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Scientists said Monday they have developed the first mobile printer that can produce thumbnail-sized patches able to deliver mRNA Covid vaccines, hoping the tabletop device will help immunise people in remote regions.

While many hurdles remain and the 3D printer is likely years away from becoming available, experts hailed the “exciting” finding.

The device prints two-centimetre-wide patches which each contain hundreds of tiny needles that administer a vaccine when pressed against the skin.

These “microneedle patches” offer a range of advantages over traditional jabs in the arm, including that they can be self-administered, are relatively painless, could be more palatable to the vaccine-hesitant and can be stored at room temperature for long periods of time.

The popular mRNA Covid-19 vaccines from Pfizer and Moderna need to be refrigerated, which has caused distribution complications — particularly in developing countries that have condemned the unequal distribution of doses during the pandemic.

The new printer was tested with the Pfizer and Moderna jabs, according to a study in the journal Nature Biotechnology, but the goal of the international team of researchers behind it is for it to be adapted to whatever vaccines are needed.

Robert Langer, co-founder of Moderna and one of the study’s authors, told AFP that he hoped the printer could be used for “the next Covid, or whatever crisis occurs”.

Ana Jaklenec, a study author also from the Massachusetts Institute of Technology, said the printer could be sent to areas such as refugee camps or remote villages to “quickly immunise the local population,” in the event of a fresh outbreak of a disease like Ebola.

Vacuum-sealed

Microneedle patch vaccines are already under development for Covid and a range of other diseases, including polio, measles and rubella.

But the patches have long struggled to take off because producing them is an expensive, laborious process often involving large machines for centrifugation.

To shrink that process down, the researchers used a vacuum chamber to suck the printer “ink” into the bottom of their patch moulds, so it reaches the points of the tiny needles.

The vaccine ink is made up of lipid nanoparticles containing mRNA vaccine molecules, as well as a polymer similar to sugar water.

Once allowed to dry, the patches can be stored at room temperature for at least six months, the study found. The patches even survived a month at a balmy 37 degrees Celsius (99 Fahrenheit).

Mice which were given a vaccine patch produced a similar level of antibody response to others immunised via a traditional injection, the study said.

The printed patches are currently being tested on primates, which if successful would lead to trials on humans.

A real breakthrough?

The printer can make 100 patches in 48 hours. But modelling suggested that — with improvements — it could potentially print thousands a day, the researchers said.

“And you can have more than one printer,” Langer added.

Joseph DeSimone, a chemist at Stanford University not involved in the research, said that “this work is particularly exciting as it realises the ability to produce vaccines on demand”.

“With the possibility of scaling up vaccine manufacturing and improved stability at higher temperatures, mobile vaccine printers can facilitate widespread access to RNA vaccines,” said DeSimone, who has invented his own microneedle patches.

Antoine Flahault, director of the Institute of Global Health at the University of Geneva, said that production and access to vaccines could be “transformed through such a printer”.

“It might become a real breakthrough,” he told AFP, while warning that this depended on approval and mass production, which could take years.

Darrick Carter, a biochemist and CEO of US biotech firm PAI Life Sciences, was less optimistic.

He said that the field of microneedle patches had “suffered for 30 years” because no one had yet been able to scale up manufacturing in a cost-effective way.

“Until someone figures out the manufacturing scale-up issues for microneedle patches they will remain niche products,” he told AFP.


Xiaomi launched its camera focussed flagship Xiaomi 13 Ultra smartphone, while Apple opened it’s first stores in India this week. We discuss these developments, as well as other reports on smartphone-related rumours and more on Orbital, the Gadgets 360 podcast. Orbital is available on Spotify, Gaana, JioSaavn, Google Podcasts, Apple Podcasts, Amazon Music and wherever you get your podcasts.
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How NASA Saved a Dying Camera Near Jupiter with Just Heat

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How NASA Saved a Dying Camera Near Jupiter with Just Heat

NASA’s Juno spacecraft, in orbit around Jupiter, had a huge problem when its JunoCam imager started to fail after sitting through the planet’s harsh radiation belts for so many orbits. Designed to only last through the initial few orbits, JunoCam astonishingly endured 34 orbits. Yet by the 47th orbit, the effects of radiation damage became visible, and by the 56th orbit, images were almost illegible. With few alternatives and time slipping away before a close flyby of Jupiter’s volcanic moon Io, engineers made a daring but creative gamble. Employing an annealing process, they sought to resuscitate the imager by warming it up—an experiment that proved successful.

Long-distance fix

According to NASA, JunoCam’s camera resides outside the spacecraft’s radiation-shielded interior and is extremely vulnerable. After several orbits, it started developing damage thought to be caused by a failing voltage regulator. From a distance of hundreds of millions of miles, the mission team implemented a last-ditch repair: annealing. The technique, which subjects materials to heat in order to heal microscopic defects, is poorly understood but has been succeeding in the lab. By heating the camera to 77°F, scientists wished to reorient its silicon-based parts.

