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Women who suffer from persistent acne have been given hope by a new cheap drug.

The drug, which is used to treat high blood pressure, could change the way acne in women is routinely treated.

Acne is common in adolescence but can occur during the adult years.

A team of researchers led by the Southampton Clinical Trials Unit carried out a trial on more than 400 women over the age of 18.

All the women had acne that had persisted for more than six months on which oral antibiotics would normally have been the next treatment.

In the first large-scale clinical trial, funded by the National Institute for Health and Care Research (NIHR), half of the participants were randomly allocated to take the drug known as spironolactone.

The other half were given a placebo or dummy pill.

What were the results?

Researchers found that spironolactone could offer an alternative for women with persistent acne.

After 12 and 24 weeks, women who were taking the drug saw significant improvements in their acne.

Professor Miriam Santer, GP and co-lead of the trial said: “The results showed that the women taking spironolactone saw a significant improvement in their acne after 12 and 24 weeks compared to those on the placebo.

“These results show that spironolactone could offer an alternative to antibiotics for many women with persistent acne to use alongside topical acne treatments.”

She added: “We hope the publication of these results will mean more GPs and dermatologists feel confident to prescribe spironolactone as a treatment for acne.

“The drug is already included in treatment guidelines for persistent acne in the US and Europe, and we hope this trial will lead to a change in the UK guidelines.”

Unfortunately, the drug is not suitable for men, according to Prof Santer and her co-author Alison Layton.

The pair wrote in the British Medical Journal: “Unfortunately, spironolactone is not considered an acceptable treatment option for men with acne. Use of spironolactone reduces blood testosterone levels which can result in gynaecomastia (breast swelling), and concerns have been raised about loss of sexual function in men.”

‘People would stare’

Kelly Cornick, 39, from Dorset, who used the drug, said that she was previously prescribed various creams and the contraceptive pill to try and control her acne.

Kelly Cornick, who suffered from persistent acne. Pic: PA
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Kelly Cornick, who suffered from persistent acne

Ms Cornick said she started with a lower dose of spironolactone and saw improvement in her acne. She was then given a higher dose of the drug and within a few months, her acne cleared up.

She said: “It was embarrassing. People would stare and you almost feel that they’re looking at you like you’re dirty and don’t wash properly.

“I think the worst thing for me was when one of my nieces said: ‘Have you got chicken pox?’.”

Ms Cornick continued: “Initially I started on the lower dose and there was an improvement. I then went on to the higher dose and within about three months everything was gone, all the spots had disappeared.

“Knowing how much it’s helped me, I hope that other people will now be given this treatment as an option instead of just trying the antibiotics. I want people to be able to experience it, because everyone should feel confident and happy, and not have spots.”

An alternative to antibiotics

Professor Andrew Farmer, director of the NIHR’s Health Technology Assessment Programme, said: “The treatment provides a valuable alternative to antibiotics and ensures clinicians can also better avoid the harms that can arise from antimicrobial resistance.”

The results come after the Commission on Human Medicines recommended new safety measures for the use of an anti-acne drug called isotretinoin.

This was after a number of people died by suicide while taking the drug – others also reported depression, anxiety and psychotic symptoms.

Cases of sexual dysfunction were also reported by patients who had been prescribed the medicine and in some cases, symptoms continued after patients stopped taking the drug.

The review of this drug has concluded that the benefits of isotretinoin – also known as Roaccutane – still outweigh the risks.

Read more from Sky News:
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What is spironolactone?

According to the NHS, spironolactone is an anti-androgen, which means it stops male hormones, such as testosterone, from working.

The drug can be used to treat the build-up of fluid in the body, which can be caused by heart failure, liver disease, kidney disease and high levels of aldosterone.

It is also used to treat high blood pressure (hypertension).

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Liam Payne’s One Direction bandmates Harry Styles and Louis Tomlinson among mourners as funeral takes place

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Liam Payne's One Direction bandmates Harry Styles and Louis Tomlinson among mourners as funeral takes place

Friends and family of Liam Payne, including his One Direction bandmates, have gathered to say goodbye at his funeral.

Harry Styles, Louis Tomlinson, Niall Horan and Zayn Malik were among the family and friends attending the private ceremony.

Simon Cowell, who put the band together on The X Factor, Payne‘s girlfriend Kate Cassidy, and former partner Cheryl were also there.

The 31-year-old died after he fell from a third-floor balcony at the Casa Sur Hotel in Buenos Aires, Argentina, on 16 October.

Fans from around the world have held their own vigils over the past few weeks, and tributes have been left today in his hometown, Wolverhampton.

