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A new drug has been found to slow the progression of Alzheimer’s, with experts hailing it as a “turning point” in the fight against the disease.

Donanemab was found to slow “clinical decline” by up to 35%, allowing people with Alzheimer’s to continue performing day-to-day tasks such as shopping, housekeeping, managing their finances and taking medication.

Following the findings of a trial of the drug, Alzheimer’s Research UK said “we’re entering a new era” where the disease “could become treatable”.

The health spending watchdog in England, the National Institute for Health and Care Excellence (NICE), is already assessing whether the drug can be used in the NHS.

Meanwhile, Alzheimer’s Society said treatments such as donanemab could one day mean the disease is comparable to long-term conditions such as asthma or diabetes.

The charity believes this “could be the beginning of the end for Alzheimer’s disease”.

Donanemab works by removing plaques of a protein called amyloid that build up in the brain of people with Alzheimer’s.

Scientists have published the final results of a trial, known as TRAILBLAZER ALZ-2, examining the safety and efficacy of the drug, manufactured by US pharmaceutical giant Eli Lilly.

Researchers examined almost 1,800 people with early-stage Alzheimer’s, with half given a monthly infusion of donanemab into the bloodstream and the other half given a placebo over 18 months.

The study concluded, after 76 weeks of treatment, donanemab slowed clinical decline by 35.1% in people with early Alzheimer’s whose brain scans showed low or medium levels of a protein called tau.

When the results were combined for people who had different levels of this protein, there was a 22.3% slowing in disease progression.

Side effects

The researchers found among a small number of people there were some serious side effects such as brain swelling.

Meanwhile, three deaths in the donanemab group and one in the placebo group were considered “treatment related”.

The findings were published in the Journal of the American Medical Association and presented to the Alzheimer’s Association International Conference in Amsterdam.

Eli Lilly said some taking the drug would be able to finish the course of treatment in six months once their amyloid plaque cleared.

It said treatment with donanemab reduced amyloid plaque on average by 84% at 18 months, compared with a 1% decrease for participants given a placebo.

Some 47% taking the drug who had early-stage disease and low or medium levels of tau were found to stall the disease for a year.

It comes after trials showed another drug called lecanemab slowed progression of Alzheimer’s symptoms by 27% in patients in the early stages of the disease. The drug was approved for use in the US earlier this month.

Alzheimer’s drugs offer hope but remain out of reach in UK

The NHS is nowhere near ready to provide the first effective Alzheimer’s drugs to the huge numbers of people who need them.

Estimates by Alzheimer’s Research UK suggest 720,000 people in the UK would meet the treatment criteria used in the clinical trials of lecanemab and donanemab.

These drugs work best when given at the very first stages of Alzheimer’s, or earlier still when patients have what doctors call mild cognitive impairment.

But that needs a diagnosis the NHS just can’t deliver at the scale needed.

Read Thomas Moore’s analysis here.

‘It is possible to slow down the disease’

Dr Mark Mintun, group vice president of neuroscience research and development at Eli Lilly and president of Avid Radiopharmaceuticals, said: “People living with early, symptomatic Alzheimer’s disease are still working, enjoying trips, sharing quality time with family – they want to feel like themselves, for longer.

“The results of this study reinforce the importance of diagnosing and treating disease sooner than we do today.”

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November 2022: Inside a lab working on Alzheimer’s treatment

Dr Richard Oakley, associate director of research at Alzheimer’s Society, said: “This is truly a turning point in the fight against Alzheimer’s and science is proving that it is possible to slow down the disease.

“Treatments like donanemab are the first steps towards a future where Alzheimer’s disease could be considered a long-term condition alongside diabetes or asthma – people may have to live with it, but they could have treatments that allow them to effectively manage their symptoms and continue to live fulfilled lives.”

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He added: “Diagnosis will be key to the access of any new treatments.

“We can’t have a situation where treatments are approved for use in the UK but people aren’t diagnosed early or accurately enough to be eligible.

“We need early, and accurate, diagnoses available for everyone and the NHS ready to roll out treatments such as donanemab and lecanemab if and when they are approved in the UK.”

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UK has no plans for conscription – but future decisions will respond to ‘new reality’, says minister

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UK has no plans for conscription - but future decisions will respond to 'new reality', says minister

The UK is not considering introducing conscription to ready the country for a potential war – but decisions may be needed in the future to respond to the “new reality” we are now living in, a minister has told Sky News.

In an interview with Trevor Phillips, Latvian President Edgars Rinkeviks has urged European countries to follow his country’s lead and “absolutely” introduce conscription, conceding the continent is “quite weak” militarily.

