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Scientists have published the first human “pangenome” — a full genetic sequence that incorporates genomes from not just one individual, but 47. 

These 47 individuals hail from around the globe and thus vastly increase the diversity of the genomes represented in the sequence, compared to the previous full human genome sequence that scientists use as their reference for study. The first human genome sequence was released with some gaps in 2003 and only made “gapless” in 2022. If that first human genome is a simple linear string of genetic code, the new pangenome is a series of branching paths.

The ultimate goal of the Human Pangenome Reference Consortium, which published the first draft of the pangenome on Wednesday (May 10) in the journal Nature (opens in new tab) , is to sequence at least 350 individuals from different populations around the world. Although 99.9% of the genome is the same from person to person, there is a lot of diversity found in that final 0.1%. 

“Rather than using a single genome sequence as our coordinate system, we should instead have a representation that is based on the genomes of many different people so we can better capture genetic diversity in humans,” Melissa Gymrek (opens in new tab) , a genetics researcher at the University of California, San Diego, who was not involved in the project, told Live Science. 

Related: More than 150 ‘made-from-scratch’ genes are in the human genome. 2 are totally unique to us. 

The newly drafted human pangenome is a collection of different genomes from which to compare an individual genome sequence. Like a map of the subway system, the pangenome graph has many possible routes for a sequence to take, represented by the different colors.   The detouring paths at the top of the image represent single nucleotide variants (SNVs), which are single letter differences. The yellow path that loops around itself and repeats the same nucleotides represents a duplication variant. The pink path that loops counterclockwise and follows the nucleotide sequence backwards represents an inversion variant. At the bottom, the green and dark blue paths miss the C nucleotide in its route and represent a deletion variant. The light blue path, which has extra nucleotides in its route, represents an insertion variant. (Image credit: Darryl Leja, NHGRI) A reference for health 

The first full human genome sequence was completed in 2003 by the Human Genome Project and was based on one person’s DNA. Later, bits and pieces from about 20 other individuals were added, but 70% of the sequence scientists use to benchmark genetic variation still comes from a single person. 

Geneticists use the reference genome as a guide when sequencing pieces of people’s genetic codes, Arya Massarat (opens in new tab) , a doctoral student in Gymrek’s lab who co-authored an editorial about the new research with her in the journal Nature, told Live Science. They match the newly decoded DNA snippets to the reference to figure out how they fit within the genome as a whole. They also use the reference genome as a standard to pinpoint genetic variations — different versions of genes that diverge from the reference — that might be linked with health conditions. 

But with a single reference mostly from one person, scientists have only a limited window of genetic diversity to study.

The first pangenome draft now doubles the number of large genome variants, known as structural variants, that scientists can detect, bringing them up to 18,000. These are places in the genome where large chunks have been deleted, inserted or rearranged. The new draft also adds 119 million new base pairs, meaning the paired “letters” that make up the DNA sequence, and 1,115 new gene duplication mutations to the previous version of the human genome.

“It really is understanding and cataloging these differences between genomes that allow us to understand how cells operate and their biology and how they function, as well as understanding genetic differences and how they contribute to understanding human disease,” study co-author Karen Miga (opens in new tab) , a geneticist at the University of California, Santa Cruz, said at a press conference held May 9. 

The pangenome could help scientists get a better grasp of complex conditions in which genes play an influential role, such as autism, schizophrenia, immune disorders and coronary heart disease, researchers involved with the study said at the press conference. 

For example, the Lipoprotein A gene is known to be one of the biggest risk factors for coronary heart disease in African Americans, but the specific genetic changes involved are complex and poorly understood, study co-author Evan Eichler (opens in new tab) , a genomics researcher at the University of Washington in Seattle, told reporters. With the pangenome, researchers can now more thoroughly compare the variation in people with heart disease and without, and this could help clarify individuals’ risk of heart disease based on what variants of the gene they carry. 

Related: As little as 1.5% of our genome is ‘uniquely human’  A diverse understanding 

The current pangenome draft used data from participants in the 1000 Genomes Project, which was the first attempt to sequence genomes from a large number of people from around the world. The included participants had agreed for their genetic sequences to be anonymized and included in publicly available databases. 