Former One Direction band member Louis Tomlinson arrives for the funeral service of One Direction singer Liam Payne at St Mary's Church in Amersham, Buckinghamshire. Picture date: Wednesday November 20, 2024. PA Photo. The singer died after falling from a third-floor balcony of the Casa Sur Hotel in Buenos Aires last month, at the age of 31. See PA story FUNERAL Payne. Photo credit should read: Jonathan Brady/PA Wire
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Louis Tomlinson is also attending the ceremony. Pic: PA

Damian Hurley (right) and Kate Cassidy (centre) arrive for the funeral service of One Direction singer Liam Payne at St Mary's Church in Amersham, Buckinghamshire. Picture date: Wednesday November 20, 2024. PA Photo. The singer died after falling from a third-floor balcony of the Casa Sur Hotel in Buenos Aires last month, at the age of 31. See PA story FUNERAL Payne. Photo credit should read: Andrew Matthews/PA Wire
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Damian Hurley (right) arrived with Payne’s girlfriend, Kate Cassidy (centre). Pic: PA

Payne’s dark blue coffin, topped with white roses, arrived for the service on a horse-drawn carriage, bearing flowers reading “son” and “daddy” – for his son, Bear, with Cheryl.

Her Girls Aloud bandmates Nicola Roberts and Kimberley Walsh were also among those at the service, along with TV and radio presenters including James Corden, Marvin and Rochelle Humes, Scott Mills, and Adrian Chiles, and former professional footballer Robbie Keane.

US influencer Cassidy, who returned home from Argentina two days before his death, arrived with Damian Hurley, son of Elizabeth Hurley.

As Payne’s mother and father, Geoff and Karen, arrived at the church in the Home Counties, standing next to the carriage, silence fell among mourners outside.

A few locals and fans also gathered nearby, but in the main largely stayed away from the private ceremony.

Zayn Malik arrives to attend the funeral of former One Direction singer Liam Payne at St. Mary's Church in Amersham, near London, Britain, November 20, 2024. REUTERS/Toby Melville
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Zayn Malik. Pic: Reuters

Former One Direction band member Niall Horan (centre) arrives for the funeral service of One Direction singer Liam Payne at St Mary's Church in Amersham, Buckinghamshire. Picture date: Wednesday November 20, 2024. PA Photo. The singer died after falling from a third-floor balcony of the Casa Sur Hotel in Buenos Aires last month, at the age of 31. See PA story FUNERAL Payne. Photo credit should read: Jonathan Brady/PA Wire
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Niall Horan. Pic: PA

Payne rose to worldwide fame alongside Styles, Tomlinson, Malik and Horan on The X Factor in 2010, when they were put together to form One Direction. They went on to become one of the most successful UK pop groups of all time.

After the band announced their hiatus, the singer launched his solo career, releasing his debut album LP1 in December 2019.

His solo hits included Strip That Down, Bedroom Floor and For You, a collaboration with singer Rita Ora – who paid tribute to Payne as she hosted the MTV Europe Music Awards in Manchester.

Prosecutors in Argentina have launched an investigation into Payne’s death and announced earlier this month that three people had been charged in connection with the incident.

File photo dated 19/02/14 of (left to right) Zayn Malik, Harry Styles, Liam Payne, Louis Tomlinson and Nial Horan from One Direction with their Awards in the press room at the 2014 Brit Awards at the O2 Arena, London.. Liam Payne has died after falling from the third floor of a hotel in Buenos Aires, according to local officials. He was 31. Issue date: Wednesday October 16, 2024.
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One Direction in 2014: Zayn Malik, Harry Styles, Liam Payne, Louis Tomlinson and Nial Horan. Pic: PA

One Direction tributes

Payne’s One Direction bandmates all publicly paid tribute following his death.

“His greatest joy was making other people happy and it was an honour to be alongside him as he did it,” said Styles in his statement. “Liam lived wide open, with his heart on his sleeve, he had an energy for life that was infectious.

“He was warm, supportive and incredibly loving. The years we spent together will forever remain among the most cherished years of my life. I will miss him always, my lovely friend.”

Tomlinson said he had “lost a brother” and offered to be an uncle to Payne’s son, Bear, if he “ever needs me”.

Read more:
One Direction made dreams a reality – but fame wasn’t easy
He had the X Factor – but less support than artists today

A horse-drawn carriage carrying the coffin of Liam Payne arrives for the funeral service.
Pic: PA
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A horse-drawn carriage carried Payne’s coffin. Pic: PA

Floral tributes to singer Liam Payne at a memorial in West Park in his hometown of Wolverhampton. The funeral of the One Direction star will be held today in the Home Counties. Picture date: Wednesday November 20, 2024. PA Photo. The singer died after falling from a third-floor balcony of the Casa Sur Hotel in Buenos Aires last month, at the age of 31. See PA story FUNERAL Payne. Photo credit should read: Jacob King/PA Wire
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Flowers have also been left in West Park in his hometown of Wolverhampton. Pic: PA

Horan, who had been touring in South America and saw Payne at his show in the weeks before his death, said: “I feel so fortunate that I got to see him recently. I sadly didn’t know that after saying goodbye and hugging him that evening, I would be saying goodbye forever. It’s heartbreaking.”