Politics latest: Calls for European nations to reintroduce conscription

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‘Debate’ in Latvia about introducing conscription for women

Asked if the UK government is considering introducing the measure to boost the armed forces, Cabinet Office minister Pat McFadden said it is important the UK does not find itself operating under “old assumptions” – and that it may be “decisions are needed in the future that respond to a new reality”.

He told Sunday Morning with Trevor Phillips: “We are not considering conscription, but of course we have announced a major increase in defence expenditure.

“We do have to recognise that the world has changed. The phrase ‘step up’ is used a lot. Europe does have to step up in terms of its own defence.

President Trump isn’t actually the first president to say that, but he said it more loudly and with more force than his predecessors – so, I think we have got to recognise that moment.”

‘UK cannot cling to old assumptions’

He added: “When the world is changing as fast as it is, it’s important that we don’t cling on to old assumptions.

“I think the prime minister has played a tremendous role in recent weeks in responding to that situation and explaining it to the public.

“That is why the decision on increasing defence expenditure was needed.

“It may be why other decisions are needed in the future that respond to a new reality, and that we don’t find ourselves caught operating under the same assumption as we used to in the past when the situation has changed.”

‘Battlefield is changing’

Sir Keir Starmer has promised to increase defence spending to 2.5% of GDP but has not set out when this will be achieved. Ministers say a defence review to be published this spring will set out a “roadmap” to it.

The number is much lower than the US president has demanded NATO members spend on defence, with Mr Trump saying they should all be spending 5% – an amount last seen during the Cold War.

Asked if the “new reality” involved a bigger army, Mr McFadden said ministers were waiting for the conclusion of the review.

But he added: “One thing is for sure, you would not spend money today on the same things as you would 10 years ago.

“The experience of the three years of the war in Ukraine has shown just how fast the battlefield is changing in terms of cyber, drones, the use of intelligence.”

History of conscription in UK

In the UK, military conscription has existed for two periods in modern times.

The first was from 1916 to 1920 following the outbreak of the First World War in 1914, due to the dwindling number of volunteers for military service.

Lord Kitchener’s campaign – promoted by his famous “Your Country Needs You” poster – had encouraged more than one million men to enlist by January 1915. But this was not enough.

In January 1916, after much debate, the Military Service Act was passed. This imposed conscription on all single men aged between 18 and 41, but exempted the medically unfit, clergymen, teachers and certain classes of industrial worker.

Conscientious objectors – men who objected to fighting on moral grounds – were also exempt, and were given civilian jobs or non-fighting roles at the front.

Conscription was not applied to Ireland because of the 1916 Easter Rising, although many Irishmen volunteered to fight.

A second Act passed in May 1916 extended conscription to married men, and in 1918, during the last months of the war, the age limit was raised to 51.

Conscription was extended until 1920 to allow the army to deal with continuing trouble spots in the Empire and parts of Europe.

In the run-up to the Second World War, plans for limited conscription applying to single men aged between 20 and 22 were given parliamentary approval in the Military Training Act in May 1939. This required men to undertake six months’ military training.

When Britain declared war against Germany on 3 September 1939, the National Service (Armed Forces) Act imposed conscription on all males aged between 18 and 41.

Those medically unfit were exempt, as were others in key industries and jobs such as baking, farming, medicine, and engineering, while conscientious objectors had to appear before a tribunal to argue their reasons for refusing to join up.

In December 1941, a second National Service Act was approved, making all unmarried women and all childless widows between the ages of 20 and 30 liable to call-up.

The last conscription term ended in 1960, although many soldiers chose to continue in the service beyond 1963.

The Conservatives’ first policy announcement of last year’s general election campaign was that the party would introduce a new form of mandatory National Service for 18-year-olds.

Asked if the Tories still stood by the plan which was in their manifesto, shadow home secretary Chris Philp told Sunday Morning with Trevor Phillips: “We are obviously not going to write our manifesto now, so I am not going to recommit to things in the previous manifesto.

“We’ll need to do the thinking properly. I am not going to speculate four years ahead of the election.

“I don’t think it was really exactly conscription that was being proposed, it was a National Citizen Service which is a bit different.

“The idea of getting younger people to do voluntary work and perform useful tasks is not a bad idea.”

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‘Right time’ to think about conscription

Last year, Britain’s former top NATO commander told Sky News it was time to “think the unthinkable” and consider introducing conscription.

General Sir Richard Sherriff, ex-deputy supreme allied commander of the military organisation, said: “I think we need to get over many of the cultural hang-ups and assumptions, and frankly think the unthinkable.

“I think we need to go further and look carefully at conscription.”

