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A universal flu jab is ready to be tested on humans and could put an end to people needing annual flu vaccinations. 

In a bad flu year, around 30,000 people in the UK die from flu, or from pneumonia, which can be a complication of flu.

Flu vaccines are available on the NHS for over-50s, pregnant people and those with certain health conditions, but they don’t cover every strain.

Instead, every year before flu season starts, experts predict which strains are likely to be more common and select three or four to be included in the next seasonal flu vaccine.

Manufacturers then need to make and distribute the vaccine – and in the meantime the virus may change, potentially making the vaccine less effective.

A universal jab that covers all flu strains could eliminate these stages and potential problems.

The jab is based on mRNA technology, which had its breakthrough moment with the success of COVID vaccines.

mRNA vaccines teach our cells how to make a protein that triggers an immune response inside our bodies.

Read more: How COVID vaccine research powered a giant leap in technological progress

The new universal flu vaccine uses a specific portion of a flu protein, hemagglutinin (HA), to produce a broad immune response.

While one portion of the HA protein, known as the head, tends to change as the flu virus spreads and evolves, a more stable portion – the stem – evolves very slowly and is similar across many different types of the virus.

By using the HA stem as the basis for a vaccine, researchers hope to induce long-term immunity against a broad range of flu virus types.

Read more on vaccination:
Cancer vaccines using the same mRNA technology as COVID vaccines are a step closer for UK
Breakthrough mRNA vaccine developed for cancer immunotherapy by Chinese scientists
The state of vaccination: Why 7,000 people died needlessly everyday before COVID

Volunteers for the clinical trial in the US are being enrolled at the Vaccine Research Centre run by the National Institute of Allergy and Infectious Diseases (NIAID).

The trial will test different doses of the vaccine to determine the optimum dose, which will then be tested again.

The study will also include a group of people who will get the normal seasonal flu vaccine.

Acting NIAID director Hugh Auchincloss said a universal vaccine would be a “major public health achievement”.

As well as potentially removing the need for yearly jabs, it has the potential to avert a possible future pandemic.

“A universal flu vaccine could serve as an important line of defence against the spread of a future flu pandemic,” he said.

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Secret Service shoots armed man near White House, agency says

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Secret Service shoots armed man near White House, agency says

The Secret Service shot an armed man near the White House, the agency said.

The incident happened shortly after midnight on Sunday after an “armed confrontation” with law enforcement, according to the agency.

Local police had reported a “suicidal individual” possibly travelling to Washington DC from Indiana, the agency said.

“As officers approached, the individual brandished a firearm, and an armed confrontation ensued, during which shots were fired by our personnel,” the Secret Service said in a statement on X posted by spokesman Anthony Guiglielmi.

The suspect was transported to hospital and his condition was not known.

This breaking news story is being updated and more details will be published shortly.

Please refresh the page for the fullest version.

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Rating Donald Trump’s second term so far: He’s rattling the cage and so many here in Pennsylvania couldn’t be happier

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Rating Donald Trump's second term so far: He's rattling the cage and so many here in Pennsylvania couldn't be happier

President Trump promised profound change. His former aide Steve Bannon said the first few weeks would be ‘days of thunder’. 

It’s been all of that and more.

Domestically and globally Donald Trump has proudly upturned norms.

One key question for me these past few weeks has been: if much of the world (and liberal America) has been buffeted and bewildered by Donald Trump, what do those who chose him back in November think, nearly 50 days in?

I’ve been back to Pennsylvania, a place I have spent plenty of time over the past few years. It’s crucial in every election and was particularly so last November.

A Trump 2024 sign

The state is sort of a microcosm for the country. To the east and west are the urban Democratic strongholds of Philadelphia and Pittsburgh.

In between are the rural Republican heartlands. And dotted throughout are the hinterlands – smaller towns where there is more of a mix of voters but still with a general lean towards the Republicans or, more specifically, to Trump.