The new study also used advanced sequencing technology called “long-read sequencing,” as opposed to the short-read sequencing that came before. Short-read sequencing is what happens when you send your DNA to a company like 23andMe, Eichler said. Researchers read out small segments of DNA and then stitch them together into a whole. This kind of sequencing can capture a decent amount of genetic variation, but there can be poor overlap between each DNA fragment. Long-read sequencing, on the other hand, captures big segments of DNA all at once. RELATED STORIES—Humans’ big-brain genes may have come from ‘junk DNA’

—Rosalind Franklin knew DNA was a helix before Watson and Crick, unpublished material reveals

—Smallest genome of living creature discovered 

While it’s possible to sequence a genome with short-read sequencing for about $500, long-read sequencing is still expensive, costing about $10,000 a genome, Eichler said. The price is coming down, however, and the pangenome team hopes to sequence their next batches of genomes at half that cost or less. 

The researchers are working to recruit new participants to continue to fill in diversity gaps in the pangenome, study co-author Eimear Kenny (opens in new tab) , a professor of medicine and genetics at  the Institute for Genomic Health at Icahn School of Medicine at Mount Sinai in New York City, told reporters. Because genetic information is sensitive and because different rules govern data-sharing and privacy in different countries, this is delicate work. Issues include privacy, informed consent, and the possibility of discrimination based on genetic information, Kenny said. 

Already, researchers are uncovering new genetic processes with the draft pangenome. In two papers published in Nature alongside the work, researchers looked at highly repetitive segments of the genome. These segments have traditionally been difficult to study, biochemist Brian McStay (opens in new tab) of the National University of Ireland Galway, told Live Science, because sequencing them via short-read technology makes it hard to understand how they fit together. The long read technology allows for long chunks of these repetitive sequences to be read at once. 

The studies found that in one type of repetitive sequence (opens in new tab) , known as segmental duplications, there is a larger than expected amount of variation, potentially a mechanism for the long-term evolution of new functions for genes. In another type of repetitive sequence (opens in new tab) that is responsible for building the cellular machines that create new proteins, though, the genome stays remarkably stable. The pangenome allowed researchers to discover a potential mechanism for how these key segments of DNA stay consistent over time.

“This is just the start,” McStay said. “There will be a whole lot of new biology that will come out of this.”

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UK-US pact neither a free-trade agreement nor broad trade deal of Brexiteer dreams

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UK-US pact neither a free-trade agreement nor broad trade deal of Brexiteer dreams

Sir Keir Starmer was at home in Downing Street, watching Arsenal lose in the Champions League, when he got a call from Donald Trump that he thought presented the chance to snatch victory from the jaws of trading defeat.

The president’s call was a characteristic last-minute flex intended to squeeze a little more out of the prime minister.

It was enough to persuade Sir Keir and his business secretary Jonathan Reynolds, dining with industry bosses across London at Mansion House, that they had to seize the opportunity.

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The result, hurriedly announced via presidential conference call, is not the broad trade deal of Brexiteer dreams, and is certainly not a free-trade agreement.

It’s a narrow agreement that secures immediate relief for a handful of sectors most threatened by Mr Trump’s swingeing tariffs, with a promise of a broader renegotiation of “reciprocal” 10% tariffs to come.

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‘A fantastic, historic day’

Most pressing was the car industry, which Mr Reynolds said was facing imminent announcements of “very difficult news” at Britain’s biggest brands, including Jaguar Land Rover, which sounds like code for redundancies.

In place of the 25% tariffs imposed last month, a 10% tariff will apply to a quota of 100,000 vehicles a year, less than the 111,000 exported to the US in 2024, but close enough for a deal.

It still leaves the car sector far worse off than it was before “liberation day”, but, with one in four exports crossing the Atlantic, ministers reason it’s better than no deal, and crucially offers more favourable terms than any major US trading partner can claim.

For steel and aluminium zero tariffs were secured, along with what sounds like a commitment to work with the US to prevent Chinese dumping. That is a clear win and fundamental for the ailing industries in Britain, though modest in broad terms, with US exports worth only around £400m a year.

US and UK announced trade deal
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US and UK announced trade deal

In exchange, the UK has had to open up access to food and agricultural products, starting with beef and ethanol, used for fuel and food production.

In place of tariff quotas on beef that applied on either side (12% in the UK and 20% in America) 13,000 tonnes of beef can flow tariff-free in either direction, around 1.5% of the UK market.

