, resistance exercises, and jogging were the most commonly preferred activities. Some studies also reported the use of tai chi and yoga.

The review discussed the mechanisms through which physical activity interventions could benefit substance use disorder patients. The increased physical awareness of the body, fitness, and health is thought to reduce dependence on drugs or alcohol.

Furthermore, changes in depressive symptoms were also associated with changes in anxiety disorder symptoms, indicating a concomitance between the two symptoms. Conclusions

To summarize, the review examined studies that investigated the application of physical activity interventions in treating substance use disorders, not including tobacco use alone.

Overall, the findings reported that physical activity interventions were associated with improvements in physical, psychological, and life outcomes.

Moderate levels of physical activity involving cycling, jogging, resistance exercises, walking, yoga, and tai chi were the preferred activities for most patients, and improvements were observed in aerobic capacity, depressive and anxiety disorder symptoms, and overall quality of life.

However, the authors believe that while physical activity interventions seem promising in treating substance abuse disorders, more rigorous and extensive research is required in the field. Journal reference:

Piché, F. et al. (2023) "Characteristics and impact of physical activity interventions during substance use disorder treatment excluding tobacco: A systematic review", PLOS ONE, 18(4), p. e0283861. doi: 10.1371/journal.pone.0283861. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0283861

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California judge rules DAO members liable under partnership laws

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California judge rules DAO members liable under partnership laws

A16z Crypto’s Miles Jennings posted on X that the ruling is a “huge blow” to decentralized governance. 

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Thousands of farmers to descend on Downing Street to protest against inheritance tax changes

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Thousands of farmers to descend on Downing Street to protest against inheritance tax changes

Thousands of farmers from across the UK are expected to gather outside Downing Street today – in the biggest protest yet against the government’s changes to inheritance tax rules.

The reforms, announced in last month’s budget, will mean farms worth over £1m will be subject to 20% inheritance tax from April 2026.

Farmers say that will lead to land being sold to pay the tax bill, impact food security and the future of British farming.

The Government insists it is “committed” to the farming industry but has had to make “difficult decisions”.

Farmers from Scotland, Northern Ireland, Wales and England will arrive in London to hear speeches from agricultural leaders.

Sky News understands TV presenter and farm owner Jeremy Clarkson, Conservative Party leader Kemi Badenoch and Lib Dem leader Ed Davey will also address crowds.

Protestors will then march around Parliament Square.

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A sign in a field by the M40 near Warwick, protesting the changes to inheritance tax (IHT) rules in the recent budget. Pic: PA
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A sign in a field by the M40 near Warwick, protesting the changes to inheritance tax rules in the recent budget. Pic: PA

‘It’s really worrying’

“It’s unfortunate, as Labour had originally said they would support farmers,” said fourth-generation farmer Will Weaver, who is attending today’s rally.

His 500-acre cow and sheep farm in South Gloucestershire has been in his family since 1939.

“We’ve probably buried our head in the sand a little bit. I think, back of a fag-packet rough estimates, tax is going to be north of half a million [pounds].”

The government is keen to stress that farmers will get a decade to pay the bill – but that comes as little comfort to Will: “It’s more than our profit in any year that we’ve had in the last 10 years. Dad’s saying we’ll have to sell something. I don’t know if we’ll be able to raise that sort of money through a mortgage. It’s really worrying.”

As anger grows, there continues to be disagreement between the National Farmer’s Union and the Government over how many farms will actually be impacted by the change.

The Treasury says only the wealthiest estates, around 500 of them, will have to pay under the new rules – claiming 72% of farms won’t be impacted.

But farmers say that calculation is incorrect – citing that DEFRA’s own figures show 66% of farms are valued at over £1m and that the government has undervalued many estates.

At the same time as the rally, the NFU is addressing 1,800 of its members in Westminster before they lobby MPs.

More on this story:
Farmers warn of food price hikes

Minister downplays risk of empty shelves if farmers strike

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The president of the National Farmers’ Union says farmers are feeling

‘Understanding has been betrayed’

Max Sealy represents the NFU Dairy Board in the South of England.

“We have a detailed job to do to explain why this is wrong not just for farming, not just for the countryside and not just for our families, but for the economy in general,” he said.

“This is a bad tax – it’s been badly implemented because it will affect growth productivity in the country.”

He told Sky News Labour made promises to farmers ahead of the election.

“Both Steve Reed and Keir Starmer came to our conference two years ago and told us farming wasn’t a business like any others and that he understood the long-term nature of farming – that understanding has been betrayed,” he said.