Malik said Payne had supported him “through some of the most difficult times” of his life, and said he always had a “positive outlook and reassuring smile”.

Cowell also paid tribute, saying he was “devastated” and “heartbroken”.

He continued: “I wanted to let you know what I would always say to the thousands of people who would always ask me. What is Liam like? And I would tell them you were kind, funny, sweet, thoughtful, talented, humble, focused. And how much you loved music. And how much love you genuinely had for the fans.”

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UK to scrap warships, military helicopters and fleet of drones to save money despite threats abroad

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UK to scrap warships, military helicopters and fleet of drones to save money despite threats abroad

The UK will scrap five warships, dozens of military helicopters and a fleet of drones to save money despite growing threats from Russia and a war raging in Europe.

John Healey, the defence secretary, announced the dramatic move in parliament on Wednesday, saying it would save up to half a billion pounds over the next five years.

The defence secretary described the equipment being axed as “outdated” and said the “common sense” decision to retire them was long overdue.

Ukraine war latest: Follow live

He signalled the decision was part of a plan to restructure and modernise the armed forces, which have already been significantly reduced in size following decades of cost-saving cuts, with new capabilities due to come online to replace the gaps.

“We face increasing global threats,” Mr Healey said in a written statement that was released at the same time as he addressed MPs.

“War in Europe, growing Russian aggression, conflict in the Middle East and technology changing the nature of warfare. As a result, defence needs increased resilience and readiness for the future.”

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At the same time, though, he said the defence budget faced “serious financial pressures”.

Defence Secretary John Healey speaking in parliament on Wednesday
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Defence Secretary John Healey speaking in parliament on Wednesday

He repeated a pledge that the government would set out a course to lift the defence budget to 2.5% of national income – but yet again without giving a date.

The defence secretary then spelt out what “difficult decisions” meant in reality.

“To ensure that Britain is kept secure at home and strong abroad in a changing world, defence needs to make changes too. Difficult decisions are required,” he said.

The weapons systems on the chopping block are:

• The Royal Navy’s two amphibious assault ships, HMS Albion and HMS Bulwark. They will be taken out of service at the end of the year – around a decade early in a blow to the ability of the Royal Marines to launch land assaults from the sea.
• A fleet of 17 Royal Air Force Puma helicopters, as well as 14 of the military’s oldest Chinook helicopters
• A fleet of 47 Watchkeeper drones – each worth about £5m – barely six years since they entered into service
• HMS Northumberland, a Type 23 frigate, which is in need of costly repairs and has already operated well beyond an 18-year out-of-service date
• Two large Royal Fleet Auxiliary ships, RFA Wave Knight and RFA Wave Ruler – vessels which carry fuel and supplies to enable the Royal Navy’s aircraft carriers to operate around the world.

HMS Albion, a British Royal Navy amphibious assault ship, arrives at Harumi Pier in Tokyo, Japan August 3, 2018. REUTERS/Toru Hanai
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HMS Albion is due for the chopping block. File pic: Reuters

HMS Bulwark.
Pic: PA
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HMS Bulwark. Pic: PA

The announcement, while uncomfortable, is designed to be the least damaging way to reduce costs while retaining capability.

It comes ahead of a plan by the government to publish a sweeping new review of defence in the spring, which is being drawn up by an external team and is expected to recommend extensive changes across the army, Royal Navy and Royal Air Force.

The Ministry of Defence says that the equipment that is being axed – the term used is “accelerated retirement” – was selected because it is outdated and military chiefs need to focus finite money and personnel instead on the weapons systems most suited to modern warfare.

However, Russia’s war in Ukraine has demonstrated that old, outdated weapons are better than no weapons at all.

The Russian armed forces have relied heavily on old tanks, artillery guns and helicopters to fight after the weapons they used in the first weeks and months of the war were destroyed.

It takes years to build warships and helicopters.

Sir Keir Starmer will face uncomfortable challenges at the sight of amphibious assault vessels and Chinook transport helicopters being sold off or scrapped regardless of how old they are.

Yet it costs money to keep equipment in storage just in case it is needed.

Limited funds allocated to defence mean that military chiefs appear to have decided that scrapping weapons early is the least worst option.

The decision to scrap the British Army’s Mark 1 version of the Watchkeeper drone at a time when drones are such a dominant asset on the battlefield may also be tricky to defend.

