Aspartame, a sweetener commonly found in diet drinks and chewing gum, has been declared a potential cancer risk by the World Health Organisation (WHO).
The sweetener has been listed as “possibly carcinogenic to humans”.
The International Agency for Research on Cancer (IARC), the WHO’s cancer research arm, said there was “limited evidence” aspartame caused cancer in humans.
“While safety is not a major concern at the doses which are commonly used, potential effects have been described that need to be investigated,” the WHO’s Dr Francesco Branca said.
And giving advice to the public, he added: “If consumers are faced with the decision of whether to take cola with sweeteners or one with sugar, I think there should be a third option considered – which is to drink water instead.”
If there’s limited evidence, why has the WHO made this declaration?
The scale used by the IARC indicates the level of evidence there is for a substance being carcinogenic.
The IARC uses four categories: 1 – causes cancer; 2A – probably causes cancer; 2B – possibly causes cancer and 3 – no evidence available on cancer risk.
Aspartame was classified as 2B, “possibly carcinogenic”, on the basis of limited evidence for cancer in humans (specifically hepatocellular carcinoma, a type of liver cancer).
Other possible 2B carcinogens in the group include aloe vera, bracken ferns, lead and working as a hairdresser.
The scale does not say how much exposure you need to raise your cancer risk – it just identifies the substances as hazards.
Alice Davies, health information manager at Cancer Research UK, told Sky News: “Something being classed as a carcinogen doesn’t tell you how much it could increase the risk of cancer.
“Sometimes there are things that might cause cancer in theory, but in reality the dose that you’re exposed to is too low to increase your risk.
“So, for example, processed meat and smoking are both carcinogens but smoking causes about 54,000 cases of cancer in the UK each year whereas processed meat only causes about 5,400.”
So how much aspartame can I have a day?
This is where another arm of the WHO comes in, the Joint WHO and Food and Agriculture Organisation’s Expert Committee on Food Additives – JECFA for short.
JECFA reviewed the data on aspartame consumption and said adults can safely consume up to 40mg per kilo of body weight.
This does not change the daily limits recommended previously.
That means an adult who weighs 70kg could consume 2,800mg of aspartame a day.
Aspartame is found in drinks including Coke Zero, Diet Coke, Diet Pepsi, Pepsi Max, Sprite Zero and Fanta Zero.
A can of diet drink typically contains about 200mg of aspartame. So a 70kg adult could drink 14 cans without going over the safe daily limit for aspartame.
Image: File pic
What does a carcinogen do to your body?
Cancer is a disease of the cells, and a carcinogen is something that disrupts the way cells work.
A carcinogen might damage the cells themselves or it might damage your DNA, Ms Davies from Cancer Research UK said.
For example, a gene that normally prevents cells from replicating too much could be damaged, leading to cells multiplying uncontrollably.
Do I need to worry about aspartame causing cancer?
Rather than worry about things that might cause cancer, Ms Davies said it is better to address confirmed causes of cancer, such as smoking, alcohol and obesity.
“The most important thing really you can do to reduce your risk of cancer is to not smoke, to keep a healthy weight, have a healthy balanced diet, cut down alcohol and stay physically active.”
The Food Standards Agency (FSA) agrees. It says the JECFA report into aspartame is not something people should worry about, as long as they follow the advice that’s already out there.
Professor Robin May, the FSA’s chief scientific adviser, said: “JECFA’s report supports the FSA’s view that aspartame is safe to consume at current permitted use levels.”
The IARC and WHO will continue to monitor new evidence and encourage independent research groups to develop further studies on the potential association between aspartame and cancer.
The FSA said it welcomed this extra research, calling for “more and better studies” into the potential risks of aspartame consumption.
Hurricane Melissa, the world’s most powerful hurricane of the year so far, is closing in on Jamaica, with forecasters warning it could have a “catastrophic” impact.
The Category 5 hurricane has reached speeds of 175mph, already making it one of the strongest ever in the Atlantic basin.
A storm of Category 4 or higher has not hit Jamaica since records began 174 years ago.
It is expected to make landfall in the coming hours, continuing towards eastern Cuba and across the southeastern or central Bahamas.
