Alex Zhavoronkov, left, founder and CEO of Insilico Medicine, and Feng Ren, co-CEO and chief scientific officer, at the company’s robotics lab in Suzhou, China.
Source: Insilico Medicine
The first drug fully generated by artificial intelligence entered clinical trials with human patients this week.
Insilico Medicine, a Hong Kong-based biotech startup with more than $400 million in funding, created the drug, INS018_055, as a treatment for idiopathic pulmonary fibrosis, a chronic disease that causes scarring in the lungs. The condition, which has increased in prevalence in recent decades, currently affects about 100,000 people in the U.S. and can lead to death within two to five years if untreated, according to the National Institutes of Health.
“It is the first fully generative AI drug to reach human clinical trials, and specifically Phase II trials with patients,” Alex Zhavoronkov, founder and CEO of Insilico Medicine, told CNBC. “While there are other AI-designed drugs in trials, ours is the first drug with both a novel AI-discovered target and a novel AI-generated design.”
The discovery process for the new drug began in 2020, with hopes to create a “moonshot” medicine to overcome challenges with current treatments for the condition, which mostly focus on slowing progression and can cause uncomfortable side effects, Zhavoronkov said.
He added that Insilico has chosen to focus on IPF in part because of the condition’s implications in aging, but the company has two other drugs partially generated by AI in the clinical stage. One is a Covid-19 drug in phase one clinical trials, and the other is a cancer drug, specifically a “USP1 inhibitor for the treatment of solid tumors,” that recently received FDA approval to initiate clinical trials.
“When this company was launched, we were focused on algorithms — developing the technology that could discover and design new molecules,” Zhavoronkov said. “I never imagined in those early days that I would be taking my own AI drugs into clinical trials with patients. But we realized that in order to validate our AI platform, we needed to not only design a new drug for a new target, but bring it into clinical trials to prove that our technology worked.”
The IPF drug’s current study is a randomized, double-blind, placebo-controlled trial taking place over 12 weeks in China, and Insilico has plans to expand the testing population to 60 subjects at 40 sites in the U.S. and China. If the current phase two study is successful, it will go on to another study with a larger cohort, and then potentially reach phase three studies with hundreds of participants.
“We expect to have results from the current Phase II trial next year,” Zhavoronkov said, adding that it’s difficult to predict exact timing for future phases, especially since the disease is relatively rare and patients must fulfill specific criteria. He added, “We are optimistic that this drug will be ready for market, and reach patients who may benefit from it, in the next few years.”
A DoorDash bag on a bicycle in New York, US, on Tuesday, May 6, 2025.
Yuki Iwamura | Bloomberg | Getty Images
DoorDash reported third-quarter earnings that missed analyst expectations and said it expects to spend “several hundred million dollars” on new initiatives and development in 2026.
The stock sank 9% following the report.
Here’s how the company did compared to LSEG estimates:
Earnings: 55 cents per share vs 69 cents per share expected
Revenue: $3.45 billion vs $3.36 billion expected.
“We wish there was a way to grow a baby into an adult without investment, or to see the baby grow into an adult overnight, but we do not believe this is how life or business works,” the company wrote in its earnings release to explain the boosted spending.
DoorDash said it is developing a new global tech platform that progressed in 2025 but is expected to accelerate in 2026, noting the direct and opportunity costs in the near term. The company announced its Dot autonomous delivery robot in September.
The food delivery platform’s revenue increased 27% from a year earlier.
DoorDash posted net income of $244 million, or 55 cents per share, in Q3, up from $162 million, or 38 cents per share, a year ago.
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Total orders grew 21% over the prior year to 776 million during the quarter that closed Sept. 30, just above the 770.13 million expected by FactSet.
The company expects Adjusted EBITDA for the fourth quarter in the range of $710 million to $810 million, a midpoint of $760 million. Analysts polled by FactSet expected $806.8 million for Q4.
DoorDash closed its acquisition of British food delivery company Deliveroo on Oct. 2, a deal that valued the UK company at about $3.9 billion.
The company expects a depreciation and amortization expense of $700 million for the fiscal year, exclusive of the acquisition. A stock-based compensation expense of $1.1 billion is also expected for fiscal 2025.
DoorDash expects Deliveroo to add $45 million to adjusted EBITDA in Q4 and about $200 million to adjusted EBITDA in 2026.
Snap shares climbed 15% on Wednesday after the company issued its third-quarter earnings, reporting revenue that beat analysts expectations and a $500 million stock repurchase program.
Here is how the company did compared with Wall Street’s expectations:
Earnings per share: Loss of 6 cents. That figure is not comparable to analysts’ estimates.
Revenue: $1.51 billion vs. $1.49 billion expected, according to LSEG
Global daily active users: 477 million vs. 476 million expected, according to StreetAccount
Global average revenue per user (ARPU): $3.16 vs. $3.13 expected, according to StreetAccount
Snap also announced that it is partnering with the startup Perplexity AI, which “will integrate its conversational search directly into Snapchat.” The feature is set to appear in Snapchat starting in early 2026, Snap said.
“Perplexity will pay Snap $400 million over one year, through a combination of cash and equity, as we achieve global rollout,” Snap said in the letter. “Revenue from the partnership is expected to begin contributing in 2026.”
The partnership represents “a first step in Snap’s effort to make Snapchat a platform where leading AI companies can connect with its global community in creative and trusted ways,” the two companies said in their announcement.
In the company’s earnings call, Snap CEO Evan Spiegel said Perplexity will have “default placement in our chat inbox” and the startup will “control the responses from their chatbot inside of Snapchat.”
