Connect with us

Published

on

Andrew Brookes | Image Source | Getty Images

Scientists have been using the same human genome sequence to study genomics for more than 20 years, but on Wednesday it got a major makeover.

Researchers published a new, more inclusive collection of reference human genome sequences in a landmark development that greatly expands on that original reference sequence.

The new pangenome reference includes genome sequences of 47 people from across the globe, according to a series of peer-reviewed papers published in the journal Nature on Wednesday. The original reference human genome sequence primarily came from one person, though it includes components from a total of around 20 people.

The pangenome better reflects the global gene pool, so scientists will be able to use it to more accurately identify genetic variations related to disease. The more diverse reference map will also eventually be used to help develop more personalized care that is tailored to an individual’s DNA, according to the researchers.

A genome is the complete set of DNA instructions necessary for an organism to grow and function. Scientists rely on a reference human genome to establish a “standard” they can use to study the variations that make people unique. On average, human beings’ genomes are around 99% identical, but small differences can give scientists insights into the traits that could affect an individual’s health. 

 “With a pangenome reference, we can accelerate clinical research by improving our understanding of the link between genes and disease traits,” Wen-Wei Liao, co-first author of the paper, said in a release

The pangenome uses advanced computational techniques to align all the genome sequences. These techniques helped fill in gaps left by the original reference by adding more than 100 million new DNA letters, the release said.  

“The human pangenome reference will enable us to represent tens of thousands of novel genomic variants in regions of the genome that were previously inaccessible,” Liao said. 

Scientists at the Human Pangenome Reference Consortium, which is funded by part of the National Institutes of Health, conducted the research.

Continue Reading

Technology

Cryptocurrencies decline as Trump’s U.S. bitcoin reserve plan falls short of expectations

Published

on

By

Cryptocurrencies decline as Trump's U.S. bitcoin reserve plan falls short of expectations

Jakub Porzycki | Nurphoto | Getty Images

Cryptocurrencies fell Thursday night after President Donald Trump signed an executive order creating a strategic bitcoin reserve for the United States and, separately, a “digital asset stockpile.”

The price of bitcoin was last lower by 3% at $87,586.86, according to Coin Metrics. Shortly after the news broke, it fell to as low as $84,688.13.

Earlier losses in other coins – specifically those that rallied at the beginning of the week after Trump said they would be included in the strategy – also eased. Ether was down 2%, trading at $2,184.08. XRP and Solana’s SOL token retreated 1% and 3%, respectively. Cardano’s ADA token tumbled 13%.

Stock Chart IconStock chart icon

hide content

Bitcoin (BTC)

White House crypto and AI czar David Sacks detailed in a post on X that the bitcoin reserve will include bitcoin already owned by the U.S. government that it seized from past law enforcement actions – a move, he emphasized, that will “not cost taxpayers a dime.” The U.S. currently owns more than 198,000 bitcoins worth about $17 billion, according to Arkham.

The stockpile of other coins will include “digital assets other than bitcoin forfeited in criminal or civil proceedings.” Sacks said the government will not acquire additional assets for it “beyond those obtained through forfeiture proceedings.” Arkham data shows the U.S. government owns about 56 ether tokens worth almost $119 million. It does not list XRP or the Solana or Cardano tokens.

Investors initially dumped their coins at the notion of the U.S. having no immediate planned purchases of bitcoin, per the order, against the backdrop of major weakness in equities.

“It is good news, but not what the market wanted in the short term,” said Steven Lubka, head of private clients and family offices at Swan Bitcoin. “People were hoping for near-term buy pressure.”

Sacks did point out that the Secretaries of Treasury and Commerce are authorized to develop “budget-neutral strategies for acquiring additional bitcoin, provided that those strategies have no incremental costs on American taxpayers,” and that there’s no plan to accumulate additional assets for the crypto stockpile beyond what’s already been obtained by the government.

The announcement came days after Trump teased new details on the highly anticipated bitcoin reserve that had become one of his biggest promises to the crypto industry on his campaign trail, and on the eve of the first White House Crypto Summit.

The crypto market has been rocked this week by the tariff war and inflation concerns, which have largely overshadowed the speculative excitement around the bitcoin reserve. JPMorgan on Wednesday said it doesn’t expect a big move higher in crypto in the near term, given the broader economic uncertainty and weakening demand.

Bitcoin briefly returned to the key $90,000 level earlier this week and is now hovering just below it. Investors and analysts have warned that until bitcoin can meaningfully hold above it, it’s at risk of a bigger pullback toward $70,000.

