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A universal flu jab is ready to be tested on humans and could put an end to people needing annual flu vaccinations. 

In a bad flu year, around 30,000 people in the UK die from flu, or from pneumonia, which can be a complication of flu.

Flu vaccines are available on the NHS for over-50s, pregnant people and those with certain health conditions, but they don’t cover every strain.

Instead, every year before flu season starts, experts predict which strains are likely to be more common and select three or four to be included in the next seasonal flu vaccine.

Manufacturers then need to make and distribute the vaccine – and in the meantime the virus may change, potentially making the vaccine less effective.

A universal jab that covers all flu strains could eliminate these stages and potential problems.

The jab is based on mRNA technology, which had its breakthrough moment with the success of COVID vaccines.

mRNA vaccines teach our cells how to make a protein that triggers an immune response inside our bodies.

Read more: How COVID vaccine research powered a giant leap in technological progress

The new universal flu vaccine uses a specific portion of a flu protein, hemagglutinin (HA), to produce a broad immune response.

While one portion of the HA protein, known as the head, tends to change as the flu virus spreads and evolves, a more stable portion – the stem – evolves very slowly and is similar across many different types of the virus.

By using the HA stem as the basis for a vaccine, researchers hope to induce long-term immunity against a broad range of flu virus types.

Read more on vaccination:
Cancer vaccines using the same mRNA technology as COVID vaccines are a step closer for UK
Breakthrough mRNA vaccine developed for cancer immunotherapy by Chinese scientists
The state of vaccination: Why 7,000 people died needlessly everyday before COVID

Volunteers for the clinical trial in the US are being enrolled at the Vaccine Research Centre run by the National Institute of Allergy and Infectious Diseases (NIAID).

The trial will test different doses of the vaccine to determine the optimum dose, which will then be tested again.

The study will also include a group of people who will get the normal seasonal flu vaccine.

Acting NIAID director Hugh Auchincloss said a universal vaccine would be a “major public health achievement”.

As well as potentially removing the need for yearly jabs, it has the potential to avert a possible future pandemic.

“A universal flu vaccine could serve as an important line of defence against the spread of a future flu pandemic,” he said.

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Diane Keaton, star of Annie Hall and The Godfather, has died

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Diane Keaton, star of Annie Hall and The Godfather, has died

Actress Diane Keaton, who starred in films including The Godfather and Annie Hall, has died aged 79.

Keaton’s daughter, Dexter Keaton White, confirmed her death in California to Sky’s US partner network NBC News.

With a long career, across a series of movies that are regarded as some of the best ever made, Keaton was widely admired.

She was awarded an Oscar, a BAFTA and two Golden Globe Awards, and was also nominated for two Emmys, and a Tony, as well as picking up a series of other Academy Award and BAFTA nominations.

Diane Keaton, with her best actress Oscar for Annie Hall in 1978. Pic: AP
Image:
Diane Keaton, with her best actress Oscar for Annie Hall in 1978. Pic: AP

Her best actress Oscar was for the Woody Allen film Annie Hall, which is said to be loosely based on her life.

She appeared in several other Allen projects, including Manhattan, as well as all three Godfather movies, in which she played Kay, the wife and then ex-wife of Marlon Brando’s son Michael Corleone, played by Al Pacino, opposite him as he descends into a life of crime and replaces his father in the family’s mafia empire.

With Woody Allen in 1978. Pic: Adam Scull/PHOTOlink.net/AP
Image:
With Woody Allen in 1978. Pic: Adam Scull/PHOTOlink.net/AP

Keaton was the kind of actor who helped make films iconic and timeless, from her heartbreaking turn as Kay Adams-Corleone to the “La-dee-da, la-dee-da” phrasing as Annie Hall, bedecked in the now famous necktie, bowler hat, vest and khakis.

Keaton also frequently worked with Nancy Meyers, starting with 1987’s Baby Boom.

Their other films together included 1991’s Father Of The Bride and its 1995 sequel, as well as 2003’s Something’s Gotta Give.

