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Amazon Web Services logo at the Web Summit in Lisbon.

Henrique Casinhas | Sopa Images | Lightrocket | Getty Images

Just as the periodic table is foundational to chemistry and the Human Genome Project revolutionized modern genetics, researchers at the Allen Institute for Brain Science have teamed up with Amazon Web Services to create what could become a “transformative” new resource for the field of neuroscience. 

AWS on Wednesday announced its technology will support the Allen Institute as it builds a map of the human brain, called the Brain Knowledge Platform. This platform, the first of its kind, is designed to be a complete reference of individual cells in the brain, and should eventually serve as the world’s largest open source brain cell database. 

To build the new platform, the Allen Institute is using single cell genomics technologies. Researchers measure the genes used by individual brain cells to create a “cell fingerprint,” and cells with similar fingerprints will be grouped into “cell types,” resulting in a high-resolution map of the entire brain. 

Once the reference is complete, scientists should better understand links between genetics and different cognitive functions. Researchers believe the platform could provide insights into why diseases like Alzheimer’s and Parkinson’s occur. 

“This really is like the periodic table for the brain,” Dr. Ed Lein, senior investigator at the Allen Institute for Brain Science, said Wednesday during a presentation about the platform in Washington, D.C. “It’s revealed in dramatically higher complexity than we’ve ever had access to before.”

The Allen Institute is a nonprofit research institute based in Seattle, Washington. It’s made up of a number of different institutes, including one that focuses on neuroscience, and is perhaps best known for creating a number of different large-scale data resources.  

But even though the Allen Institute is no stranger to data, there are hundreds of billions of cells in the brain — so creating a reference like the Brain Knowledge Platform means researchers will have to contend with massive amounts of data. 

“We’re just running into these enormous, enormous problems of data size,” Lein said during a briefing with reporters Wednesday. “The scale of data just keeps getting bigger and bigger.”

As such, the Allen Institute is leveraging AWS’ cloud computing and machine learning to standardize and consolidate complex brain data into one place. 

When carrying out research involving genetics and imaging, scientists are often working with petabytes and even exabytes of data. Dr. Rowland Illing, director of international public sector health at AWS, said at the briefing that consuming 40 petabytes of data would require someone to watch 4k video for 24 hours a day, seven days a week, for 100 years. 

The amount of data available to researchers is expected to keep growing in coming years, but Lein said there is also a lot of existing brain data in the neuroscience field. The problem, he said, is that much of it is disorganized and decentralized, which makes it difficult for researchers to access. 

The Allen Institute plans to use AWS’ technology to successfully interpret this disparate data even if it’s stored across different formats and locations, which Lein said will hopefully further democratize access to knowledge and bring parts of the neuroscience community together. 

“While this is really in its early phases now, the goal of the Brain Knowledge Platform is to transform this fragmented landscape of neuroscience information into a unified ecosystem,” he said.

The Allen Institute will work to build the Brain Knowledge Platform over the next five years. Lein said it is still in its early phases, but the potential for the tech is immense. 

“If we can do this, imagine the impact on the field,” he said. “We can unify the disparate parts of the field that can’t talk to one another at the moment. We can accelerate our understanding of brain function, as well as new approaches for treating diseases.”

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Spotify restores service after Wednesday outage

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Spotify restores service after Wednesday outage

The Spotify logo is displayed on a screen on the floor of the New York Stock Exchange on Dec. 4, 2023.

Brendan Mcdermid | Reuters

Spotify was down Wednesday, with about 50,000 reports of an outage on Downdetector.

The company posted an all-clear to social media site X just after noon EDT, thanking listeners for their patience.

“Spotify experienced an outage today beginning around 6:20am EDT. As of 11:45am EDT, Spotify is back up and functioning normally,” the company said in a statement.

The music-streaming giant did not provide additional details about the scope of the outage.

Users peppered the replies to the company’s outage announcement with frustrations and memes.

“I’ll just hum to myself,” wrote user @alexissTyler.

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The company recently reported its first profitable year and said it paid a record $10 billion in royalties to the music industry.

