DDNS technique could reduce the time to detect polio, study shows

Published

2 years ago

August 18, 2023

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Reviewed by Lily Ramsey, LLM Aug 18 2023

A new study, 'Sensitive poliovirus detection using nested PCR and nanopore sequencing: a prospective validation study', published today (17 August 2023) in Nature Microbiology, proves that using DDNS to detect polio outbreaks can save public health authorities crucial time and money.

This research was jointly conducted by researchers at the Institut National de Recherche Biomédicale in Kinshasa who implemented DDNS in the Democratic Republic of the Congo (DRC) for the detection of polio outbreaks in collaboration with the MHRA, Imperial College London, the University of Edinburgh and various laboratories of the World Health Organization (WHO) Global Polio Laboratory Network (GPLN), with support from the Bill and Melinda Gates Foundation.

This is the first time that this type of scientific technique has been used to detect polio. Similar techniques have previously been used to detect COVID-19, Ebola, measles and monkeypox.

By enabling samples to be tested in the country where the outbreak originated rather than being sent to specialist laboratories abroad, the costs and delays of transport and testing can be reduced from an average of 42 days to an average of 19 days.

Currently, stool samples from countries with active polio outbreaks such as the DRC must be shipped around the world for lengthy, complex laboratory tests to confirm a polio case. Faster detection of polio in the regions where outbreaks still occur allows for a faster response by authorities through targeted, localised vaccination campaigns, minimising the opportunity for the virus to spread.

Javier Martin, Principal Scientist in Virology at the MHRA said: We are standing at a delicate and pivotal moment for the eradication of polio. While vaccination programmes have seen polio disappear in many countries, the delayed detection of outbreaks poses a major threat to those efforts.

By implementing detection methods such as DDNS, we can identify where outbreaks are and which polio strain is present much more quickly, allowing us to act at the earliest opportunity.

This is the result of years of work, collaborating with our partners. Together, we will continue to build on this research and support countries at risk of outbreaks to implement DDNS testing to help make polio a disease of the past."

This research showed that DDNS tests done locally in the DRC over a six-month period were an average of 23 days faster than the standard method, with over 99% accuracy.

Researchers also tested this technique in the UK and detected poliovirus in London in 2022, leading to the recent drive to ensure children under the age of 12 are vaccinated through the London polio catch-up campaign 2023.

Professor Placide Mbala-Kingebeni, Medical Doctor and Virologist at the Institut National de Recherche Biomédicale said: This is the perfect example of collaboration, where combining and sharing knowledge together with all our partners has supported the vital work of the INRB in the DRC where poliomyelitis remains a serious public health problem.

Collaboration and training with our partners has empowered the local team not only to master and confidently carry out this new technique but also to transfer the knowledge and skills to other African countries where poliovirus outbreaks are reported regularly.

The support and guidance of the Bill and Melinda Gates Foundation and the GPLN, who make these collaborations possible, enables the application and expansion of DDNS across Africa for the rapid detection of poliovirus and outbreak response, helping us move closer towards polio eradication."

Dr Alex Shaw, Research Fellow in the School of Public Health at Imperial College London said: This method allows the rapid confirmation of polio strains, facilitating swifter vaccine responses that can reduce the number of polio cases stemming from an outbreak. Development and validation of the method has been the result of fruitful collaboration between a consortium of many partners.

As a consortium we look forward to the training of additional national laboratories in this method, with prior trainees, including members of INRB, now taking on the role of trainers.

The sequencing technology used in this method is easily adapted for the detection and typing of other organisms. This rollout will therefore provide a foundation of skills and experience that can be redirected to the genomic surveillance of other pathogens as needed." Related StoriesCutting-edge research: machine learning identifies early predictors of type 1 diabetesBibliometric analysis reveals research trends connecting Alzheimer's disease and the gut microbiomeResearch uncovers new insights into post-COVID-19 syndrome (PCS) phenotypes and impact on quality of life

Polio is an infectious disease caused by the poliovirus, most commonly transmitted through contact with infected feces via contaminated food and water.

While many people may never show symptoms, in extreme cases, especially for babies and children under the age of five, polio can lead to permanent paralysis or death.

The WHO has identified delays in detection as one of the major challenges facing their Polio eradication strategy 2022-2026.

While faster detection methods such as DDNS cannot eradicate polio on their own, they play an essential part in managing outbreaks.

Scientists at the MHRA will continue to support the testing and validation of DDNS as a polio detection technique and training WHO laboratories around the world in how to use it. Source:

GOV.UKJournal reference:

Shaw, A. G., et al. (2023). Sensitive poliovirus detection using nested PCR and nanopore sequencing: a prospective validation study. Nature Microbiology. doi.org/10.1038/s41564-023-01453-4.

UK

Home secretary vows to end UK’s ‘golden ticket’ for asylum seekers – as Denmark-based reforms to be unveiled

Published

18 mins ago

November 16, 2025

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Home secretary vows to end UK's 'golden ticket' for asylum seekers - as Denmark-based reforms to be unveiled

The home secretary is set to unveil sweeping measures to tackle illegal migration, vowing to end the UK’s ‘golden ticket’ for asylum seekers.