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And the government say:

In a joint statement, Chancellor Rachel Reeves and Secretary of State for Environment, Food and Rural Affairs Steve Reed said: “Farmers are the backbone of Britain, and we recognise the strength of feeling expressed by farming and rural communities in recent weeks. We are steadfast in our commitment to Britain’s farming industry because food security is national security.

“It’s why we are investing £5bn into farming over the next two years – the largest amount ever directed towards sustainable food production, rural economic growth and nature’s recovery in our country’s history.

“But with public services crumbling and a £22bn fiscal hole that this Government inherited, we have taken difficult decisions.

“The reforms to Agricultural Property Relief ensure that wealthier estates and the most valuable farms pay their fair share to invest in our schools and health services that farmers and families in rural communities rely on.”

A Met Police spokesperson said it was “well prepared” for the protest and would have officers deployed to ensure it passes off “safely, lawfully and in a way that prevents serious disruption”.

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Fintech unicorns are watching Klarna’s debut for signs of when IPO window will reopen

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Fintech unicorns are watching Klarna's debut for signs of when IPO window will reopen

Hiroki Takeuchi, co-founder and CEO of GoCardless. 

Zed Jameson | Bloomberg | Getty Images

LISBON, Portugal — Financial technology unicorns aren’t in a rush to go public after buy now, pay later firm Klarna filed for a U.S. IPO — but they’re keeping a watchful eye on it for signs of when the market will open up again.

Last week, Klarna made a confidential filing to go public in the U.S., ending months of speculation over where the Swedish digital payments firm would list. Timing of the IPO is still unclear, and Klarna has yet to decide on pricing or the number of shares it’ll issue to the public.

Still, the development drew buzz from fintech circles with market watchers asking if the move marks the start of a resurgence in big fintech IPOs. For now, that doesn’t appear to be the case — however, founders say they’ll be watching the IPO market, eyeing pricing and eventually stock performance.

Hiroki Takeuchi, CEO of online payments startup GoCardless, said last week that it’s not yet time for his company to fire the starting gun on an IPO. He views listing as more of a milestone on a journey than an end goal.

“The markets have been challenging over the last few years,” Takeuchi, whose business GoCardless was last valued at over $2 billion, said in a CNBC-moderated panel at the Web Summit tech conference in Lisbon, Portugal.

“We need to be focused on building a better business,” Takeuchi added, noting that “the rest will follow” if the startup gets that right. GoCardless specializes in recurring payments, transactions that come out of a consumer’s bank account in a routine fashion — such as a monthly donation to charity.

Lucy Liu, co-founder of cross-border payments firm Airwallex, agreed with Takeuchi and said it’s also not the right time for Airwallex to go public. In a separate interview, Liu directed CNBC to what her fellow Airwallex co-founder and CEO Jack Zhang has said previously — that the firm expects to be “IPO-ready” by 2026.

“Every company is different,” Liu said onstage, sat alongside Takeuchi on the same panel. Airwallex is more focused on becoming the best it can be at solving friction in global cross-border payments, she said.

An IPO is a goal in the company’s trajectory — but it’s not the final milestone, according to Liu. “We’re constantly in conversations with our investors shareholders,” she said, adding that will change “when the time is right.”

‘Stars aligning’ for fintech IPOs

One thing’s for sure, though — analysts are much more optimistic about the outlook for fintech IPOs now than they were before.

'Phantom debt' is flying under the radar — and it could be a problem for the U.S. economy

“We outlined five handles to open the [IPO] window, and I think those stars are aligning in terms of the macro, interest rates, politics, the elections are out the way, volatility,” Navina Rajan, senior research analyst at private market data firm PitchBook, told CNBC.

“It’s definitely in a better place, but at the end of the day, we don’t know what’s going to happen, there’s a new president in the U.S.,” Rajan continued. “It will be interesting to see the timing of the IPO and also the valuation.”

Fintech companies have raised around 6.2 billion euros ($6.6 billion) in venture capital from the beginning of the year through Oct. 30, according to PitchBook data.

Jaidev Janardana, CEO and co-founder of British digital bank Zopa, told CNBC that an IPO is not an immediate priority for his firm.

“To be honest, it’s not the top of mind for me,” Janardana told CNBC. “I think we continue to be lucky to have supportive and long-term shareholders who support future growth as well.”

He implied private markets are currently still the most accommodative place to be able to build a technology business that’s focused on investing in growth.

However, Zopa’s CEO added that he’s seeing signs pointing toward a more favorable IPO market in the next couple of years, with the U.S. likely opening up in 2025.

That should mean that Europe becomes more open to IPOs happening the following year, according to Janardana. He didn’t disclose where Zopa is looking to go public.

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