Microsoft announced Thursday it is teaming up with digital pathology provider Paige to build the world’s largest image-based artificial intelligence model for identifying cancer.
The AI model is training on an unprecedented amount of data that includes billions of images, according to a release. It can identify both common cancers and rare cancers that are notoriously difficult to diagnose, and researchers hope it will eventually help doctors who are struggling to contend with staffing shortages and growing caseloads.
Paige develops digital and AI-powered solutions for pathologists, which are doctors who carry out lab tests on bodily fluids and tissues to make a diagnosis. It’s a specialty that often operates behind the scenes, and it’s crucial for determining a patient’s path forward.
“You don’t have cancer until the pathologist says so. That’s the critical step in the whole medical edifice,” Thomas Fuchs, co-founder and chief scientist at Paige, told CNBC in an interview.
But despite pathologists’ essential role in medicine, Fuchs said their workflow has not changed much in the last 150 years. To diagnose cancer, for instance, pathologists usually examine a piece of tissue on a glass slide under a microscope. The method is tried and true, but if pathologists miss something, it can have dire consequences for patients.
As a result, Paige has been working to digitize the pathologists’ workflow to improve accuracy and efficiency within the specialty.
Doctors working with Paige technology
Source: Paige
The company has received approval from the Food and Drug Administration for its viewing tool FullFocus, which allows pathologists to examine scanned digital slides on a screen instead of relying on a microscope. Paige also built an AI model that can help pathologists identify breast cancer, colon cancer and prostate cancer when it appears on the screen.
Digital pathology is costly
Paige is the only company that has received FDA approval for pathologists to use its AI as a secondary tool for identifying prostate cancer, and CEO Andy Moye said this is likely in part because of barriers related to storage costs and data collection.
Digitizing a single slide can require over a gigabyte of storage, so the infrastructure and costs associated with large-scale data collection balloon quickly. Fuchs said the storage costs can be inhibiting for smaller health systems, which is why wealthy academic centers have historically been the only organizations that can afford to invest in digital pathology.
Paige spun out of the Memorial Sloan Kettering Cancer Center in New York in 2017 and has a “fantastic wealth of data,” according to Moye, which is why the company was able to build its own AI-powered solutions in the first place. To put the scale in perspective, Paige has 10 times more data than Netflix, including all the shows and movies that exist on the platform.
But in order to expand its operations and build an AI tool that can identify more cancer types, Paige turned to Microsoft for help. Over the past year and a half, Paige has been using Microsoft’s cloud storage and supercomputing infrastructure to build an advanced new AI model.
Paige’s original AI model used more than 1 billion images from 500,000 pathology slides, but Fuchs said the model the company has built with Microsoft is “orders of magnitude larger than anything out there.” The model is training on 4 million slides to identify both common and rare cancers, which can be difficult to diagnose. Paige said it is the largest computer vision model that has ever been announced publicly.
“Until ChatGPT got released, no one really understood how this is going to impact their lives. I would argue this is very similar for cancer patients going forward,” Moye said. “This is sort of a groundbreaking, land-on-the-moon kind of moment for cancer care.”
Moye added that the company is thinking of ways to incorporate predictive modeling to give pathologists and patients easy access to information about their biomarkers and genomic mutations down the line.
Desney Tan, vice president and managing director of Microsoft Health Futures, said Microsoft’s infrastructure is a key component of the partnership, but that the company is also working to develop the new algorithms, detection and diagnostics that Paige is hoping to deliver in the next couple of years.
He added that though the technology is powerful, it’s meant to enrich pathologists, not replace them.
“We think of these AI implements, these technologies, as tools, really just as the stethoscope is a tool, just as the X-ray machine is a tool,” Tan told CNBC in an interview. “AI is a tool that is to be wielded by a human.”
On Thursday, Paige and Microsoft will publish a paper on the model through Cornell University’s preprint server arXiv. The paper quantifies the impact of the new model compared with existing models, and Fuchs said it outperforms anything that has been built in academia up to this point.
But the preprint is just the first step of a much longer journey. Paige wanted to make the research available to the broader community while it is under peer review, and the company intends to submit to the scientific journal Nature. The process can take months, if not longer. Paige also has years of work ahead before it will be able to roll the model out as a product — including thorough testing and collaboration with regulators to ensure it is safe and accurate.
Ultimately, Fuchs said the AI model will solve the storage problem for health systems, while also helping pathologists work through cases and arrive at a diagnosis more quickly. For some patients, it could mean the difference between waiting two days and two weeks to find out what’s wrong.