People granted asylum in the UK will only be allowed to stay in the country temporarily, in the changes expected to be unveiled on Monday by Shabana Mahmood.

Modelled on the Danish system, the aim is to make the UK less attractive for illegal immigrants and make it easier to deport them.

Planned changes mean that refugee status will become temporary and subject to regular review, with refugees removed as soon as their home countries are deemed safe.

The Home Office said the “golden ticket” deal has seen asylum claims surge in the UK, drawing people across Europe, through safe countries, onto dangerous small boats.

Under current UK rules, those granted refugee status have it for five years and can then apply for indefinite leave to remain and get on a route to citizenship.

As part of the changes, the statutory legal duty to provide asylum seeker support, including housing and weekly allowances, will be revoked.

The government will seek to remove asylum support, including accommodation and handouts, to those who have a right to work and who can support themselves but choose not to or those who break UK law.

‘Last chance for a decent politics’

A government source said Ms Mahmood believes her reforms are about “more than the electoral fortunes of her party”.

“This is the last chance for a decent, mainstream politics. If these moderate forces fail, she believes, something darker will follow,” they said.

“But this demands that moderates are willing to do things that will seem immoderate to some. She has reminded those who are reluctant to embrace her ambition for bold reform, with an ultimatum: ‘if you don’t like this, you won’t like what follows me.'”

Ms Mahmood said they were the most sweeping changes to the asylum system “in a generation”, as she vowed the government will “restore order and control to our borders”.

The home secretary also told The Sunday Times that “I can see – and I know my colleagues can – that illegal migration is tearing our country apart”.

System being ‘gamed’

The source said Ms Mahmood believes the system is being “gamed by those travelling on boats or abusing legal visas”.

Some 39,075 people have arrived in the UK after making the journey across the Channel so far this year, according to the latest Home Office figures.

That is an increase of 19% on the same point in 2024 and up 43% on 2023, but remains 5% lower than at the equivalent point in 2022, which remains the peak year for crossings.

What happened in Denmark?

The UK government points to Denmark remaining a signatory of the European Convention on Human Rights, while also cutting the number of asylum applications to the lowest number in 40 years and successfully removing 95% of rejected asylum seekers.

What are Denmark’s migration rules?

Denmark has adopted increasingly restrictive rules in order to deal with migration over the last few years.

In Denmark, most asylum or refugee statuses are temporary. Residency can be revoked once a country is deemed safe.

In order to achieve settlement, asylum seekers are required to be in full-time employment, and the length of time it takes to acquire those rights has been extended.

Denmark also has tougher rules on family reunification – both the sponsor and their partner are required to be at least 24 years old, which the Danish government says is designed to prevent forced marriages.

The sponsor must also not have claimed welfare for three years and must provide a financial guarantee for their partner. Both must also pass a Danish language test.

In 2018, Denmark introduced what it called a ghetto package, a controversial plan to radically alter some residential areas, including by demolishing social housing. Areas with over 1,000 residents were defined as ghettos if more than 50% were “immigrants and their descendants from non-Western countries”.

In 2021, the left of centre government passed a law that allowed refugees arriving on Danish soil to be moved to asylum centres in a partner country – and subsequently agreed with Rwanda to explore setting up a program, although that has been put on hold.

Shadow home secretary Chris Philp said the Labour government has “lost control” of the UK’s borders” with illegal channel crossings “surging to over 62,000 since the election”.

He said some of the new measures were welcome but “they stop well short of what is really required and some are just yet more gimmicks – like the previous ‘smash the gangs’ gimmick”.

Mr Philp added: “Only the Conservative borders plan will end illegal immigration – by leaving the ECHR, banning asylum claims for illegal immigrants, deporting all illegal arrivals within a week and establishing a Removals Force to deport 150,000 illegal immigrants each year.”

And Enver Solomon, chief executive of Refugee Council, said: “These sweeping changes will not deter people from making dangerous crossings, but they will unfairly prevent men, women and children from putting down roots and integrating into British life.”

Ms Mahmood will be appearing on Sunday Morning with Trevor Phillips from 8.30am on Sunday.

Environment

Rumor: Polestar ($PSNY) planning reverse stock split to stay on NASDAQ

Published

2 hours ago

November 15, 2025

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Rumor: Polestar ($PSNY) planning reverse stock split to stay on NASDAQ

The automaker turned penny stock is doing a reverse stock split to stay listed on the Nasdaq

In a bid to get it above the $1.00/share NASDAQ-required minimum, fledgling EV brand Polestar ($PSNY) is rumored to be considering a 1:30 reverse stock split that could see the per-share price rocket up to nearly $16.

Geely-owned Volvo spinoff Polestar is working as hard as Tesla to prove that stock prices have little or nothing to do with traditional business fundamentals in 2025.

That’s because Polestar posted a 36.5% increase in retail sales and a heady 48.8% increase in revenue (to $2.17 billion) over the year before, Polestar’s share price has plummeted more than 35% in a matter of a few weeks – culminating in an unwelcome nastygram from NASDAQ threatening to delist the company’s shares from the NASDAQ if they didn’t climb back up above $1.