More on Donald Trump

Gettysburg and Waynesboro both voted broadly two-thirds for Trump and one-third for Kamala Harris back in November.

On the edge of Gettysburg, a bleak rocky outcrop marks the location of the battle which changed the course of the civil war. The threads which stitch America run through this place.

A few hundred metres away is the spot where Abraham Lincoln delivered his Gettysburg address.

It was 1863 and America’s 16th president marked the end of the battle with a reminder to a country divided by a civil war that it was a nation founded years earlier on the principles of liberty and equality.

Lincoln was America’s most consequential president, until now, maybe.

In the town’s Lincoln Square, a statue of the 16th president stands tall. My focus was the new White House occupant.

Lincoln Square in Gettysburg

“10!” It was the first of many ‘tens’ on my Trump scorecard.

“Oh he’s doing great…Yeah he’s doing real great,” one man said.

I asked what, in particular, he was happy with. “The money he’s making me.” The theme was the same with the next person.

“Trying to pass no tax on social security for one, no tax on tips, no tax on overtime – help out the workers, help out the retirees, that’s very important to me,” Mike said.

Mike speaks to Mark Stone

My third conversation was with a couple. I suggested to them that the federal firings had felt quite chaotic; a sledgehammer approach.

“No. I think they’re using a scalpel. They’re finding so much. It looks bad,” the man said.

“We had too many people that were in those jobs, they weren’t doing anything,” his wife added.

A couple tell Mark Stone that Donald Trump has been a 'scalpel' - not a 'sledgehammer'
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A couple say that Donald Trump has been a ‘scalpel’ – not a ‘sledgehammer’

“He’s upsetting Europe as well…” I said in my next conversation. “That’s not good, is it? We’re supposed to be friends.” I suggested with a smile.

“Yeah, well we need Europe to step up too,” the man replied.

'We need Europe to step up too'

Zelenskyy was here for a pay cheque and got a reality check,” another said, referring to the Oval Office showdown.

“I believe he wants to keep this war going, because as soon as this war is over, he’s going to be voted out,” he said.

“We’re an ocean apart. We’re doing him a big favour by supporting him.”

So much of what I heard was parroting President Trump almost word for word.

“You know, we gave him, what, $300bn? Where did that money go?”

There was no point in telling him that the true American contribution was about half that, and that it is all fully and publicly accounted for.

Lunch was at Chubby’s, a local pizza joint where I met Tom Jaskulski, a retired federal worker, now a handyman.

“He campaigned on all these policies, and he’s fulfilling them,” Tom told me. “It seems like the world’s waking up when Donald Trump came in office.

“A lot of things are happening worldwide, not just in this country.”

Tom Jaskulski speaks to Mark Stone
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‘He’s rattling the hornet’s nest,’ Tom Jaskulski says

Tom’s score? “10! Not because I’m wearing his hat, but a 10 because he’s doing what he says he’s going to do.

“You know, he’s rattling the hornet’s nest.”

Down the road, at the Yankee Doodle Pet Spa, Tina and her 22-year-old apprentice Molly had no regrets and were baffled that anyone could think they would.

“He’s doing what he said he was going to do and I am quite happy with him right now,” Tina said.

Tina speaks to Mark Stone
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‘I don’t think (Ukrainians) deserve our money,’ Tina says

Our conversation turned to Ukraine. I wanted to know her thoughts on President Trump’s abruptly shifting position and near-abandonment of Kyiv.

“It’s not our war. We have enough people in this country suffering, that’s how I feel about it. I don’t think they deserve our money,” Tina said, quoting the president’s exaggerated figures for how much America had spent in Ukraine.

But then our conversation cut to the core of where America is right now: siloed worlds.

Read more:
Russia ‘appears to have ignored Trump warning’
‘Trump bump’ turns to a Trump slump

We were discussing Elon Musk and his efforts to cut government bureaucracy.

“The social security, blowing that open with all of the people that are over 124 still getting social security,” Molly said of Musk’s claim that he had discovered social security was being paid to dead people.