“The more you go away from academic medical centers, especially in community clinics where pathologists are completely overwhelmed across all cancer types with so many cases, there, the impact is quite drastic,” Fuchs said. “That really helps to democratize access to health care in these places.”
Mark Zuckerberg, chief executive officer of Meta Platforms Inc., wears a pair of Meta Ray-Ban Display AI glasses during the Meta Connect event in Menlo Park, California, US, on Wednesday, Sept. 17, 2025.
David Paul Morris | Bloomberg | Getty Images
When it comes to the new $799 Meta Ray-Ban Display glasses, it’s the device’s accompanying fuzzy, gray wristband that truly dazzles.
I was able to try out Meta’s next-generation smart glasses that the social media company announced Wednesday at its annual Connect event. These are the first glasses that Meta sells to consumers with a built-in display, marking an important step for the company as it works toward CEO Mark Zuckerberg’s vision of having headsets and glasses overtake smartphones as people’s preferred form of computing.
The display on the new glasses, though, is still quite simplistic. Last year at Connect, Meta unveiled its Orion glasses, which are a prototype capable of overlaying complex 3D visuals onto the physical world. Those glasses were thick, required a computing puck and were built for demo purposes only.
The Meta Ray-Ban Display, however, is going on sale to the public, starting in the U.S. on Sept. 30.
Though the new glasses include just a small digital display in their right lens, that screen enables unique visual functions, like reading messages, seeing photo previews and reading live captions while having a conversation with someone.
Controlling the device requires putting on its EMG sensor wristband that detects the electrical signals generated by a person’s body so they can control the glasses via hand gestures. Putting it on was just like strapping on a watch, except for the small, electric jolt I felt when it activated. It wasn’t as much of a shock as you feel taking clothes out of the dryer, but it was noticeable.
Donning the new glasses was less shocking, until I had them on and saw the little display emerge, just below my right cheek. The display is like a miniaturized smartphone screen but translucent so as to not obscure real-world objects.
Despite being a high-resolution display, the icons weren’t always clear when contrasted with my real-world field of view, causing the letters to appear a bit murky. These visuals aren’t meant to wrap around your head in crystal-clear fidelity, but are there for you to perform simple actions, like activating the glasses’ camera and glancing at the songs on Spotify. It’s more utility than entertainment.
The Meta Ray-Ban Display AI glasses with the Meta Neural Band wristband at Meta headquarters in Menlo Park, California, US, on Tuesday, Sept. 16, 2025.
David Paul Morris | Bloomberg | Getty Images
I had the most fun trying to perform hand gestures to navigate the display and open apps. By clenching my fist and swiping my thumb on the surface of my pointer finger, I was able to scroll through the apps like I was using a touchpad.
It took me several attempts at first to open the camera app through pinching my index finger and thumb together, and when the app wouldn’t activate I would find myself pinching twice, mimicking the double clicking of a mouse on a computer. But whereas using a mouse is second nature to me, I learned I have subpar pinching skills that lack the correct cadence and timing required to consistently open the app.
It was a bit strange and amusing to see people in front of me while I continuously pinched my fingers to interact with the screen. I felt like I was reenacting an infamous comedy scene from the TV show “The Kids in The Hall” in which a misanthrope watches people from afar while pinching his fingers and saying, “I’m crushing your head, I’m crushing your head!”
With the camera app finally opened, the display showed what I was looking at in front of me, giving me a preview of how my photos and videos would turn out. It was like having my own personal picture-in-picture feature like you would on a TV.
I found myself experiencing some cognitive dissonance at times as my eyes were constantly figuring out what to focus on due to the display always sitting just outside the center of my field of view. If you’ve ever taken a vision test that involves identifying when you see squiggly lines appearing in your periphery, you have a sense of what I was feeling.
Besides pinching, the Meta Ray-Ban Display glasses can also be controlled using the Meta AI voice assistant, just as users can with the device’s predecessors.
When I took a photo of some of the paintings decorating the demo room’s halls, I was told by support staff to ask Meta AI to explain to me what I was looking at. Presumably, Meta AI would have told me I was looking at various paintings from the Bauhaus art movement, but the digital assistant never activated correctly before I was escorted to another part of the demo.
I could see the Meta Ray-Ban Display’s live captions feature being helpful in noisy situations, as it successfully picked up the voice of the demo’s tour guide while dance music from the Connect event blared in the background. When he said “Let’s all head to the next room,” I saw his words appear in the display like closed-captions on a TV show.
