UK scientists have begun developing vaccines as an insurance against a new pandemic caused by an unknown “Disease X”.
The work is being carried out at the government’s high-security Porton Down laboratory complex in Wiltshire by a team of more than 200 scientists.
They have drawn up a threat list of animal viruses that are capable of infecting humans and could in future spread rapidly around the world.
Which of them will break through and trigger the next pandemic is unknown, which is why it’s referred to only as “Disease X”.
Sky News was escorted around the site, which is run by the UK Health Security Agency, to see the work being done in high-containment labs.
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0:26
Risk of future pandemics ‘rising globally’
Professor Dame Jenny Harries, the head of the UK Health Security Agency (UKHSA), told Sky News: “What we’re trying to do here is ensure that we prepare so that if we have a new Disease X, a new pathogen, we have done as much of that work in advance as possible.
“Hopefully we can prevent it [a pandemic]. But if we can’t and we have to respond, then we have already started developing vaccines and therapeutics to crack it.”
The Vaccine Development and Evaluation Centre at Porton Down has been expanded to take on the work.
Originally, it was focused on COVID and testing the effectiveness of vaccines against new variants.
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But scientists at the centre are now involved in monitoring several high-risk pathogens, including bird flu, monkeypox and hantavirus, a disease spread by rodents.
Image: File photo of a high containment lab at Porton Down
One early success is the world’s first vaccine against Crimean-Congo haemorrhagic fever, a disease that’s spread by ticks and has a fatality rate of 30%.
Early-stage clinical trials have just started, with 24 volunteers expected to test the jab.
The disease is becoming more common in Europe as global temperatures rise and some travellers have returned to the UK with the infection.
Prof Harries said climate change and population shifts are making another pandemic more likely.
“What we’re seeing is a rising risk globally,” she said.
“Some of that is because of things like urbanisation where you may get virus jumping into humans [living close-by], as we’ve seen with bird flu.
“And some of it is because of climate change where you get things like ticks and mosquitoes moving to where it was previously cold and is now becoming increasingly warm.
“So this is a growing risk agenda. But it’s one we can use our science actively to prevent human impact.”
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Bird flu is currently thought to be the most likely pandemic threat.
The Royal Society for the Protection of Birds says at least 30,000 seabirds have died around the UK this summer as a more virulent strain of the H5N1 virus has swept around the world.
There is also evidence of limited spread in some mammals.
Image: Bird flu is currently thought to be the most likely pandemic threat
And four people working on poultry farms in the UK have also tested positive, but were only mildly affected.
The UKHSA has started monitoring people in close contact with birds in case it can spread without causing symptoms.
The agency is part of a global effort to develop a vaccine within 100 days of a new pathogen being recognised as having pandemic potential.
“Historically, that would be unheard of,” said Prof Harries.
“It would normally take five or 10 years. For COVID it was around 360 days.
“So this is a really high ambition. But for some viruses, it is definitely possible.”
In common with many parents across the country, here’s a conversation that I have with my young daughter on a semi-regular basis (bear with me, this will take on some political relevance eventually).
Me: “So it’s 15 minutes until your bedtime, you can either have a little bit of TV or do a jigsaw, not both.”
Daughter: “Ummmm, I want to watch TV.”
Me: “That’s fine, but it’s bed after that, you can’t do a jigsaw as well.”
Fast-forward 15 minutes.
Me: “Right, TV off now please, bedtime.”
(Pause)
Daughter: “I want to do a jigsaw.”
Now replace me with the government, the TV and jigsaw options with axing welfare cuts and scrapping the two-child cap, and my daughter with rebellious backbenchers.
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6:36
Rachel Reeves’s fiscal dilemma
That is the tension currently present between Downing Street and Labour MPs. And my initial ultimatum is the messaging being pumped out from the government this weekend.
In essence: you’ve had your welfare U-turn, so there’s no money left for the two-child cap to go as well.
As an aside – and before my inbox fills with angry emails lambasting me for using such a crude metaphor for policies that fundamentally alter the lives of some of the most vulnerable in society – yes, I hear you, and that’s part of my point.
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9:11
Welfare U-turn ‘has come at cost’
For many in Labour, this approach feels like the lives of their constituents are being used in a childish game of horse-trading.
So what can be done?
Well, the government could change the rules.
Altering the fiscal rules is – and will likely remain – an extremely unlikely solution. But as it happens, one of Labour’s proverbial grandparents has just popped round with a different suggestion.
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5:31
Welfare: ‘Didn’t get process right’ – PM
A wealth tax, Lord Neil Kinnock says, is the necessary outcome of the economic restrictions the party has placed on itself.
Ever the Labour storyteller, Lord Kinnock believes this would allow the government to craft a more compelling narrative about whose side this administration is on.
That could be valuable, given one of the big gripes from many backbench critics is that they still don’t really understand what this prime minister stands for – and by extension, what all these “difficult decisions” are in aid of.
The downside is whether it will actually raise much money.
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16:02
Is Corbyn an existential risk to Labour?
The super-rich may have lots of assets to take a slice from, but they also have expensive lawyers ready to find novel ways to keep their client’s cash away from the prying eyes of the state.
Or, of course, they could just leave – as many are doing already.
In the short term, the future is a bit easier to predict.
If Downing Street is indeed now saying there is no money to scrap the two-child cap (after heavy briefing in the opposite direction just weeks ago), an almighty tantrum from the backbenches is inevitable.
And as every parent knows, the more you give in, the harder it becomes to hold the line.
The UK has re-established diplomatic ties with Syria, David Lammy has said, as he made the first visit to the country by a British minister for 14 years.
The foreign secretary visited Damascus and met with interim president Ahmed al Sharaa, also the leader of the rebel group Hayat Tahrir al-Sham (HTS), and foreign minister Asaad al Shaibani.
In a statement, Mr Lammy said a “stable Syria is in the UK’s interests” and added: “I’ve seen first-hand the remarkable progress Syrians have made in rebuilding their lives and their country.
“After over a decade of conflict, there is renewed hope for the Syrian people.
“The UK is re-establishing diplomatic relations because it is in our interests to support the new government to deliver their commitment to build a stable, more secure and prosperous future for all Syrians.”
Image: Foreign Secretary David Lammy with Syria’s interim president Ahmed al Sharaa in Damascus. Pic: X / @DavidLammy
The Foreign, Commonwealth and Development Office has also announced a £94.5m support package for urgent humanitarian aid and to support the country’s long-term recovery, after a number of British sanctions against the country were lifted in April.
While HTS is still classified as a proscribed terror group, Sir Keir Starmer said last year that it could be removed from the list.
The Syrian president’s office also said on Saturday that the president and Mr Lammy discussed co-operation, as well as the latest developments in the Middle East.
Since Assad fled Syria in December, a transitional government headed by Mr al Sharaa was announced in March and a number of western countries have restored ties.
In May, US President Donald Trump said the United States would lift long-standing sanctions on Syria and normalise relations during a speech at the US-Saudi investment conference.
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1:12
From May: Trump says US will end sanctions for Syria
He said he wanted to give the country “a chance at peace” and added: “There is a new government that will hopefully succeed.
“I say good luck, Syria. Show us something special.”
Secret Service quietly amasses one of the world’s largest crypto cold wallets with $400 million seized, exposing scams through blockchain sleuthing and VPN missteps.