At first, efforts were for naught, but only days before the December 2023 flyby of Io, the camera unexpectedly recovered—restoring close-to-original image quality just in time to photograph previously unseen volcanic landscapes.

Radiation Lessons for the Future

Though the camera showed renewed degradation during Juno’s 74th orbit, the successful restoration has led to broader applications. The team has since applied similar annealing strategies to other Juno instruments, helping them withstand harsh conditions longer. Juno’s findings are now informing spacecraft design across the board. “We’re learning how to build radiation-tolerant systems that benefit both defense and commercial satellites,” said Juno’s principal investigator Scott Bolton. These findings would inform future missions, such as those visiting outer planets or working in high-radiation environments near Earth, in the Van Allen belts. Juno’s mission continues to pay dividends with unexpected innovations—a lesson in how a small amount of heat can do wonders.

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NASA’s X-59 Moves Closer to First Flight with Advanced Taxi Tests and Augmented Vision

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NASA’s X-59 Moves Closer to First Flight with Advanced Taxi Tests and Augmented Vision

X-59 of NASA has been designed from the ground to fly at a faster speed of sound without making thunderous sonic booms, which are usually associated with supersonic flight. This 99-foot aircraft, which features a logically elongated design, jettisons the front windscreen and is now heading towards the runway. Pilots can see what is at the front through an augmented reality (AR) enabled closed-circuit camera system, which is termed by NASA as the External Vision System (XVS). NASA took control of an experimental aircraft and performed taxi tests on it during this month.

X-59’s Futuristic Design: Eliminating Sonic Booms with External Vision System

According to As per NASA, the test pilot Nils Larson, during the test, drove the X-59 at the runway by keeping a low speed. This is done to ensure the working of the steering and braking systems of the jet. Lockheed Martina and NASA would perform the taxi tests at high speed, in which the X-59 will move faster to make it to the speed at which it will go for takeoff.

Taxi tests are held at the U.S. Air Force’s Plant 42 facility in Palmdale, California. The contractors and the Air Force utilise the plant for manufacturing and testing the aircraft. Lockheed Martin has developed this aircraft, whose Skunk Works is found in Plant 42.

Taxi Tests at Plant 42: NASA and Lockheed Martin Prepare X-59 for First Flight

Some advanced aircraft of the U.S. military were developed to a certain extent at Plant 42, together with the B-2 Spirit, the F-22 Raptor, and the uncrewed RQ-170 Sentinel spy drone.

SOFIA airborne observatory aircraft, which is a flying telescope called Plant 42, home recently retired. The space shuttle of the agency is the world’s first reusable spacecraft; these were assembled and tested at the facility.

Such taxi tests have started over the last months. NASA worked in collaboration with the Japan Aerospace Exploration Agency for testing a scale model of the X-59 in the supersonic wind tunnel to measure the noise created under the aircraft.

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Unusual Plasma Waves Above Jupiter’s North Pole Can Possibly Be Explained

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Unusual Plasma Waves Above Jupiter’s North Pole Can Possibly Be Explained

In recent observations, NASA’s Juno spacecraft has significantly detected the presence of a variety of plasma waves. The emergence of these waves on Jupiter’s powerful magnetic field is projected to be surprising, as their existence was never marked in the planetary magnetospheres. However, scientists might have come out with an explanation. Furthermore, the current studies have been questioned by scientists surfacing the activity at the North Pole. The article below will exemplify the findings and shed light on the plasmas. 

Uncovering Mystery at Jupiter’s North Pole 

According to a paper published in the Physical Review Letters, the scientists have uncovered the explanation behind the presence of these strange waves. They mainly suspect that the formation of these waves lies behind their evolution as a plasma, which later transforms into something different. 

Inside Jupiter’s Plasmas and Their Variants 

Plasmas are best referred to as the waves that pass through the amalgamation of the charged particles in the planet’s magnetosphere.These plasma waves come across in two forms: One, Langmuir waves, which are high-pitched lights crafted with electrons, while the other, Alfven waves, are slower, formed by ions (heavy particles). 

About Juno’s Findings

As unveiled by the Juno, the findings turned out to be questionable after the scientists noted that in Jupiter’s far northern region, the plasma waves were relatively slower. The magnetic field is about 40 times stronger than the Earth’s, but scientists were shocked to witness the results as the waves were slower. To analyse this further, a team from the University of Minnesota, led by Robert Lysak, identified the possibility of Alfven waves transforming into Langmuir waves. Post studying the data extracted from the Juno, the researchers then began to compare the relationship between the plasma wave frequency and number. 

According to Lysak’s research team, near Jupiter’s north pole, there might be a potential pathway of Alfven waves, which are massive in numbers, transforming into Langmuir waves. Scientists are also predicting that the reason behind evolution might be strong electrons that are shooting upwards at a very high energy. This discovery was made in the year 2016. Considering the current findings, the researchers indicate that Jupiter’s magnetosphere may comprise a new type of plasma wave mode that occurs during high magnetic field strength. 

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