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UK scientists have begun developing vaccines as an insurance against a new pandemic caused by an unknown “Disease X”.

The work is being carried out at the government’s high-security Porton Down laboratory complex in Wiltshire by a team of more than 200 scientists.

They’ve drawn up a threat list of animal viruses that are capable of infecting humans and could in future spread rapidly around the world.

Which of them will break through and trigger the next pandemic is unknown, which is why it’s referred to only as “Disease X.”

Sky News was escorted around the site, which is run by the UK Health Security Agency, to see the work being done in high-containment labs.

Professor Dame Jenny Harries, the head of the UKHSA.
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Professor Dame Jenny Harries, the head of the UKHSA

Professor Dame Jenny Harries, the head of the UKHSA, told Sky News: “What we’re trying to do here is ensure that we prepare so that if we have a new Disease X, a new pathogen, we have done as much of that work in advance as possible.

“Hopefully we can prevent it [a pandemic]. But if we can’t and we have to respond, then we have already started developing vaccines and therapeutics to crack it.”

The Vaccine Development and Evaluation Centre at Porton Down has been expanded to take on the work.

Originally, it was focussed on COVID and testing the effectiveness of vaccines against new variants.

But scientists at the centre are now involved in monitoring several high-risk pathogens, including bird flu, monkeypox and hantavirus, a disease spread by rodents.

File photo dated 25/02/21 of the Dstl high containment lab building at Porton Down in Salisbury, Wiltshire
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File photo of a high containment lab at Porton Down

One early success is the world’s first vaccine against Crimean-Congo haemorrhagic fever, a disease that’s spread by ticks and has a fatality rate of 30%.

Early stage clinical trials have just started, with 24 volunteers expected to test the jab.

The disease is becoming more common in Europe as global temperatures rise and some travellers have returned to the UK with the infection.

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UK scientists have begun developing vaccines as an insurance against a new pandemic caused by an unknown ‘Disease X’. The work is being carried out at the government’s high-security Porton Down laboratory complex in Wiltshire by a team of more than 200 scientists.

Prof Harries said climate change and population shifts are making another pandemic more likely.

“What we’re seeing is a rising risk globally,” she said.

“Some of that is because of things like urbanisation where you may get virus jumping into humans [living close-by], as we’ve seen with bird flu.

“And some of it is because of climate change where you get things like ticks and mosquitoes moving to where it was previously cold and is now becoming increasingly warm.

“So this is a growing risk agenda. But it’s one we can use our science actively to prevent human impact.”

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Bird flu is currently thought to be the most likely pandemic threat.

The Royal Society for the Protection of Birds says at least 30,000 seabirds have died around the UK this summer as a more virulent strain of the H5N1 virus has swept around the world.

There is also evidence of limited spread in some mammals.

Bird flu is currently thought to be the most likely pandemic threat. The RSPB says at least 30,000 seabirds have died around the UK this summer as a more virulent strain of the H5N1 virus has swept around the world.
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Bird flu is currently thought to be the most likely pandemic threat

And four people working on poultry farms in the UK have also tested positive, but were only mildly affected.

The UKHSA has started monitoring people in close contact with birds in case it can spread without causing symptoms.

The agency is part of a global effort to develop a vaccine within 100 days of a new pathogen being recognised as having pandemic potential.

“Historically, that would be unheard of,” said Prof Harries.

“It would normally take five or 10 years. For COVID it was around 360 days.

“So this is a really high ambition. But for some viruses, it is definitely possible.”

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M4 and M48 closed after human remains found

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M4 and M48 closed after human remains found

Two motorways have been shut after human remains were found on the road. 

Several drivers reported a body on the carriageway between junctions 20 and 21 of the M4 – between Almondsbury and Awkley – at about 6.40pm this evening.

The body is believed to be that of a man in his forties, whose next of kin have been told.

A police investigation to establish how the person came to be on the motorway continues.

Parts of the M4 and M48 motorways near Bristol are likely to remain closed until the early hours of Sunday morning, Avon and Somerset Police said.

In a statement, the force said: “Police are keen to hear from anyone who was travelling along that stretch of the M4 has any relevant information or dashcam footage.”

The road closures were likely to cause significant delays in and out of Wales tonight, with closures starting on the English side of the Prince of Wales Bridge and the Severn Bridge.

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National Highways said the M4 is shut in both directions between junctions 20 and 21, while the M48 eastbound is closed from junction 1 near Aust.