Nearly 1,500 artists generated more than $1 million individually, according to Spotify’s annual Loud and Clear Report, and more than 80% of those in that pool did not have a song reach the app’s Global Daily Top 50 Chart.

The app has added new advertising features in recent months.

Earlier in April, the company released new generative artificial intelligence ads and reported that automated ad channels drove $2 billion in ad spending with digital audio since the beginning of the year.

Out of the company’s 675 million monthly active users, more than half are free users who are served ads when they stream music.

This is a developing story. Please check back for updates.

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AMD expects $800 million hit from U.S. chip restrictions on China

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AMD expects 0 million hit from U.S. chip restrictions on China

Lisa Su, CEO of AMD, attends the Artificial Intelligence Action Summit at the Grand Palais in Paris, Feb. 10, 2025.

Benoit Tessier | Reuters

Shares of Advanced Micro Devices slid more than 5% on Wednesday after the company said it could incur charges of up to $800 million for exporting its MI308 products to China and other countries.

“The Company expects to apply for licenses but there is no assurance that licenses will be granted,” AMD said in the filing with the Securities and Exchange Commission.

The new U.S. license requirement, which applies to exports of certain semiconductor products, would hit inventory, purchase commitments and related reserves, AMD said in the filing.

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AMD is one of the companies that builds the hardware behind the artificial intelligence boom. The company claims its AMD Instinct MI300 Series accelerators are “uniquely well-suited to power even the most demanding AI and HPC workloads,” according to its website.

It generated a “record” revenue of $25.8 billion in 2025, according to its February earnings release, but the new export restrictions could slow growth.

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AMD one month stock chart.

Nvidia, an AMD competitor, released a similar disclosure on Tuesday. The company said it will take a quarterly charge of about $5.5 billion for exporting H20 graphics processing units.

China is Nvidia’s fourth-largest region by sales, after the U.S., Singapore, and Taiwan, according to the company’s annual report. More than half of its sales went to U.S. companies in its fiscal year that ended in January.

–CNBC’s Kif Leswing and Jordan Novet contributed to this report.

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Chip stocks fall as Nvidia, AMD warn of higher costs from China export controls

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Chip stocks fall as Nvidia, AMD warn of higher costs from China export controls

Nvidia CEO Jensen Huang delivers the keynote for the Nvidia GPU Technology Conference at the SAP Center in San Jose, California, on March 18, 2025.

Brittany Hosea-small | Reuters

Technology stocks declined Wednesday, led by a 5% drop in Nvidia, as the chipmaking sector signaled that President Donald Trump‘s sweeping tariff plans could hamper demand and growth.

Nvidia revealed in a filing Tuesday that it will take a $5.5 billion charge tied to exporting its H20 graphics processing units to China and other countries and said that the government will require a license to ship the chips there and other destinations.

The chip was designed specifically for China use during President Joe Biden’s administration to meet U.S. export restrictions barring the sale of advanced AI processors, which totaled an estimated $12 billion to $15 billion in revenue in 2024. Advanced Micro Devices said in a filing Wednesday that the latest export controls on its MI308 products could lead to an $800 million hit.

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Chipmaking stocks have struggled in the wake of President Donald Trump’s sweeping U.S. trade restrictions, sparked by fears that higher tariffs will stifle demand.

The disclosures from Nvidia and AMD are the first major signs that Trump’s fierce battle with China could significantly hamper chip growth. The administration has made some exemptions for electronics, including semiconductors, but has warned that separate tariffs could come down the road.

Adding to the sector worries was a disappointing print from Dutch semiconductor equipment maker ASML. The company missed order expectations and said that tariff restrictions create demand uncertainty. Shares fell about 5%.

The VanEck Semiconductor ETF fell more than 4%, with AMD plunging more than 5%. Micron Technology, Marvell Technology and Broadcom sank about 2% each. Equipment makers Applied Materials and Lam Research fell about 3% each.

The declines spilled over into the broader market and tech-heavy Nasdaq Composite, which dropped nearly 2%. Meta Platforms, Alphabet and Tesla lost about 2% each. Amazon, Microsoft and Apple were last down about 1% each.

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