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UK scientists have begun developing vaccines as an insurance against a new pandemic caused by an unknown “Disease X”.

The work is being carried out at the government’s high-security Porton Down laboratory complex in Wiltshire by a team of more than 200 scientists.

They have drawn up a threat list of animal viruses that are capable of infecting humans and could in future spread rapidly around the world.

Which of them will break through and trigger the next pandemic is unknown, which is why it’s referred to only as “Disease X”.

Sky News was escorted around the site, which is run by the UK Health Security Agency, to see the work being done in high-containment labs.

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Risk of future pandemics ‘rising globally’

Professor Dame Jenny Harries, the head of the UK Health Security Agency (UKHSA), told Sky News: “What we’re trying to do here is ensure that we prepare so that if we have a new Disease X, a new pathogen, we have done as much of that work in advance as possible.

“Hopefully we can prevent it [a pandemic]. But if we can’t and we have to respond, then we have already started developing vaccines and therapeutics to crack it.”

The Vaccine Development and Evaluation Centre at Porton Down has been expanded to take on the work.

Originally, it was focused on COVID and testing the effectiveness of vaccines against new variants.

But scientists at the centre are now involved in monitoring several high-risk pathogens, including bird flu, monkeypox and hantavirus, a disease spread by rodents.

File photo dated 25/02/21 of the Dstl high containment lab building at Porton Down in Salisbury, Wiltshire
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File photo of a high containment lab at Porton Down

One early success is the world’s first vaccine against Crimean-Congo haemorrhagic fever, a disease that’s spread by ticks and has a fatality rate of 30%.

Early-stage clinical trials have just started, with 24 volunteers expected to test the jab.

The disease is becoming more common in Europe as global temperatures rise and some travellers have returned to the UK with the infection.

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The NHS COVID app is closing down – but is the pandemic really over?

UK scientists have begun developing vaccines as an insurance against a new pandemic caused by an unknown ‘Disease X’. The work is being carried out at the government’s high-security Porton Down laboratory complex in Wiltshire by a team of more than 200 scientists.

Prof Harries said climate change and population shifts are making another pandemic more likely.

“What we’re seeing is a rising risk globally,” she said.

“Some of that is because of things like urbanisation where you may get virus jumping into humans [living close-by], as we’ve seen with bird flu.

“And some of it is because of climate change where you get things like ticks and mosquitoes moving to where it was previously cold and is now becoming increasingly warm.

“So this is a growing risk agenda. But it’s one we can use our science actively to prevent human impact.”

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Bird flu is currently thought to be the most likely pandemic threat.

The Royal Society for the Protection of Birds says at least 30,000 seabirds have died around the UK this summer as a more virulent strain of the H5N1 virus has swept around the world.

There is also evidence of limited spread in some mammals.

Bird flu is currently thought to be the most likely pandemic threat. The RSPB says at least 30,000 seabirds have died around the UK this summer as a more virulent strain of the H5N1 virus has swept around the world.
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Bird flu is currently thought to be the most likely pandemic threat

And four people working on poultry farms in the UK have also tested positive, but were only mildly affected.

The UKHSA has started monitoring people in close contact with birds in case it can spread without causing symptoms.

The agency is part of a global effort to develop a vaccine within 100 days of a new pathogen being recognised as having pandemic potential.

“Historically, that would be unheard of,” said Prof Harries.

“It would normally take five or 10 years. For COVID it was around 360 days.

“So this is a really high ambition. But for some viruses, it is definitely possible.”

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DC attorney general sues Athena Bitcoin over alleged hidden fees

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DC attorney general sues Athena Bitcoin over alleged hidden fees

DC attorney general sues Athena Bitcoin over alleged hidden fees

The attorney general for the District of Columbia, Brian Schwalb, alleges that Athena Bitcoin charged undisclosed fees and had insufficient safeguards to stop fraud and scams.

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Immigration becomes voters’ top issue for first time since Brexit

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Immigration becomes voters' top issue for first time since Brexit

Immigration and asylum is back as the top issue of public concern the first time since Brexit, according to exclusive polling for Sky News.

It overtook the economy as the number one issue facing the country in YouGov’s latest poll in May, even before the summer dominated by the migration debate.

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It is now at the highest point level of concern in over five years, since the small boats started crossing the Channel in significant numbers.

In the most recent YouGov poll, 58% picked immigration as one of the three top issues facing the country at the moment, while 51% pointed to the economy, 29% health and 22% crime.

The overwhelming majority of the public think this is because immigration is too high, with 70% saying this, 18% saying it’s about right, and 3% saying it is too low.

For decades, until very recently, successive prime ministers and chancellors have told voters that migration is a public good, but the public has not bought this argument.

Some 50% think immigration is having a negative impact on the UK, with 22% saying the benefits are equally weighed and 22% also saying that it has a positive effect.