The biggest wins

Crucially, sanitary and phytosanitary (SPS) production standards that apply to food and animal products, and prevent the sale of hormone-treated meat, will remain. Mr Trump even suggested the US was moving towards “no chemical” European standards.

This may be among the biggest wins, as it leaves open the prospect of an easing of SPS checks on trade with the European Union, a valuable reduction in red tape that is the UK’s priority in reset negotiations with Brussels.

Farmers also believe the US offers an opportunity for their high-quality, grass-fed beef, though there is concern that the near-doubling of ethanol quotas is a threat to domestic production.

Technology deals to come?

There were broad commitments to do deals on technology, AI and an “economic security blanket”, and much hope rests on the US’s promise of “preferential terms” when it comes to pharmaceuticals and other sectors.

There was no mention of proposed film tariffs, still unclear even in the Oval Office.

Taken together, officials describe these moves as “banking sectoral wins” while they continue to try and negotiate down the remaining tariffs.

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The challenge from here is that Mr Trump’s “reciprocal” tariff is not reciprocal at all. As commerce secretary Howard Lutnick proudly pointed out in the Oval Office, tariffs on US trade have fallen to less than 2%, while the UK’s have risen to 10%.

As a consequence, UK exporters remain in a materially worse position than they were at the start of April, though better than it was before the president’s call, and for now, several British industries have secured concessions that no other country can claim.

From a protectionist, capricious president, this might well be the best deal on offer.

Quite what incentive Mr Trump will have to renegotiate the blanket tariff, and what the UK has left to give up by way of compromise, remains to be seen. Sir Keir will hope that, unlike the vanquished Arsenal, he can turn it round in the second leg.

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Why Ukraine’s European allies will be nervously watching VE Day events in Red Square

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Why Ukraine's European allies will be nervously watching VE Day events in Red Square

Donald Trump has a soft spot for military spectacles and autocrats.

He will be looking on with envy as Vladimir Putin parades both in Moscow today, with Chinese leader Xi Jinping flying in to join Victory Day events in Red Square.

European allies of Ukraine will be watching nervously, wary of anything that could upturn the delicate quest for peace.

President Trump‘s patience with peddling his much vaunted “peace deal” has been wearing thin and allies had feared Ukraine could be punished for it.

That would have been grotesquely unfair, of course. Ukraine has bent over backwards to accommodate Mr Trump’s one-sided diplomacy that has so far seemed to favour the aggressor in this obscene war.

Russian army soldiers marching during a dress rehearsal for Victory Day parade in St. Petersburg on 7 May. Pic: AP/Dmitri Lovetsky
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Pic: AP

True, the Trump proposal does not agree to Russian annexation of all the land already taken by force and stops short of ordering the complete demilitarisation of Ukraine, but otherwise the proposals are pretty much everything that Moscow has asked for.

The deal is being pushed by Steve Witkoff, Mr Trump’s golf partner turned chief negotiator, a man regarded by diplomats as out of his depth and lost in the rough when it comes to the arts of statecraft.

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Like his president, Mr Witkoff has a history of doing business with Russian oligarchs, an apparently starry-eyed view of the Russian leader and has called Ukraine a “false country”.

Moment of truth approaching

Mr Witkoff and Mr Trump have so far given Mr Putin the benefit of the doubt, but a moment of truth is approaching. While Ukraine has agreed to a longer ceasefire in principle, Mr Putin will not.

Ukraine’s European allies feared that Mr Trump was about to despair of progress, blame Ukraine and take US military support with him.

Then came the minerals agreement between the US and Ukraine. The breakthrough gave the US president something to show for his efforts and assuaged his desire for some kind of deal. He seems to have moved on for now, at least, and approved the first $50m of arms sales to Ukraine.

Russian Air Force fly over Red Square, leaving trails of smoke in the colors of the Russian national flag during rehearsal. Pic: AP/Alexander Zemlianichenko
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Members of the Russian Air Force fly over Red Square during the rehearsal. Pic: AP

But these remain a tense few days ahead with plenty at stake.

Mr Putin’s self-declared three-day ceasefire raises the spectre paradoxically of escalation if either side breaks it.

The Russian lull is seen here in Kyiv as little more than a ploy.

If the Russian leader was serious about giving peace a chance, they say, he would have signed up to the permanent ceasefire being proposed by the Trump team.