But ultimately, I was most drawn to the wristband, particularly when I listened to some music with the glasses via Spotify. By rotating my thumb and index finger as if I was turning an invisible stereo knob, I was able to adjust the volume, an expectedly delightful experience.
It was this neural wristband that really drilled into my brain how much cutting-edge technology has been crammed into the new Meta Ray-Ban Display glasses. And while the device’s high price may turn off consumers, the glasses are novel enough to potentially attract developers seeking more computing platforms to build apps for.
Navan, the business travel, payments, and expense management startup, filed on Friday afternoon to go public.
Its S-1 filing with the Securities and Exchange Commission indicates that the company plans to list on the Nasdaq Global Select Market under the symbol “NAVN.”
Navan reported trailing 12-month revenue of $613 million (up 32%) across over 10,000 customers, and gross bookings of $7.6 billion (up 34%), according to the S-1 filing.
Goldman Sachs and Citigroup will act as lead book-running managers for the proposed offering.
Navan ranked No. 39 on this year’s CNBC Disruptor 50 list, and also made the 2024 list.
The IPO market has bounced back this year, with deal activity up 56% across 156 deals (roughly 200 IPO filings in all) and $30 billion in proceeds, up over 23% year over year, according to IPO tracker Renaissance Capital. It has been the best year for IPOs since 2021, though still far below the Covid offering boom years, when over $142 billion (2021) and $78 billion (2020) was raised by IPOs.
This year’s deal flow has been highlighted by hot AI names like Coreweave, as well as some of the startup world’s most highly valued firms from the past decade, such as fintech Klarna and design firm Figma, crypto companies Circle, Bullish and Gemini, and some long-awaited IPO candidates finally hitting the market, such as Stubhub this week, though its shares have slumped since the first day of trading. Top Amazon reseller Pattern went public on Friday.
Launched by CEO Ariel Cohen and co-founder Ilan Twig in 2015, Navan set out to disrupt a business travel sector where incumbents relied on clunky legacy tools and fragmented workflows.
The Palo Alto-based company, formerly called TripActions, refers to itself as an “all-in-one super app” for corporate travel and expenses.
Customers include Unilever, Adobe, Christie’s, Blue Origin and Geico.
It has also been pushing further into AI, with a virtual assistant named Ava handling approximately 50% of user interactions during the six months ended July 31, according to the filing, and a proprietary AI framework called Navan Cognition supporting its platform, as well as proprietary cloud infrastructure.
“We built Navan for the road warriors, for CEOs and CFOs who understand travel’s critical importance to their strategy, the finance teams who demand precision and control, the executive assistants juggling itineraries, and the program admins ensuring seamless events,” the co-founders wrote in an IPO filing letter.
“We saw firsthand the frustration of clunky, outdated systems. Travelers were forced to cobble together solutions, wait for hours on hold to book or change travel, and negotiate with travel agents. They struggled to adhere to company policies, with little visibility into those policies, and after all that, they spent even more time on tedious expense reports after a trip. We felt the pain of finance teams struggling to gain visibility into fragmented travel spending and to enforce policies, and the frustration of suppliers unable to connect directly with the high-value business travelers they sought to serve,” they wrote in the filing.
Revenue grew 33% year-over-year from $402 million in fiscal 2024 to $537 million in fiscal 2025, according to the S-1 filing. The company reported a net loss that decreased 45% year-over-year from $332 million in fiscal 2024 to $181 million in fiscal 2025. Gross margin improved from 60% in fiscal 2024 to 68% in fiscal 2025.
The business travel and expense space is crowded, with fellow Disruptors Ramp and Brex, and TravelPerk, as well as incumbents like SAP Concur and American Express Global Business Travel.
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A gamer plays soccer title Pro Evolution Soccer 2019 on an Xbox console.
Sezgin Pancar | Anadolu Agency via Getty Images
Microsoft said on Friday that it will increase the recommended retail price of several Xbox consoles in the U.S. starting in October because of “changes in the macroeconomic environment.”
The company said it would not increase prices for accessories such as controllers and headsets, and that prices in other countries would stay the same.
While Microsoft didn’t explicitly attribute the increase to the Trump administration’s tariffs, many consumer companies have been warning for months that higher prices are on the way. President Donald Trump has issued tariffs this year on multiple countries with a stated goal to bring more manufacturing to the U.S.
“We understand that these changes are challenging, and they were made with careful consideration,” Microsoft said on its website.
It’s the second time Microsoft has raised prices on its consoles in the U.S. this year. Rivals Sony and Nintendo have also raisedconsole prices in the U.S. as Trump’s tariffs went into effect.