Live worm found in woman’s brain in world-first discovery
A woman who was experiencing forgetfulness and depression has had an 8cm-long parasitic roundworm removed from her brain.
The 64-year-old English woman, who was living in New South Wales, Australia, was admitted to hospital in January 2021 after three weeks of abdominal pain and diarrhoea, followed by a dry cough and night sweats.
By 2022, her symptoms had evolved to include forgetfulness and depression, prompting medical professionals to refer her to Canberra hospital.
An MRI scan of her brain revealed that a motile helminth – a parasitic roundworm – was living in the right frontal lobe lesion of her brain.
Surgical intervention became the only option, and doctors successfully removed the roundworm, which measured 8cm (80mm) in length and 1mm in diameter.
The live roundworm after it has been removed from the patient’s right frontal lobe. Pics: Centers for Disease Control and Prevention
Identified as a third-stage larva of the Ophidascaris robertsi nematode species, the case is unprecedented in medical history, and has been documented in the journal of Emerging Infectious Diseases.
Typically, this parasitic worm lives in the digestive tracts of carpet pythons indigenous to the Australian state of New South Wales.
Medical professionals suspect the woman inadvertently ingested the worm’s eggs by eating edible grasses that were tainted with snake faeces, however, the actual cause cannot be confirmed.
After the eggs hatched within her body, medics believe the larvae embarked on a journey to her brain. This could have been influenced by the medication she was taking, which compromised her immune system.
“We hypothesised that she inadvertently consumed eggs either directly from the vegetation or indirectly by contamination of her hands or kitchen equipment,” the medics said.
An image of the woman’s brain showing the right frontal lobe lesion
Ordeal began in 2021 – with evolving symptoms
The woman’s ordeal began in January 2021 when she was admitted to a hospital in Canberra.
Despite comprehensive tests, the results of her numerous medical tests remained inconclusive. Eventually, she received a diagnosis of pneumonia originating from an undisclosed source and was prescribed steroids.
Although her condition initially showed signs of improvement, she found herself readmitted to the hospital a few weeks later, plagued by a fever and an unrelenting cough.
Doctors suspected the presence of T-cell driven hypereosinophilic syndrome, a condition that can be life-threatening, characterised by the immune system going into overdrive. To address this, she was administered immunosuppressing medication as part of her treatment.
The worm seen under a microscope
A CT scan also unveiled multiple troubling findings, including pulmonary opacities, hepatic and splenic lesions.
Three weeks later, her condition worsened, prompting her admission to a tertiary hospital. With persistent fever and cough, her medical team escalated the investigation.
By January 2022, she experienced further changes, including forgetfulness and worsening depression over a three-month period, prompting doctors to examine her brain.
Subsequent scans unveiled a brain lesion, leading to her undergoing surgery in June of the previous year.
‘String-like structure’ discovered in brain
During the surgical procedure, an unusual “string-like structure” was discovered within the lesion, and to doctors’ astonishment, it began to wriggle.
Examination of the worm indicated its affiliation with a family of parasites typically exclusive to snakes. This marked the first documented instance of such a parasite infecting a human.
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Subsequent medical procedures revealed the absence of any additional worms residing within her body.
Half a year after the surgery, while the woman’s forgetfulness and depression had shown signs of improvement, they persisted to some extent.
Medical experts emphasised the significance of ongoing monitoring, as studies on rats have demonstrated that the worm’s eggs can endure within the body for over four years.
But they added that while the species of worm had been known to infect animals’ digestive systems, it had not been discovered in the brain of any species before.
The medics said that while the particular worm in question is exclusive to Australia, there are similar species located in other parts of the world, suggesting the potential for further occurrences in the future.
They also emphasised that the case underscored the persisting danger of zoonotic diseases transmitted between humans and animals.
Zoonotic diseases, which transfer from animals to humans, are frequently mentioned as potential triggers for pandemics.
UK
No 10 backs Chancellor Rachel Reeves and says she ‘is going nowhere’ after tearful appearance in Commons
Rachel Reeves has not offered her resignation and is “going nowhere”, Downing Street has said, following her tearful appearance in the House of Commons.
A Number 10 spokesperson said the chancellor had the “full backing” of Sir Keir Starmer, despite Ms Reeves looking visibly upset during Prime Minister’s Questions.
Politics latest: ‘A moment of intense peril’ for PM
A spokesperson for the chancellor later clarified that Ms Reeves had been affected by a “personal matter” and would be working out of Downing Street this afternoon.
Politics latest: Reeves looks visibly upset in Commons
UK government bond prices fell by the most since October 2022, and the pound tumbled after Ms Reeves’s Commons appearance, while the yield on the 10-year government bond, or gilt, rose as much as 22 basis points at one point to around 4.68%.
Downing Street’s insistence came despite Sir Keir refusing to guarantee that Ms Reeves would stay as chancellor until the next election following the fallout from the government’s recent welfare U-turn.
Tory leader Kemi Badenoch branded the chancellor the “human shield” for the prime minister’s “incompetence” just hours after he was forced to perform a humiliating U-turn over his controversial welfare bill.
Speaking at Prime Minister’s Questions, Ms Badenoch said: “This man has forgotten that his welfare bill was there to plug a black hole created by the chancellor. Instead they’re creating new ones.”