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Police recover body in search for suspect in Valentine’s Day pub shooting

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Police recover body in search for suspect in Valentine's Day pub shooting

Police searching for the suspect in the Kent pub shooting on Valentine’s Day have recovered a body from the River Thames.

Lisa Smith, 43, was killed after she was shot outside The Three Horseshoes in Knockholt on the evening of Friday 14 February.

Later that night, the suspect, named as Edvard Smith, was believed to have fallen into the Thames from the Queen Elizabeth II Bridge which crosses the river at Dartford 17 miles away.

Lisa Smith
Image:
Lisa Smith

Around that time, the suspect’s car containing a handgun was found abandoned on the bridge and a man was seen on the wrong side of the barrier.

About a week after the shooting, Kent Police said they believed Edvard Smith had died after falling into the water.

The force has now said a body was found in the Thames near Rainham in Essex on Friday afternoon. It has not been formally identified but the suspect’s family have been told of the development.

Edvard Smith was known to Ms Smith and there had been no prior contact between the police and the victim or suspect.

‘So much commotion’

Following the shooting, the landlady of The Three Horseshoes, Michelle Thomas, told Sky News she heard two loud bangs that she initially “thought were fireworks” on the night of the attack.

She said there was “so much commotion – screaming, shouting, crying” and the shooting had left the community in “absolute shock”.

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CCTV captures sound of gunshots near fatal shooting site

She said Ms Smith, from Slough, had been to the pub before, “mostly in the summer” but “wasn’t a regular”.

Ms Thomas also said about 30 people were at the pub for dinner, while 20 more were in the bar as the incident unfolded just after 7pm.

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Kent Police said on Saturday: “A body has been recovered by police from the River Thames, which is being linked to a murder investigation in Knockholt.

“On Friday 14 February 2025, Lisa Smith, 43, was killed after she was shot outside a pub in Main Road. The suspect was known to Lisa and later that evening officers found his car abandoned on the Queen Elizabeth II Bridge. Enquiries established he had fallen into the water below.

“At around 3.45pm on Friday 7 March, a body was located near Rainham, Essex. Formal identification has not yet taken place; however, the man’s family have been informed.”

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UK weather: Warm weekend brings 20C temperatures – hotter than Spain and Italy

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UK weather: Warm weekend brings 20C temperatures - hotter than Spain and Italy

Parts of the UK are expected to be hotter than the Balearic Islands, Costa del Sol and the Amalfi Coast this weekend.

The country is set to reach the highest temperatures of the year so far, with central England heating up to 20C on Sunday.

Saturday is also set to reach temperatures in the high teens, with East Anglia, northwest England, the north Midlands and North Wales hitting 18-19C, the Met Office said.

Those temperatures are believed to be above average for this time of year.

Get the latest forecast for your area here

Craig Snell, a meteorologist at the Met Office, said there are a “few exceptions” to the “fine and sunny” weekend weather, including areas in the far north of Scotland, but those areas will still be generally dry and sunny.

A map showing warm weather over the UK on Saturday
Image:
A map showing warm fronts over the UK on Saturday

Meanwhile, popular holiday destinations in Europe are expected to record cooler temperatures.

A high of 15C is forecast this weekend for Marbella on the south coast of Spain, a maximum of 17C is expected in Ibiza, and 18C is forecast for Sorrento on Italy’s Amalfi Coast.

People enjoy the warm weather at Clevedon Marine Lake in Clevedon. Parts of the UK are expected to be warmer this weekend than holiday hotspots including the Balearic islands, Costa del Sol and the Amalfi Coast. Picture date: Saturday March 8, 2025. PA Photo. Photo credit should read: Ben Birchall/PA Wire
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People were out in force on Saturday, enjoying the warmer weather. Pic: PA

Joggers run along the sea front in Southend-on-Sea, Essex.
Pic: PA
Image:
Joggers run along the sea front in Southend-on-Sea, Essex.
Pic: PA

Sky News meteorologist Chris England said the warm weekend is not expected to last, with conditions “cooling off from the North on Sunday night and through Monday”.

Colder fronts will start to move across the UK on Monday
Image:
Colder fronts will start to move across the UK on Monday

By Wednesday the UK will experience colder temperatures
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By Wednesday the UK will experience wintry showers and cold temperatures

A spell of rain will move south across the country early next week, bringing the return of a few wintry showers in the North and North East.

“While there is uncertainty in the extent of rain and wintry showers through the middle of next week, there is higher confidence that below average temperatures will continue through the week, bringing a very different feel to the mild weather over the weekend,” deputy chief meteorologist Chris Bulmer said.

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Temperatures will drop back below average across the UK from Tuesday, according to the Met Office.

Rural spots in Scotland could plummet as low as -4C, with maximum daytime temperatures typically between 5-8C.

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