Here’s what we know so far.
How bad could it be?
“Catastrophic” flash flooding and numerous landslides are likely when the hurricane hits, according to the US National Hurricane Centre, which warned of “total structural failure”.
Parts of the Caribbean island could see rainfall of up to 40 inches and it could cause a “life-threatening” storm surge on Jamaica’s southern coast, peaking around 13ft above ground level, the US centre said.
The storm is expected to be particularly bad along the coast of Kingston, which is home to critical infrastructure, including Jamaica’s main international airport and power plants.
Image: Hurricane Melissa moves towards Jamaica and Cuba. Pic: CIRA/NOAA via Reuters
Jamaica’s prime minister Andrew Holness said he expected “major damage to our road infrastructure, bridges, drains and possibly some damage to ports and airports” and warned it would take “far more resources than Jamaica has to recover”.
There are 850 shelters across the island, he added, enough for more than 20,000 people. Jamaica has a population of roughly 2.8 million.
All of Jamaica is expected to experience hurricane-force winds, heavy rainfall and flooding.
Has anyone died because of the hurricane?
Officials have said the storm is already responsible for at least seven deaths in the Caribbean, including three in Jamaica, three in Haiti and one in the Dominican Republic, where another person remains missing.
The three deaths in Jamaica happened during preparations for the storm’s arrival as people were cutting trees, health minister Christopher Tufton said. Thirteen people were injured, mostly due to falling off ladders and rooftops.
He urged Jamaicans to be careful during preparations, adding they should ensure all homes are stocked with enough drinking water and non-perishable food.
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Jamaica braces for Hurricane Melissa
On Monday evening Matthew Samuda, the environment minister, said thetime to prepare for the storm was overand that “the time now is to listen to instruction”, advising the public to start using resources sparingly.
Evacuation orders issued as power outages hit
Image: Map showing areas of Jamaica which have evacuation orders
Jamaica’s government has issued mandatory evacuation orders for at least seven areas in the southeast that are designated as high risk.
As of Monday night, many people had remained in their homes, according to Jamaica’s minister for science, energy, transport and telecommunication, Daryl Vaz.
“It’s very difficult, and it has always been a problem because people basically don’t take the event as seriously as they ought to,” Mr Vaz told Sky News.
He added that evacuation numbers were still “way below” the government’s targets.
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‘Very difficult’ to convince Jamaicans to evacuate
Colin Bogle, a Mercy Corps adviser based near Kingston, suggested many families were sheltering in their homes due to fears rather than complacency.
“Many have never experienced anything like this before, and the uncertainty is frightening,” he said.
“There is profound fear of losing homes and livelihoods, of injury, and of displacement.”
An estimated 52,000 people lost power as the hurricane approached, mostly in the western part of the country, the Jamaica Public Service said.
In the early hours of Tuesday morning, it said crews had managed to restore power for 30,000 of those affected and that they were continuing to work on the issues.
It added heavy rain and difficult terrain were “creating access challenges” and that “the safety of our crews and the public is our top priority”.
British holidaymakers locked down in hotels
Jamaica’s peak holiday season runs from mid-December to mid-April, but its tropical climate brings warmth all year round.
Hurricane season runs from June until November, but the country continues to attract tourists.
One of them is Andrew Tracey, a British holidaymaker who told Sky News he has been locked down in his hotel room until Wednesday at the earliest, having arrived on 20 October.
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Briton in Jamaica: ‘There is an undercurrent of panic’
He also estimated there were at least 200 people from the UK staying at the same complex.
With all airports in Jamaica closed, his flight was cancelled and there was “nothing really we could do”, he said.
“If I knew that the hurricane would hit while I was out here, I wouldn’t have gone at all,” he said.
“It’s hard to comprehend what we’re about to expect. I’ve never experienced any kind of hurricane, let alone a Category 5.
“The tension in the hotel last night when we went down for dinner was definitely one of nerves, even locals.”
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Hotel owner preparing for ‘catastrophic situation’
What route will Hurricane Melissa take?
Eastern Cuba is next in the path of Melissa, with tropical storm conditions expected to hit on Tuesday evening, including rainfall of up to 20 inches.