Keaton (centre) with Goldie Hawn (L) and Bette Midler at the premiere of  The First Wives Club in 1996. Pic: AP
Image:
Keaton (centre) with Goldie Hawn (L) and Bette Midler at the premiere of The First Wives Club in 1996. Pic: AP

In 1996, she starred opposite Goldie Hawn and Bette Midler in The First Wives Club, about three women whose husbands had left them for younger women.

More recently, she collaborated with Jane Fonda, Mary Steenburgen and Candice Bergen on the Book Club films.

‘Brilliant, beautiful’

The unexpected news of Keaton’s death was met with shock around the world.

Diane Keaton shows her hands after placing them on fresh cement during a ceremony TCL Chinese Theatre in 2022. Pic: Reuters
Image:
Diane Keaton shows her hands after placing them on fresh cement during a ceremony TCL Chinese Theatre in 2022. Pic: Reuters

Her First Wives Club co-star Midler wrote on Instagram: “The brilliant, beautiful, extraordinary Diane Keaton has died. I cannot tell you how unbearably sad this makes me.

“She was hilarious, a complete original, and completely without guile, or any of the competitiveness one would have expected from such a star. What you saw was who she was … oh, la, lala!”

Fellow co-star Goldie Hawn said Keaton had left “a trail of fairy dust, filled with particles of light and memories beyond imagination”.

“How do we say goodbye? What words can come to mind when your heart is broken? You never liked praise, so humble, but now you can’t tell me to ‘shut up’ honey. There was, and will be, no one like you,” Hawn added in a post on Instagram.

“You stole the hearts of the world and shared your genius with millions, making films that made us laugh and cry in ways only you could.”

Actor Ben Stiller paid tribute on X, writing: “Diane Keaton. One of the greatest film actors ever. An icon of style, humor and comedy. Brilliant. What a person.”

Kate Hudson, Goldie Hawn’s daughter, posted simply: “We love you so much Diane.”

Last year at New York Fashion Week. Pic: AP
Image:
Last year at New York Fashion Week. Pic: AP

In her Instagram tribute, Emmy, Grammy, Oscar, and Tony award-winning actress and producer Viola Davis said: “No!! No!!! No!! God, not yet, NO!!! Man… you defined womanhood.

“The pathos, humor, levity, your ever-present youthfulness and vulnerability – you tattooed your SOUL into every role, making it impossible to imagine anyone else inhabiting them.

“You were undeniably, unapologetically YOU!!! Loved you. Man… rest well. God bless your family, and I know angels are flying you home.”

Diane Keaton and her children, Duke (left) and Dexter Keaton, at the premiere of 'Book Club' in 2018. Pic: AP
Image:
Diane Keaton and her children, Duke (left) and Dexter Keaton, at the premiere of ‘Book Club’ in 2018. Pic: AP

Keaton never married.

She adopted her daughter Dexter at the age of 50 in 1996 and a son, Duke, four years later.

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‘No survivors’ in munitions factory explosion after 18 reported missing, police say

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'No survivors' in munitions factory explosion after 18 reported missing, police say

There are no survivors from a factory explosion that ripped through a munitions plant in rural Tennessee, police have confirmed.

Eighteen people were missing after the huge blast, but Humphreys County Sheriff Chris Davis has now confirmed all died.

It happened on Friday morning at Accurate Energetic Systems, a company which supplies and researches explosives for the military.

Officers guard the gate at Accurate Energetic Systems military explosives plant. Pic: Reuters
Image:
Officers guard the gate at Accurate Energetic Systems military explosives plant. Pic: Reuters

It scattered debris over at least half a mile (800m) and was felt by residents more than 15 miles (24km) away, Mr Davis said.

Aerial footage showed the company’s hilltop location smouldering and obliterated by smoke for much of Friday, with just a mass of twisted metal, burned-out shells of cars, and an array of debris left behind.

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Emergency services have been unable to fully attend the site due to secondary blasts.

Mr Davis described it as one of the worst scenes he had ever seen.

“What we need right now is we need our communities to come together and understand that we’ve lost a lot of people,” he said.

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The cause of the blast, which occurred about 60 miles southwest of Nashville, is not yet known but Mr Davis said it could be days, weeks or even months before foul play is ruled out.

