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New figures show a shocking rise in deaths on US streets linked to a drug which rots the skin of those who use it.

Xylazine, often referred to as Tranq or the zombie drug, has spread across America at such alarming speed that the White House has now released a new six-point action plan to tackle the crisis.

The drug, an animal tranquillizer, is increasingly mixed or “cut” by drug dealers into supplies of fentanyl which itself is already killing over 100,000 Americans every year.

According to the most recent data from 20 US states and the District of Columbia, the monthly percentage of fentanyl-associated deaths where xylazine was detected has increased from 2.9% to 10.9% – a jump of 276%.

Revealing the new figures and announcing the action plan, Dr Raul Gupta, the White House director of national drug control policy, said: “This administration recognises the grave threat that fentanyl combined with xylazine presents to our nation.”

'Tranq dope' is causing horror on US streets

The latest numbers are stark, shocking and suggest that the skin-rotting animal tranquiliser is now firmly established in America’s drug market.

In the 12 months ending in January, 109,000 Americans died from a drug overdose. Nearly seven in ten of those deaths were attributed to synthetic opioids like fentanyl and a growing number were linked to xylazine.

The Drug Enforcement Agency (DEA) has seized xylazine-fentanyl mixtures in 48 of the 50 US states. And according to the DEA laboratories, in 2022, 23% of fentanyl powder and 7% of fentanyl tablets contained xylazine.

Spelling out the scale of the crisis, Dr Gupta said: “As a physician, I’ve never seen one this bad, at this scale… I visited the wound care clinic in Kensington neighbourhood of Philadelphia, one of the hardest hit communities in the nation.”

He added: “So what I want everyone to understand is this: if we thought fentanyl was dangerous, fentanyl combined with xylazine is even deadlier.”

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What is ‘Tranq’? The new drug emerging in America

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The deadly drug fuelling a gang war

The streets of Philadelphia

In March, Sky News revealed the scale of the xylazine crisis in the northeastern city of Philadelphia, where the drug cocktail first emerged, with a report that exposed the true cost of America’s evolving drug challenge.

On block after block in the Kensington district we saw people suffering from addiction who were increasingly finding their opioid supply was being cut by dealers with xylazine.

We saw the open wounds, the rotting skin and the volunteer outreach workers overwhelmed by the scale of the challenge.

Speaking to Sky News four months since we visited, one of the volunteers we met said the situation is now much worse.

“The hospitals can’t keep the patients comfortable – because of their addiction – to keep them long enough to get the wounds under control,” Ronnie Kaiser told me.

When the wounds caused by the xylazine get to a certain stage, the user may either admit themselves to the hospital or be taken to hospital. But their urge for another ‘hit’ will often be greater than the recognition that the wounds need to be treated. It is a cruel and vicious cycle of addiction.

“There’s always new people and sadly some we’ve seen for years and, of course, there’s some who passed.” Ronnie said.

Sky News visited Kensington in Philadelphia to investigate the impact of tranq
Image:
Sky News visited Kensington in Philadelphia to investigate the impact of Tranq

Read more:
‘Tranq’ designated ’emerging threat to the US’
What is fentanyl, the drug that killed rapper Coolio?

The White House six-point plan

According to Neera Tanden, the domestic policy adviser at the White House, the new six-point plan seeks to: “Aggressively expand access to prevention, harm reduction, treatment and recovery support for those with substance use disorders. And [take] bold actions to disrupt the supply of illicit drugs, especially fentanyl that is harming communities or all across the country.”

The plan, released on Tuesday, focuses on six pillars of action: testing, data collection, evidence-based prevention, harm reduction/treatment, supply reduction, scheduling (categorising the drug) and research.

The White House’s drug policy director, Dr Gupta said: “We’re calling on Congress to fully fund President Biden’s historic $46.1bn (£35.7bn) budget request for national drug control programs, including key funding to address illicit fentanyl and emerging threats like xylazine.”

Ronnie, who runs the Philadelphia-based charity Angels in Motion
Image:
Ronnie, who runs the Philadelphia-based charity Angels in Motion, speaking to Sky News earlier in 2023

The reaction on the streets

Ronnie, who runs the Philadelphia-based charity Angels in Motion, welcomed the fact that the federal government was finally recognising the scale of the crisis.

“Perhaps awareness is there now. It’s good that solutions are being looked at,” she said.