More than 500,000 people living in coastal and mountainous areas vulnerable to heavy winds and flooding have been evacuated, according to authorities.
Some 250,000 people were also accommodated in shelters around Santiago de Cuba, the second-largest city that lies right in the hurricane’s expected path.
A hurricane watch is in effect across the southeastern and central Bahamas, along with the British Overseas Territory, Turks and Caicos Islands.
They could be affected on Wednesday and the National Hurricane Centre expects flash floods with up to 8 inches of rainfall in tropical storm and hurricane conditions.
US warships in the region, the green light for covert operations, and deadly strikes on what the Trump administration claims are “narco terrorists” – could America’s next move be to strike Venezuela?
President Donald Trump has accused President Nicolas Maduro of leading an organised crime gang (without providing evidence) and declined to answer when questioned if the CIA has the authority to assassinate him.
In return, the Venezuelan leader has accused Mr Trump of seeking regime change and of “fabricating a new eternal war” against his country, as he appealed to the American people for peace.
The rhetoric coming out of the White House, coupled with the presence of military ships in the region, has raised questions about a possible armed conflict between the US and Venezuela.
The question in the air is: Will the US actually attack Venezuela?
Image: The USS Gravely destroyer arrives in Port-of-Spain, Trinidad and Tobago, on 26 October. Pic: AP
Venezuela’s government condemned the arrival and called it a provocation by Trinidad and Tobago and the US.
The USS Gerald R Ford aircraft carrier – the largest warship in the world – is also moving closer to Venezuela.
Image: Satellite image shows USS Gerald R Ford on 25 October off the coast of Croatia, a day after the announcement it would be deployed to the Caribbean. Pic: EU Copernicus
It comes as the US has acknowledged carrying out at least seven strikes since September on vessels near Venezuela that it claims were transporting drugs, killing at least 32 people.
Venezuela’s government says the strikes are illegal, amount to murder, and are acts of aggression.
Earlier this month, Trump confirmed he has authorised the CIA to carry out covert operations – including lethal operations – in Venezuela.
The CIA has a long history of operations in Latin America, with actions varying widely from direct paramilitary engagement to intelligence gathering and support roles with little to no physical footprint.
What could happen?
To get an idea of what could happen next, Sky News spoke to Dr Carlos Solar, an expert on Latin American security at the RUSI defence thinktank.
He says the level of military strategy the US is applying around Venezuela seems “unproportionate” for the task of tackling drug trafficking.
Image: In Venezuela, the government has civilians trained in the use of weapons to defend the country in the event of a US attack. Pic: AP
“A build-up this size can only suggest there’s a strategic military goal,” he added.
Dr Solar says the role of the CIA is “not surprising”, as the US often deploys spying capabilities in countries deemed adversarial.
“With the chances of a military conflict looming, having the most intelligence capable on the ground would be reasonable.”
Image: The world’s largest warship, the USS Gerald R Ford, has been tasked to the Caribbean. File pic: Reuters
Asked what could happen next, Dr Solar told Sky News: “One scenario is Trump authorises a round of long-range precision attacks in Venezuela’s territory linked to drug trafficking operations, eventually forcing Maduro to reciprocate later.
“We saw this early in the year when the US attacked Iran’s nuclear facilitates and Tehran returned missiles to US bases in Qatar.
“If the US decides to move more strongly, destroying all critical military targets from the Venezuelan forces, then the US could have Maduro surrender and leave the country immediately.
“This would be the least disruptive without causing greater destabilisation of the country.”
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Venezuelan President: ‘We don’t want a war’
What does Trump say about Venezuela?
Trump said his reasons for the strikes on vessels were the migration of Venezuelans, allegedly including former prisoners, to the US – and drug trafficking.
“I authorised for two reasons really,” he said. “Number one, they have emptied their prisons into the United States of America…they came in through the border. They came in because we had an open border,” he told reporters. “And the other thing are drugs.”
He has accused Venezuela of trafficking huge amounts of cocaine into the US, and alleged Mr Maduro is the leader of the Tren de Aragua gang – a claim most of his own intelligence agencies do not support.