Guy McCormick, a supervisory special agent with the Bureau of Alcohol, Tobacco, Firearms and Explosives said experts need to make the area safe before specialist investigators begin combing through the remains.

He said the safety and security of the scene could change quickly because of the heat and pressure caused by the explosion.

Signs near the site on Saturday asked for prayers for the families.

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Terry Bagsby, 68, who works at a petrol station nearby, said people in the close-knit community were “very, very sad”.

“I don’t know how to explain it… Just a lot of grief,” he added.

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Diane Keaton, star of Annie Hall and The Godfather, has died

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on

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Diane Keaton, star of Annie Hall and The Godfather, has died

Actress Diane Keaton, who starred in films including The Godfather and Annie Hall, has died aged 79.

Keaton’s daughter, Dexter Keaton White, confirmed her death to Sky’s US partner network NBC News.

With a long career, across a series of movies that are regarded as some of the best ever made, Keaton was widely admired.

She was awarded an Oscar, a BAFTA and two Golden Globe Awards, and was also nominated for two Emmys, and a Tony, as well as picking up a series of other Academy Award and BAFTA nominations.

Diane Keaton, with her best actress Oscar for Annie Hall in 1978. Pic: AP
Image:
Diane Keaton, with her best actress Oscar for Annie Hall in 1978. Pic: AP

Her best actress Oscar was for the Woody Allen film Annie Hall which is said to be loosely based on her life.

She appeared in several other Allen projects, including Manhattan, as well as all three Godfather movies, in which she played Kay, the wife and then ex-wife of Marlon Brando’s son Michael Corleone, played by Al Pacino, opposite him as he descends into a life of crime and replaces his father in the family’s mafia empire.

With Woody Allen in 1978. Pic: Adam Scull/PHOTOlink.net/AP
Image:
With Woody Allen in 1978. Pic: Adam Scull/PHOTOlink.net/AP

Keaton was the kind of actor who helped make films iconic and timeless, from her heartbreaking turn as Kay Adams-Corleone to the “La-dee-da, la-dee-da” phrasing as Annie Hall, bedecked in the now famous necktie, bowler hat, vest and khakis.

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Keaton also frequently worked with Nancy Meyers, starting with 1987’s Baby Boom.

Their other films together included 1991’s Father Of The Bride and its 1995 sequel, as well as 2003’s Something’s Gotta Give.

In 1996, she starred opposite Goldie Hawn and Bette Midler in The First Wives Club, about three women whose husbands had left them for younger women.

Keaton (centre) with Goldie Hawn (L) and Bette Midler at the premiere of  The First Wives Club in 1996. Pic: AP
Image:
Keaton (centre) with Goldie Hawn (L) and Bette Midler at the premiere of The First Wives Club in 1996. Pic: AP

More recently, she collaborated with Jane Fonda, Mary Steenburgen and Candice Bergen on the Book Club films.

‘Brilliant, beautiful’

Diane Keaton. Pic: AP
Image:
Diane Keaton. Pic: AP

The unexpected news was met with shock around the world.

Her First Wives Club co-star Midler wrote on Instagram: “The brilliant, beautiful, extraordinary Diane Keaton has died. I cannot tell you how unbearably sad this makes me.

“She was hilarious, a complete original, and completely without guile, or any of the competitiveness one would have expected from such a star. What you saw was who she was … oh, la, lala!”

Actor Ben Stiller paid tribute on X, writing: “Diane Keaton. One of the greatest film actors ever. An icon of style, humor and comedy. Brilliant. What a person.”

Kate Hudson, whose mother is Goldie Hawn, posted simply: “We love you so much Diane.”

In her Instagram tribute, Emmy, Grammy, Oscar, and Tony award-winning actress and producer Viola Davis said: “No!! No!!! No!! God, not yet, NO!!! Man… you defined womanhood.

“The pathos, humor, levity, your ever-present youthfulness and vulnerability – you tattooed your SOUL into every role, making it impossible to imagine anyone else inhabiting them.

“You were undeniably, unapologetically YOU!!! Loved you. Man… rest well. God bless your family, and I know angels are flying you home.”

Keaton never married. She adopted her daughter Dexter in 1996 and a son, Duke, four years later.

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