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Source: Precision Neuroscience

It happened so fast that Craig Mermel missed it. 

He was standing in a busy operating room in West Virginia, waiting for a surgeon to place Precision Neuroscience’s neural implant system onto a conscious patient’s brain for the first time. Mermel, the president and chief product officer at Precision, said he looked away for a moment, and by the time he turned back, the company’s paper-thin electrode array was in position. 

In seconds, a real-time, high-resolution rendering of the patient’s brain activity washed over a screen. According to Precision, the system had provided the highest resolution picture of human thought ever recorded. 

“It was incredibly surreal,” Mermel said in an interview with CNBC. “The nature of the data and our ability to visualize that, you know, I got… chills.”

The procedure Mermel observed was the company’s first-ever in-human clinical study.

Founded in 2021 by a co-founder of Neuralink, Elon Musk’s brain-computer interface startup, Precision Neuroscience is an industry competitor working to help patients with paralysis operate digital devices by decoding their neural signals. A BCI is a system that deciphers brain signals and translates them into commands for external technologies, and several companies like Synchron, Paradromics and Blackrock Neurotech have also created devices with this capability. Precision announced a $41 million Series B funding round in January.

The company’s flagship BCI system, the Layer 7 Cortical Interface, is an electrode array resembling a piece of scotch tape. Since it’s thinner than a human hair, Precision says it can conform to the brain’s surface without damaging any tissue, and in the study, Precision’s system was temporarily placed onto the brains of three patients who were already undergoing neurosurgery to have tumors removed. 

Since the technology worked as expected, future studies will explore further applications in clinical and behavioral contexts, Mermel said. If the trials go according to Precision’s plan, patients with severe degenerative diseases like ALS could eventually regain some ability to communicate with loved ones by moving cursors, typing and even accessing social media with their minds.

Although an in-human study is a major milestone, the road to market for this type of technology is a long one. Precision has not yet received FDA approval for its device, and the company will have to work closely with regulators to successfully conduct several extremely thorough rounds of testing and data safety collection.

As of June, no BCI company has managed to clinch the FDA’s final seal of approval.

“The goal is to deliver a device that can help people living with permanent disability, so this is like the first step,” Mermel said. “Now the real work begins.”

Doctors prepare Precision’s system. Precision’s array compared to a penny.

Photo: Anna von Scheling

A number of different academic medical centers offered to support the company’s pilot clinical study, according to Dr. Benjamin Rapoport, co-founder and chief science officer at Precision. The company partnered with West Virginia University’s Rockefeller Neuroscience Institute, and the two organizations prepared for the procedures for more than a year in advance, Rapoport said.

Rapoport, who has been working on BCI technology for more than 20 years, said seeing Precision’s technology on the brain of a human patient for the first time was an “incredibly gratifying” milestone.

“I can’t really describe emotionally what that’s like,” he said. “It was tremendous.”

Dr. Peter Konrad, chairman of the Department of Neurosurgery at the Rockefeller Neuroscience Institute, was the surgeon who physically placed Precision’s system onto the patients’ brains during their procedures.

Konrad said it was a simple process that felt like laying a piece of tissue paper on the brain. 

Patients had Precision’s system on their brains for 15 minutes. One of them remained asleep during the procedure, but two patients were woken up so the Layer 7 could capture their brain activity as they spoke. 

“I’ve never seen that amount of data, 1,000 channels in real-time, of electrical activity, just washing over the brain as somebody was talking,” Konrad said in an interview with CNBC. “It was literally like you’re watching somebody think. It’s pretty amazing.”

Electrodes are already used in practice to help neurosurgeons monitor brain activity during a procedure, but the resolution provided by conventional systems is low. Konrad said standard electrodes are about four millimeters big, while Precision’s array can put 500 to 1,000 contacts on that size.   

“It’s the difference between looking at the world with an old black and white camera versus seeing in hi-def,” he said.

Konrad said it is too early for the patients in this study to see the direct benefits of this technology.

Precision’s array compared to a penny.

Photo: Anna von Scheling

Precision ultimately hopes its technology will not require open brain surgery at all. In an interview with CNBC in January, co-founder and CEO Michael Mager said a surgeon should be able to implant the array by making a thin slit in the skull and sliding in the device like a letter into a letter box. The slit would be less than a millimeter thick – so small that patients don’t need their hair shaved for the procedure. 

Precision’s minimally invasive approach is intentional, as competing BCI companies like Paradromics and Neuralink have designed systems meant to be inserted directly into the brain tissue. 

Rapoport said that inserting a BCI into the brain would provide a clear picture of what each neuron is doing, but it risks damaging the tissue and is difficult to scale. He said that level of detail is not necessary to decode speech or achieve the other functions Precision is striving for, so it was a tradeoff the company was ultimately willing to make.  

In the coming weeks, Precision will carry out the same procedure with two more patients as part of its pilot clinical study. Rapoport said the company has submitted its initial results to a scientific journal, and that having the data publicly available will be a “huge next step.”