Although Snap will not be selling “advertising against the Perplexity responses,” Spiegel said that the integration “will help Perplexity drive additional subscribers, which I think is something that will be valuable to their business.”
“We have a really unique opportunity ahead to help distribute AI agents through our chat interface,” Spiegel said.
While Snapchat users will still be able to engage with the company’s My AI chatbot, the integrated Perplexity AI service will provide them with “real-time answers from credible sources and explore new topics within the app,” the companies said.
Regarding Snap’s expensive foray into developing augmented reality glasses, Spiegel said the company plans to create a separate subsidiary around the Specs AR glasses to speed up development with partners.
Snap said fourth-quarter sales will come in between $1.68 billion and $1.71 billion. That figure’s midpoint of $1.695 billion is slightly ahead of Wall Street expectations of $1.69 billion.
For the third quarter, Snap said sales grew 10% year over year while it logged a net loss of $104 million. During the same quarter last year, Snap recorded a net loss of $153 million.
The Snapchat parent said that third-quarter adjusted earnings before interest, taxes, depreciation and amortization, or EBITDA, came in at $182 million, ahead of the $125 million that StreetAccount was projecting.
The company also said that its adjusted EBITDA for the fourth quarter will be between $280 million and $310 million, which tops StreetAccount’s projections of $255.4 million.
Snap shares were down 32% for the year, as of Wednesday’s close, compared to the Nasdaq’s 22% gain.
Although the company’s shares soared as high as 25% in after-hours trading on Wednesday, they began their descent after Snap finance chief Derek Andersen detailed some of the company’s sales-related challenges on the earnings call.
“The North America LCS segment remains the primary headwind to our overall revenue growth,” said Andersen, adding that the company is seeing more growth and demand for Snap’s ad products from small-to-medium sized businesses in other regions.
In a letter to investors, Snap said that government regulations like Australia’s social media minimum age bill and related policy developments “are likely to have negative impacts on user engagement metrics that we cannot currently predict.”
“While we remain committed to our goal of serving 1 billion global monthly active users, we expect overall DAU may decline in Q4 given these internal and external factors, and as noted above we expect particularly negative impacts in certain jurisdictions,” Snap said in the letter.
The Australian senate passed the bill in November 2024, and when the law comes into effect next month, companies like Facebook and Instagram parent Meta, TikTok and Snap will be penalized if they fail to adequately prevent children under 16 from possessing accounts on their respective platforms.
Snap also said in the investor letter that the “upcoming rollout of platform-level age verification” from companies like Apple and Google could also negatively impact user metrics in the future.
Utah and California have signed online-child safety bills that put the onus on app store makers to verify user ages. Utah’s law is set to fully take effect in May 2026.
“We are also preparing for the upcoming rollout of platform-level age verification, which will use new signals provided by Apple — and soon Google — to help us better determine the age of our users and remove those we learn are under 13,” Snap said in the letter.
Snap’s warning to investors underscores how new laws, policies and regulations around the globe are beginning to impact tech firms.
In the letter, Snap also said that some of its efforts to improve monetization, such as its Snapchat+ subscription service, could result in “adverse impact on engagement metrics as these experiences are rolled out globally.”
Pinterest shares tanked on Tuesday after the company reported third-quarter results that missed on earnings per share and provided weaker-than-expected guidance. The company’s finance chief Julia Donnelly told analysts that Pinterest expects “broader trends and market uncertainty continuing with the addition of a new tariff in Q4 impacting the home furnishing category.”
Alphabet said that its total advertising revenue for the third quarter rose 13% year-over-year to $74.18 billion, while YouTube’s online ad sales climbed 15% to $10.26 billion.
Reddit said last Thursday that third-quarter sales surged 68% year-over-year to $585 million. The company’s global daily active uniques increased 19% year-over-year to 116 million, surpassing estimates of 114 million.
A pedestrian walks past Amazon Ireland corporate offices in Dublin, as Amazon.com, Inc., said on Tuesday it plans to cut its global corporate workforce by as many as 14,000 roles and seize the opportunity provided by artificial intelligence (AI), in Dublin, Ireland, Oct. 28, 2025.
Damien Eagers | Reuters
A new bipartisan bill seeks to provide a “clear picture” of how artificial intelligence is affecting the American workforce.
Sens. Mark Warner, D-Va., and Josh Hawley, R-Mo., on Wednesday announced the AI-Related Job Impacts Clarity Act. It would require publicly traded companies, certain private companies and federal agencies to submit quarterly reports to the Department of Labor detailing any job losses, new hires, reduced hiring or other significant changes to their workforce as a result of AI.
The data would then be compiled by the Department of Labor into a publicly available report.
“This bipartisan legislation will finally give us a clear picture of AI’s impact on the workforce,” Warner said in a statement. “Armed with this information, we can make sure AI drives opportunity instead of leaving workers behind.”
The proposed legislation comes as politicians, labor advocates and some executives have sounded the alarm in recent years about the potential for widespread job loss due to AI.
In May, Anthropic CEO Dario Amodei said that the AI tools that his company and others are building could eliminate half of all entry-level white-collar jobs and cause unemployment to spike up to 20% in the next one to five years. Anthropic makes the chatbot Claude.
Layoffs have been announced recently at companies across the tech, retail, auto and shipping industries, with executives citing myriad reasons, from AI and tariffs to shifting business priorities and broader cost-cutting efforts. Job cuts announced at Amazon, UPS and Target last month totaled more than 60,000 roles.
Some experts have questioned whether AI is fully to blame for the layoffs, noting that companies could be using the technology as cover for concerns about the economy, business missteps or cost cutting initiatives.