James Lavish of Bitcoin Opportunity Fund reacts to proposed U.S. strategic crypto reserve

Don’t miss these cryptocurrency insights from CNBC Pro:

Continue Reading

Technology

Oracle’s Federal Electronic Health Record experienced a nation-wide outage

Published

on

By

Oracle's Federal Electronic Health Record experienced a nation-wide outage

Jaque Silva | Nurphoto | Getty Images

Oracle’s Federal Electronic Health Record experienced a nation-wide outage on Tuesday, the Department of Veterans Affairs confirmed to CNBC.

The agency said “all users” of the company’s Federal EHR, including the VA, the Department of Defense, the U.S. Coast Guard and the National Oceanic and Atmospheric Administration, were impacted. Six VA medical centers, 26 community clinics, and remote VA sites experienced disruptions, the agency said.

“Affected VA medical facilities followed standard contingency procedures during the outage to ensure continuity of care for Veterans,” a VA spokesperson said in a statement Thursday.

An electronic health record, or an EHR, is a digital version of a patient’s medical history that’s updated by doctors and nurses. It’s crucial software within the U.S. health-care system, and outages can cause serious disruptions to patient care.

Oracle is one of the largest EHR vendors thanks to it’s $28 billion acquisition of the medical records giant Cerner in 2022. 

The company’s Federal EHR initially started experiencing issues at around 8:37 a.m. Eastern on Tuesday, the VA said. Users reported that the software froze and they were unable to access applications. Access was restored and cleared by 2:05 p.m. Eastern that day after Oracle restarted the system.

Oracle is carrying out an investigation to determine what caused the outage, the VA said. Oracle did not immediately respond to CNBC’s request for comment.

The outage marks Oracle’s latest stumble in a thorny, years-long EHR rollout with the VA, which has been marred by patient safety concerns. The agency launched a strategic review of Cerner in 2021, before Oracle’s acquisition, and it temporarily paused deployment of the software in 2023.

Four VA facilities in Michigan are slated to deploy Oracle’s Federal EHR in 2026.

In October, Oracle unveiled a brand-new EHR equipped with fresh cloud and artificial intelligence capabilities. The early adopter program for the software begins this year, though it’s not clear if the VA has plans to utilize it.

Oracle is slated to report third-quarter fiscal 2025 earnings on Monday.

Watch: Oracle CEO Safra Catz: Being number one is very important

Oracle CEO Safra Catz: Being number one is very important

Continue Reading

Technology

Broadcom shares soar 16% as earnings top estimates on demand for custom AI chips

Published

on

By

Broadcom shares soar 16% as earnings top estimates on demand for custom AI chips

Broadcom CEO Hock Tan.

Lucas Jackson | Reuters

Broadcom reported first-quarter earnings on Thursday that topped analysts’ expectations, and the chipmaker offered strong guidance for the current quarter. The stock jumped 16% in extended trading.

Here’s how the company did versus LSEG consensus estimates:

  • Earnings per share: $1.60 adjusted vs. $1.49 expected
  • Revenue: $14.92 billion vs. $14.61 billion expected

Broadcom said it expects about $14.9 billion in second-quarter revenue, higher than the $14.76 billion forecast by Wall Street analysts. Revenue in the last quarter rose 25% from $11.96 billion a year earlier.

The company said net income increased to $5.5 billion, or $1.14 per share, from $1.33 billion, or 28 cents per share, in the same period last year.

Broadcom’s artificial intelligence business is at the center of the company’s recent boom, which saw its stock price more than double last year. The company is one of the primary data center infrastructure vendors for AI, working both on Google’s custom AI chips as well as providing essential components for networking thousands of other chips together to develop advanced AI software.

Prior to the after-hours pop, the stock was down about 23% so far in 2025, as investors rotate out of risk partly due to concern about President Donald Trump’s tariffs.

Broadcom said it recorded $4.1 billion in AI revenue during the first quarter, which is 77% higher on a year-over-year basis. Those sales are reported as part of Broadcom’s semiconductor solutions business, which grew 11% on an annual basis to $8.21 billion during the quarter.

Broadcom CEO Hock Tan said in a statement that the company expects “continued strength in AI semiconductor revenue,” reaching a projected $4.4 billion in the second quarter.

In December, Broadcom said it was developing custom AI chips with three large cloud customers. Tan said on Thursday that in addition to those customers, it had “deeply engaged” with two other hyperscalers, and are working with four other potential customers to develop their own custom AI chips.

Tan said that Broadcom closely chooses partners for developing custom AI chips who can deploy the resulting product in large quantities. “To put it bluntly, we don’t do it for startups,” Tan said.

The other major part of Broadcom’s revenue comes from its infrastructure software division, which includes software from the company’s acquisition of VMware in the fourth fiscal quarter of 2023. Broadcom said it saw $6.7 billion in software sales during the quarter, a 47% increase on an annual basis.

WATCH: Chip stocks see strong performance punished by markets

Chip stocks see strong performances punished by markets

Continue Reading

Trending