Besides, Russia broke the last truce in Easter as soon as it had begun and used it to carry out surveillance and reinforcement operations says Kyiv. Why risk another pointless pause that is exploited by the invaders?

Escalation possible

If Russia plays the same games this time and Ukraine retaliates, there could be a significant escalation. Likewise, with any Ukrainian drone attack on Moscow during Victory Day.

Any major flare-up will not be looked on favourably by the US president if it upstages his first trip abroad this presidency, a three-day tour of the Middle East.

For now, his attention is not so much on the Ukraine conflict and he is no longer issuing threats to walk away and stop supporting the Ukrainians.

Russian servicemen march towards the Red Square before Victory Day military parade general rehearsal on 7 May. Pic: AP/Pavel Bednyakov
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Russian servicemen march towards Red Square in the rehearsal. Pic: AP

Read more from Sky News:
Ukraine and Russia accuse each other of breaching ceasefire
Putin prepares to host dozens of world leaders for Victory Day parade

That will be a relief here in the Ukrainian capital. They would be unwise to do anything to reengage him, for now at least.

Their European allies, though, know American involvement in this war appears to be receding.

Can they fill the vacuum?

This week, they remember the sacrifices made to bring peace and security to their continent 80 years ago.

Can they find the political will and unity to do so again, even without America?

Astonishingly, given all we have been through, that is still an open question.

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India will respond ‘in exactly the same light’ if Pakistan retaliates, high commissioner tells Sky News

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India will respond 'in exactly the same light' if Pakistan retaliates, high commissioner tells Sky News

India will respond to any escalation from Pakistan “proportionally and in exactly the same light”, the country’s high commissioner has told Sky News.

Weeks after 26 tourists were shot dead by gunmen in Indian-controlled Kashmir last month, India carried out missile strikes in Pakistan and Islamabad-administered parts of the disputed region.

On Wednesday, India said it hit nine “terrorist infrastructure” sites, while Pakistan said it was not involved in the April attack and the sites were not militant bases.

Pakistan’s Prime Minister Shehbaz Sharif has since vowed that India will “now have to pay the price” for their “blatant mistake,” and skirmishes have also been reported along the Line of Actual Control (LAC).

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Speaking to Sky’s The World with Yalda Hakim on Thursday, India’s high commissioner to the UK, Vikram Doraiswami, said “the original escalation is Pakistan’s sponsored terror groups’ attack on civilians”.

India strikes ‘reasonable,’ says high commissioner

He then insisted India’s strikes in Pakistan and Kashmir were “precise, targeted, reasonable and moderate,” adding: “It was focused principally and solely on terrorist infrastructure.

“We made it abundantly clear that the object of this exercise was clearly to avoid military escalation.

“A fact that was actually acknowledged – in a left-handed way of course – by the Pakistani side in terms of their own statements, which said the airspace hadn’t been violated.”

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India awaits Pakistan’s response

Pakistan chose ‘to escalate the matter’

The high commissioner also said about claims Pakistan shot down Indian aircraft with Chinese-made fighter jets: “If it satisfies Pakistan’s ego to say that they’ve done something, they could have used that as an off-ramp to move on.

“Clearly they’ve chosen not to, and they’ve chosen to escalate the matter.”

A boy collects papers from the debris of a residential house damaged by a cross-border shelling in Gingal village near the Line of Control (LoC) between India and Pakistan, in Indian Kashmir's Baramulla district, May 9, 2025. REUTERS/Stringer
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A boy collects papers from the debris of a damaged house in Gingal village. Pic: Reuters

And when asked about Pakistan’s threats of retaliation, Mr Doraiswami said: “We’re not looking for an escalation, but if Pakistan responds, as we have done, we will respond proportionally and in exactly the same light.”

He then referenced the border skirmishes, saying: “I do want to remind everybody: For the last 15 days, they’ve also opened artillery fire along the Line of Actual Control… That’s led to civilian casualties.”

Read more:
The story of India and Pakistan’s deadly conflict
How India and Pakistan’s militaries match up

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It comes after India said Pakistan attacked its military stations in the Kashmir region with drones and missiles on Thursday.

The country’s defence ministry said stations at Jammu, Pathankot and Udhampur were “targeted by Pakistani-origin” weapons, and added “the threats were swiftly neutralised”.

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