Turning to the chancellor, the Tory leader added: “[She] is pointing at me – she looks absolutely miserable.
“Labour MPs are going on the record saying that the chancellor is toast, and the reality is that she is a human shield for his incompetence. In January, he said that she would be in post until the next election. Will she really?”
Not fully answering the question, the prime minister replied: “[Ms Badenoch] certainly won’t.
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Welfare vote ‘a blow to the prime minister’
“I have to say, I’m always cheered up when she asks me questions or responds to a statement because she always makes a complete mess of it and shows just how unserious and irrelevant they are.”
Mrs Badenoch interjected: “How awful for the chancellor that he couldn’t confirm that she would stay in place.”
The prime minister’s watered-down Universal Credit and Personal Independent Payment Bill, aimed at saving £5bn, was backed by a majority of 75 in a tense vote on Tuesday evening.
A total of 49 Labour MPs voted against the bill – the largest rebellion in a prime minister’s first year in office since 47 MPs voted against Tony Blair’s Lone Parent benefit in 1997, according to Professor Phil Cowley from Queen Mary University.
After multiple concessions made due to threats of a Labour rebellion, many MPs questioned what they were voting for as the bill had been severely stripped down.
They ended up voting for only one part of the plan: a cut to Universal Credit (UC) sickness benefits for new claimants from £97 a week to £50 from 2026/7.
Ms Badenoch said the climbdown was proof that Sir Keir was “too weak to get anything done”.
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Ms Reeves has also borne a lot of the criticism over the handling of the vote, with some MPs believing that her strict approach to fiscal rules has meant she has approached the ballooning welfare bill from the standpoint of trying to make savings, rather than getting people into work.
Experts have now warned that the welfare U-turn, on top of reversing the cut to winter fuel, means that tax rises in the autumn are more likely – with Ms Reeves now needing to find £5bn to make up for the policy U-turns.
Asked by Ms Badenoch whether he could rule out further tax rises – something Labour promised it would not do on working people in its manifesto – Sir Keir said: “She knows that no prime minister or chancellor ever stands at the despatch box and writes budgets in the future.
“But she talks about growth, for 14 years we had stagnation, and that is what caused the problem.”
Prosecutors are considering whether to bring further criminal charges against Lucy Letby over the deaths of babies at two hospitals where she worked
The Crown Prosecution Service said it had received “a full file of evidence from Cheshire Constabulary asking us to consider further allegations in relation to deaths and non-fatal collapses of babies at the Countess of Chester Hospital and Liverpool Women’s Hospital”.
“We will now carefully consider the evidence to determine whether any further criminal charges should be brought,” it added.
“As always, we will make that decision independently, based on the evidence and in line with our legal test.”
Letby, 35, was found guilty of murdering seven children and attempting to murder seven more between June 2015 and June 2016 while working in the neonatal unit of the Countess of Chester Hospital and is currently serving 15 whole-life orders.
Letby worked at the Countess of Chester Hospital and Liverpool Women’s Hospital
She is understood to have carried out two work placements at Liverpool Women’s Hospital, where she trained as a student, between October and December 2012, and January and February 2015.
Police said in December that Letby was interviewed in prison as part of an investigation into more baby deaths and non-fatal collapses.
A Cheshire Constabulary spokesperson said: “We can confirm that Cheshire Constabulary has submitted a full file of evidence to the CPS for charging advice regarding the ongoing investigation into deaths and non-fatal collapses of babies at the neo-natal units of both the Countess of Chester Hospital and the Liverpool Women’s Hospital as part of Operation Hummingbird.”
Detectives previously said the investigation was looking into the full period of time that Letby worked as a nurse, covering the period from 2012 to 2016 and including a review of 4,000 admissions of babies.
Letby’s lawyer Mark McDonald said: “The evidence of the innocence of Lucy Letby is overwhelming,” adding: “We will cross every bridge when we get to it but if Lucy is charged I know we have a whole army of internationally renowned medical experts who will totally undermine the prosecution’s unfounded allegations.”
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Three managers at the hospital where Lucy Letby worked have been arrested on suspicion of gross negligence manslaughter.
On Tuesday, it was confirmed that three managers at the Countess of Chester hospital had been arrested on suspicion of gross negligence manslaughter in a separate investigation.
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Police said the suspects, who occupied senior positions at the hospital between 2015 and 2016, have all been bailed pending further inquiries.
There is also an investigation into corporate manslaughter at the hospital, which began in October 2023.
A public inquiry has also been examining the hospital’s response to concerns raised about Letby before her arrest.
In May, it was announced the inquiry’s final report into how the former nurse was able to commit her crimes will now be published early next year.
Earlier this year, Letby’s lawyers called for the suspension of the inquiry, claiming there was “overwhelming and compelling evidence” that her convictions were unsafe.
In February, an international panel of neonatologists and paediatric specialists told reporters that poor medical care and natural causes were the reasons for the collapses and deaths.
Their evidence has been passed to the Criminal Cases Review Commission (CCRC), which investigates potential miscarriages of justice, and Letby’s legal team hopes her case will be referred back to the Court of Appeal.
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