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SINGAPORE – Nearly six months after China lifted all Covid-19-related curbs, investors are still waiting for the strong economic rebound they had assumed the policy pivot would unleash.

The much-vaunted recovery in lockdown-free China has thus far fallen short of expectations, underscored by data released earlier this week by Chinas National Bureau of Statistics.

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Science

First Mouse with Two Fathers Thrives into Adulthood

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First Mouse with Two Fathers Thrives into Adulthood

A major development in stem cell science has been achieved with the creation of a bi-paternal mouse, marking a significant step in reproductive biology. Scientists have successfully engineered a mouse with two male biological parents, which managed to survive into adulthood. This research, conducted by a team of stem cell experts, has addressed longstanding barriers in unisexual mammalian reproduction by modifying specific imprinting genes. The findings, which could have implications for regenerative medicine, highlight the challenges and potential future applications of the technology.

Genetic Modifications Enable Bi-Paternal Development

According to the study published in Cell Stem Cell, led by Wei Li of the Chinese Academy of Sciences (CAS), the team focused on overcoming imprinting-related challenges that previously prevented embryos with same-sex genetic origins from developing fully. Modifications were made to 20 imprinting genes using techniques such as frameshift mutations, gene deletions, and regulatory region edits. These changes allowed some bi-paternal embryos to survive to birth and, in rare cases, reach adulthood.

Co-corresponding author Qi Zhou of CAS explained to phys.org, that imprinting genes have been identified as a key obstacle in unisexual reproduction. Despite previous attempts using ovarian organoids derived from male stem cells, imprinting abnormalities caused severe developmental defects. By directly editing these genes, the research team improved embryonic viability and the stability of pluripotent stem cells.

Survival and Reproductive Challenges Remain

As per reports, only 11.8 percent of the engineered embryos developed to birth, and those that survived exhibited developmental abnormalities, reduced lifespan, and sterility. Guan-Zheng Luo of Sun Yat-sen University, a co-corresponding author, stated that imprinting abnormalities have been confirmed as the primary factor preventing unisexual reproduction in mammals.

Despite the limitations, this approach has demonstrated the potential for refining stem cell-based therapies and improving cloning efficiency. Researchers plan to expand the study to larger mammals, though substantial challenges remain due to differences in imprinting gene patterns across species.

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Massive 500,000-Mile Coronal Hole on the Sun Blasts Solar Wind Toward Earth



Huawei Could Be Developing New Smartwatch With In-Display Fingerprint Scanner

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Science

Scientists Discover Hidden Clues to the Dark Universe in 3D Galaxy Maps

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Scientists Discover Hidden Clues to the Dark Universe in 3D Galaxy Maps

New insights into the “dark universe,” which includes both dark matter and dark energy, have emerged from a new method of studying 3D maps of galaxies. Scientists have used sophisticated computer algorithms to analyse the relative positions of galaxies in a 3D framework, unveiling previously hidden information that could challenge or support the standard model of cosmology. This method, unlike older techniques, preserves the three-dimensional integrity of the data, offering a deeper understanding of the universe’s structure.

New Approach to Galactic Mapping

According to the study led by astronomer Minh Nguyen of the University of Tokyo, the latest approach utilises advanced field-level inference (FLI) techniques combined with algorithms to model galaxy growth and dark matter halos. This technique builds upon the traditional method of galaxy surveys, which in the past relied on two-dimensional measurements. By adding a third dimension through redshift data, scientists have been able to map galaxies more accurately and analyse their distribution in space.

In traditional methods, data is often compressed into “n-point correlation functions,” which, while efficient, have been shown to obscure key details. The FLI technique, which works directly with 3D data, allows for a more nuanced and detailed analysis of galaxy positioning. As Nguyen told space.com, this new method reveals hidden information about the distribution and behaviour of galaxies and their surrounding dark matter, shedding light on potential inconsistencies in current cosmological theories.

Unlocking Dark Matter Mysteries

The breakthrough could lead to new discoveries about the evolution of galaxies and their interactions with dark matter. Initial tests have shown a significant improvement in accuracy when compared to traditional methods, with researchers noting a three to five times greater level of detail. The next phase of testing will involve real data from upcoming space missions and observatories, including the Dark Energy Spectroscopic Instrument and the Vera C. Rubin Observatory.

This technique could ultimately provide insights into the nature of dark matter and its role in the universe’s formation, potentially unlocking answers to some of the most pressing questions in modern astrophysics.

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Politics

XRP’s 50% rally outperforms crypto market in January — Is $4 the next stop?

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<div>XRP's 50% rally outperforms crypto market in January — Is  the next stop?</div>

XRP decoupled from the crypto market after positive regulatory developments for Ripple Labs reinforced investors’ bullish conviction in the altcoin.

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