The links from the M5 junction 15 south to the M4 junction 20 west, and the M5 junction 16 north to M4 junction 20 west were also closed.

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Starmer asks US to stand by Ukraine with security guarantee as bad peace deal would be ‘disaster’ for all

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Starmer asks US to stand by Ukraine with security guarantee as bad peace deal would be 'disaster' for all

Sir Keir Starmer has urged Donald Trump to stand by Ukraine with a security guarantee as he warned a bad peace deal would be a “disaster for everyone”.

The prime minister is due to meet the US president for talks in Washington DC next week amid fragile relations between America and Europe after Mr Trump launched a verbal attack on President Volodymyr Zelenskyy.

The US president called Ukraine’s leader a “dictator” on Wednesday and later said Sir Keir and French President Emmanuel Macron, both of whom will visit the White House in the coming days, “haven’t done anything” to end the war.

Sir Keir Starmer leaves after a meeting in Paris with European leaders on Ukraine on 17 February. Pic: Reuters
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Sir Keir Starmer met with European leaders in Paris on Monday to discuss Ukraine. Pic: Reuters

Sir Keir said a good peace “can only be won through strength” and Ukraine “must have a voice in negotiations about its future”.

And he warned that a “peace deal which does not stop Putin from attacking again would be a disaster for everyone”.

Writing in The Sun on Sunday, he said Kyiv needs strong security guarantees “so the peace will last” and America “must be part of that guarantee”.

This could mean providing air defence and a promise that the US will come to the aid of a NATO country if Russia attacks them, the paper reported.

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So far, talks aimed at ending the war have been taking place between US and Russian delegations in Saudi Arabia, which have not included the Ukrainians.

UK Defence Secretary John Healey has said “any negotiations about Ukraine cannot happen without Ukraine. We all want the fighting to end, but an insecure peace risks more war”.

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‘Turn the screws’ on Russia

The third anniversary of Russia’s full-scale invasion of Ukraine is on Monday.

Foreign Secretary David Lammy has said he will unveil new sanctions to “turn the screws” on Russia on Monday to coincide with the anniversary.

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Sir Keir also said the UK must increase its defence spending and play a bigger role in NATO.

And he is open to British troops playing a role in any European force in Ukraine after a peace agreement.

He added: “This is not something I say lightly.”

Sir Keir, along with other European allies and UK opposition parties, has backed Mr Zelensky as a “democratically elected leader”.

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Conflicting views over Ukraine deal

Also, Washington has warned that Europe must shoulder more of the cost of its own security.

Sir Keir is expected to use his upcoming trip to the US to confirm a timeline to raise UK defence spending from 2.3% to 2.5% of gross domestic product (GDP) in a bid to ease tensions.

It comes amid pressure from defence chiefs and opposition critics including Tory leader Kemi Badenoch, who wrote to the prime minister on Saturday demanding he set out a plan for meeting the target.

:: Education secretary Bridget Phillipson, campaigner for global health and education Sarah Brown, and shadow defence secretary James Cartlidge will be discussing all the latest political stories in the UK and around the world on the Trevor Phillips on Sunday show on Sky News from 8.30am

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Girl, 3, dies after tram and van crash in Manchester city centre

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Girl, 3, dies after tram and van crash in Manchester city centre

A three-year-old girl has died after a collision between a tram and a van in Manchester city centre.

The girl was taken to hospital but died from her injuries, Greater Manchester Police (GMP) said.

“No arrests have been made and inquiries are ongoing,” the force said.

The child was a pedestrian and was not travelling in either the tram or van, GMP said.

The fatal collision happened on Mosley Street shortly before 10am, a Transport for Greater Manchester (TfGM) spokesperson said.

“All of our thoughts are with her family and loved ones at this incredibly difficult time. We are supporting police with their investigation,” a statement said.

A North West Ambulance Service spokesperson said two ambulances, a rapid response vehicle and two air ambulance crews attended the scene.

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TfGM said there was continued disruption across the Metrolink after the incident and advised people to check the Bee Network website and app for the latest travel information.

Manchester‘s Bee Network said: “Due to a road traffic collision on Mosley Street in the city centre, no tram services are operating between St Peter’s Square and Piccadilly Gardens.”

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An X post from GMP’s traffic officers said: “Our officers are currently in attendance at a collision, involving a tram and another vehicle in Manchester city centre.

“We are presently trying to establish the circumstances however we envisage there will be a lengthy closure of surrounding streets near to St Peters Square.”

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