“160 years old, I heard…” said Tina.

“Yeah, that’s insane,” Molly said.

Tina and Molly speak to Mark Stone

I interrupted: “You know that’s been debunked? That wasn’t true. I’m worried that people are believing things that actually aren’t true. That the Trump administration is telling you stuff that is not true. What do you think?”

“I think it’s both ways,” Molly said, “I think both sides put out fake news and fake propaganda for each other.”

It was clear she didn’t know who to believe. She’d lost all trust in the legacy media. She and Tina had been drawn to social media and they’d concluded President Trump was trustworthy.

Back in Lincoln Square, a chance meeting exposed the other side of all this – deep anxiety.

“I’m a trans person so a lot of his policies have been impacting transgender people and that is just, it’s a scary time to live in,” 22-year-old Em told me.

Em, a 22-year-old transwoman, speaks to Mark Stone
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Em said ‘there’s a lot of hatred in the world right now’

“There’s a lot of hatred in the world right now, especially at so many groups of people. I mean, it’s really… yeah…” Em said before trailing off, face filled with anxiety and emotion.

By nightfall my journey of conversations had taken me to the quiz night at a bar and brewery in Waynesboro.

“I’ve never been more embarrassed to be American…” one woman called Jacqueline said.

Jacqueline and Andrew speak to Mark Stone
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Jacqueline has ‘never been more embarrassed to be American,’ and Andrew says everyone is in their ‘own echo chambers’

Her quiz night partner, Andrew, chipped in. “I think it’s the access to information. I think we don’t go out and talk to each other.

“I think we’re on the internet all day. A lot of people are just on the internet and they’re getting news sources from their own echo chambers.”

“Things have been going downhill for a long time,” another man called Marco, at the next door table, said.

“I’m not saying Trump’s right about everything, but you know what? At least he’s trying, he’s doing something different. And I agree with what he’s doing.”

Marco speaks to Mark Stone
Image:
Marco says Donald Trump is ‘doing something different’

This wave of change has been profound. But to assume that those who chose this change – who chose Donald Trump – would have any regrets would be to fundamentally misunderstand America today.

The profound sentiment among everyone we spoke to who voted for him is that he is putting America first with a tangibility that they have never felt before.

It may turn out to be an illusion. But they feel no sense of that at the moment.

He is rattling the cage and so many here couldn’t be happier.

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State of emergency issued as fires sweep through New York’s Long Island

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State of emergency issued as fires sweep through New York's Long Island

A state of emergency has been issued in New York as brush fires sweep through swathes of Long Island and near Brooklyn.

Firefighters are battling the flames with National Guard helicopters providing air support, according to New York State governor Kathy Hochul.

The flames are being fanned by high winds that spewed thick smoke into the sky and caused the evacuation of a military base and the closure of a major highway.

Governor Hochul said emergency workers were responding to the fires around the Pine Barrens, a wooded area that is home to commuter towns east of New York City.

“This is still out of control at this moment,” she told Long Island TV station News 12.

“We’re seeing people having to be evacuated from the Westhampton area.”

Around the same time as videos started appearing on social media showing the fires, the Town of Southampton issued a warning against starting recreational fires due to the wildfire risk.

More on New York

“Exercise caution handling any potential ignition sources, including machinery, cigarettes, and matches,” the weather service warned.

“Any fires that ignite will have the potential to spread quickly.”

Read more from Sky News:
US pausing military aid is ‘betrayal’, soldier tells Sky News
Russia ‘appears to have ignored Trump warning’ after deadly strike
Gene Hackman’s wife died from rare infectious disease

NASA satellite data showed fire and smoke stretching roughly 2.5 miles along Sunrise Highway, a thoroughfare to the east end of Long Island.

Governor Hochul said homes, a chemical factory and an Amazon warehouse were at risk.

Video on social media showed plumes of smoke billowing from a fire near the Belt Parkway by Brooklyn.

The cause of the fires is not known at this time.

There have been no reports of injuries.

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