It looks bad

To goose the share price, CarScoops is reporting that Polestar aims to move forward with the reverse stock split before the end of 2025. The expected 1:30 reverse split would boost the PSNY price to an estimated $15.90 per share at current prices, keeping the brand well out of risk of a delisting.

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In a reverse stock split, each share of the company is converted into a fraction of a share – so, if a company announces a one for ten reverse stock split (1:10), every ten shares that you own will be converted into a single share. In a 1:30 reverse split like the one rumored here, every thirty shares in Polestar would become a single share.

The reverse split increases share price, but it’s not without risk:

A company may declare a reverse stock split in an effort to increase the trading price of its shares – for example, when it believes the trading price is too low to attract investors to purchase shares, or in an attempt to regain compliance with minimum bid price requirements of an exchange on which its shares trade … investors may lose money as a result of fluctuations in trading prices following reverse stock splits.

INVESTOR.ORG

That’s especially relevant because, despite the increased sales and revenue, the company is also posting increased losses. Through September, the brand posted a $1.56 billion net loss compared to an $867 million loss in the first nine months of 2024. The company is also getting hit hard by Trump-imposed tariffs in the US and increased downward pressure on pricing coming from aggressive post-tax credit discounts from rival brands like BMW and Kia.

If the split does happen, here’s hoping Polestar can make the most of their borrowed time and they don’t end up like Lordstown Motors or Faraday Future – two brands that have pulled similar reverse stock splits with dubious results.

Electrek’s Take

Make the switch to Polestar. Save up to $20,000 on a Polestar 3 lease as a Tesla owner. — Polestar showroom; via Polestar.

Product-wise, at least, Polestar’s future appears to be bright. The new 3 crossover is a viable competitor to the industry-leading Tesla Model Y, and the upcoming Polestar 4 and 5 models seem like winners, too. To drive that point home, Polestar is promoting up to $18,000 in lease incentives to lure Tesla buyers into their showrooms.

You can find out more about Polestar’s killer EV deals on the full range of Polestar models, from the 2 to the 4, below, then let us know what you think of the three-pointed star’s latest discount dash in the comments section at the bottom of the page.

SOURCE: CarScoops; images via Polestar.

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Environment

Maybe it really SHOULD have been the new Maxima: meet the Nissan N6 EREV

Published

4 hours ago

November 15, 2025

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Maybe it really SHOULD have been the new Maxima: meet the Nissan N6 EREV

Nissan’s New Hybrid Sedan Is As Big An Altima For Thousands Less Than A Versa

With its sleek, uncluttered styling and more than 100 miles of battery-electric range before the extended range electric sedan’s gas engine kicks on, maybe the new Nissan N6 really should have been the next Maxima!

Struggling Japanese carmaker Nissan is dealing with an aging lineup and a brand identity driven more by subprime financing than any suggestion of reliability or sportiness here in the US – but overseas? The brand is rolling out hit after hit, and the latest Nissan N6 plug-in sedan promises exactly the sort of entry-level panache that could change its American fortunes.

“Under our Re:Nissan plan, we are redefining what Nissan delivers today and beyond,” explains Nissan President and CEO Ivan Espinosa. “It’s about strengthening our core, reigniting Nissan’s heartbeat, and creating products that inspire excitement and trust. It is about a sharper, more focused product strategy, a stronger brand, and a renewed commitment to our customers. Integral to this transformation is China — an essential market whose speed, technological leadership, and customer insights are setting the pace for the global auto industry.”

Developed by the Nissan Dongfeng JV in China, the new N6 is more compact that the well-received N7 BEV. In fact, the new Nissan N6, at 190.1″ long, compares nicely to the 192.8″ length of the most recent (and largest-ever) US Maxima, discontinued in 2023. Like the Maxima, the top-shelf version features modern, near-luxe features like soft, leather-like surfaces, LED mood lighting, multi-way adjustable seats, and mimosas or something.

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Mimosas or something

The four or five passengers inside the N6 are propelled down the road exclusively by the car’s 208 hp electric motor, which is efficient enough to take you 112 miles on a full charge of its 21.1 kWh LFP battery. Once that charge is depleted, a 1.5L gas engine kicks on as a high-efficiency generator to keep the good times rolling.

Nissan says the N6′ exterior design, “features a V-Motion signature grille and expressive LED lighting at the front and rear.” And says that the car’s crisp lines give it, “a confident, dynamic presence.”

All of which sounds good on its own, but sounds absolutely miraculous when you consider the car’s Chinese price: ¥106,900 – or about $15,000 US for the base Nissan N6 180 Pro, as I type this.

Even with a nearly 100% markup to give it a $29,990 price tag in the US, I think the N6 would be a huge hit in the North American market. And – good news! – thanks to Canada’s apparent willingness to give Chinese carmakers a shot, we might find out if I’m right somewhat sooner than later.

Check out the Nissan N6 image gallery, below, then let us know what you think of the car’s US and Canadian appeal in the comments.

Nissan N6 gallery

SOURCE | IMAGES: Nissan.

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