Precision also has similar studies in the works with health systems like Mount Sinai in New York City and Massachusetts General Hospital in Boston, and Rapoport said Precision is hoping to receive full FDA clearance for its first-generation device next year. 

“The early results for us are tremendously gratifying to see,” Rapoport said. “If you’re lucky, there’s a few times in your life when you get to sort of see something before anybody else sees it in the world.”

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Meet Partiful, the Gen Z party-planning staple that’s taking on Apple

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Meet Partiful, the Gen Z party-planning staple that's taking on Apple

Partiful’s CEO, Shreya Murthy, and CTO, Joy Tao

Courtesy: Partiful

When Shreya Murthy and Joy Tao decided to launch a party-planning startup in 2020, they settled on a business goal of “bringing people together in person.”

The Covid-19 pandemic demanded the exact opposite.

Despite the challenge of the pandemic, Partiful survived, and five years later, the New York startup is now used by millions of people to plan events such as birthday parties, housewarmings and weddings.

The app’s a favorite of those ages 20 to 30, and it’s added 2 million new users since January, Partiful CEO Murthy told CNBC. The company has never revealed its exact base of monthly users.

Partiful drew attention on social media after Apple, known for replicating features from popular apps on the iPhone, launched its own event-planning service in February, and the startup posted a joke about “copycats” on its X account.

Of course, Partiful isn’t the first party-planning app. It competes against not only Apple Invites, but also Eventbrite, Evite, Punchbowl and others.

Each service differs slightly in its target markets and features. Evite, for example, uses a “freemium” model, where certain invitation designs and other features are paywalled. Eventbrite is often used to promote and sell admission to large public events.

What sets Partiful apart from its competitors — and appeals to its Gen Z user base — is its often humorous, casual designs, some of which are created by Partiful’s in-house designers.

“Friend invited me to a gathering that doesn’t have a Partiful….feeling lost, confused, unprepared…much like when I (Gen Z) receive a phone call out of the blue,” X user Athena Kan posted in August.

For the first quarter of 2025, Partiful averaged 500,000 monthly active users, up 400% year over year, with 9 out of 10 users on the app based in the U.S., according to estimates provided to CNBC by Sensor Tower, a market research firm. That compares with Eventbrite’s 4.4 million monthly active users, which is up 2% year over year, and Punchbowl with approximately 85,000 monthly users, which is down about 2% compared to a year ago. A spokesperson for Evite told CNBC that the service saw more than 20 million monthly active users for the first quarter of 2025.

It’s unclear how many people still use Facebook’s once-popular event-planning feature Facebook Events. Facebook’s parent company, Meta, shut down the standalone app.

Sample invitations from the Partiful app

Source: Partiful

Bringing people together in real life

Murthy and Tao both went to Princeton University and worked at Palantir Technologies at the same time, but they didn’t meet until they were introduced later by a mutual friend. Both were looking to move to the consumer-facing side of tech. 

Tao, then a software engineer at Meta, wanted to leave the company to focus on products that were more relatable to daily life, and said that the social media company’s goal of keeping users engaged on their apps sometimes can create “perverse incentives.”

“For me, driving more people to spend more time staring at their phone, staring at this endless feed of content, wasn’t super motivating, wasn’t super meaningful to me personally,” said Tao, Partiful’s tech chief and a self-described “avid party planner.”

Meta declined to comment.

Tao and Murthy went through a sort of “dating period” where they asked each other what they thought leading a startup together could look like. Among the voids they identified was how intimate social events, such as birthday parties where a host would be likely to see the attendees again, were still planned on text chains that made it difficult to track, communicate or plan an ideal event time with guests.

“If you’re not sure when people are free, that’s a really annoying problem,” Murthy said.

She and Tao took the leap.

With few in-person events happening during the 2020 lockdowns, Partiful’s engineering team focused on building the platform’s text message-based infrastructure so that the service could be used by both iPhone and Android users. 

Partiful’s team, which has now grown to 25, operates out of downtown Brooklyn. The service is no longer limited to text messages and its website. The company launched apps for the iPhone and Android devices in 2023 and 2024, respectively, and Partiful now serves as a one-stop destination for organizing the different phases of planning and hosting a party. The company has reportedly raised $20 million in a funding round led by Andreessen Horowitz.

Speaking Gen Z’s language

What makes Partiful fun for users is how customizable an invite can be.

Hosts can create a free birthday invite with a lime-green parody cover of Charli XCX’s “brat” album, for example, or plan a girls’ night out with a cover photo of Shrek in sunglasses. They can track “yes,” “no” or “maybe” RSVPs under a portrait of Martha Stewart and Snoop Dogg, and invited guests can use a “boop” feature to send random emojis rather than a direct message to each other.

Party planners can also send out uniform text blasts to the group before and after the event and manage an in-app photo album for uploading memories.

Partiful is available for anyone to use, but Murthy said the company sees the most need for the service among young users in the “postgrad” period of life. That’s a stage where people might be moving to new cities and away from their established college friend groups.