A Watchkeeper drone on display in France in 2012.
File pic: AP
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A Watchkeeper drone on display in France in 2012. File pic: AP

However, the programme has been beset by delays, cost overruns and flaws.

The first Watchkeeper drones only started operating around 2018 – some eight years late.

They also struggle to operate in poor weather conditions – limiting their utility.

The rapid pace of evolving technology in drone warfare – where the development cycle is a mere six to eight weeks – means that the technology inside Watchkeeper, which was conceived of more than 14 years ago, may well be easily defeated in a fight.

It is understood that scrapping the aircraft means that the army will be able to focus money on developing new innovative drone capabilities.

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‘We need help’: Workers say shoplifting is ‘out of control’ as brazen thefts explode

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'We need help': Workers say shoplifting is 'out of control' as brazen thefts explode

A woman casually walks into a convenience store and starts filling a bread crate with goods from one of the aisles.

A shop assistant tries to stop her, but she shrugs him off, undeterred. With the crate now full of items, she leaves without paying.

It is a scenario that is played out day in and day out across Britain, as retailers warn the surge in shoplifting is now “out of control”.

A Nisa supermarket storefront
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Four in five store owners tell Sky News they’ve experienced shoplifting in the last week.

I’m sitting in the security office of a busy city centre shop and I’m watching as a schoolboy walks in and helps himself to a sandwich, stuffing it into his jacket.

Watching with me is shop worker Anton Mavroianu who positions himself by the main entrance waiting for the youngster to leave.

When the boy does leave, Anton demands the item back. Instead of being frozen with fear that he’s been caught, the boy laughs and walks off.

“All we can do is try to stop them,” Anton tells me. “But this is just another day for us.”

Anton Mavroianu
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Anton Mavroianu said he has been threatened with a knife while trying to stop shoplifters

A few weeks earlier, when Anton tried to stop a shoplifter who had stolen from the store, the man pulled out a knife and tried to attack him.

This terrifying incident is an example of the very real threat posed to shop workers as they try to stem the tide of brazen thefts.

Shoplifting offences recorded by police in England and Wales have risen to the highest level in 20 years.

The British Retail Consortium (BRC) also reports that theft-related losses cost the retail sector millions each year, adding strain to an industry already grappling with post-pandemic recovery and economic uncertainty.

For small businesses, which lack the resources of larger chains, persistent theft can threaten their very survival.

Read more on shoplifting:
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Theft and fraud costs Co-op nearly £40m in just 6 months

CCTV of a Nisa supermarket

Ricky Dougall owns a chain of convenience stores and says shoplifting cost his business around £100,000 last year.

“Shoplifting is a huge problem and it is what stops us from growing the business.

“People come in and help themselves like they own the place and when you call the police, most of the time, they don’t turn up.”

Supermarket owner Ricky Dougall - who says shoplifting cost his business around £100,000 last year
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Ricky Dougall said part of the problem is how shoplifting is classified during sentencing

Mr Dougall says part of the problem is how this type of crime is classified.

Sentencing guidelines for thefts of under £200, so-called “low level shoplifting”, were relaxed in 2016. That is being blamed for the surge in cases.

An exclusive Sky News and Association of Convenience Stores survey shows that 80% of shopkeepers surveyed had an incident of retail crime in the past week.

The poll also found 94% of shopkeepers say that in their experience, shoplifting has got worse over the last year, with 83% not confident that the police will take action against the perpetrators of retail crime on their premises.

Paul Cheema from the Association of Convenience Stores says retailers are looking to Government to support them.

“I would say officials do not give a s*** about us retailers,” he tells me. “The losses are too big and I don’t think we can sustain that anymore.

“I would urge Keir Starmer to come and meet us and see up close the challenges that we are facing.”

Retailers have responded by investing heavily in security measures, from advanced surveillance systems to hiring more security staff.

But these investments come at a cost, often passed down to consumers through higher prices.

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I get chatting to Matt Roberts, head of retail in the store I am in. He worries about shoplifting, but he worries about the staff more.

“I would imagine they dread coming to work because they’re always on tenterhooks wondering whether something is going to happen today, whether they are going to have to try and confront someone.

“It’s a horrible feeling. It’s out of control and we need help.”

Matt Roberts, head of retail at a Nisa supermarket
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Matt Roberts says he is concerned for his staff, who have to confront shoplifters

The government has acknowledged the urgency of the issue. Home Secretary-led discussions with retail associations and law enforcement are underway to craft a comprehensive strategy.

In the King’s Speech, the government outlined details of a Crime and Policing Bill, which promised to “introduce stronger measures to tackle low level shoplifting”, as well as introducing a separate offence for assaulting a shop worker.

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