But she questioned the practicalities of the proposals: “Test strips? Why? Do they think the dealer will take the bag [of drugs] back if it comes up positive?!”

“We need more help with prevention, harm reduction, rehab and recovery houses – these should be the absolute solution now!” she said.

“Those of us on the ground know that these are the things needed. Unfortunately, I think funding goes to certain people, not so much to the boots on the ground.”

She pointed to the perennial American problem of medical insurance and the ‘for profit’ medical facilities. Even those living on the streets and suffering from addiction are required to navigate the country’s complex health system if they are to stand a real chance of recovery.

“We need federal rehabs, federal recovery houses, the ability for longer rehab stays and definitely all insurances to be accepted at all rehabs,” she said.

“That’s what we need so that all ‘for profit’ places go away. There are recovery houses that are so bad – throwing people out because they can’t find a job to pay fast enough.”

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Too late for America

In February, Philadelphia’s substance use prevention and harm reduction chief, Dr Andrew Best, warned that cities across America should brace for xylazine and called on the federal government to do more.

“Right now there’s no state or federal funding available,” he told Sky News. “I don’t want this to spread to other cities.”

The new data shows it’s too late, and in May the first UK death linked to xylaxine was announced.

The Biden administration has also announced plans to disrupt the supply of both fentanyl and xylazine into the country. The precursor products come from China and are mostly converted to tablet or powder form by cartels in Mexico as Sky News exposed earlier this year.

The fear now, given the ever-growing supply of xylazine-adulterated fentanyl, is that it will infiltrate other sectors of society.

In May, Sky News saw how small-town communities were struggling with accidental fentanyl overdoses by children in schools

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Prince Andrew accuser Virginia Giuffre leaves hospital after saying she had ‘four days to live’ following car crash

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Prince Andrew accuser Virginia Giuffre leaves hospital after saying she had 'four days to live' following car crash

Prince Andrew accuser Virginia Giuffre has reportedly left hospital after recently saying she had “four days to live”.

Her representative said she was discharged on Monday, according to US celebrity website People.

Photos in Australian media on Wednesday are said to show Ms Giuffre being driven in a vehicle north of Perth.

The 41-year-old appeared with a bruised face last week when she posted an Instagram video saying her car had been hit by a speeding school bus as she slowed for a turn.

She said: “I’ve gone into kidney renal failure, they’ve given me four days to live, transferring me to a specialist hospital in urology.

“I’m ready to go, just not until I see my babies one last time…”

Police said they had received a report of a “minor crash” between a school bus and a car in Neergabby, about 12 miles from Perth, on 24 March.

More on Australia

“The collision was reported by the bus driver the following day,” said a spokeswoman. “There were no reported injuries as a result of the crash.”

A few days after the Instagram video, it emerged Ms Giuffre had been charged with allegedly breaching a family violence restraining order.

Ms Giuffre is reported to have separated from her husband.

The case was due back in court today (9 April).

File pic: AP
Image:
Ms Giuffre reached a settlement with the duke in 2022. File pic: AP

Ms Giuffre sued the Duke of York for sexual abuse in August 2021, saying Andrew had sex with her when she was 17 and had been trafficked by his friend, the billionaire paedophile Jeffrey Epstein.

The duke has repeatedly denied the claims, and he has not been charged with any criminal offences.

In March 2022, it was announced Ms Giuffre and Andrew had reached an out-of-court settlement – believed to include a “substantial donation to Ms Giuffre’s charity in support of victims’ rights”.

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What China could do next as Trump’s tariff war ramps up

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What China could do next as Trump's tariff war ramps up

The severity cannot be overstated, if an additional 50% tariffs are levied on all Chinese goods it will decimate trade between the world’s two biggest economies.

Remember, 50% would sit on top of what is already on the table: 34% announced last week, 20% announced at the start of US President Donald Trump’s term, and some additional tariffs left over from his first term in office.

In total, it means all Chinese goods would face tariffs of over 100%, some as high as 120%.

It’s a price that makes any trade almost impossible.

China is really the only nation in the world at the moment that is choosing to take a stand.

While others are publicly making concessions and sending delegations to negotiate, China has clearly calculated that not being seen to be bullied is worth the cost that retaliation will bring.

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Tariffs: Xi hits back at Trump

The real question, though, is if the US does indeed impose this extra 50% tomorrow, what could or would China do next?