“You’re starting your adult life and have to not only figure out, ‘How do I rent an apartment? How do I work a new job? How do I exist in this new version of myself?'” Murthy said. “On top of that, you’re also having to rebuild your entire social circle.”

For the hosts and partiers in its user base, Partiful has become part of their social routine, and it has continued to gain traction online. The company told CNBC that over 60% of its active app users check Partiful every week.

As for Apple, Partiful isn’t sweating its new rival just yet.

Apple Invites requires that users have an iCloud+ subscription to create events, though it’s free to RSVP if a guest doesn’t have an Apple account. That service starts at 99 cents a month in the United States. Apple did not respond to a request for comment.

Partiful is free, at least for now.

Like many other tech companies that rely on distribution services such as Apple’s App Store, Partiful has a nuanced relationship with its much-larger counterpart. Partiful could lose some users to Apple, but it can also benefit from promotion by the app distributor.

That’s what happened in 2024, when Partiful was named a finalist for Apple’s App Store Awards for Cultural Impact, and won Google Play’s “Best App of 2024.” The app remained an “editor’s choice” pick on the App Store as of publication.

For now, Partiful remains confident.

“We haven’t really seen any users that have been leaving Partiful for Apple Invites,” Murthy said.

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How quantum could supercharge Google’s AI ambitions

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How quantum could supercharge Google’s AI ambitions

Inside a secretive set of buildings in Santa Barbara, California, scientists at Alphabet are working on one of the company’s most ambitious bets yet. They’re attempting to develop the world’s most advanced quantum computers.

“In the future, quantum and AI, they could really complement each other back and forth,” said Julian Kelly, director of hardware at Google Quantum AI.

Google has been viewed by many as late to the generative AI boom, because OpenAI broke into the mainstream first with ChatGPT in late 2022.

Late last year, Google made clear that it wouldn’t be caught on the backfoot again. The company unveiled a breakthrough quantum computing chip called Willow, which it says can solve a benchmark problem unimaginably faster than what’s possible with a classical computer, and demonstrated that adding more quantum bits to the chip reduced errors exponentially. 

“That’s a milestone for the field,” said John Preskill, director of the Caltech Institute for Quantum Information and Matter. “We’ve been wanting to see that for quite a while.”

Willow may now give Google a chance to take the lead in the next technological era. It also could be a way to turn research into a commercial opportunity, especially as AI hits a data wall. Leading AI models are running out of high-quality data to train on after already scraping much of the data on the internet.

“One of the potential applications that you can think of for a quantum computer is generating new and novel data,” said Kelly. 

He uses the example of AlphaFold, an AI model developed by Google DeepMind that helps scientists study protein structures. Its creators won the 2024 Nobel Prize in Chemistry. 

“[AlphaFold] trains on data that’s informed by quantum mechanics, but that’s actually not that common,” said Kelly. “So a thing that a quantum computer could do is generate data that AI could then be trained on in order to give it a little more information about how quantum mechanics works.” 

Kelly has said that he believes Google is only about five years away from a breakout, practical application that can only be solved on a quantum computer. But for Google to win the next big platform shift, it would have to turn a breakthrough into a business. 

Watch the video to learn more.

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Nintendo Switch 2 retail preorder to begin April 24 following tariff delays

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Nintendo Switch 2 retail preorder to begin April 24 following tariff delays

An attendee wearing a Super Mario costume uses a Nintendo Switch 2 game console while playing a video game during the Nintendo Switch 2 Experience at the ExCeL London international exhibition and convention centre in London, Britain, April 11, 2025. 

Isabel Infantes | Reuters

Nintendo on Friday announced that retail preorder for its Nintendo Switch 2 gaming system will begin on April 24 starting at $449.99.

Preorders for the hotly anticipated console were initially slated for April 9, but Nintendo delayed the date to assess the impact of the far-reaching, aggressive “reciprocal” tariffs that President Donald Trump announced earlier this month.

Most electronics companies, including Nintendo, manufacture their products in Asia. Nintendo’s Switch 1 consoles were made in China and Vietnam, Reuters reported in 2019. Trump has imposed a 145% tariff rate on China and a 10% rate on Vietnam. The latter is down from 46%, after he instituted a 90-day pause to allow for negotiations.

Nintendo said Friday that the Switch 2 will cost $449.99 in the U.S., which is the same price the company first announced on April 2.

“We apologize for the retail pre-order delay, and hope this reduces some of the uncertainty our consumers may be experiencing,” Nintendo said in a statement. “We thank our customers for their patience, and we share their excitement to experience Nintendo Switch 2 starting June 5, 2025.”

The Nintendo Switch 2 and “Mario Kart World bundle will cost $499.99, the digital version “Mario Kart World” will cost $79.99 and the digital version of “Donkey Kong Bananza” will cost $69.99, Nintendo said. All of those prices remain unchanged from the company’s initial announcement.

However, accessories for the Nintendo Switch 2 will “experience price adjustments,” the company said, and other future changes in costs are possible for “any Nintendo product.”

It will cost gamers $10 more to by the dock set, $1 more to buy the controller strap and $5 more to buy most other accessories, for instance.

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