The exclusive polling also reveals whether the public think other governments would be better at dealing with migration and small boats than Labour are.

Less than one in five – just 18% – think a Tory government would be doing much better, with 55% thinking they would be the same and 12% worse.

The more hardline approach outlined by Reform UK appears to have be noticed by the public. Some 40% think a Reform government would be handling migration and small boats better, and 26% the same, with 19% worse.

YouGov interviewed 2,268 GB adults between 31 August and 1 September.

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What’s driven UK’s astounding immigration levels – including some unprecedented highs

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What's driven UK's astounding immigration levels - including some unprecedented highs

One of the great tragedies of the way immigration policy has been debated in this country for years, if not decades, is that the conversation is mostly voiced in emotive rather than rational terms.

Those who air fears about the flows of foreign-born people into the UK are dismissed as bigots (most famously by Gordon Brown). Those who argue that immigrants are good for the economy are dismissed as being deluded or blind to a mounting crisis.

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So what’s actually going on? Well, let’s take a deep breath, try if we can to ignore all the emotions, and focus instead on the numbers. What do those numbers tell us?

Highest net migration in British history

Well, the big picture is… big. The total flows of migrants coming into the country in recent years have been nothing short of astounding. While the figures have plateaued in the past 18 months or so, as of late 2023, immigration (which is to say, people coming to live here) was running at roughly 1.3 million people a year. Subtract those emigrating in that period (roughly 400,000), and that leaves you with net migration of nearly 900,000 people.

This is such a large number it’s actually quite hard to get your head around it, but here’s one way. As a percentage of the population (it comes out at about 1.25%), this is the highest net migration this country has ever experienced, since roughly comparable records began hundreds of years ago. Indeed, I cannot find another similar episode running back to the reign of Henry VIII.

A recent anti-immigration protest in Bristol. Pic: PA
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A recent anti-immigration protest in Bristol. Pic: PA

How did we get here?

It wasn’t all that long ago that David Cameron was promising to reduce net migration to the “tens of thousands” each year. So how did we get to a place where net migration was close to running into seven figures?

In large part, the answer comes back to the introduction of the new post-Brexit migration rules implemented under Boris Johnson’s government. Among these reforms were measures making it comparatively easier for non-EU nationals to get visas. There were also, perhaps even more importantly, new student visa rules making it easier to come and study in this country.

Boris Johnson's post-Brexit migration policy brought huge numbers of people to the UK. Pic: Reuters
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Boris Johnson’s post-Brexit migration policy brought huge numbers of people to the UK. Pic: Reuters

Students and government policy

The upshot is that numbers of students from countries around the world (but mostly outside the EU, led by India, China, Nigeria, and Pakistan) flowed into this country. The extent to which these visas were really quasi-working visas, enabling young workers to come into this country to work in the gig economy, is something economists and officials are still picking over even now. But what is clear is that there is nothing normal about this influx.

It’s perhaps worth underlining at this stage that this immigration – the record flows, greater than anything we’ve seen since at least Henry VIII – is nearly all legal. These are people coming into the country not illegally or on small boats or via the asylum system, but having been issued with visas by the Home Office. This was a direct result of government policy (as well as the economic incentives of coming to a country like the UK). But that raises another question: how much of this was small boats?

After all, the vast majority of coverage in papers and television news in recent weeks has fixated on the small boats. So how much of that total do they account for? In short, just under 5% of the total.

None of this is to say small boats aren’t a very big issue for the UK. But, surprising as this might sound, given how many column inches are devoted to them, they are absolutely dwarfed by the legal flows.

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Labour’s new hard stance on migration

High legal migration – but small boats still at record levels

And while the flows of legal immigration to Britain (and, for that matter, student immigration) are among the highest in the developed world, flows of asylum seekers are considerably lower than in most other countries. Britain may rank number one in the OECD on students and number two on overall immigration, but it only saw the eighth-biggest flows of asylum seekers in the most recent year for which we have data (2023).

Of the total flows into the UK in the most recent time period, small boat arrivals accounted for a mere 4.8%. The vast majority is legal migration.

But that being said, the totals coming in on small boats and into the asylum system are nonetheless at unprecedented highs. Moreover, in recent years, asylum seekers have been less likely to be removed from the country. A growing proportion have been bailed, pending their cases, with the upshot that right now the total number of asylum seekers around the UK is close to 125,000 – about the size of Cambridge.

All of which is to say, both of the following statements are true: Firstly, small boats are a tiny fraction of overall immigration, and secondly, Small boat numbers are higher than ever before and are contributing to unprecedented levels of asylum seekers in the UK.

Britain is far from the only country to face these challenges. The question now is whether it can succeed in bringing down the flows and the backlog in the coming years.

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