Image: President Donald Trump is currently on a tour of Asia. Pic: Reuters
The US leader has not provided evidence for the claim about prisoners, and Sky News chief correspondent Stuart Ramsay pointed out the fentanyl drug that is causing destruction in America is largely manufactured in Mexico, not Venezuela.
“We are looking at land now, because we’ve got the sea very well under control,” Mr Trump added. It is not clear what actions this could entail.
The Pentagon recently disclosed to US Congress that the president has determined the US is engaged in “a non-international armed conflict” with drug cartels.
When asked if the CIA has the authority to execute Maduro, which would be a massive intervention, Trump declined to answer. Instead, he said: “I think Venezuela is feeling heat.”
Image: Venezuela’s President Nicolas Maduro. Pic: Reuters
What does Venezuela’s leader say?
Maduro has been in power since 2013, including re-elections in contests marred by accusations of fraud.
The last decade has seen his country gripped by spiralling hyperinflation and a humanitarian crisis that has seen an estimated eight million Venezuelans flee the country.
As the USS Gerald R Ford aircraft carrier moved closer to Venezuela, Maduro accused the US government of “fabricating a new eternal war” against his country.
Image: Venezuelan ambassador to the UN, Samuel Moncada, holds a newspaper article about a recent US military strike. Pic: Reuters
“They promised they would never again get involved in a war, and they are fabricating a war that we will avoid,” he said in a national address.
“They are fabricating an extravagant narrative, a vulgar, criminal and totally fake one,” he added, perhaps a reference to Trump’s claim that he is the leader of the Tren de Aragua gang and that his country trafficks cocaine into the US.
“Venezuela is a country that does not produce cocaine leaves.”
Image: Members of Venezuela’s Bolivarian National Guard. Pic: Reuters
Tren de Aragua, which traces its roots to a Venezuelan prison, is not known for having a big role in global drug trafficking but instead for its involvement in contract killings, extortion, and people smuggling.
Venezuela has raised a complaint to the UN Security Council and demanded accountability from the US.
An estimated 1.2 million people a week have conversations with ChatGPT that indicate they are planning to take their own lives.
The figure comes from its parent company OpenAI, which revealed 0.15% of users send messages including “explicit indicators of potential suicide planning or intent”.
Earlier this month, the company’s chief executive Sam Altman estimated that ChatGPT now has more than 800 million weekly active users.
While the tech giant does aim to direct vulnerable people to crisis helplines, it admitted “in some rare cases, the model may not behave as intended in these sensitive situations”.
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OpenAI launches web browser
OpenAI evaluated over 1,000 “challenging self-harm and suicide conversations” with its latest model GPT-5 and found it was compliant with “desired behaviours” 91% of the time.
But this would potentially mean that tens of thousands of people are being exposed to AI content that could exacerbate mental health problems.
The company has previously warned that safeguards designed to protect users can be weakened in longer conversations – and work is under way to address this.
“ChatGPT may correctly point to a suicide hotline when someone first mentions intent, but after many messages over a long period of time, it might eventually offer an answer that goes against our safeguards,” OpenAI explained.
OpenAI’s blog post added: “Mental health symptoms and emotional distress are universally present in human societies, and an increasing user base means that some portion of ChatGPT conversations include these situations.”
Adam Raine’s parents claim the tool “actively helped him explore suicide methods” and offered to draft a note to his relatives.
Court filings suggest that, hours before he died, the teenager uploaded a photo that appeared to show his suicide plan – and when he asked whether it would work, ChatGPT offered to help him “upgrade” it.
Last week, the Raines updated their lawsuit and accused OpenAI of weakening the safeguards to prevent self-harm in the weeks before his death in April this year.
In a statement, the company said: “Our deepest sympathies are with the Raine family for their unthinkable loss. Teen wellbeing is a top priority for us – minors deserve strong protections, especially in sensitive moments.”
Anyone feeling emotionally distressed or suicidal can call Samaritans for help on 116 123 or email jo@samaritans.org in the UK. In the US, call the Samaritans branch in your area or 1 (800) 273-TALK.