It has said it will “fight to the end”, but what does that mean?

In reality, there are few good options.

There are some obvious measures that China will almost certainly enact.

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Further export controls on rare earth minerals (crucial for the development of high-tech products) are one example. China controls a huge proportion of the world’s supply, but the US would likely find workarounds in time.

Hiking tariffs on high-impact US products such as agricultural goods is another option, but there is only so far this could go.

The potentially more impactful options have significant drawbacks for Beijing.

It could, for instance, target high-profile American companies such as Apple and Tesla, but this isn’t ideal at a time when China is trying to attract more foreign investment, and some devaluation of the currency is possible, but it would also come with adverse effects.

Other options are more political and come with the risk of escalation beyond the economic arena.

In an opinion piece this morning, the editor of Xinhua, China’s state news agency, speculated that China could cease all cooperation with the US on the war against fentanyl.

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This has been a major political issue for Mr Trump, and it’s hard to see it would not constitute some sort of red line for him.

Other options touted include banning the import of American films, or perhaps calling for the Chinese public to boycott all American products.

Anything like this comes with a sense that the world’s two most powerful superpowers might be teetering on the edge of not just a total economic decoupling, but cultural separation too.

There is understandably serious nervousness about how that could spiral and the precedent it sets.

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Donald Trump’s 104% tariffs on China – and other levies on ‘worst offenders’ – in effect this mornong

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Donald Trump's 104% tariffs on China - and other levies on 'worst offenders' - in effect this morning

Donald Trump’s trade tariffs on what he calls “the worst offenders” come into effect at 5am UK time, with China facing by far the biggest levy.

The US will hit Chinese imports with 104% tariffs, marking a significant trade escalation between the world’s two largest superpowers.

At a briefing on Tuesday, White House press secretary Karoline Leavitt said Donald Trump “believes that China wants to make a deal with the US,” before saying: “It was a mistake for China to retaliate.

“When America is punched, he punches back harder.”

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White House announces 104% tariff on China

After Mr Trump announced sweeping levies last week – hitting some imported goods from China with 34% tariffs – Beijing officials responded with like-for-like measures.

The US president then piled on an extra 50% levy on China, taking the total to 104% unless it withdrew its retaliatory 34% tariff.

China’s commerce ministry said in turn that it would “fight to the end”, and its foreign ministry accused the US of “economic bullying” and “destabilising” the world’s economies.

More on China

‘Worst offender’ tariffs also in effect

Alongside China’s 104% tariff, roughly 60 countries – dubbed by the US president as the “worst offenders” – will also see levies come into effect today.

The EU will be hit with 20% tariffs, while countries like Vietnam and Cambodia see a 46% levy and 49% rate respectively.

The UK was not included on this list, and instead saw a “baseline”, worldwide 10% tariff on imported goods in effect from last Saturday.

At the weekend, Sir Keir Starmer promised the government was ready to “shelter British businesses from the storm”.

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What’s going on with the US and China?

Since the tariffs were announced last Wednesday, global stock markets have plummeted, with four days of steep losses for all three of the US’ major indexes.

As trading closed on Tuesday evening, the S&P 500 lost 1.49%, the Nasdaq Composite fell 2.15%, and the Dow Jones Industrial Average dropped 0.84%.

According to LSEG data, S&P 500 companies have lost $5.8tn (£4.5tn) in stock market value since last Wednesday, the deepest four-day loss since the benchmark was created in the 1950s.

New York Stock Exchange on 8 April 2025. Pic: AP
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Global stock markets have been reeling since Trump’s tariff announcement last week. Pic: AP

Read more:
What China could do next as Trump’s tariff war ramps up
Chancellor to hold tariff crisis talks with top City executives

Trump signs coal orders

Meanwhile, the US president signed four executive orders to boost American coal mining and production.

The directives order:
• keeping some coal plants that were set for retirement open;
• directing the interior secretary to “acknowledge the end” of an Obama-era moratorium that paused coal leasing on federal lands;
• requiring federal agencies to rescind policies transitioning the US away from coal production, and;
• directing the Department of Energy and other federal agencies to assess how coal energy can meet rising demand from artificial intelligence.

Read more:
The good, the bad and the ugly in Trump’s coal plans

At a White House ceremony, Mr Trump said the orders end his predecessor Joe Biden’s “war on beautiful clean coal,” and miners “will be put back to work”.

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